Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(134 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6222 prodotti di "Apoptosi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
N-Stearoyltyrosine
CAS:N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) is an analog of Anandamide. It exhibits neuroprotective effects by safeguarding the CA1 region of the hippocampus in a gerbil ischemia-reperfusion model. Additionally, N-Stearoyltyrosine inhibits free radical generation, enhances antioxidant capacity, and reduces IR-induced apoptosis (cell apoptosis).Formula:C27H45NO4Colore e forma:SolidPeso molecolare:447.65BM-962
CAS:BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.Formula:C53H58ClF3N6O7S3Colore e forma:SolidPeso molecolare:1079.71Sandacanol
CAS:Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Formula:C14H24OPurezza:99.59%Colore e forma:SolidPeso molecolare:208.34EGFR/VEGFR2-IN-1
EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.Colore e forma:Odour SolidKHKI-01215
KHKI-01215 is a NUAK2 inhibitor with anticancer activity, inhibiting the proliferation of SW480 cancer cells and inducing apoptosis.Formula:C24H26F3IN6OPurezza:98.19%Colore e forma:SolidPeso molecolare:598.4SDU-071
CAS:SDU-071 is a BRD4-p53 inhibitor, suppressing MDA-MB-231 cell proliferation, inducing cell cycle arrest and apoptosis.Formula:C28H25N3O2Purezza:99.54%Colore e forma:SolidPeso molecolare:435.52PI3Kδ-IN-16
CAS:PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.Formula:C22H26N6O2Purezza:99.68%Colore e forma:SoildPeso molecolare:406.48Uvarigrin
CAS:Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.Formula:C37H68O6Purezza:98%Colore e forma:SolidPeso molecolare:608.93Mcl1-IN-12
CAS:Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.Formula:C45H46N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:803Pomalidomide-C5-Dovitinib
CAS:Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity inFormula:C39H38FN9O6Purezza:98%Colore e forma:SolidPeso molecolare:747.771-Alaninechlamydocin
CAS:1-Alaninechlamydocin, a fungal metabolite from Tolypocladium sp., inhibits HDACs and reduces cell proliferation with GI50s 5.3-14 nM.
Formula:C27H36N4O6Colore e forma:SolidPeso molecolare:512.607(-)-Irofulven
CAS:Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.Formula:C15H18O3Colore e forma:SolidPeso molecolare:246.30Sincalide ammonium
CAS:Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.Formula:C49H65N11O16S3Purezza:98.46%Colore e forma:SolidPeso molecolare:1160.3Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.Formula:C38H56N2O4Purezza:98%Colore e forma:SolidPeso molecolare:604.86Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Formula:C18H26AsClN4O9SPurezza:99.74%Colore e forma:SoildPeso molecolare:584.86Photosensitizer-6
CAS:Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.Formula:C47H35AuF6N4P2SColore e forma:SolidPeso molecolare:1060.78MS41
CAS:MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.Formula:C56H70N8O9SColore e forma:SolidPeso molecolare:1031.27HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Formula:C25H33FO3Colore e forma:SolidPeso molecolare:400.53FC-116
CAS:FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.Formula:C21H20FNO4Purezza:98.18%Colore e forma:SoildPeso molecolare:369.39Ref: TM-T77519
1mg52,00€5mg111,00€1mL*10mM (DMSO)127,00€10mg177,00€25mg313,00€50mg447,00€100mg587,00€200mg800,00€KT5823
CAS:KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.Formula:C29H25N3O5Purezza:95%Colore e forma:SolidPeso molecolare:495.53CAY10726
CAS:CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.Formula:C24H36ClF3N2O3Colore e forma:SolidPeso molecolare:493Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Formula:C56H81N13O10SPurezza:99.23%Colore e forma:SolidPeso molecolare:1128.39Ref: TM-T75720
1mg49,00€5mg105,00€10mg172,00€1mL*10mM (DMSO)200,00€25mg268,00€50mg416,00€100mg600,00€Mcl-1 antagonist 1
CAS:Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.Formula:C41H54ClF2N5O8SPurezza:98%Colore e forma:SolidPeso molecolare:850.42VEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.Formula:C72H123N9O6Colore e forma:SolidPeso molecolare:1210.8Phenamet
CAS:Phenamet is a bioactive chemical.Formula:C19H28Cl2N2O3SColore e forma:SolidPeso molecolare:435.41Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Formula:C44H38O14Purezza:98%Colore e forma:Red To Brown PowderPeso molecolare:790.76Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Colore e forma:SolidPeso molecolare:711.729Ajoene
CAS:Ajoene from garlic has antibacterial, anticancer, antiplatelet, and antioxidant effects; it combats various bacteria, yeasts, and cancer cells.
Formula:C9H14OS3Colore e forma:SolidPeso molecolare:234.39FTO-IN-14
FTO-IN-14 (Compound F97) is an inhibitor of the RNA demethylase Fat mass and obesity-associated protein (FTO), with an IC50 of 0.45 μM. It modulates the expression of the ASB2, RARA, and MYC proteins. FTO-IN-14 demonstrates antiproliferative activity in AML cancer cells, with IC50 values of 0.7-5.5 μM against MOLM13, NB4, HEL, OCI-AML3, MV4-11, and MONOMAC6, and induces apoptosis in NB4 cells. Additionally, FTO-IN-14 exhibits antitumor activity in a mouse NB4 xenograft model.Formula:C22H23N3O2SColore e forma:SolidPeso molecolare:393.502Pamlectabart
Pamlectabart is a humanised antibody targeting TNFRSF17/BCMA, (ADC) Pamlectabart tismanitin multiple myeloma.Purezza:95%Colore e forma:LiquidPeso molecolare:145.20 kDaThalidomide-PEG2-NH2
CAS:Thalidomide-PEG2-NH2: synthetic E3 ligase ligand-linker, combines Thalidomide-based cereblon and PROTAC linker.Formula:C17H19N3O6Colore e forma:SolidPeso molecolare:361.354PD-1/PD-L1-IN-49
PD-1/PD-L1-IN-49 (compound 1c) is a potent inhibitor of PD-1/PD-L1 with an IC50 of 77 nM. This compound can activate Jurkat T cells and effectively block the PD-1/PD-L1 immune checkpoint.Formula:C27H32N4O5Colore e forma:SolidPeso molecolare:492.567VK-28
CAS:VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.Formula:C16H21N3O2Purezza:99.87%Colore e forma:SolidPeso molecolare:287.36Ref: TM-T9956
1mg109,00€1mL*10mM (DMSO)225,00€5mg235,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€2,4,6-trichloroanisole
CAS:2,4,6-trichloroanisole inhibits the cell viability of CHO and C32 cell lines and apoptosis, antibacterial activity against Plasmodium falciparum.Formula:C7H5Cl3OPurezza:99.93%Colore e forma:SolidPeso molecolare:211.47Diphenhydramine hydrochloride
CAS:DPH: antihistamine for cough, nausea, itching, allergy, Parkinson's, sleep aid, cold remedy.Formula:C17H22ClNOPurezza:99.84%Colore e forma:Taste Ph (5% Aqueous Solution) 4-6 (Ntp 1992)Peso molecolare:291.82Mcl-1 inhibitor 16
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells.Formula:C25H29Cl2N3PtColore e forma:SolidPeso molecolare:637.51EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormula:C20H21N7O2SPurezza:98%Colore e forma:SolidPeso molecolare:423.49Ganoderic acid Mk
CAS:GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.Formula:C34H50O7Colore e forma:SolidPeso molecolare:570.76YW-N-7 TFA
YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.Formula:C58H63F3N12O9Colore e forma:SolidPeso molecolare:1129.19Hematein
CAS:Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formula:C16H12O6Purezza:98%Colore e forma:Dark Brown Crystalline PowderPeso molecolare:300.268-Aminoadenosine
CAS:8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formula:C10H14N6O4Colore e forma:SolidPeso molecolare:282.26S-Adenosyl-L-methionine
CAS:S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formula:C15H22N6O5SPurezza:99.08%Colore e forma:SolidPeso molecolare:398.44PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Purezza:98%Colore e forma:Odour SolidKRAS inhibitor-40
CAS:KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.Formula:C53H66ClF4N9O8SColore e forma:SolidPeso molecolare:1100.66SRE-II
SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence andFormula:C15H9ClINO2Purezza:98%Colore e forma:SolidPeso molecolare:397.59Tubulin/HDAC-IN-2
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μMFormula:C21H19FN2O4Colore e forma:SolidPeso molecolare:382.382-aminobenzo[d]thiazol-6-ol
CAS:2-aminobenzo[d]thiazol-6-ol: antimicrobial, antioxidant, anticancer; may trigger cancer cell apoptosis.Formula:C7H6N2OSPurezza:98.92%Colore e forma:SolidPeso molecolare:166.22,2'-Dihydroxy chalcone
CAS:2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.Formula:C15H12O3Purezza:99.70%Colore e forma:SolidPeso molecolare:240.25PROTAC GPX4 degrader-1
CAS:PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080Formula:C50H57ClN10O10Colore e forma:SolidPeso molecolare:993.5PROTAC KDM4 degrader-1
PROTACKDM4 degrader-1 (Compound 11) is a proteolysis-targeting chimera (PROTAC) degrader specifically designed for KDM4. It effectively degrades KDM4A-C while sparing KDM4D. In esophageal cancer cells, PROTACKDM4 degrader-1 demonstrates strong antiproliferative activity, inducing apoptosis and cell cycle arrest, and inhibits lysine demethylation of histone H3.Colore e forma:Odour Solid
![2-aminobenzo[d]thiazol-6-ol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT77346.webp&w=3840&q=75)
