Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(11 prodotti)
- Caspasi(142 prodotti)
- FOXO1(3 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(138 prodotti)
- PDK(9 prodotti)
- PERK(25 prodotti)
- Chinasi di serina/treonina(14 prodotti)
- Survivin(14 prodotti)
- TNF(89 prodotti)
- c-RET(56 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 5903 prodotti di "Apoptosi"
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RIP1-IN-1
<p>RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.</p>Colore e forma:Odour SolidPI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inPurezza:98%Colore e forma:Odour SolidPZ703b
CAS:PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formula:C80H102ClF3N10O11S4Colore e forma:SolidPeso molecolare:1600.44Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formula:C41H64N12O12SPurezza:98%Colore e forma:SolidPeso molecolare:949.09(±)-Enterodiol
CAS:"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.36p38-α MAPK-IN-8
<p>p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.</p>Formula:C49H62BrO4PColore e forma:SolidPeso molecolare:825.892PG-11047 2HCl
PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.Formula:C14H34Cl2N4Purezza:97.47%Colore e forma:SolidPeso molecolare:329.35β-Apopicropodophyllin
CAS:<p>β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,</p>Formula:C22H20O7Colore e forma:SolidPeso molecolare:396.39ChoKα inhibitor-5
ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.Formula:C54H68Br2N4S4Colore e forma:SolidPeso molecolare:1061.21AS-99 free base
CAS:AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.Formula:C27H30F3N5O3S2Colore e forma:SolidPeso molecolare:593.68Balstilimab
CAS:<p>Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .</p>Colore e forma:LiquidRopeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Colore e forma:LiquidEchitamine chloride
CAS:Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).Formula:C22H29ClN2O4Colore e forma:SolidPeso molecolare:420.93TD52 dihydrochloride
TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.Formula:C24H18Cl2N4Purezza:97.23%Colore e forma:SoildPeso molecolare:433.33AZT triphosphate TEA
AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.Colore e forma:SolidMofarotene
CAS:<p>Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of</p>Formula:C29H39NO2Purezza:99.96%Colore e forma:SolidPeso molecolare:433.63Mcl-1 inhibitor 12
CAS:Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].Formula:C47H45ClFN7O6Colore e forma:SolidPeso molecolare:858.35Amino-PEG6-Thalidomide
Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.Formula:C27H39N3O10Purezza:98%Colore e forma:SolidPeso molecolare:565.61Aviculin
CAS:Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.Formula:C26H34O10Colore e forma:SolidPeso molecolare:506.54eIF4A3-IN-5
CAS:eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.Formula:C26H22N2O7Colore e forma:SolidPeso molecolare:474.469EAD1
CAS:<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Formula:C24H27Cl2N7Purezza:98%Colore e forma:SolidPeso molecolare:484.42HJC0416 hydrochloride
CAS:HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.Formula:C18H18Cl2N2O4SColore e forma:SolidPeso molecolare:429.31Thalidomide-Piperazine-PEG2-NH2
CAS:Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.Formula:C23H31N5O6Colore e forma:SolidPeso molecolare:473.53Bcl-2-IN-2
CAS:Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Formula:C48H57N7O7SColore e forma:SolidPeso molecolare:876.09hMAO-B-IN-11
hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.Colore e forma:Odour SolidThalidomide-4-C3-NH2 hydrochloride
CAS:Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.Formula:C16H18ClN3O4Colore e forma:SolidPeso molecolare:351.785Antitumor agent-61
CAS:Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.Formula:C54H63FN5O10PColore e forma:SolidPeso molecolare:992.08QN523
CAS:QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.Formula:C14H10N4OPurezza:99.83%Colore e forma:SolidPeso molecolare:250.263-Hydroxykynurenine
CAS:<p>3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.</p>Formula:C10H12N2O4Purezza:98.83% - 99.69%Colore e forma:SolidPeso molecolare:224.21Dimethachlor
CAS:Dimethachlor is a pesticide and herbicide used in wetland areas.Formula:C13H18ClNO2Colore e forma:SolidPeso molecolare:255.74Thalidomide-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.Formula:C19H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:404.42Sudubrilimab
Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.Colore e forma:Odour LiquidPeginterferon β-1a
CAS:Peginterferon beta-1a: first pegylated interferon for cancer, RMS research; induces tumor cell apoptosis.Colore e forma:SolidPomstafib-2
CAS:Pomstafib-2, a potent and selective inhibitor of STAT5b, reduces pSTAT5b expression and effectively induces apoptosis [1] [2].Formula:C52H66N2O20P2Colore e forma:SolidPeso molecolare:1101.0327-O-(tert-Butyldimethylsilyl)withaferin A
CAS:Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.Formula:C34H52O6SiColore e forma:SolidPeso molecolare:584.86Thalidomide-O-C10-NH2
CAS:Thalidomide-O-C10-NH2: synthetic cereblon-based E3 ligase ligand-linker for PROTACs.Formula:C23H31N3O5Colore e forma:SolidPeso molecolare:429.517Thalidomide-O-C2-acid
CAS:Thalidomide-O-C2-acid: E3 ligase ligand-linker for PROTAC, with cereblon-derived Thalidomide component.Formula:C16H14N2O7Colore e forma:SolidPeso molecolare:346.2916Fascaplysin chloride
CAS:Fascaplysin inhibits CDK4/D1 (IC50=0.35μM), triggers caspase-activated autophagy-apoptosis crosstalk, and blocks PI3K/AKT/mTOR in HL-60 cells.Formula:C18H11ClN2OColore e forma:SolidPeso molecolare:306.75Anticancer agent 52
CAS:Anticancer agent 52 exhibits potent cytotoxicity, induces apoptosis, and has potential in bladder cancer research.Formula:C50H43Br2N2PColore e forma:SolidPeso molecolare:862.67INF 195
CAS:INF 195 is an inflammasome NLRP3 inhibitor that can be used to study myocardial ischemia and myocardial infarction.Formula:C17H22ClNO3Purezza:99.78%Colore e forma:SoildPeso molecolare:323.81Thalidomide-Piperazine-PEG3-NH2
CAS:Thalidomide-Piperazine-PEG3-NH2: a cereblon ligand-linker for PROTAC E3 ligase recruitment.Formula:C25H35N5O7Colore e forma:SolidPeso molecolare:517.583Antiproliferative agent-23
Antiproliferative agent-23: destabilizes microtubules, induces apoptosis in cancer cells via mitochondrial path, and triggers ER stress.Formula:C23H28Cl3N3O6PtColore e forma:SolidPeso molecolare:743.93ASR-488
CAS:ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].Formula:C33H40O7SColore e forma:SolidPeso molecolare:580.73Zeluvalimab
CAS:Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].Colore e forma:LiquidDehydrobruceine B
CAS:Dehydrobruceine B, from Brucea javanica, enhances Cisplatin-induced apoptosis by affecting AIF, Bax, and Keap1-Nrf2.Formula:C23H26O11Colore e forma:SolidPeso molecolare:478.45Antibiotic DC 81
CAS:DC 81: Streptomyces-derived antitumor antibiotic, potent nucleic acid synthesis inhibitor, binds DNA sequences, forms covalent adducts.Formula:C13H14N2O3Colore e forma:SolidPeso molecolare:246.262,4-D sodium salt
CAS:<p>Sodium 2,4-dichlorophenoxyacetate: selective herbicide, controls broadleaf weeds by disrupting growth and protein/DNA synthesis.</p>Formula:C8H5Cl2NaO3Colore e forma:SolidPeso molecolare:243.02Opucolimab
CAS:<p>Opucolimab is a human antibody targeting PD-L1, used in advanced solid tumor research and antibody-drug conjugate synthesis.</p>Colore e forma:LiquidOICR12694 TFA
CAS:OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways.Formula:C29H28ClF3N8O4·xC2HF3O2Colore e forma:SolidNSC90616
NSC90616 is a mutant p53 rescue compound [1] .Formula:C23H30FNa2O9PColore e forma:SolidPeso molecolare:546.43
