Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(5 prodotti)
- Caspasi(151 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(105 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(58 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6043 prodotti di "Apoptosi"
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Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.Formula:C38H56N2O4Purezza:98%Colore e forma:SolidPeso molecolare:604.86Sincalide ammonium
CAS:Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.Formula:C49H65N11O16S3Purezza:98.46%Colore e forma:SolidPeso molecolare:1160.3(-)-Irofulven
CAS:Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.Formula:C15H18O3Colore e forma:SolidPeso molecolare:246.30Hydrocinchonine
CAS:Hydrocinchonine is an Alkaloid from Olea europaea and is found in fruits.Formula:C19H24N2OColore e forma:SolidPeso molecolare:296.41Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Colore e forma:Odour Solid1-Alaninechlamydocin
CAS:1-Alaninechlamydocin, a fungal metabolite from Tolypocladium sp., inhibits HDACs and reduces cell proliferation with GI50s 5.3-14 nM.
Formula:C27H36N4O6Colore e forma:SolidPeso molecolare:512.607mTOR inhibitor-27
mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.Colore e forma:Odour SolidAnticancer agent 268
Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.Colore e forma:Odour SolidMitoTam bromide, hydrobromide
CAS:MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.Formula:C52H60Br2NOPPurezza:98%Colore e forma:SolidPeso molecolare:905.821,2,3,4-Tetrahydronaphthalen-2-ol
CAS:1,2,3,4-Tetrahydronaphthalen-2-ol exhibits weak inhibitory activity against Bcl-xL and is widely used in biochemical experiments and drug synthesis research.Formula:C10H12OColore e forma:SolidPeso molecolare:148.2Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formula:C51H84O22Purezza:98%Colore e forma:SolidPeso molecolare:1049.21TNF-α (31-45), human
CAS:TNF-α (31-45), human is a peptide of tumor necrosis factor-α.Formula:C69H122N26O22Purezza:98%Colore e forma:SolidPeso molecolare:1667.895Pomalidomide-C5-Dovitinib
CAS:Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity inFormula:C39H38FN9O6Purezza:98%Colore e forma:SolidPeso molecolare:747.77CV-4-26
CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).Colore e forma:Odour SolidSudubrilimab
Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.Colore e forma:Odour LiquidFW-1
FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.
Formula:C24H27N7OColore e forma:SolidPeso molecolare:429.517BWA-522
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)Formula:C43H51ClN4O7Purezza:98%Colore e forma:SolidPeso molecolare:771.34CDK/HDAC-IN-4
CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.Colore e forma:Odour SolidSF1126
CAS:SF1126 is a first-in-class PI3K/BRD4 inhibitor and RGDS-conjugated LY294002 prodrug, enhancing solubility and targeting tumor integrins.Formula:C39H48N8O14Purezza:98%Colore e forma:SolidPeso molecolare:852.84Theophyllol
CAS:Theophyllol (theophylline sodium acetate) can alter calcium levels in subcellular fractions of rat brain cortex.Formula:C9H10N4Na2O4Colore e forma:SolidPeso molecolare:284.18p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.Formula:C40H51Cl4N5O4Purezza:98%Colore e forma:SolidPeso molecolare:807.68DB818 dihydrochloride
DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).Colore e forma:Odour SolidH3B-8800
CAS:H3B-8800 is an SF3B1 modulator that can be used to study transfusion-dependent anemia.Formula:C31H45N3O6Purezza:98.31%Colore e forma:SoildPeso molecolare:555.71TNF-α-IN-6
CAS:TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
Formula:C26H25N9O2Colore e forma:SolidPeso molecolare:495.547Fisetin quarterhydrate
Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotectiveFormula:C15H10O6H2OColore e forma:SolidPeso molecolare:304.0583SDH-IN-26
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.Colore e forma:Odour SolidPZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Formula:C80H103Cl2F3N10O11S4Colore e forma:SolidPeso molecolare:1636.9Caspase-3 activator 3
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemicPurezza:98%Colore e forma:Odour SolidThalidomide-O-amido-C8-NH2 hydrochloride
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.Formula:C23H31ClN4O6Purezza:98%Colore e forma:SolidPeso molecolare:494.97Tubulin polymerization-IN-72
Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.Formula:C19H19FN4OColore e forma:SolidPeso molecolare:338.379Thalidomide-O-PEG2-propargyl
CAS:Thalidomide-O-PEG2-propargyl is a cereblon-based E3 ligase ligand with a PEG linker for PROTAC-induced protein degradation.Formula:C20H20N2O7Purezza:98%Colore e forma:SolidPeso molecolare:400.38Moracin N
CAS:Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].Formula:C19H18O4Purezza:98%Colore e forma:SolidPeso molecolare:310.34USP7-IN-9
USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.Formula:C32H33ClF6N6O8Colore e forma:SolidPeso molecolare:779.08PROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColore e forma:SolidPeso molecolare:1070.33PROTAC Mcl1 degrader-1
CAS:PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.
Formula:C45H45BrN6O8SPurezza:98.74%Colore e forma:SolidPeso molecolare:909.84MRT-2359
CAS:"MRT-2359: Oral GSPT1 reducer, anti-cancer, targets NSCLC/SCLC, effective on MYC-driven cells."
Formula:C22H17F4N3O6Purezza:98.69%Colore e forma:SoildPeso molecolare:495.38Uvarigrin
CAS:Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.Formula:C37H68O6Purezza:98%Colore e forma:SolidPeso molecolare:608.93BIO8898
BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.Formula:C53H64N8O6Colore e forma:SolidPeso molecolare:909.13Secalonic acid D
CAS:Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.Formula:C32H30O14Colore e forma:SolidPeso molecolare:638.57PZ703b
CAS:PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formula:C80H102ClF3N10O11S4Colore e forma:SolidPeso molecolare:1600.442-deoxy-D-Glucose-13C6
CAS:2-deoxy-D-Glucose-13C6 is an internal standard for GC/LC-MS, a glycolysis inhibitor, and induces apoptosis in certain cells at 2 mg/ml.Formula:C5CH12O5Colore e forma:SoildPeso molecolare:165.15Lisaftoclax
CAS:Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Formula:C45H48ClN7O8SPurezza:97.14% - 99.66%Colore e forma:SolidPeso molecolare:882.42Ref: TM-T10483
1mg177,00€5mg394,00€10mg565,00€25mg837,00€50mg1.121,00€100mg1.520,00€1mL*10mM (DMSO)558,00€Thalidomide-O-C8-NH2
CAS:Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.Formula:C21H27N3O5Colore e forma:SolidPeso molecolare:401.4635-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).Colore e forma:Odour SolidBleomycin A5
CAS:Bleomycin A5, or Pingyangmycin, is an oral glycopeptide antibiotic and acts as an antineoplastic and apoptosis inducer.Formula:C57H89N19O21S2Colore e forma:SolidPeso molecolare:1440.56PD-L1/VISTA-IN-2
PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.Formula:C22H22N2O3Colore e forma:SolidPeso molecolare:362.42Bornyl acetate
CAS:Bornyl acetate (Isobornyl acetate) has an anti-inflammatory effect. It is the volatile ingredient in some Chinese traditional herbs and numerous conifer oils.Formula:C12H20O2Purezza:99.19%Colore e forma:LiquidPeso molecolare:196.29GDCNF-11
CAS:GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.Formula:C48H53Cl2N13O5SColore e forma:SolidPeso molecolare:994.99Hypoxia inducer-1
Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.Formula:C14H12FN3O4Colore e forma:SolidPeso molecolare:305.261Thalidomide-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.Formula:C19H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:404.42
