Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(2 prodotti)
- Caspasi(153 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(94 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(49 prodotti)
- c-RET(60 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6034 prodotti di "Apoptosi"
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Thalidomide-Piperazine-PEG3-NH2
CAS:Thalidomide-Piperazine-PEG3-NH2: a cereblon ligand-linker for PROTAC E3 ligase recruitment.Formula:C25H35N5O7Colore e forma:SolidPeso molecolare:517.583Betamethasone
CAS:Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.Formula:C22H29FO5Purezza:98% - 99.71%Colore e forma:White Or Almost White Powder Solid CrystallinePeso molecolare:392.46Ac-AAVALLPAVLLALLAP-DEVD-CHO
CAS:Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) serves as a potent and reversible inhibitor of caspase-3 [1].Formula:C94H158N20O27Purezza:98%Colore e forma:SolidPeso molecolare:2000.38YB-0158 ammonium
YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic with translation-enhancing potential and anticancer activity.Formula:C32H40N9O7PPurezza:99.14% - 99.18%Colore e forma:SolidPeso molecolare:693.69AFMK
CAS:AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.Formula:C13H16N2O4Purezza:98.34% - 99.81%Colore e forma:SolidPeso molecolare:264.28Desmethyl-WEHI-345 analog
CAS:Desmethyl-WEHI-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.Formula:C22H23N7OColore e forma:SolidPeso molecolare:401.474RIPK1-IN-25
RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.Colore e forma:Odour SolidYN14-H
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.Colore e forma:Odour SolidRasagiline
CAS:Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons
Formula:C12H13NPurezza:98% - 99.87%Colore e forma:SolidPeso molecolare:171.24Calcimycin hemimagnesium
CAS:Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.Formula:C58H72MgN6O12Colore e forma:SolidPeso molecolare:1069.53DS-5272
CAS:DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.Formula:C34H38Cl2F2N6O2SColore e forma:SolidPeso molecolare:703.67Thalidomide-NH-PEG4-COOH
CAS:Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.Formula:C24H31N3O10Colore e forma:SolidPeso molecolare:521.523RA-XII
CAS:RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.Formula:C46H58N6O14Colore e forma:SolidPeso molecolare:918.998M24
CAS:M24 inhibits Mcl-1 (Ki = 0.33μM), blocks HepG2 cell growth, and triggers apoptosis.Formula:C44H40Cl3N5O11SColore e forma:SolidPeso molecolare:953.24SM-164 Hydrochloride
SM-164 Hydrochloride: Smac mimetic, cell-permeable, binds XIAP BIR2 and BIR3, IC50 of 1.39 nM, potent XIAP antagonist.Formula:C62H85ClN14O6Colore e forma:SolidPeso molecolare:1157.88YX0798
YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM). It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.Formula:C21H19ClF3N5O2Colore e forma:SolidPeso molecolare:465.86EGFR-IN-143
EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.Formula:C20H21ClN6O3Colore e forma:SolidPeso molecolare:428.87227-O-(tert-Butyldimethylsilyl)withaferin A
CAS:Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.Formula:C34H52O6SiColore e forma:SolidPeso molecolare:584.86PROTAC 20S proteasome subunit β5 degrader 1
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.Colore e forma:Odour SolidMDM2 ligand 4
MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].Formula:C31H33Cl2FN2O4Colore e forma:SolidPeso molecolare:587.509EGFR/VEGFR2-IN-1
EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.Colore e forma:Odour SolidNMC-001
NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidOpnurasib
CAS:Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-smallFormula:C29H28ClN7OPurezza:98.88%Colore e forma:SolidPeso molecolare:526.03Ref: TM-T40292
1mg105,00€5mg354,00€10mg527,00€25mg848,00€50mgPrezzo su richiesta1mL*10mM (DMSO)406,00€Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.37PRLX-93936 HCL
CAS:PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formula:C21H26Cl2N4O2Purezza:98.4% - 99.94%Colore e forma:SolidPeso molecolare:437.37Anticancer agent 130
Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].Formula:C38H46FN5O5Purezza:98%Colore e forma:SolidPeso molecolare:671.8Asparanin A
CAS:Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.Formula:C39H64O13Purezza:98%Colore e forma:SolidPeso molecolare:740.92eIF4E-IN-1
CAS:eIF4E-IN-1 inhibits eIF4E and boosts immunity by targeting PD-1, PD-L1, LAG3, TIM3, IDO, aiding cancer and infection treatment.Formula:C33H28ClF3N6O4SColore e forma:SolidPeso molecolare:697.13PTP1B-IN-30
PTP1B-IN-30 (Compound 3j) is an inhibitor of PTP1B with an IC50 of 0.51 µM. It suppresses the proliferation of T47D cancer cells with an IC50 of 21.21 µM, induces cell cycle arrest at the S phase, and triggers apoptosis in T47D cells.Formula:C22H21N3O5SColore e forma:SolidPeso molecolare:439.48Schisandronic acid
CAS:Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.Formula:C30H46O3Colore e forma:SolidPeso molecolare:454.68FLT3/HDAC-IN-1
FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.Colore e forma:Odour SolidPRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purezza:98%Colore e forma:SolidPeso molecolare:336.43ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formula:C110H210N52O26Purezza:99.55%Colore e forma:SolidPeso molecolare:2677.18VEGFR-2-IN-53
VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.Colore e forma:Odour SolidMethylene Violet 3RAX
CAS:Methylene Violet 3RAX is a cationic dye that is a potential photosensitizer in photodynamic therapy and has antitumor activity.Formula:C22H23ClN4Purezza:97.03% - 97.17%Colore e forma:SolidPeso molecolare:378.9Eriosematin
CAS:Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.Formula:C19H20O4Purezza:98%Colore e forma:SolidPeso molecolare:312.36DJ4
CAS:DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.Formula:C19H16N4OSPurezza:97.22%Colore e forma:SoildPeso molecolare:348.42Pyridinium bisretinoid A2E TFA
CAS:Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediatesFormula:C44H58F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:705.93Cholicamideβ
Cholicamideβ (compound 6), a self-assembling small molecule cancer vaccine adjuvant, forms low cytotoxicity virus-like particles and upon binding to peptideFormula:C55H94N2O6Purezza:98%Colore e forma:SolidPeso molecolare:879.34EAD1
CAS:EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.
Formula:C24H27Cl2N7Purezza:98%Colore e forma:SolidPeso molecolare:484.42MC-25B
MC-25B is a selective FKBP12 PROTAC degrader. It effectively degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a mechanism dependent on DCAF16.Formula:C65H92ClN7O14Colore e forma:SolidPeso molecolare:1230.92Anticancer agent 205
Anticanceragent 205 (compound 9) is an effective anticancer agent that binds to the G4-mtDNA target, inhibiting the replication, transcription, and translation of mtDNA (mitochondrial genome). It induces mitochondrial dysfunction, increases ROS production, and triggers DNA damage and cellular senescence. Anticanceragent 205 also promotes apoptosis and causes cell cycle arrest at the G0/G1 phase, showing potential for research in colorectal cancer.Formula:C52H60I2N4Peso molecolare:994.29074Anticancer agent 134
Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normalFormula:C34H36ClN7O3S2Purezza:98%Colore e forma:SolidPeso molecolare:690.28CDK9-IN-36
CDK9-IN-36 (Compound T7) is a potent, selective, and metabolically stable CDK9 inhibitor with an IC50 value of 1.2 nM. It effectively suppresses the proliferation of Osimertinib-resistant NSCLC cells by downregulating Mcl-1, reducing colony formation, and inducing apoptosis. Additionally, CDK9-IN-36 exhibits antitumor activity in xenograft models.Formula:C30H33F2N5O4Colore e forma:SolidPeso molecolare:565.61Aphidicolin
CAS:Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.Formula:C20H34O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:338.48Topoisomerase II inhibitor 14
CAS:Topoisomerase II inhibitor 14: powerful anticancer agent that induces apoptosis, halts S phase, and lowers GSH, MDA, and NO levels.Formula:C15H11Cl2N5Purezza:99.95%Colore e forma:SoildPeso molecolare:332.19Hypoxia inducer-1
Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.Formula:C14H12FN3O4Colore e forma:SolidPeso molecolare:305.261AXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1 (compound 11b) is an inhibitor of AXL/triple angiokinase, with an IC50 of 3.75 nM for AXL expression. This compound suppresses epithelial-mesenchymal transition (EMT) in Bxpc-3 cells and prevents metastasis in lung cancer cells. Additionally, AXL/Angiokinase-IN-1 impairs the functions of vascular and fibroblast cells and induces apoptosis in both cancer and fibroblast cells. It is characterized by low toxicity and favorable metabolic stability.Formula:C31H34ClN5O2Colore e forma:SolidPeso molecolare:544.09cis-Clovamide
CAS:cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.Formula:C18H17NO7Colore e forma:SolidPeso molecolare:359.334Type-I/-II Photosensitizer-1
Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer properties. It exhibits significant phototoxicity against A549 and 4T1 tumor cells. Under laser irradiation, Type-I/-II Photosensitizer-1 demonstrates strong oxygen-independent antitumor activity with an IC50 ranging from 1.50 to 1.76 μM.Formula:C60H48F12N8P2RuColore e forma:SolidPeso molecolare:1272.07
