Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(3 prodotti)
- Caspasi(153 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(92 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(49 prodotti)
- c-RET(60 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6031 prodotti di "Apoptosi"
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Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Formula:C44H38O14Purezza:98%Colore e forma:Red To Brown PowderPeso molecolare:790.76Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Colore e forma:SolidPeso molecolare:711.729Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)
Anti-MousePD-1(LALA-PG) Antibody (RMP1-14) is an IgG2a, κ antibody inhibitor derived from mice that targets and inhibits mouse PD-1.Colore e forma:Odour LiquidChoKα inhibitor-3
ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability toFormula:C50H54Br2Cl2N4S2Colore e forma:SolidPeso molecolare:1005.83Caspase-3/7 activator 1
Caspase-3/7 activator 1 is an effective activator of Caspase-3/7 that exhibits tumor-selective, antiproliferative activity and high apoptosis (Apoptosis) induction capability.Formula:C26H28N2O5Peso molecolare:448.19982PBE-AMF
PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.Colore e forma:Odour SolidThalidomide-Piperazine-Piperidine
CAS:Thalidomide-based E3 ligase ligand linked to a PROTAC piperazine-piperidine chain.Formula:C22H27N5O4Colore e forma:SolidPeso molecolare:425.489CIGB-300 acetate
CIGB-300 acetate (P15-Tat acetate) is a peptide that acts as an inhibitor of casein kinase 2 (CK2). It exhibits anticancer properties by disrupting the phosphorylation activity of CK2. CIGB-300 acetate induces apoptosis in various tumor cell lines and is applicable for cancer research.Colore e forma:Odour SolidTQB-2858
TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).
Colore e forma:Odour LiquidGNE-1567
GNE-1567 is a potent ERα PROTAC degrader and a selective antagonist of XIAP, with a Kd of 0.03 μM. It is applicable in breast cancer research.Colore e forma:Odour SolidAjoene
CAS:Ajoene from garlic has antibacterial, anticancer, antiplatelet, and antioxidant effects; it combats various bacteria, yeasts, and cancer cells.
Formula:C9H14OS3Colore e forma:SolidPeso molecolare:234.39Bcl-2-IN-14
Bcl-2-IN-14 (Compound 13c), a BCL-2 inhibitor, exhibits an inhibitory concentration (IC 50) of 0.471 μM, and is applicable in cancer research [1].Colore e forma:Odour SolidPD-1/PD-L1-IN-40
PD-1/PD-L1-IN-40 (Compound EP16) is a PD-1/PD-L1 inhibitor. It effectively suppresses the production of exosomal PD-L1 with an IC50 of 0.108 μM. PD-1/PD-L1-IN-40 serves as a lead compound for the elimination of exosomal PD-L1 and is applicable in cancer research.Formula:C20H22N4O2Peso molecolare:350.17428SHOC2-RAS PPI-IN-1
SHOC2–RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor that targets the interaction between SHOC2 and RAS proteins. It exhibits an IC50 of 0.048 μM and a KD of 0.065 μM against NRASQ61R. This compound inhibits SMP phosphatase-complex activity, increasing CRAFS259 phosphorylation levels and thus blocking the MAPK signaling pathway (by reducing pMEK and pERK levels). It induces cell cycle arrest and apoptosis in tumor cells. SHOC2–RAS PPI-IN-1 is used in targeting studies for malignancies, such as NRASQ61R-mutant melanoma and colorectal cancer.Colore e forma:Odour SolidPZ671
PZ671 is a potent PROTAC degrader targeting Bcl-xL, exhibiting an IC50 of 1.3 nM in MOLT-4 cells and a DC50 of 0.9 nM for Bcl-xL. It induces apoptosis in MOLT-4 cells and effectively inhibits tumor growth in MOLT-4 xenograft mice, while quickly restoring transiently reduced platelet counts. PZ671 is applicable in cancer research, including studies on small cell lung cancer.Colore e forma:Odour Solid4-N-Nonyloxyphenol
CAS:4-N-Nonyloxyphenol, kaolinite nanotube photosensitizer, degrades phenolic pesticides, and disrupts endocrine.
Formula:C15H24O2Purezza:99.94%Colore e forma:SoildPeso molecolare:236.35Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Formula:C197H295N47O56Peso molecolare:4215.16808NL13
NL13, a Polo-like kinase 4 (PLK4) inhibitor, exhibits an IC 50 value of 2.32 μM. It demonstrates the ability to suppress the viability of PC3 and DU145 prostate cancer cells with respective IC 50 values of 3.51 μM and 2.53 μM. NL13 also inhibits tumor growth in prostate cancer mice. Additionally, it deactivates the AKT signaling pathway by reducing CCNB1/CDK1 levels, leading to G2/M cell cycle arrest and initiating apoptosis through caspase-9/caspase-3 cleavage.Formula:C22H19Cl2NO2Colore e forma:SolidPeso molecolare:400.3(E)-Ajoene
CAS:(E)-Ajoene, found in A. sativum, fights bacteria (MICs: 10-500 μg/ml), fungi (MICs: 15-50 μg/ml), cancer cells, and protects neurons in ischemia.Formula:C9H14OS3Colore e forma:SolidPeso molecolare:234.39Thalidomide-O-C7-acid
CAS:Thalidomide-O-C7-acid: A cereblon ligand from Thalidomide linked via a PROTAC-used linker.Formula:C21H24N2O7Colore e forma:SolidPeso molecolare:416.43EGCG-4″-sulfate
CAS:EGCG-4″-sulfate, a predominant polyphenol in green tea, demonstrates notable anticancer, antioxidant, and anti-inflammatory effects, particularly againstFormula:C22H18O14SColore e forma:SolidPeso molecolare:538.43WH244
CAS:WH244 is a second-generation dual degrader (PROTAC) targeting BCL-2 and BCL-xL proteins. It effectively degrades these proteins with high specificity, exhibiting a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2. By promoting ubiquitination and subsequent proteasomal degradation of these proteins, WH244 restores apoptotic pathways in cells. The compound shows strong antitumor activity.Formula:C83H105ClF3N13O11S4Colore e forma:SolidPeso molecolare:1681.51DAPK Substrate Peptide
CAS:DAPK Substrate Peptide is a synthetic peptide substrate for death-associated protein kinase (DAPK) (Km = 9 μM).
Formula:C70H115N25O17Purezza:98%Colore e forma:SolidPeso molecolare:1578.82Methyl-4-oxoretinoate
CAS:Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.Formula:C21H28O3Purezza:99.95%Colore e forma:SolidPeso molecolare:328.45FASN/SCD-IN-1
FASN/SCD-IN-1 is a Silybin derivative and an orally active inhibitor of fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD). In vitro, FASN/SCD-IN-1 demonstrates the ability to inhibit lipid deposition, reduce the transcription levels of FASN and SCD, and exhibits antioxidant, anti-inflammatory, and antifibrotic activities. It shows significant hepatoprotective effects in rat models of acute liver injury and improves pathological features such as steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative-associated steatohepatitis (MASH). FASN/SCD-IN-1 can be used for MASH research.Colore e forma:Odour SolidAzalamellarin N
CAS:Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].Formula:C28H22N2O7Colore e forma:SolidPeso molecolare:498.48Biotin-PEG6-Thalidomide
CAS:Biotin-PEG6-Thalidomide is a PROTAC linker based on PEG.Formula:C37H53N5O12SPurezza:98%Colore e forma:SolidPeso molecolare:791.91Tat-ASIC1a (1-20) (mouse, rat)
Tat-ASIC1a (1-20) (mouse, rat) is a competitive ASIC1a transmembrane peptide with significant neuroprotective effects. It alleviates acidotoxic neuronal damage by targeting the ASIC1a-RIPK1 pathway and an auto-inhibition mechanism. This compound effectively safeguards the brain in ischemic stroke mouse models against damage from ischemia and is applicable in research on neurodegenerative diseases, such as Huntington's disease and Parkinson’s disease.Colore e forma:Odour SolidTTQ-SA
TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.Formula:C78H53N7SColore e forma:SolidPeso molecolare:1120.37VEGFR2/HDAC1-IN-1
VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC.Purezza:98%Colore e forma:Odour SolidHQY1428
HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.Formula:C25H28ClFN6O3SColore e forma:SolidPeso molecolare:546.16162XIAP ligand-Linker Conjugate 2
XIAPligand-Linker Conjugate 2 is an E3 ubiquitin ligase ligand-linker conjugate (E3 ligase Ligand-linker conjugate) that includes the XIAPBIR2 ligand XB2M54 and a linker. It is utilized in the synthesis of PROTACGNE-1567.Colore e forma:Odour SolidIsoharringtonine
CAS:Isoharringtonine, an alkaloid from Cephalotaxus koreana, inhibits and induces apoptosis in cancer cells.Formula:C28H37NO9Colore e forma:SolidPeso molecolare:531.59(+)-Mcl-1 inhibitor 22
CAS:(+)-Mcl-1 inhibitor 22 (Example 37) is an MCL-1 inhibitor that impedes the anti-apoptotic function of MCL-1 by blocking its interaction with pro-apoptotic proteins. It demonstrates antiproliferative activity against various cancer cell lines and is applicable for cancer research.Formula:C33H33ClFN3O4Colore e forma:SolidPeso molecolare:590.084c-MYC/BCL2 ligand 1 iodide
c-MYC/BCL2 ligand 1 iodide is a dual-target ligand that specifically interacts with the G-quadruplex (G4) regions of the c-MYC and Bcl-2 promoters, exhibiting Kd values of 0.90 μM for c-MYCG4 and 0.56 μM for Bcl-2G4. It works by binding to these G4-forming sequences to inhibit transcription of the c-MYC and Bcl-2 genes, leading to reduced protein expression. This compound effectively suppresses MCF-7 cell proliferation and migration, induces G1 phase cell cycle arrest, and triggers apoptosis. Additionally, it significantly hampers tumor growth in the 4T1 homogenous model with negligible toxicity. c-MYC/BCL2 ligand 1 iodide is applicable in breast cancer research.Colore e forma:Odour SolidPROTAC FGFR2 degrader 1
PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0/G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.Colore e forma:Odour Solid(E)-C-HDMAPP (ammonium salt)
CAS:Alkyl phosphates like (E)-C-HDMAPP activate γδ-T cells, resist hydrolysis, and boost TNF-α synthesis and γδ-T cell count in vivo.
Formula:C6H23N3O7P2Colore e forma:SolidPeso molecolare:311.21FGFR1/VEGFR2-IN-2
FGFR1/VEGFR2-IN-2 (compound 6) is a dual inhibitor targeting both VEGFR2 and FGFR1 with IC50 values of 0.025 µM and 0.026 µM, respectively. This compound also exhibits inhibitory effects on EGFR and PDGFR-β, with IC50 values of 0.106 µM and 0.077 µM, respectively. FGFR1/VEGFR2-IN-2 demonstrates significant anticancer activity in the NCI-60 cell lines, showing a growth inhibition (GI) of 60.38%. In T-47D cell lines, it achieves an IC50 of 8.51 µM, exhibits anti-migratory properties, induces cell cycle arrest in the G1 phase, and promotes both apoptosis and necrosis. Additionally, while it has an IC50 greater than 100 µM in MCF-7 cell lines, it does so with an IC50 of 69.17 µM in MDA-MB-231 cell lines and shows no toxicity to normal cells.Formula:C21H15ClF3NO4SColore e forma:SolidPeso molecolare:469.86RET-IN-26
RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].Colore e forma:Odour SolidGlutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Formula:C18H26AsClN4O9SPurezza:99.74%Colore e forma:SoildPeso molecolare:584.86TNF-α-IN-6
CAS:TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
Formula:C26H25N9O2Colore e forma:SolidPeso molecolare:495.547ADH-6 TFA
ADH-6 TFA disrupts mutant p53 self-assembly in cancer, restores function, and induces cell cycle arrest and apoptosis.Formula:C31H37F3N8O11Colore e forma:SolidPeso molecolare:754.67Apoptosis inducer 24
CAS:Apoptosisinducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with an IC50 range of 1.2-4.8 μM. It arrests the cell cycle at the G2/M phase, induces apoptosis in BGC-823 cells, and causes mitochondrial dysfunction. In mice, Apoptosisinducer 24 exhibits antitumor activity without significant toxicity, having an LD50 of 91.2 mg/kg.Formula:C55H70BNO9Colore e forma:SolidPeso molecolare:899.96SL-01
CAS:SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.Formula:C18H18ClNO3Purezza:98%Colore e forma:White PowderPeso molecolare:331.79HDSI-18
HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.Formula:C28H28N4O5Colore e forma:SolidPeso molecolare:500.20597PROTAC EGFR degrader 14
PROTACEGFRdegrader 14 is a potent and selective EGFR PROTAC degrader with a DC50 value of approximately 2.9 nM against EGFRL858R/T790M/C797S and a Dmax of 93.1%. It induces the selective degradation of EGFRC797S via a VHL and proteasome-dependent mechanism, downregulating EGFR-related transcriptomes. PROTACEGFRdegrader 14 exhibits high selectivity for EGFRWT, induces cell cycle arrest and apoptosis, and effectively inhibits tumor growth. It is applicable for research on non-small cell lung cancer (NSCLC).Colore e forma:Odour SolidDB0614
CAS:DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.Formula:C41H42N8O7S2Colore e forma:SolidPeso molecolare:822.95p53-HDM2-IN-1
p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM.Formula:C35H38F6N4O7SColore e forma:SolidPeso molecolare:772.75XY221
XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.Formula:C32H34FN3O5Colore e forma:SolidPeso molecolare:559.628Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formula:C40H38F6N8O13Colore e forma:SolidPeso molecolare:952.77
