Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(126 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(90 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6170 prodotti di "Apoptosi"
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Thalidomide-O-amido-C3-NH2
CAS:Thalidomide-derived cereblon ligand linked to a PROTAC technology linker, Thalidomide-O-amido-C3-NH2, is a synthetic E3 ligase ligand-linker.Formula:C18H20N4O6Colore e forma:SolidPeso molecolare:388.37Thalidomide-O-amido-C4-N3
CAS:Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand andFormula:C19H20N6O6Purezza:97.01%Colore e forma:SolidPeso molecolare:428.4Mcl-1 inhibitor 16
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells.Formula:C25H29Cl2N3PtColore e forma:SolidPeso molecolare:637.51HG-7-85-01
CAS:HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Formula:C31H31F3N6O2SPurezza:98.08%Colore e forma:SolidPeso molecolare:608.68GPLGIAGQ
CAS:GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Formula:C31H53N9O10Purezza:98%Colore e forma:SolidPeso molecolare:711.81Anticancer agent 102
CAS:Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].Formula:C20H19F6N3OColore e forma:SolidPeso molecolare:431.37HDAC3-IN-6
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.Formula:C23H23N5O3Colore e forma:SolidPeso molecolare:417.46Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Colore e forma:SolidPeso molecolare:695.742Thalidomide-O-amido-C6-NH2
CAS:Thalidomide-O-amido-C6-NH2 is a synthetic E3 ligase used for PROTAC creation, containing cereblon ligand and linker.Formula:C21H26N4O6Colore e forma:SolidPeso molecolare:430.45Hematein
CAS:Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formula:C16H12O6Purezza:98%Colore e forma:Dark Brown Crystalline PowderPeso molecolare:300.26Curcumin 5-8
CAS:CUR5-8: potent, oral CUR analog, reduces lipid droplets, boosts autophagy, hinders apoptosis, enhances insulin sensitivity.Formula:C20H21NO4Colore e forma:SolidPeso molecolare:339.39LH1307
CAS:LH1307 blocks PD-1/PD-L1 interaction, IC50 = 3 nM (HTRF assay), activates Jurkat cells, EC50s: 79 nM (U2OS), 763 nM (CHO).
Formula:C54H58N8O6Colore e forma:SolidPeso molecolare:915.108FF2039
FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.Formula:C43H56Cl3N5O6Colore e forma:SolidPeso molecolare:845.29PROTAC EGFR degrader 7
Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.Formula:C46H48N10O6Colore e forma:SolidPeso molecolare:836.948-Aminoadenosine
CAS:8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formula:C10H14N6O4Colore e forma:SolidPeso molecolare:282.26Antiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.Formula:C20H21BrN2O2Purezza:98%Colore e forma:SolidPeso molecolare:401.3PB28
CAS:PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.Formula:C24H38N2OColore e forma:SolidPeso molecolare:370.581Linsidomine
CAS:Lincydomine relaxes smooth muscles, treats unstable angina, and opens human and guinea pig respiratory tracts.Formula:C6H10N4O2Colore e forma:Solid Off-WhitePeso molecolare:170.17S-Adenosyl-L-methionine
CAS:S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formula:C15H22N6O5SPurezza:99.08%Colore e forma:SolidPeso molecolare:398.44Oxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formula:C14H9D3O3Colore e forma:SolidPeso molecolare:231.26EGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Purezza:98%Colore e forma:Odour SolidABBV-167
CAS:ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.Formula:C46H53ClN7O11PSColore e forma:SolidPeso molecolare:978.45TNF/IFNγ-IN-1
CAS:TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formula:C20H23N3O6Purezza:99.39%Colore e forma:SoildPeso molecolare:401.41PAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formula:C14H8Au5B2F8N2Colore e forma:SolidPeso molecolare:1348.66Thalidomide-NH-PEG7
Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.Formula:C27H39N3O11Purezza:98%Colore e forma:SolidPeso molecolare:581.61PD0166285 dihydrochloride
CAS:PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.Formula:C26H29Cl4N5O2Colore e forma:SolidPeso molecolare:585.354-Epianhydrotetracycline hydrochloride
CAS:EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.Formula:C22H23ClN2O7Colore e forma:SolidPeso molecolare:462.88Z-Asp-CH2-DCB
CAS:Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.Formula:C20H17Cl2NO7Purezza:99.08%Colore e forma:SolidPeso molecolare:454.262,2'-Dihydroxy chalcone
CAS:2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.Formula:C15H12O3Purezza:99.70%Colore e forma:SolidPeso molecolare:240.25PROTAC GPX4 degrader-1
CAS:PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080Formula:C50H57ClN10O10Colore e forma:SolidPeso molecolare:993.5RMC-6291
CAS:RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.Formula:C55H78FN9O8Purezza:98.73% - 99.92%Colore e forma:SolidPeso molecolare:1012.26PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purezza:98%Colore e forma:SolidPeso molecolare:336.43S65487 hydrochloride
CAS:S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Formula:C41H42Cl2N6O4Colore e forma:SolidPeso molecolare:753.73Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.37Thalidomide-NH-C6-NH2 TFA
CAS:Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.Formula:C21H25F3N4O6Purezza:98%Colore e forma:SolidPeso molecolare:486.44YN14-H
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.Colore e forma:Odour SolidBMf-BH3
BMf-BH3 is a Bcl-2 family peptide, key in HDAC inhibition affecting acetylation balance.Formula:C131H214N45O35SPurezza:98%Colore e forma:SolidPeso molecolare:3012.5Thalidomide-NH-C5-NH2 hydrochloride
CAS:Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.Formula:C18H23ClN4O4Colore e forma:SolidPeso molecolare:394.85EPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formula:C25H39ClN4O3Purezza:99.88%Colore e forma:SolidPeso molecolare:479.05Ref: TM-T22325
1mg57,00€5mg124,00€10mg203,00€25mg350,00€50mg533,00€100mg763,00€1mL*10mM (DMSO)138,00€PROTAC HDAC6 degrader 1
CAS:Compound A6, a potent PROTAC HDAC6 degrader, has a DC50 of 3.5 nM and induces apoptosis in myeloid leukemia cells.Formula:C37H46N6O10Colore e forma:SolidPeso molecolare:734.8Thalidomide-NH-C6-NH2
CAS:Thalidomide-NH-C6-NH2 is a synthetic conjugate compound designed as an E3 ligase ligand-linker.Formula:C19H24N4O4Purezza:98%Colore e forma:SolidPeso molecolare:372.42MET/PDGFRA-IN-2
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positiveFormula:C29H29N7OPurezza:98%Colore e forma:SolidPeso molecolare:491.59Etoposide phosphate disodium
CAS:Etoposide phosphate disodium, a prodrug of etoposide, is a powerful anticancer drug inhibiting DNA topoisomerase II.
Formula:C29H31Na2O16PColore e forma:SolidPeso molecolare:712.5DPP-4-IN-8
DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM.Formula:C16H12ClNO6Colore e forma:SolidPeso molecolare:349.72EGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Formula:C22H17F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:410.39MPP hydrochloride
MPP hydrochloride is a selective estrogen receptor (ERR) modulator.Formula:C29H32ClN3O3Purezza:99.75% - 99.90%Colore e forma:SolidPeso molecolare:506.04Ref: TM-T21897L
1mg50,00€5mg99,00€10mg160,00€25mg313,00€50mg528,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)110,00€EGFR-IN-144
EGFR-IN-144 (Compound 4B) inhibits EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). It exhibits cytotoxicity in various cancer cells with a GI50 at the nanomolar level. EGFR-IN-144 reduces the expression of mTOR, TNF-α, and IL-6, causes G1/S phase cell cycle arrest, and induces apoptosis.Formula:C20H17Cl2N3O3Colore e forma:SolidPeso molecolare:418.273CXCR4-IN-2
CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50:Formula:C21H20F6N4SPurezza:98%Colore e forma:SolidPeso molecolare:474.47EM 163
CAS:EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。Formula:C44H60IN5O4Purezza:98.62%Colore e forma:SolidPeso molecolare:849.88Ref: TM-T41142
1mg114,00€5mg264,00€10mg354,00€25mg592,00€50mg843,00€100mg1.144,00€500mg2.295,00€1mL*10mM (DMSO)414,00€Taxamairin B
CAS:Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces theFormula:C22H24O4Colore e forma:SolidPeso molecolare:352.42
