Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(126 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(90 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6165 prodotti di "Apoptosi"
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Endoplasmic Reticulum Stress Compound Library
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);Colore e forma:Odour SolidRef: TM-L9700
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaCytostatin
CAS:Cytostatin: Natural antitumor, inhibits cell adhesion, blocks B16 melanoma, induces apoptosis, selectively targets PP2A (IC50 = 29 nM).Formula:C21H33O7PColore e forma:SolidPeso molecolare:428.462Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.37S65487 hydrochloride
CAS:S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Formula:C41H42Cl2N6O4Colore e forma:SolidPeso molecolare:753.73PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purezza:98%Colore e forma:SolidPeso molecolare:336.43Iparomlimab
CAS:Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.Colore e forma:LiquidDB818 dihydrochloride
DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).Colore e forma:Odour SolidVB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Colore e forma:Odour SolidNrf2 activator 19
Nrf2 activator 19 is a compound capable of crossing the blood-brain barrier and acts as an NRF2/HO-1 activator, offering potent antioxidant and neuroprotective effects. It effectively reduces brain damage and minimizes the accumulation of Reactive Oxygen Species (ROS). Additionally, Nrf2 activator 19 inhibits neuronal apoptosis, aiding in the recovery of neural function and motor skills. It has demonstrated significant potential in ischemic stroke research.Colore e forma:Odour SolidPimagedine
CAS:Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts.Formula:CH6N4Colore e forma:SolidPeso molecolare:74.09tetrathiomolybdate
CAS:Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristicFormula:MoS4Colore e forma:SolidPeso molecolare:224.2RMC-6291
CAS:RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.Formula:C55H78FN9O8Purezza:98.73% - 99.92%Colore e forma:SolidPeso molecolare:1012.26Thalidomide-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.Formula:C19H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:404.42hCAIX-IN-13
CAS:hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.Formula:C37H33F3N6O7PtS2Colore e forma:SolidPeso molecolare:989.9p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.Formula:C40H51Cl4N5O4Purezza:98%Colore e forma:SolidPeso molecolare:807.68Chaetoglobosin A
CAS:Chaetoglobosin A, the active compound extracted of Penicillium aquamarinium, is a member of the cytochalasan family. It preferentially induces apoptosis.Formula:C32H36N2O5Purezza:98%Colore e forma:SolidPeso molecolare:528.649Human PD-L1 inhibitor III
CAS:Human PD-L1 inhibitor III is a human PD-L1 inhibitor.Formula:C97H155N29O29SColore e forma:SolidPeso molecolare:2223.54HDAC6-IN-22
HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro andFormula:C24H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:400.47Thalidomide-O-C6-NH2
CAS:Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].Formula:C19H23N3O5Purezza:98%Colore e forma:SolidPeso molecolare:373.4Ranevetmab
CAS:Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.Colore e forma:LiquidWaltonitone
CAS:Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.Formula:C30H48O2Purezza:98%Colore e forma:SolidPeso molecolare:440.7RIPK1-IN-25
RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.Colore e forma:Odour Solid2,2'-Dihydroxy chalcone
CAS:2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.Formula:C15H12O3Purezza:99.70%Colore e forma:SolidPeso molecolare:240.25FPR1 antagonist 2
Compound 25b, an FPR1 antagonist, exhibits potent inhibition of the formyl peptide receptor 1 with an IC50 of 70 nM.Formula:C25H25F3O5Colore e forma:SolidPeso molecolare:462.46Pyridinium bisretinoid A2E
CAS:Pyridinium bisretinoid A2E (A2E) is a fluorescent molecule isolated from the lipofuscin of retinal pigment epithelium, a weak photosensitizer.Formula:C42H58NOPurezza:83.65%Colore e forma:SolidPeso molecolare:592.92MY-943
MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, andFormula:C30H36N4O6S2Colore e forma:SolidPeso molecolare:612.76VEGFR2/HDAC1-IN-1
VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC.Purezza:98%Colore e forma:Odour SolidPD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Colore e forma:Odour SolidAc-DNLD-CHO
CAS:Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, exhibiting IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7Formula:C20H31N5O10Purezza:98%Colore e forma:SolidPeso molecolare:501.49IRF1-IN-1
CAS:IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Formula:C22H24N4O4SPurezza:99.88%Colore e forma:SolidPeso molecolare:440.52Sorafenib-d4
CAS:Sorafenib D4 is deuterium-labeled Sorafenib, a multi-kinase inhibitor (Raf-1, B-Raf, VEGFR-3) with IC50s: 6, 20, 22 nM.Formula:C21H16ClF3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:468.85PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Colore e forma:Odour Solidβ-Glucuronide-dPBD-PEG5-NH2 TFA
CAS:β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer employed in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-Formula:C80H102F3N7O37Colore e forma:SolidPeso molecolare:1810.69Human PD-L1 inhibitor V
CAS:Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFormula:C65H104N20O18SPurezza:98%Colore e forma:SolidPeso molecolare:1485.71AFMK
CAS:AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.Formula:C13H16N2O4Purezza:98.34% - 99.81%Colore e forma:SolidPeso molecolare:264.28IETD-CHO TFA
IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].Formula:C95H162N20O26·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:2000.42 (free acid)Ac-AAVALLPAVLLALLAP-LEHD-CHO
CAS:Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated withFormula:C97H162N22O25Purezza:98%Colore e forma:SolidPeso molecolare:2036.46LSD1-IN-24
CAS:LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing responseFormula:C18H20N2OSPurezza:99.61%Colore e forma:SoildPeso molecolare:312.43Ref: TM-T67871
1mg34,00€5mg77,00€10mg110,00€25mg212,00€50mg349,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)84,00€Thalidomide-O-amido-C8-NH2
CAS:Thalidomide-O-amido-C8-NH2 is a thalidomide-based ligand-linker for PROTAC synthesis.Formula:C23H30N4O6Purezza:98%Colore e forma:SolidPeso molecolare:458.514-Epianhydrotetracycline hydrochloride
CAS:EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.Formula:C22H23ClN2O7Colore e forma:SolidPeso molecolare:462.88Thalidomide-Piperazine-Piperidine
CAS:Thalidomide-based E3 ligase ligand linked to a PROTAC piperazine-piperidine chain.Formula:C22H27N5O4Colore e forma:SolidPeso molecolare:425.489icFSP1
CAS:icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.Formula:C26H25N3O5Purezza:99.87% - 99.93%Colore e forma:SoildPeso molecolare:459.491,2-Naphthoquinone
CAS:1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.Formula:C10H6O2Purezza:98.01%Colore e forma:Golden Yellow Needles Color On Standing (Ntp 1992)Peso molecolare:158.15LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formula:C53H59Cl2N3O7S2Colore e forma:SolidPeso molecolare:985.09DAPK-IN-2
CAS:DAPK-IN-2: DAPK inhibitor with anticancer potential. Used in cerebral infarction and ischemia research.Formula:C17H14N2O4Purezza:97.36%Colore e forma:SolidPeso molecolare:310.3Ac-VDQQD-pNA
CAS:Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Formula:C31H43N9O14Colore e forma:SolidPeso molecolare:765.732-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formula:C22H17N3O2Colore e forma:SolidPeso molecolare:355.39CIGB-300 acetate
CIGB-300 acetate (P15-Tat acetate) is a peptide that acts as an inhibitor of casein kinase 2 (CK2). It exhibits anticancer properties by disrupting the phosphorylation activity of CK2. CIGB-300 acetate induces apoptosis in various tumor cell lines and is applicable for cancer research.Colore e forma:Odour SolidApoptosis inducer 33
Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.Formula:C16H13N3O2Colore e forma:SolidPeso molecolare:279.293Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Formula:C24H28Cl2N2O3S2Colore e forma:SolidPeso molecolare:527.53
