Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(2 prodotti)
- Caspasi(153 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(94 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(49 prodotti)
- c-RET(60 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6034 prodotti di "Apoptosi"
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Emavusertib Phosphate
CAS:Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.Formula:C24H28N7O9PPeso molecolare:589.49Anticancer agent 134
Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normalFormula:C34H36ClN7O3S2Purezza:98%Colore e forma:SolidPeso molecolare:690.28KT5823
CAS:KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.Formula:C29H25N3O5Purezza:95%Colore e forma:SolidPeso molecolare:495.53Euphjatrophane M
Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that reduces NF-κBp65 phosphorylation and exhibits anti-inflammatory properties. It can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in LPS-induced RAW 264.7 macrophages.Formula:C20H28O4Colore e forma:SolidPeso molecolare:332.43Gal-ARV-771
Gal-ARV-771 is a PROTAC prodrug, modified with galactose, based on ARV-771. It is activated in senescent cancer cells that express SA-β-Gal, thereby releasing ARV-771. Through the ubiquitin-proteasome pathway, Gal-ARV-771 induces selective degradation of the BRD4 protein in senescent cells and promotes apoptosis (apoptosis) of these cancer cells.Formula:C71H84ClN9O19S2Peso molecolare:1465.50134RET-IN-29
RET-IN-29 (Compound 8W) is a selective RET kinase inhibitor. It demonstrates inhibitory effects on BaF3 cells with the CCDC6-RETV804M mutation, with an IC50 of 0.715 μM. RET-IN-29 shows potential for research in non-small cell lung cancer (NSCLC).Formula:C22H22N6OColore e forma:SolidPeso molecolare:386.45Lactoferrin (17-41)
CAS:Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.Formula:C141H224N46O29S3Purezza:98%Colore e forma:SolidPeso molecolare:3123.77Diethyl phthalate
CAS:Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.Formula:C12H14O4Purezza:99.68% - 99.8%Colore e forma:SolidPeso molecolare:222.24Tectorigenin sodium sulfonate
CAS:Tectorigenin sodium sulfonate, a derivative of tectorigenin, is synthesized through sulfonation with sulfuric acid followed by neutralization in saturatedFormula:C16H11NaO9SColore e forma:SolidPeso molecolare:402.31TAT-NEP1-40 acetate
TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucoseFormula:C268H438N88O77·xC2H4O2Purezza:98%Colore e forma:SolidPeso molecolare:6124.89 (free base)ARV-393 HCl
ARV-393 HCl is an orally active and potent PROTAC targeting BCL6 with antitumor activity for the study of non-Hodgkin's lymphoma.Formula:C46H54Cl2FN9O7Purezza:99.79%Colore e forma:SolidPeso molecolare:934.88cpm-1285
CAS:CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists.Formula:C153H240N44O42SPurezza:98%Colore e forma:SolidPeso molecolare:3399.88Angiogenesis inhibitor 3
CAS:Angiogenesis Inhibitor 3 (compound 8) is a potent anti-cancer agent, blocking HUVEC/HCT-15 cell growth and inducing apoptosis.Formula:C44H42BrN3O9Colore e forma:SolidPeso molecolare:836.72(±)-Silybin
CAS:(±)-Silybin, a racemate of Silybin, demonstrates a range of biological activities including inducing apoptosis and possessing hepatoprotective, antioxidant, anti-inflammatory, and anti-cancer properties [1] [2].Formula:C25H22O10Colore e forma:SolidPeso molecolare:482.44GSPT1 degrader-1
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and inducesFormula:C28H33ClN4O5Purezza:98%Colore e forma:SolidPeso molecolare:541.04TAT-BH4 (Bcl-xL) (TFA)
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.Formula:C159H268N58O45·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:3712.19 (free acid)FD2157
FD2157, a photosensitive PI3K inhibitor, exhibits inhibitory IC50 values of 43 nM for PI3Kα, 83 nM for PI3Kβ, 84 nM for PI3Kγ, and 14 nM for PI3Kδ.Formula:C27H21ClN6O8SPurezza:98%Colore e forma:SolidPeso molecolare:625.01XY077
XY077 (compound 14a) is a RORγ inverse agonist with an IC50 value of 0.004 μM. It induces cell apoptosis (cellapoptosis) and exhibits antiproliferative activity both in vitro and in vivo.Formula:C27H27F3N2O5S2Peso molecolare:580.13135Fludarabine triphosphate
CAS:Fludarabine triphosphate inhibits key enzymes, causing cell death.Formula:C10H15FN5O13P3Colore e forma:SolidPeso molecolare:525.17Dynorphin A TFA
Dynorphin A TFA: endogenous peptide, potent KOR agonist, affects CNS, involved in neuron death research.Formula:C101H156F3N31O25Peso molecolare:2261.5Topoisomerase I inhibitor 17
CAS:TopoisomeraseI inhibitor 17 (Compound 7h) is an inhibitor of TopoisomeraseI (Top1). It reduces DDX5 and reverses the locking effect of DDX5 on Top1 activity. This compound induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. It triggers apoptosis by decreasing anti-apoptotic proteins XIAP, Bcl-2, and Survivin, while increasing pro-apoptotic proteins Bax and γH2AX. Moreover, TopoisomeraseI inhibitor 17 halts progression at the G2/M checkpoint, leading to cell cycle arrest. It significantly impairs colorectal cancer cell colony formation and migration, and effectively reduces tumor size in human PDX tumor mouse models.Formula:C28H21FN2O7Colore e forma:SolidPeso molecolare:516.47Se-Aspirin
CAS:Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.Formula:C12H12N2O3SePurezza:98.07%Colore e forma:SolidPeso molecolare:311.2WKYMVM TFA
CAS:WKYMVm is a selective FPR2 agonist with high affinity, which was identified through screening of a synthetic peptide library.Formula:C43H62F3N9O9S2Purezza:98%Colore e forma:SolidPeso molecolare:970.13MY-943
MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, andFormula:C30H36N4O6S2Colore e forma:SolidPeso molecolare:612.76Anticancer agent 106
Compound 106 (compound 10ic) induces apoptosis in B16-F10 melanoma cells and potently inhibits metastatic nodules in mouse models of lung metastatic melanoma,Formula:C26H25N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:475.563-Hydroxyterphenyllin
CAS:3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.Formula:C20H18O6Colore e forma:SolidPeso molecolare:354.35LL-K9-3
CAS:LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM forFormula:C31H49N5O6S3Colore e forma:SolidPeso molecolare:683.94BODIPY FL thalidomide
CAS:BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].Formula:C37H43BF2N6O7Colore e forma:SolidPeso molecolare:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.Formula:C25H17N6O8ReColore e forma:SolidPeso molecolare:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].Formula:C17H18ClFN4O4Colore e forma:SolidPeso molecolare:396.8Bcl-2-IN-21
Bcl-2-IN-21 (compound C1), an iridium-based anticancer agent, effectively targets and inhibits Bcl-2, thereby impeding cancer cell colony formation and promoting increased levels of Bax and caspase 3.Formula:C45H33F6IrN5PPeso molecolare:980.96MD-265
CAS:MD-265 is a PROTAC degrader that targets and degrades MDM2, leading to the activation of p53 in cancer cells with wild-type p53. MD-265 achieves complete tumor regression and enhances long-term survival in leukemic mice.Formula:C50H51Cl2FN6O6Peso molecolare:921.88CDD-2807
CDD-2807 is a serine/threonine kinase 33 (STK33) inhibitor with an IC50 of 9.2 nM. In mice, CDD-2807 demonstrates no significant toxicity and can cross the blood-testis barrier without accumulating in the brain. It offers reversible contraceptive effects, indicating potential for development as a male contraceptive.Formula:C29H26N4OPeso molecolare:446.21066Antitumor photosensitizer-4
Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2.Formula:C65H77ClN12O11SPurezza:98%Colore e forma:SolidPeso molecolare:1269.9Obestatin (human)
CAS:Obestatin (human) is an endogenous ligand for G-protein eurythmic entity 39 formed by shearing of preproghrelin and can be used to study obesity.Formula:C116H176N32O33Purezza:99.75%Colore e forma:SolidPeso molecolare:2546.83VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Colore e forma:Odour LiquidPROTAC ROR1 degrader-1
PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S,R,S)-AHPC]Formula:C55H74BrN11O5SColore e forma:SolidPeso molecolare:1081.22JAK-IN-40
JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.Formula:C26H32N8O3SColore e forma:SolidPeso molecolare:536.65Cholesteryl Hemisuccinate Tris Salt
CAS:Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.Formula:C35H61NO7Purezza:≥98%Colore e forma:SolidPeso molecolare:607.86DSTYSLSSTLTLSK TFA
DSTYSLSSTLTLSK TFA detects infliximab, a chimeric IgG1 antibody targeting TNF-α.Formula:C66H108F3N15O28Colore e forma:SolidPeso molecolare:1616.64PROTAC EGFR degrader 14
PROTACEGFRdegrader 14 is a potent and selective EGFR PROTAC degrader with a DC50 value of approximately 2.9 nM against EGFRL858R/T790M/C797S and a Dmax of 93.1%. It induces the selective degradation of EGFRC797S via a VHL and proteasome-dependent mechanism, downregulating EGFR-related transcriptomes. PROTACEGFRdegrader 14 exhibits high selectivity for EGFRWT, induces cell cycle arrest and apoptosis, and effectively inhibits tumor growth. It is applicable for research on non-small cell lung cancer (NSCLC).Colore e forma:Odour SolidXY221
XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.Formula:C32H34FN3O5Colore e forma:SolidPeso molecolare:559.628PI3Kδ-IN-16
CAS:PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.Formula:C22H26N6O2Purezza:99.68%Colore e forma:SoildPeso molecolare:406.48AMPK-IN-6
AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.Formula:C18H20FN5OColore e forma:SolidPeso molecolare:341.383CQ627
CQ627 is a molecular glue that targets the degradation of RIOK2. It effectively recruits the E3 ubiquitin ligase RNF126, inducing the proteasomal degradation of RIOK2 via the ubiquitin-proteasome system (UPS) in MOLT4 leukemia cell lines, with a DC50 value of 410 nM. Additionally, CQ627 induces apoptosis in a dose-dependent manner in these cells, blocking the cell cycle at the G2/M phase, and exhibits antiproliferative activity across various cancer cell lines. It also demonstrates in vivo anticancer activity in MOLT4 xenograft mouse models.Formula:C36H27F4N7O4Colore e forma:SolidPeso molecolare:697.638STEP-IN-1
STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.Formula:C21H10ClNO7Colore e forma:SolidPeso molecolare:423.76PROTAC XPO1 degrader-1
PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.Formula:C33H35ClF3N7O7Colore e forma:SolidPeso molecolare:734.122VEGFR-2-IN-61
VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.Formula:C27H25N5OColore e forma:SolidPeso molecolare:435.52Anti-inflammatory agent 74
Anti-inflammatory agent 74 (B5) is known for its ability to inhibit NO, IL-6, and TNF-α, with IC50 values of 10.88 μM and 4.93 μM for NO and IL-6, respectively. It alleviates acute lung injury (ALI) by modulating inflammatory mediators and inhibiting the MAPK and NF-κB signaling pathways.Formula:C41H51NO14Peso molecolare:781.33096TAT-GluN2BCTM
CAS:TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, therebyFormula:C224H374N86O54Purezza:98%Colore e forma:SolidPeso molecolare:5135.91
