Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(2 prodotti)
- Caspasi(153 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(94 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(49 prodotti)
- c-RET(60 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6037 prodotti di "Apoptosi"
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Anticancer agent 178
Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.Formula:C32H30ClFeN2O6Peso molecolare:629.11418HDAC6-IN-28
HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.
Formula:C23H16FN3O2Peso molecolare:385.12265Chlopynostat
Chlopynostat (Compound 6c) is an HDAC1 inhibitor with an IC50 value of 67 nM. It induces apoptosis by inhibiting HDAC1, thereby reversing STAT4/p66Shc defects.Formula:C22H17ClN4O2Peso molecolare:404.104MALT1-IN-13
MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.Formula:C20H15BrClN3O3S2Peso molecolare:522.94267Cu(I) chelator 1
Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.Formula:C16H27NO4S3Peso molecolare:393.11022P-gp inhibitor 16
P-gp inhibitor 16 (compound 14) is an inhibitor of p-glycoprotein. It significantly enhances apoptosis induced by doxorubicin and displays anticancer properties.Formula:C35H35N5O4Peso molecolare:589.2689Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formula:C21H28ClN5O5Peso molecolare:465.1779Lw13
Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.Formula:C46H55F3N8O8Peso molecolare:904.4095SB 699551
CAS:SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formula:C34H45N3OPurezza:99.83%Colore e forma:SoildPeso molecolare:511.74Ref: TM-T23325L
1mg190,00€5mg471,00€10mg662,00€25mg1.036,00€50mg1.429,00€100mg1.821,00€200mg2.489,00€Pacmilimab
CAS:Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Purezza:98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Colore e forma:LiquidProlgolimab
CAS:Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.Purezza:>95%Colore e forma:LiquidPeso molecolare:146.28 kDa4-Nitro-3-cresol
CAS:4-Nitro-3-cresol exhibits ciliate toxicity against Tetrahymena pyriformis and is widely used in biochemical experiments and drug synthesis research.Formula:C7H7NO3Purezza:99.87%Colore e forma:Beige PowderPeso molecolare:153.14WF 10129
CAS:WF 10129 is a new angiotensin converting enzyme inhibitor generated by a fungus, Doratomyces putredinis.Formula:C20H28N2O8Purezza:98%Colore e forma:SolidPeso molecolare:424.45Ac-Pro-Gly-Pro-OH
CAS:Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.Formula:C14H21N3O5Purezza:98.32%Colore e forma:SolidPeso molecolare:311.33Pro-GA
CAS:Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.Formula:C12H19NO7Colore e forma:SolidPeso molecolare:289.28C188
CAS:C188, a naphthol-based STAT3 inhibitor, blocks IL-6-induced STAT3 activity in HepG2 cells, sparing STAT1.Formula:C19H15NO7S2Colore e forma:SolidPeso molecolare:433.45MBC-11 triethylamine
MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.Formula:C17H35N4O14P3Purezza:98%Colore e forma:SolidPeso molecolare:612.4MBC-11 trisodium
CAS:MBC-11 trisodium, a bisphosphonate-Ara-C conjugate, may treat TIBD.Formula:C11H17N3Na3O14P3Purezza:98%Colore e forma:SolidPeso molecolare:577.16Cobimetinib hemifumarate
CAS:Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.Formula:C46H46F6I2N6O8Colore e forma:SolidPeso molecolare:1178.707Nafamostat
CAS:Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis, inhibiting SARS-CoV-2 and COVID-19.Formula:C19H17N5O2Purezza:98%Colore e forma:SolidPeso molecolare:347.37Olanzapine D3
CAS:Olanzapine D3 is the deuterium labeled Olanzapine.Formula:C17H20N4SPurezza:98%Colore e forma:SolidPeso molecolare:315.45Fmoc-D-Cha-OH
CAS:Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.Formula:C24H27NO4Purezza:98.62%Colore e forma:SolidPeso molecolare:393.482'-Aminoacetophenone
CAS:Compound Fr14273 is a natural product for research related to life sciences. The catalog number is Fr14273 and the CAS number is 551-93-9.Formula:C8H9NOPurezza:99.88%Colore e forma:Pale Yellow Solid Solid CrystallinePeso molecolare:135.17VK3-OCH3
CAS:Formula:C14H14O3SPurezza:>98.0%(HPLC)Colore e forma:Light yellow to Yellow to Orange powder to crystalPeso molecolare:262.32Deferasirox (Fe3+ chelate)
CAS:Deferasirox (Fe3+ chelate) is an iron chelator with anticancer activity and can be used to study iron overload.Formula:C21H12FeN3O4Purezza:≥98.0%Colore e forma:SolidPeso molecolare:426.18Fluorizoline
CAS:Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity and induces apoptosis.Formula:C15H8Cl2F3NSPurezza:98.22% - 99.52%Colore e forma:SolidPeso molecolare:362.20Barbadin
CAS:Barbadin is an inhibitor of β-arrestin/β2-adaptin interaction.Barbadin enhances the effects of lorcaserin on weight loss and can be used to study obesity.Formula:C19H15N3OSPurezza:98.93% - 99.10%Colore e forma:SolidPeso molecolare:333.41N-3-oxo-dodecanoyl-L-Homoserine lactone
CAS:N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].Formula:C16H27NO4Colore e forma:SolidPeso molecolare:297.39Demethoxycurcumin
CAS:Formula:C20H18O5Purezza:>98.0%(HPLC)Colore e forma:Light red to Yellow to Red powder to crystalPeso molecolare:338.36Mycophenolic acid-d3
CAS:Mycophenolic acid-d3 is a derivative that lowers GTP, affects RNA polymerase II transcription, changes polyadenylation, and counters cordyceps.Formula:C17H20O6Purezza:98%Colore e forma:SolidPeso molecolare:323.36RKI-1447 dihydrochloride
CAS:RKI 1447 dihydrochloride: selective ROCK inhibitor, inhibits colorectal cancer growth, promotes apoptosis (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM).Formula:C16H16Cl2N4O2SColore e forma:SolidPeso molecolare:399.29Propylparaben sodium
CAS:Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.Formula:C10H12NaO3Colore e forma:SolidPeso molecolare:203.193Zardaverine
CAS:Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the study of acute renal failure and chronic airflow obstructionFormula:C12H10F2N2O3Purezza:99.11%Colore e forma:SolidPeso molecolare:268.221-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)uracil
CAS:1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a Nucleoside, fluoro-modified nucleoside; Arabino-nucleosidde.Formula:C9H11FN2O5Purezza:98.36%Colore e forma:SolidPeso molecolare:246.19Fenitrothion
CAS:Fenitrothion (Arbogal) is a insecticide that exhibits reproductive toxicity, inhibits acetylcholinesterase, and is commonly used in agriculture.Formula:C9H12NO5PSPurezza:95.07%Colore e forma:Yellow-Brown Liquid Insecticide Against Chewing And Sucking Insects On Rice Orchard Fruits Vegetables Cereals CottonPeso molecolare:277.23NCX 4040
CAS:COX-2 expression inhibitorFormula:C16H13NO7Purezza:98%Colore e forma:SolidPeso molecolare:331.28JRD-SIK1/2i-4
CAS:JRD-SIK1/2i-4 is a SIK1/2 inhibitor that induces nuclear translocation of CRTC3 at low micromolar concentrations. It is expected to saturate SIK1 and SIK2, but not SIK3.Formula:C21H20N6O2Colore e forma:SolidPeso molecolare:388.42Traumatic Acid
CAS:Traumatic Acid aids wound healing in plants by stimulating cell division to create a callus.Formula:C12H20O4Purezza:99.64%Colore e forma:SolidPeso molecolare:228.28Tamoxifen-d5
CAS:Tamoxifen-d5 is a deuterium labeled Tamoxifen.Formula:C26H29NOPurezza:98%Colore e forma:SolidPeso molecolare:376.55Thalidomide-piperazine-Boc
CAS:Thalidomide-piperazine-Boc is an intermediate utilized for synthesizing BCL6 PROTAC, which targets B-cell lymphoma 6 protein.Formula:C22H26N4O6Colore e forma:SolidPeso molecolare:442.463,4,5-Trihydroxycinnamic acid decyl ester
CAS:3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).Formula:C19H28O5Purezza:98.28%Colore e forma:SolidPeso molecolare:336.42FMAU
CAS:FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to labelFormula:C10H13FN2O5Purezza:98.6%Colore e forma:SolidPeso molecolare:260.22Thalidomide-piperazine hydrochloride
CAS:Thalidomide-piperazine HCl may aid leprosy, multiple myeloma research, and developmental biology studies.Formula:C17H19ClN4O4Colore e forma:SolidPeso molecolare:378.81Sodium catechol sulfate
CAS:Sodium catechol sulfate is a bioactive chemical.Formula:C6H4Na2O8S2Purezza:98%Colore e forma:Light Tan PowderPeso molecolare:314.205-(N,N-Hexamethylene)-amiloride
CAS:5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.Formula:C12H18ClN7OPurezza:85.48%Colore e forma:SolidPeso molecolare:311.77Acyclovir hydrochloride
CAS:Acyclovir (Aciclovir) hydrochloride is an effective oral antiviral agent with potent anti-herpetic activity. It exhibits IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2, indicating strong inhibitory effects against these strains. Additionally, Acyclovir hydrochloride induces cell cycle disturbances and apoptosis. This compound also prevents bacterial infections during induction therapy for acute leukemia.Formula:C8H12ClN5O3Colore e forma:SolidPeso molecolare:261.67Melatonin-d4
CAS:Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.Formula:C13H16N2O2Purezza:98%Colore e forma:SolidPeso molecolare:236.3FTI-277
CAS:FTI-277, an FTase inhibitor, blocks H-Ras/K-Ras signaling and HDV infection; mimics Ras CAAX peptide.Formula:C22H29N3O3S2Colore e forma:SolidPeso molecolare:447.61Alantolactone
CAS:Formula:C15H20O2Purezza:>95.0%(GC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:232.324-Thiothymidine
CAS:4-Thiothymidine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside.Formula:C10H14N2O4SPurezza:99.92%Colore e forma:SolidPeso molecolare:258.29
