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Apoptosi

Apoptosi

Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.

Sottocategorie di "Apoptosi"

Mostrare 6 più sottocategorie

Trovati 6059 prodotti di "Apoptosi"

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  • BHA536
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    BHA536

    CAS:
    BHA536 is an orally effective inhibitor of PKCα/β and the NF-kB signaling pathway. This compound inhibits the proliferation of ABC DLBCL cells harboring CD79 mutations by causing cell cycle arrest in the G1 phase and induces apoptosis in TMD8 cells. Additionally, BHA536 exhibits antitumor activity in mice.
    Formula:C30H30ClN3O5
    Colore e forma:Solid
    Peso molecolare:548.03

    Ref: TM-T200350

  • DC-U4106
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    DC-U4106

    CAS:
    DC-U4106: USP8 inhibitor, Kd 4.7μM, IC50 1.2μM, degrades Erα, low-toxicity tumor suppressor for breast cancer research.
    Formula:C29H27N5O5
    Colore e forma:Solid
    Peso molecolare:525.56

    Ref: TM-T63685

  • CLM3
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    CLM3

    CAS:
    CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways.
    Formula:C21H21N5
    Colore e forma:Solid
    Peso molecolare:343.43

    Ref: TM-T200080

  • Logo CymitQuimica
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    VEGFR-2-IN-11

    <p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>
    Formula:C29H22BrN5S
    Colore e forma:Solid
    Peso molecolare:552.49

    Ref: TM-T63900

  • Caspase-3 activator 4
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    Caspase-3 activator 4

    CAS:
    Caspase-3 Activator 4 (compound 4o) is an effective caspase-3 activator that can cross the blood-brain barrier. This compound exhibits antiproliferative activity and can induce cell apoptosis (apoptosis). Additionally, Caspase-3 Activator 4 enhances the gene expression of TNF-α and reduces the expression of cleaved caspase-3/caspases 3.
    Formula:C31H27N5O3
    Colore e forma:Solid
    Peso molecolare:517.58

    Ref: TM-T89835

  • Cernuumolide J
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    Cernuumolide J

    CAS:
    Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.
    Formula:C24H34O8
    Colore e forma:Solid
    Peso molecolare:450.52

    Ref: TM-T200239

  • ONC213
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    ONC213

    CAS:
    ONC213, an αKGDH inhibitor, functions by hindering αKGDH activity, thus suppressing mitochondrial respiration and elevating α-ketoglutarate levels, ultimately inducing apoptosis (Apoptosis) in AML cells. It is utilized in the study of acute myeloid leukemia.
    Formula:C23H22F2N4O
    Colore e forma:Solid
    Peso molecolare:408.44

    Ref: TM-T89999

  • Logo CymitQuimica
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    JH-XVII-10

    JH-XVII-10: potent, oral DYRK1A/B inhibitor (IC50: 3/5 nM), shows antitumor activity in HNSCC.
    Formula:C21H16F4N8O
    Colore e forma:Solid
    Peso molecolare:472.4

    Ref: TM-T63050

  • EMT inhibitor-3
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    EMT inhibitor-3

    CAS:
    EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.
    Formula:C29H21F2N3O4Se
    Colore e forma:Solid
    Peso molecolare:592.45

    Ref: TM-T205130

  • Mps-BAY1
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    Mps-BAY1

    CAS:
    Mps-BAY1, an MPS1 inhibitor, exhibits anticancer activity. It inhibits cell proliferation and induces cell apoptosis by activating mitotic aberrations in cancer cells, leading to overall aneuploidy and polyploidy. Mps-BAY1 is used in research pertaining to colorectal and cervical cancer.
    Formula:C27H20N6O
    Colore e forma:Solid
    Peso molecolare:444.49

    Ref: TM-T200344

  • Tubulin polymerization-IN-68
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    Tubulin polymerization-IN-68

    CAS:
    Tubulin polymerization-IN-68 (compound 32) serves as a tubulin inhibitor, disrupting cellular microtubule networks by hindering tubulin polymerization. It also upregulates PARP-1 and caspase-3 expression, thereby inducing apoptosis and exhibiting anticancer properties. Notably, Tubulin polymerization-IN-68 effectively suppresses HepG2 cells with an IC50 of 93 nM and markedly reduces the growth of HepG2 xenograft tumors in nude mice through oral administration.
    Formula:C16H13N3O
    Colore e forma:Solid
    Peso molecolare:263.29

    Ref: TM-T200167

  • TZEP7
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    TZEP7

    CAS:
    <p>TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.</p>
    Formula:C27H19ClFNS
    Colore e forma:Solid
    Peso molecolare:443.963

    Ref: TM-T205353

  • PF-3837
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    PF-3837

    CAS:
    PF-3837 is an inhibitor of the Mps1 kinase, with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, thereby reducing genomic stability and leading to cancer cell apoptosis (Apoptosis). PF-3837 is utilized in the study of breast cancer.
    Formula:C21H26N8O2
    Colore e forma:Solid
    Peso molecolare:422.48

    Ref: TM-T200061

  • TrxR/EGFR-IN-1
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    TrxR/EGFR-IN-1

    CAS:
    TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.
    Formula:C24H24AuClFN6O2P
    Colore e forma:Solid
    Peso molecolare:710.878

    Ref: TM-T205519

  • ASTX295
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    ASTX295

    CAS:
    ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.
    Formula:C33H34Cl2FNO6
    Colore e forma:Solid
    Peso molecolare:630.531

    Ref: TM-T206682

  • Logo CymitQuimica
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    JAK2/FLT3-IN-1 TFA

    JAK2/FLT3-IN-1 (TFA), an oral JAK2/FLT3 inhibitor, shows anticancer properties; IC50: JAK2 (0.7 nM), FLT3 (4 nM), JAK1 (26 nM), JAK3 (39 nM).
    Formula:C27H35F4N7O3
    Colore e forma:Solid
    Peso molecolare:581.61

    Ref: TM-T64104

  • Sinulatumolin E
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    Sinulatumolin E

    CAS:
    Sinulatumolin E, a terpenoid, inhibits TNF-α (IC 50: 3.6 μM); has anti-inflammatory properties.
    Formula:C15H22O2
    Colore e forma:Solid
    Peso molecolare:234.33

    Ref: TM-T72799

  • Logo CymitQuimica
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    Antitumor agent-43

    Antitumor agent-43 (Compound 4B) is a potent antitumor agent that induces cell cycle arrest at G2/M phase.
    Formula:C16H8N2O3
    Colore e forma:Solid
    Peso molecolare:276.25

    Ref: TM-T60505

  • Sampangine
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    Sampangine

    CAS:
    Sampangine, an alkaloid, induces apoptosis by causing cell cycle arrest at the G0/G1 phase and inhibits the biosynthesis of heme.
    Formula:C15H8N2O
    Colore e forma:Solid
    Peso molecolare:232.24

    Ref: TM-T200281

  • DAPK1-IN-1
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    DAPK1-IN-1

    CAS:
    DAPK1-IN-1 (compound 10) is an inhibitor of Death-associated protein kinase 1 (DAPK1), with a dissociation constant (Kd) of 0.63 μM. It is utilized in the study of Alzheimer's disease.
    Formula:C15H11BrO4
    Colore e forma:Solid
    Peso molecolare:335.15

    Ref: TM-T200717