Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(11 prodotti)
- Caspasi(144 prodotti)
- FOXO1(3 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(139 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(91 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6039 prodotti di "Apoptosi"
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MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formula:C20H18N4O5Purezza:98%Colore e forma:SolidPeso molecolare:394.38MRK003
CAS:MRK003, a γ-secretase inhibitor, induces apoptosis, halts cell growth in myeloma/NHL, and affects notch signaling and PI3K/Akt pathway.Formula:C25H31F6N3O2SColore e forma:SolidPeso molecolare:551.59Antitumor agent-76
CAS:Antitumor agent-76 is a water-soluble, orally active, rapid-release prodrug of Triptolide that exhibits anticancer effects.Formula:C28H36ClNO10Colore e forma:SolidPeso molecolare:582.04RET-IN-11
RET-IN-11 selectively inhibits RET (IC50: 6.20 nM), promotes apoptosis, and hinders cell proliferation and migration.Formula:C27H30FN9OColore e forma:SolidPeso molecolare:515.59Neuroprotective agent 11
CAS:Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.Formula:C32H30O12Colore e forma:SolidPeso molecolare:606.57Nampt-IN-16
CAS:Nampt-IN-16 (Compound 9a) is an orally active NAMPT inhibitor with an IC50 of 0.15 μM. It reduces intracellular NAD+ and ATP levels. Nampt-IN-16 inhibits the proliferation, migration, and invasion of gastric cancer cells, induces cell cycle arrest and apoptosis, and alters cellular metabolism. This compound is applicable for research in tumors such as gastric cancer.Formula:C25H25FN4O3Colore e forma:SolidPeso molecolare:448.49Antitumor agent-77
Antitumor agent-77 suppresses cancer cell growth, migration, induces apoptosis, and hinders EMT.Formula:C7H11F3N2O5PtColore e forma:SolidPeso molecolare:455.25TNF-α-IN-2
CAS:TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.Formula:C25H21ClF2N6OPurezza:99.92%Colore e forma:SolidPeso molecolare:494.92ASK1 ligand 1
CAS:ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Formula:C17H16F2N6OColore e forma:SolidPeso molecolare:358.35Tuspetinib dihydrochloride
CAS:Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).Formula:C29H35Cl3N6Colore e forma:SolidPeso molecolare:573.99PARP10/15-IN-3
Compound 8a, a dual PARP10 & PARP15 inhibitor, has IC50s: PARP10 at 0.14μM & PARP15 at 0.40μM; it's cell-permeable & anti-apoptotic.Formula:C12H12N2O3Colore e forma:SolidPeso molecolare:232.24Anticancer agent 14
Anticancer agent 14: a potent breast cancer inhibitor; induces cell death, disrupts mito. membrane potential (IC50: 0.20-0.65 μM).Formula:C29H34N2O3Colore e forma:SolidPeso molecolare:458.59MAPK-IN-5
CAS:MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 μM in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.Formula:C30H29F3N6O4Colore e forma:SolidPeso molecolare:594.58ZLHQ-5f
ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.Formula:C28H25N5O2Colore e forma:SolidPeso molecolare:463.53Rezatapopt
CAS:Rezatapopt (PC14586) is a p53 reactivator with antitumor activity for the study of locally advanced or metastatic solid tumors.Formula:C28H31F4N5O2Purezza:98.12%Colore e forma:SolidPeso molecolare:545.572-Deoxy-L-ribose
CAS:2-Deoxy-L-ribose is the stereoisomer of 2-Deoxy-D-ribose and can inhibit the anti-apoptotic effects of 2-Deoxy-D-ribose. Additionally, 2-Deoxy-L-ribose is capable of suppressing tumor cell metastasis by downregulating thymidine phosphorylase overexpression.Formula:C5H10O4Colore e forma:SolidPeso molecolare:134.13CCT369260
CAS:CCT369260 (compound 1), an orally active inhibitor targeting B-cell lymphoma 6 (BCL6), demonstrates anti-tumor efficacy with an IC50 value of 520 nM [1].Formula:C24H31ClF2N6O2Colore e forma:SolidPeso molecolare:508.99Apoptosis inducer 42
CAS:Apoptosis inducer42 is an apoptosis inducer that triggers late-stage apoptosis and inhibits the secretion of IL-6. It exhibits high cytotoxicity toward cancer cells and is applicable in cancer research, including studies on colon cancer.Formula:C11H13OPSColore e forma:SolidPeso molecolare:224.26MG-B-28
MG-B-28, a BTLA-HVEM inhibitor, demonstrates an IC50 value of 906 nM. It promotes T cell activation dose-dependently by inhibiting the interaction between BTLA and HVEM.Formula:C28H25N5O3Colore e forma:SolidPeso molecolare:479.53T-1-PMPA
CAS:T-1-PMPA, a potent EGFR inhibitor, demonstrates apoptotic properties and effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively [1].Formula:C16H17N5O3Peso molecolare:327.34
