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Apoptosi

Apoptosi

Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.

Sottocategorie di "Apoptosi"

Mostrare 6 più sottocategorie

Trovati 6039 prodotti di "Apoptosi"

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  • Logo CymitQuimica
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    KDM1/CDK1-IN-1

    KDM1/CDK1-IN-1 inhibits KDM1 (IC50: 0.096 μM) & CDK1 (IC50: 0.078 μM), blocks HOP-92 G2/M phase, induces apoptosis, toxic to cancer cells.
    Formula:C22H17N5O3S
    Colore e forma:Solid
    Peso molecolare:431.47

    Ref: TM-T62405

  • RIP3 activator 1
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    RIP3 activator 1

    CAS:
    RIP3 Activator 1 (compound C8) is an effective RIP3 activator that inhibits cell growth and induces necroptotic cell death (necroptosis) and autophagy through the RIP3/p62/Keap1 signaling pathway. Additionally, this compound enhances the expression of p-MLKL and promotes the accumulation of LC3-II and p62 proteins.
    Formula:C26H50N4O3
    Colore e forma:Solid
    Peso molecolare:466.7

    Ref: TM-T201677

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    Anticancer agent 69

    Anticancer agent 69 targets PC3 cells (IC50=26 nM), raises ROS, lowers EGFR, and induces apoptosis.
    Formula:C19H26N8S
    Colore e forma:Solid
    Peso molecolare:398.53

    Ref: TM-T61902

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    AKN-028 acetate

    AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.
    Formula:C19H18N6O2
    Colore e forma:Solid
    Peso molecolare:362.39

    Ref: TM-T61358

  • YK5
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    YK5

    CAS:
    YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.
    Formula:C18H24N8O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:432.50

    Ref: TM-T26343

  • Tubulin inhibitor 41
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    Tubulin inhibitor 41

    CAS:
    Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].
    Formula:C20H15N3O
    Colore e forma:Solid
    Peso molecolare:313.35

    Ref: TM-T87573

  • MD102
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    MD102

    CAS:
    MD102, with an IC50 value of 0.35 μM, is a potent TG2 inhibitor that stabilizes p53 by inhibiting TG2. This results in a decrease in p-AKT and p-mTOR downstream signaling, ultimately inducing tumor cell apoptosis [1].
    Formula:C13H4BrCl2FN2O2
    Colore e forma:Solid
    Peso molecolare:389.99

    Ref: TM-T86873

  • GLI1-IN-1
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    GLI1-IN-1

    CAS:
    GLI1-IN-1 (CBC-1), a GLI-1 inhibitor, exhibits superior water solubility and anticancer properties. It effectively induces apoptosis and inhibits colorectal cancer growth by targeting the Hedgehog (HH) pathway (IC 50 = 1.3 μM) [1].
    Formula:C42H60N2O9
    Colore e forma:Solid
    Peso molecolare:736.93

    Ref: TM-T86501

  • ASK1-IN-7
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    ASK1-IN-7

    CAS:
    ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.
    Formula:C13H8N2O2S2
    Colore e forma:Solid
    Peso molecolare:288.345

    Ref: TM-T205427

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    TH-6

    TH-6, a potent HDAC inhibitor (IC50: HDAC1-0.115, 2-0.135, 3-0.242, 6-0.138, 8-2.120 μM), blocks cell migration, invasion, and has anti-tumor properties.
    Formula:C22H24FN3O5
    Colore e forma:Solid
    Peso molecolare:429.44

    Ref: TM-T62366

  • pan-KRAS-IN-5
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    pan-KRAS-IN-5

    CAS:
    <p>Pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor targeting 5′-UTR RNA G-quadruplexes (rG4s). It induces cell cycle arrest and promotes apoptosis in KRAS-driven cancer cells [1].</p>
    Formula:C31H36FIN4O2
    Colore e forma:Solid
    Peso molecolare:642.55

    Ref: TM-T87101

  • Necrosis inhibitor 3
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    Necrosis inhibitor 3

    CAS:
    Necrosis Inhibitor 3 (compound B3) effectively inhibits necrosis, demonstrating an IC50 of 0.29 nM in HT29 cells [1].
    Formula:C25H26N4O4S
    Colore e forma:Solid
    Peso molecolare:478.56

    Ref: TM-T86990

  • GQN-B37-E
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    GQN-B37-E

    CAS:
    GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.
    Formula:C29H23ClN4O4
    Colore e forma:Solid
    Peso molecolare:526.97

    Ref: TM-T88454

  • HBV/HDV-IN-2
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    HBV/HDV-IN-2

    CAS:
    <p>HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.</p>
    Formula:C38H44ClN7O5
    Colore e forma:Solid
    Peso molecolare:714.25

    Ref: TM-T88316

  • Tubulin inhibitor 43
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    Tubulin inhibitor 43

    CAS:
    Tubulin inhibitor 43 exhibits significant antitumor activity by impeding the proliferation and growth of cancer cells through the inhibition of β-microtubulin activity, ultimately inducing apoptosis [1].
    Formula:C20H21NO6
    Colore e forma:Solid
    Peso molecolare:371.38

    Ref: TM-T87575

  • ZB-R-55
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    ZB-R-55

    CAS:
    ZB-R-55 is an oral and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.
    Formula:C25H23N5O3
    Purezza:98.26%
    Colore e forma:Solid
    Peso molecolare:441.48

    Ref: TM-T87661

  • PDEδ/NAMPT IN-1
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    PDEδ/NAMPT IN-1

    CAS:
    PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.
    Formula:C26H30N4O4S
    Colore e forma:Solid
    Peso molecolare:494.61

    Ref: TM-T207578

  • GI-Y2
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    GI-Y2

    CAS:
    GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL). In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.
    Formula:C18H14N2O6S
    Colore e forma:Solid
    Peso molecolare:386.379

    Ref: TM-T206350

  • NSC308848
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    NSC308848

    CAS:
    NSC308848 is an effective apoptosis (cell death) inducer that operates in a Myc-dependent manner. It acts by inhibiting Myc transactivation and disrupting the DNA binding activity of Myc family proteins.
    Formula:C18H21N3O2
    Colore e forma:Solid
    Peso molecolare:311.378

    Ref: TM-T204258

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    XIAP degrader-1

    XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).
    Formula:C34H45N5O4
    Colore e forma:Solid
    Peso molecolare:587.75

    Ref: TM-T64161