Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(140 prodotti)
- PDK(9 prodotti)
- PERK(24 prodotti)
- Chinasi di serina/treonina(19 prodotti)
- Survivin(14 prodotti)
- TNF(94 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6498 prodotti di "Apoptosi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Topoisomerase I/II inhibitor 3
Topoisomerase I/II inhibitor 3 suppresses cell growth and induces apoptosis in liver cancer by blocking PI3K/Akt/mTOR.Formula:C24H24N2O4Colore e forma:SolidPeso molecolare:404.46Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride
CAS:Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, used in the synthesis of PROTAC.Formula:C19H24ClN5O6Peso molecolare:453.88NCI-006
CAS:NCI-006, an LDH inhibitor, slows tumor growth and enhances pyruvate's role in mitochondrial metabolism.Formula:C31H24F2N4O4S3Colore e forma:SolidPeso molecolare:650.74GL0388
GL0388, a Bax activator, induces apoptosis, hinders breast cancer growth, and has IC50 of 0.299-1.57 μM.Formula:C21H17FN2OColore e forma:SolidPeso molecolare:332.37Tubulin inhibitor 41
CAS:Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].Formula:C20H15N3OColore e forma:SolidPeso molecolare:313.35ASK1-IN-7
CAS:ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formula:C13H8N2O2S2Colore e forma:SolidPeso molecolare:288.345Topo II/HDAC-IN-1
CAS:Topo II/HDAC-IN-1 (7d) demonstrates potent dual inhibitory effects on Topo II and HDAC, while Topo II/HDAC-IN-1 (8d) effectively induces apoptosis [1].Formula:C15H16N4O3SColore e forma:SolidPeso molecolare:332.38PD-1/PD-L1-IN-55
CAS:PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.Formula:C25H23ClN2O3Colore e forma:SolidPeso molecolare:434.92HDAC/PSMD14-IN-1
CAS:HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.Formula:C20H24N4O3S2Colore e forma:SolidPeso molecolare:432.56Tubulin polymerization-IN-4
CAS:Tubulin polymerization-IN-4: inhibits tubulin (IC50=4.6 μM), blocks G2/M phase, induces apoptosis, hinders cell cloning/migration, damages vasculature.Formula:C21H21ClN2O4Colore e forma:SolidPeso molecolare:400.86BRD4/CK2-IN-1
CAS:BRD4/CK2-IN-1 is a small-molecule inhibitor targeting BRD4 and CK2, inducing apoptosis and autophagy-related cell death.Formula:C29H30ClN5O5Purezza:99.02%Colore e forma:SolidPeso molecolare:564.03Topo II/HDAC-IN-2
CAS:Topo II/HDAC-IN-2 (8d) demonstrates remarkable dual inhibitory effects on Topo II and HDAC, and also induces apoptosis [1].Formula:C17H20N4O3SColore e forma:SolidPeso molecolare:360.43hCAIX/XII-IN-5
Coumarin 9a: Selective inhibitor of hCA IX/XII (Ki 93.3/85.7 nM), blocks cancer cell growth, and induces apoptosis.Formula:C18H13NO3Colore e forma:SolidPeso molecolare:291.3PI3K/AKT-IN-1
CAS:PI3K/AKT-IN-1 is a dual inhibitor of PI3K and AKT with anti-cancer activity, inhibiting the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis.Formula:C23H23N5O4SPurezza:99.84%Colore e forma:SoildPeso molecolare:465.53Ref: TM-T62997
1mg71,00€5mg152,00€1mL*10mM (DMSO)156,00€10mg205,00€25mg356,00€50mg485,00€100mg708,00€200mg982,00€Z-VAD
CAS:Z-VAD is an irreversible pan-caspase inhibitor, suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy in tumour cells.
Formula:C20H27N3O8Purezza:98.961%Colore e forma:SolidPeso molecolare:437.44Ferroptosis-IN-15
CAS:Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.Formula:C17H14O5Colore e forma:SolidPeso molecolare:298.29EGFR-IN-3
EGFR-IN-3 is an EGFR inhibitor with antitumor activity.EGFR-IN-3 inhibits EGFRwt-TK, induces apoptosis (cell death), and can block cells in the G2/M phase.Formula:C24H18F4N6O2SPurezza:98.1%Colore e forma:SolidPeso molecolare:530.5Bcl-2-IN-3
CAS:Bcl-2-IN-3 (Compound 10) is an inhibitor of Bcl-2, utilized in cancer research.Formula:C16H16N2O4Colore e forma:SolidPeso molecolare:300.31HER2-IN-10
HER2-IN-10 is a psoralen derivative that induces apoptosis. HER2-IN-10 shows anti-breast cancer activity and light-activated cytotoxicity [1].Formula:C15H13NO5Colore e forma:SolidPeso molecolare:287.27BRD-K56819078
CAS:BRD-K56819078, a Bcl-2 inhibitor, significantly reduces the burden of senescent cells and the mRNA expression of aging-related genes in the kidneys. It exerts its anti-aging effects by inhibiting cell apoptosis (apoptosis).Formula:C24H20FN3O4S2Colore e forma:SolidPeso molecolare:497.56
