Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(126 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(91 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6170 prodotti di "Apoptosi"
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S65487 hydrochloride
CAS:S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Formula:C41H42Cl2N6O4Colore e forma:SolidPeso molecolare:753.73Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.37Thalidomide-NH-C6-NH2 TFA
CAS:Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.Formula:C21H25F3N4O6Purezza:98%Colore e forma:SolidPeso molecolare:486.44Thalidomide-NH-C5-NH2 hydrochloride
CAS:Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.Formula:C18H23ClN4O4Colore e forma:SolidPeso molecolare:394.85NC-R17
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-Formula:C53H67N7O7Purezza:98%Colore e forma:SolidPeso molecolare:914.14Etoposide phosphate disodium
CAS:Etoposide phosphate disodium, a prodrug of etoposide, is a powerful anticancer drug inhibiting DNA topoisomerase II.
Formula:C29H31Na2O16PColore e forma:SolidPeso molecolare:712.5DPP-4-IN-8
DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM.Formula:C16H12ClNO6Colore e forma:SolidPeso molecolare:349.72Narasin
CAS:Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.Formula:C43H72O11Colore e forma:SolidPeso molecolare:765.03cis,trans-Germacrone
CAS:cis,trans-Germacrone is an antitumor, antioxidant isomer that inhibits lung cancer and affects Akt/MDM2/p53.Formula:C15H22OColore e forma:SolidPeso molecolare:218.33PROTAC EGFR degrader 6
CAS:PROTAC EGFR degrader 6 effectively degrades EGFR Del19 in HCC827 cells (DC50=45.2 nM) and induces apoptosis and G1 arrest.Formula:C49H57FN12O5Colore e forma:SolidPeso molecolare:913.05CYP51/PD-L1-IN-2
CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.Formula:C25H23N7O3Colore e forma:SolidPeso molecolare:469.5MitoTam bromide, hydrobromide
CAS:MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.Formula:C52H60Br2NOPPurezza:98%Colore e forma:SolidPeso molecolare:905.82EM 163
CAS:EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。Formula:C44H60IN5O4Purezza:98.62%Colore e forma:SolidPeso molecolare:849.88Ref: TM-T41142
1mg114,00€5mg264,00€10mg354,00€25mg592,00€50mg843,00€100mg1.144,00€500mg2.295,00€1mL*10mM (DMSO)414,00€Bfl-1-IN-6
Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.Formula:C22H24ClFN2O2Colore e forma:SolidPeso molecolare:402.89BGC4
BGC4 is a gold(III) complex based on biphenyl. It inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity with an IC50 of 5.4 μM in MDA-MB-231 cells, and induces apoptosis. Additionally, BGC4 demonstrates antitumor activity in mouse models.Formula:C30H32AuClF3N3Colore e forma:SolidPeso molecolare:724.01FAK-IN-24
CAS:FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formula:C39H45Cl2F3N8O3Colore e forma:SolidPeso molecolare:801.728TCF4/β-catenin-IN-1
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.Formula:C23H15N7O3Colore e forma:SolidPeso molecolare:437.41GD3 Ganglioside sodium
GD3 Ganglioside sodium is a crucial ganglioside in human melanoma and functions as an inducer of mitochondrial permeability. It targets mitochondria directly in a manner controlled by bcl-2. Following the aggregation of death-inducing receptors, ceramide accumulates rapidly, synthesizes GD3 ganglioside, and triggers apoptosis.Colore e forma:SolidHYS-072
HYS-072 is an orally active derivative of chrysin with antitumor properties. It induces apoptosis (Apoptosis) and autophagy (Autophagy) by inhibiting the PI3K/AKT/mTOR signaling pathway, and suppresses tumor growth in xenograft models in vivo by modulating autophagy-related pathways. HYS-072 is applicable for research in treating triple-negative breast cancer.Formula:C27H26N2O5Colore e forma:SolidPeso molecolare:458.51FKBP12 Ligand-Linker Conjugate 1
CAS:FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.Formula:C42H63N3O11Colore e forma:SolidPeso molecolare:785.963
