Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 141 prodotti di "Topoisomerasi"
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XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.Formula:C23H25ClN4O2Purezza:98.52%Colore e forma:SoildPeso molecolare:424.92Ciprofloxacin
CAS:Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!Formula:C17H18FN3O3Purezza:98.77% - 99.91%Colore e forma:White PowderPeso molecolare:331.34Nalidixic acid
CAS:Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.Formula:C12H12N2O3Purezza:99.9% - 99.95%Colore e forma:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Peso molecolare:232.24Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Formula:C37H48F2N5O11PPurezza:99.79%Colore e forma:SolidPeso molecolare:807.77DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.Formula:C22H21ClN2O6Purezza:97.93%Colore e forma:SolidPeso molecolare:444.87Pefloxacin Mesylate
CAS:Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-Formula:C18H24FN3O6SPurezza:99.86%Colore e forma:SolidPeso molecolare:429.46Hycanthone
CAS:<p>Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.</p>Formula:C20H24N2O2SPurezza:98.78%Colore e forma:Yellow-Orange Powder (Ntp 1992)Peso molecolare:356.48Irinotecan Hydrochloride
CAS:Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Formula:C33H39ClN4O6Purezza:98% - 99.94%Colore e forma:Yellow Crystalline PowderPeso molecolare:623.14Levofloxacin hydrate
CAS:Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formula:C18H20FN3O4H2OPurezza:98.26%Colore e forma:Pale Yellow SolidPeso molecolare:370.38Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formula:C33H45ClN4O9Purezza:98.22% - >99.99%Colore e forma:Pale Yellow To Yellow Crystalline PowderPeso molecolare:677.18Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Formula:C22H30Cl2N4O6Purezza:97.05% - >99.99%Colore e forma:Blue-Black Solid From Water Ethanol SolidPeso molecolare:517.4Berberine chloride
CAS:Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Formula:C20H18ClNO4Purezza:99.47% - 99.93%Colore e forma:Yellow Crystalline PowderPeso molecolare:371.80Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Formula:C27H29NO11·HClPurezza:98% - 99.52%Colore e forma:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecolare:579.99Ciprofloxacin monohydrochloride
CAS:Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.Formula:C17H18FN3O3·HClPurezza:99.5% - 99.73%Colore e forma:White Or Light Yellow Crystalline PowderPeso molecolare:367.80Enoxacin hydrate
CAS:<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formula:C15H17FN4O3H2OPurezza:99.50%Colore e forma:SolidPeso molecolare:347.34Teniposide
CAS:Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFormula:C32H32O13SPurezza:97.7% - 99.45%Colore e forma:White Or Off-White Crystalline PowderPeso molecolare:656.65Flumequine
CAS:Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.Formula:C14H12FNO3Purezza:98.92% - 99.4%Colore e forma:White Crystalline Powder SolidPeso molecolare:261.25Lurtotecan
CAS:<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Formula:C28H30N4O6Purezza:99.18%Colore e forma:SoildPeso molecolare:518.56Topotecan hydrochloride
CAS:Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.Formula:C23H24ClN3O5Purezza:97.88% - 99.41%Colore e forma:White Crystalline SolidPeso molecolare:457.92Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Formula:C15H17FN4O3Purezza:98.68% - 99.89%Colore e forma:Off-White To Yellow CrystalsPeso molecolare:320.32Daunorubicin hydrochloride
CAS:Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFormula:C27H29NO10·HClPurezza:96.21% - 99.53%Colore e forma:Cancer DrugPeso molecolare:563.99Moxifloxacin hydrochloride
CAS:Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.Formula:C21H25ClFN3O4Purezza:99.91% - >99.99%Colore e forma:SolidPeso molecolare:437.89Nalidixic acid sodium salt
CAS:<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Formula:C12H11N2NaO3Purezza:99.72% - 99.95%Colore e forma:White To Off-White PowderPeso molecolare:254.22Gatifloxacin
CAS:Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.Formula:C19H22FN3O4Purezza:99.50% - 99.85%Colore e forma:White PowderPeso molecolare:375.39Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formula:C29H32O13Purezza:99.19% - 99.94%Colore e forma:Crystals From Methanol SolidPeso molecolare:588.56Epirubicin hydrochloride
CAS:Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.Formula:C27H30ClNO11Purezza:98.13% - 99.79%Colore e forma:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecolare:579.98Lomefloxacin
CAS:Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.Formula:C17H19F2N3O3Purezza:98.59%Colore e forma:Off-White To Yellow CrystalsPeso molecolare:351.35AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowPurezza:98%Colore e forma:Odour SolidTopoisomerase II inhibitor 13
CAS:WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Formula:C22H23N9Purezza:99.84%Colore e forma:SoildPeso molecolare:413.48TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurezza:98%Colore e forma:SoildPeso molecolare:466.94Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purezza:98%Colore e forma:SolidPeso molecolare:426.41Nifurpirinol
CAS:Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.Formula:C12H10N2O4Purezza:99.7%Colore e forma:SolidPeso molecolare:246.22Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formula:C53H83FN6O15Colore e forma:SolidPeso molecolare:1063.26Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Colore e forma:SolidPeso molecolare:347.41DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Colore e forma:Odour SolidAntitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targetsFormula:C70H82N8O18SPurezza:98%Colore e forma:SolidPeso molecolare:1355.51Topoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.Purezza:98%Colore e forma:Odour SolidGimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H26ClN3O5Purezza:97.04%Colore e forma:SoildPeso molecolare:483.94NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)Formula:C26H24ClN3O6Purezza:98%Colore e forma:SolidPeso molecolare:509.94Banoxantrone-d12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formula:C22H30Cl2N4O6Purezza:98%Colore e forma:SolidPeso molecolare:529.48AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.Purezza:98%Colore e forma:Odour SolidBanoxantrone (D12)
CAS:Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formula:C22H28N4O6Purezza:98%Colore e forma:SolidPeso molecolare:456.55CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purezza:98%Colore e forma:SolidPeso molecolare:458.51Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColore e forma:SolidPeso molecolare:278.32Dichlorogelignate
CAS:Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].Formula:C32H34O18Colore e forma:SolidPeso molecolare:706.6DTS-108
CAS:DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Formula:C145H233N43O33S2Colore e forma:SolidPeso molecolare:3170.8Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formula:C15H13N3S2Colore e forma:SolidPeso molecolare:299.414Voreloxin
CAS:Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formula:C18H19N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:401.44Chimmitecan
CAS:<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formula:C23H20N2O5Purezza:98.35%Colore e forma:SoildPeso molecolare:404.42AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Colore e forma:SolidPeso molecolare:736.61CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formula:C169H240FN35O49S2Peso molecolare:3629.05Daun02
CAS:Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.Formula:C41H44N2O20Purezza:98%Colore e forma:SolidPeso molecolare:884.79(4-NH2)-Exatecan
CAS:(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formula:C23H21N3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:403.43Marbofloxacin
CAS:Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.Formula:C17H19FN4O4Purezza:99.76% - 99.84%Colore e forma:SolidPeso molecolare:362.36Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purezza:98.07% - 99.18%Colore e forma:SolidPeso molecolare:240.25Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formula:C30H48O3Purezza:98.22% - 99.7%Colore e forma:White Crystalline PowderPeso molecolare:456.70Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formula:C26H27NO9·HClPurezza:98.91% - 99.96%Colore e forma:SolidPeso molecolare:533.95Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formula:C18H20ClN5O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:437.9SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purezza:98% - 99.97%Colore e forma:Light-Yellow SolidPeso molecolare:392.4Topotecan
CAS:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formula:C23H23N3O5Purezza:96.14% - 98.23%Colore e forma:Light Yellow Needle Crystal Or Crystalline PowderPeso molecolare:421.45Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formula:C25H27N5O10Purezza:98.70% - 99.11%Colore e forma:SolidPeso molecolare:557.21Indotecan
CAS:Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).Formula:C26H26N2O7Purezza:97% - 98%Colore e forma:SolidPeso molecolare:478.49Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purezza:97.47% - 99.97%Colore e forma:WhitePeso molecolare:1429.15(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purezza:99.09% - 99.81%Colore e forma:SolidPeso molecolare:364.35Artemisitene
CAS:Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Formula:C15H20O5Purezza:99.58%Colore e forma:SolidPeso molecolare:280.32Bisantrene
CAS:Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formula:C22H22N8Purezza:96.07% - 98.57%Colore e forma:SolidPeso molecolare:398.46Razoxane
CAS:Razoxane is used as an antimitotic agent with immunosuppressive properties.Formula:C11H16N4O4Purezza:99.75%Colore e forma:SolidPeso molecolare:268.27Amonafide
CAS:Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Formula:C16H17N3O2Purezza:99.39%Colore e forma:SolidPeso molecolare:283.33β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purezza:99.76% - 99.88%Colore e forma:SolidPeso molecolare:242.27Ellipticine hydrochloride
CAS:Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Formula:C17H15ClN2Purezza:97.18%Colore e forma:SolidPeso molecolare:282.76Bimolane
CAS:Bimolane is a topoisomerase II inhibitor.Formula:C20H32N6O6Purezza:99.13% - 99.29%Colore e forma:SolidPeso molecolare:452.5Gatifloxacin hydrochloride
CAS:Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Formula:C19H23ClFN3O4Purezza:99.85% - 99.89%Colore e forma:SolidPeso molecolare:411.86Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formula:C22H14O9Purezza:97.1%Colore e forma:Deep Red Coarse Crystalline PowderPeso molecolare:422.34Groenlandicine
CAS:Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Formula:C19H16NO4Purezza:98.59% - 99.77%Colore e forma:SolidPeso molecolare:322.34Topovale
CAS:Topovale (ARC111) is a potent inhibitor of topoisomerase I.Formula:C23H23N3O5Purezza:99.94%Colore e forma:SolidPeso molecolare:421.45Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formula:C33H38N4O6Purezza:98% - 99.92%Colore e forma:SolidPeso molecolare:586.68Dxd
CAS:Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!Formula:C26H24FN3O6Purezza:98.21% - ≥98%Colore e forma:SolidPeso molecolare:493.48Amsacrine hydrochloride
CAS:Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Formula:C21H20ClN3O3SPurezza:99.05% - 99.92%Colore e forma:SolidPeso molecolare:429.92Rubitecan
CAS:Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.Formula:C20H15N3O6Purezza:97.54%Colore e forma:Yellow Amorphous PowderPeso molecolare:393.351,4-Naphthoquinone
CAS:1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formula:C10H6O2Purezza:99.24% - 99.56%Colore e forma:SolidPeso molecolare:158.15Levofloxacin
CAS:Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Formula:C18H20FN3O4Purezza:98.14% - 99.80%Colore e forma:Off-White To Yellow CrystalsPeso molecolare:361.37TAS-103 dihydrochloride
CAS:TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.Formula:C20H21Cl2N3O2Purezza:97.78%Colore e forma:SolidPeso molecolare:406.319-amino-CPT
CAS:9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.Formula:C20H17N3O4Purezza:99.13% - 99.82%Colore e forma:Orange-Yellow PowderPeso molecolare:363.379-Hydroxycamptothecin
CAS:9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Formula:C20H16N2O5Purezza:98.28%Colore e forma:SolidPeso molecolare:364.35Isosteviol
CAS:Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.Formula:C20H30O3Purezza:99.72% - 99.97%Colore e forma:SolidPeso molecolare:318.45SW044248
CAS:SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.Formula:C22H23N5O2SPurezza:99.56% - 99.87%Colore e forma:SolidPeso molecolare:421.52Niranthin
CAS:Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.Formula:C24H32O7Purezza:99.8%Colore e forma:SolidPeso molecolare:432.51EIDD-1931
CAS:<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formula:C9H13N3O6Purezza:99.14% - 99.73%Colore e forma:SolidPeso molecolare:259.22Pirarubicin
CAS:Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Formula:C32H37NO12Purezza:97.80% - 99.15%Colore e forma:Red Crystalline PowderPeso molecolare:627.64Coralyne chloride
CAS:Coralyne chloride is a protoberberine with strong anticancer activity.Formula:C22H22ClNO4Purezza:98.88%Colore e forma:SolidPeso molecolare:399.87Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormula:C23H20F2N2O4·CH4O3S·H2OPurezza:99.56%Colore e forma:SolidPeso molecolare:540.53Exatecan Mesylate
CAS:<p>Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).</p>Formula:C25H26FN3O7SPurezza:97.32% - 99.9%Colore e forma:SolidPeso molecolare:531.55Levofloxacin hydrochloride
CAS:Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formula:C18H21ClFN3O4Purezza:99.78% - 99.98%Colore e forma:SolidPeso molecolare:397.8Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82Prulifloxacin
CAS:Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.Formula:C21H20FN3O6SPurezza:99.47%Colore e forma:Yellow Or Slightly Yellow PowerPeso molecolare:461.46Belotecan hydrochloride
CAS:Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormula:C25H28ClN3O4Purezza:99.63% - ≥95%Colore e forma:SolidPeso molecolare:469.96Rabdosiin
CAS:Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Formula:C36H30O16Purezza:98.64% - 99.49%Colore e forma:SolidPeso molecolare:718.61Berberine hydrogen sulphate
CAS:Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Formula:C20H19NO8SPurezza:99% - 99.82%Colore e forma:Yellow Crystals Off-White To Yellow PowderPeso molecolare:433.43Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formula:C22H21N3O5Purezza:97.49%Colore e forma:SolidPeso molecolare:407.429-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formula:C21H18N2O5Purezza:98.49% - 99.56%Colore e forma:SolidPeso molecolare:378.38Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formula:C22H28N4O6Purezza:96.29% - 98.74%Colore e forma:Blue PowderPeso molecolare:444.48(±)-10-Hydroxycamptothecin
CAS:<p>(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.</p>Formula:C20H16N2O5Purezza:98% - 99.06%Colore e forma:SolidPeso molecolare:364.35IndiMitecan
CAS:<p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>Formula:C25H21N3O6Purezza:98.53%Colore e forma:SoildPeso molecolare:459.45Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formula:C27H29NO11Purezza:99.31%Colore e forma:Red Crystalline Solid SolidPeso molecolare:543.52Exatecan
CAS:Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used inFormula:C24H22FN3O4Purezza:99.69% - 99.96%Colore e forma:SolidPeso molecolare:435.45PNU-159682
CAS:PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Formula:C32H35NO13Purezza:98.24%Colore e forma:SolidPeso molecolare:641.62Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Formula:C20H16N2O4Purezza:99.52% - 99.88%Colore e forma:Solid PowderPeso molecolare:348.35Ellipticine
CAS:Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Formula:C17H14N2Purezza:97.26% - 99.88%Colore e forma:SolidPeso molecolare:246.31IID432
IID432 can inhibit the topoisomerase II of Trypanosoma cruzi, with an EC50 value of 8 nM.Formula:C19H19N7OPeso molecolare:361.4T638
CAS:T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.Formula:C18H16N4OSColore e forma:SolidPeso molecolare:336.41BNS-22
CAS:BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.Formula:C24H25NO5Purezza:99.62%Colore e forma:SolidPeso molecolare:407.46Exatecan mesylate dihydrate
CAS:<p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>Formula:C25H30FN3O9SPurezza:98%Colore e forma:SolidPeso molecolare:567.58PluriSIn #2
CAS:PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Formula:C11H8FN3O3Purezza:98% - 99.79%Colore e forma:SolidPeso molecolare:249.2Daniquidone
CAS:Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasmsFormula:C15H11N3OPurezza:98.39% - 99.52%Colore e forma:SolidPeso molecolare:249.27Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurezza:99.2% - 99.34%Colore e forma:Yellow Crystalline Powder SolidPeso molecolare:393.46Aldoxorubicin
CAS:Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.Formula:C37H42N4O13Purezza:98%Colore e forma:SolidPeso molecolare:750.75Pyrazoloacridine
CAS:Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Formula:C19H21N5O3Purezza:99.72%Colore e forma:SolidPeso molecolare:367.4Pegamotecan
CAS:Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cellFormula:C52H48N6O14Purezza:96.40% - 97.83%Colore e forma:SolidPeso molecolare:980.984LMP744 hydrochloride
CAS:<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Formula:C24H25ClN2O7Purezza:99.59% - 99.85%Colore e forma:SolidPeso molecolare:488.92SDOX
CAS:SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formula:C69H97NO20S2Purezza:98%Colore e forma:SolidPeso molecolare:1324.63ARN-21934
CAS:ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formula:C21H24N6Purezza:99.8%Colore e forma:SolidPeso molecolare:360.46Anticancer agent 216
CAS:Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formula:C23H21N3O6Colore e forma:SolidPeso molecolare:435.43Ac-Exatecan
CAS:Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.Formula:C26H24FN3O5Purezza:97.09%Colore e forma:SolidPeso molecolare:477.48Pradofloxacin
CAS:Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.Formula:C21H21FN4O3Purezza:98.76%Colore e forma:SolidPeso molecolare:396.41Topoisomerase inhibitor 2
CAS:<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Formula:C23H23N5O4Purezza:98%Colore e forma:SolidPeso molecolare:433.46Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormula:C23H15Br2FN2Purezza:98%Colore e forma:SolidPeso molecolare:498.19NH2-methylpropanamide-Exatecan TFA
CAS:Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Formula:C30H30F4N4O7Purezza:98%Colore e forma:SolidPeso molecolare:634.58Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurezza:99.18%Colore e forma:SolidPeso molecolare:512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormula:C22H18ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:428.84Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurezza:98%Colore e forma:SolidPeso molecolare:348.44Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Formula:C25H27N3O7Colore e forma:SolidPeso molecolare:481.498Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formula:C23H22FN3O4Colore e forma:SolidPeso molecolare:423.44Topoisomerase I/II inhibitor 7
CAS:<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Formula:C18H13ClN2O3Colore e forma:SolidPeso molecolare:340.76Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purezza:98.47%Colore e forma:SolidPeso molecolare:447.48TH1338
CAS:<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formula:C22H21N3O4Purezza:98.77%Colore e forma:SolidPeso molecolare:391.42Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formula:C20H21N3OSColore e forma:SolidPeso molecolare:351.47Karenitecin
CAS:<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formula:C25H28N2O4SiPurezza:98%Colore e forma:SolidPeso molecolare:448.59LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formula:C22H19FN2O5Colore e forma:SolidPeso molecolare:410.4Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formula:C29H28N4O11Purezza:98%Colore e forma:SolidPeso molecolare:608.55Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formula:C18H10O7Colore e forma:SolidPeso molecolare:338.27
