Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 333 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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CX-6258 hydrochloride
CAS:
- 1353859-00-3
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
Formula:C₂₆H₂₄ClN₃O₃·HCl
Purezza:96.03% - 98.60%
Colore e forma:Solid
Peso molecolare:498.4
Ref: TM-T6148
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NVP-BSK805
CAS:
- 1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
Formula:C₂₇H₂₈F₂N₆O
Purezza:98%
Colore e forma:Solid
Peso molecolare:490.55
Ref: TM-T5049
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ZM39923
CAS:
- 273727-89-2
ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).
Formula:C₂₃H₂₅NO
Purezza:98%
Colore e forma:Solid
Peso molecolare:331.45
Ref: TM-T17295
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(3S,4S)-Tofacitinib
CAS:
- 1092578-47-6
(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.
Formula:C₁₆H₂₀N₆O
Purezza:98%
Colore e forma:Solid
Peso molecolare:312.37
Ref: TM-T13426L
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TLC1566-0618
CAS:
- 708218-62-6
TLC1566-0618 shows antitumor activity and targets stat.
Formula:C₂₀H₁₅NO₃S₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:413.53
Ref: TM-T121011
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Golotimod TFA
CAS:
- 2828433-07-2
Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity, alleviates radiation-induced oral mucositis.
Formula:C₁₈H₂₀F₃N₃O₇
Purezza:98%
Colore e forma:Soild
Peso molecolare:447.36
Ref: TM-T11449L2
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Peficitinib hydrochloride
CAS:
- 1353219-06-3
Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).
Formula:C₁₈H₂₃ClN₄O₂
Colore e forma:Solid
Peso molecolare:362.86
Ref: TM-T61365
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PF-00956980
CAS:
- 1262832-74-5
PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.
Formula:C₁₈H₂₆N₆O
Colore e forma:Solid
Peso molecolare:342.44
Ref: TM-T71089
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EP009
CAS:
- 1462951-30-9
EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.
Formula:C₁₄H₂₄O₂
Colore e forma:Solid
Peso molecolare:224.34
Ref: TM-T27274
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CX-6258
CAS:
- 1202916-90-2
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.
Formula:C₂₆H₂₄ClN₃O₃
Purezza:97.46%
Colore e forma:Solid
Peso molecolare:461.94
Ref: TM-T1834
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LLL12
CAS:
- 1260247-42-4
LLL12 inhibits STAT3 phosphorylation, boosting Cisplatin and Paclitaxel effects against ovarian cancer cell activities.
Formula:C₁₄H₉NO₅S
Colore e forma:Solid
Peso molecolare:303.29
Ref: TM-T71099
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INCB16562
CAS:
- 933768-63-9
INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.
Formula:C₁₉H₁₁Cl₂N₅
Colore e forma:Solid
Peso molecolare:380.23
Ref: TM-T68306
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TK4g
CAS:
- 2232890-86-5
TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.
Formula:C₁₉H₁₉N₃O₄S
Colore e forma:Solid
Peso molecolare:385.44
Ref: TM-T61698
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BP-5-087
CAS:
- 1803281-30-2
BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.
Formula:C₃₆H₃₀F₈N₂O₆S
Colore e forma:Solid
Peso molecolare:770.69
Ref: TM-T70167
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Galiellalactone
CAS:
- 133613-71-5
inhibits IL-6-mediated JAK/STAT signal transduction
Formula:C₁₁H₁₄O₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:194.23
Ref: TM-T22796
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JAK3i
CAS:
- 1918238-72-8
JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.
Formula:C₁₈H₁₅FN₄O₃
Purezza:98.61% - 99.81%
Colore e forma:Solid
Peso molecolare:354.34
Ref: TM-T27650
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Niclosamide monohydrate
CAS:
- 73360-56-2
Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.
Formula:C₁₃H₁₀Cl₂N₂O₅
Purezza:98%
Colore e forma:Solid
Peso molecolare:345.14
Ref: TM-T23068
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CP-690550A
CAS:
- 1243290-37-0
Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.
Formula:C₁₅H₂₁N₅O₂
Colore e forma:Solid
Peso molecolare:303.36
Ref: TM-T31074
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AC430
CAS:
- 1361415-84-0
AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.
Formula:C₁₉H₁₆FN₅O
Colore e forma:Solid
Peso molecolare:349.36
Ref: TM-T70870
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M-110
CAS:
- 1395048-49-3
M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).
Formula:C₂₂H₂₈ClN₅O₃
Purezza:99.55%
Colore e forma:Solid
Peso molecolare:445.94
Ref: TM-T15830