Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 333 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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AMG-47a
CAS:
- 882663-88-9
AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.
Formula:C₂₉H₂₈F₃N₅O₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:535.56
Ref: TM-T7123
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STAT5-IN-1
CAS:
- 285986-31-4
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
Formula:C₁₆H₁₁N₃O₃
Purezza:99.44% - ≥95%
Colore e forma:Solid
Peso molecolare:293.28
Ref: TM-T4216
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Ruxolitinib
CAS:
- 941678-49-5
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.
Formula:C₁₇H₁₈N₆
Purezza:99.4% - >99.99%
Colore e forma:Solid
Peso molecolare:306.36
Ref: TM-T1829
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SC99
CAS:
- 882290-02-0
SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.
Formula:C₁₅H₈Cl₂FN₃O
Purezza:99.56%
Colore e forma:Solid
Peso molecolare:336.15
Ref: TM-T8719
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Hispidulin
CAS:
- 1447-88-7
Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).
Formula:C₁₆H₁₂O₆
Purezza:98.53% - 99.87%
Colore e forma:Solid
Peso molecolare:300.26
Ref: TM-TQ0201
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Brevilin A
CAS:
- 16503-32-5
Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.
Formula:C₂₀H₂₆O₅
Purezza:99.97% - >99.99%
Colore e forma:Solid
Peso molecolare:346.42
Ref: TM-T4672
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Fosifidancitinib
CAS:
- 1237168-58-9
Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.
Formula:C₂₁H₂₁FN₅O₇P
Purezza:99.54%
Colore e forma:Solid
Peso molecolare:505.39
Ref: TM-T38624
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Peramivir Trihydrate
CAS:
- 1041434-82-5
Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are
Formula:C₁₅H₂₈N₄O₄·3H₂O
Purezza:99.52% - ≥95%
Colore e forma:Solid
Peso molecolare:382.45
Ref: TM-T2522
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Itacitinib
CAS:
- 1334298-90-6
Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.
Formula:C₂₆H₂₃F₄N₉O
Purezza:96.4% - 99.5%
Colore e forma:Solid
Peso molecolare:553.51
Ref: TM-T3998
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NVP-BSK805 trihydrochloride
CAS:
- 2320258-95-3
NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.
Formula:C₂₇H₃₁Cl₃F₂N₆O
Colore e forma:Solid
Peso molecolare:599.93
Ref: TM-T39858
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Oclacitinib maleate
CAS:
- 1640292-55-2
Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.
Formula:C₁₅H₂₃N₅O₂S·C₄H₄O₄
Purezza:99.17% - 99.92%
Colore e forma:Solid
Peso molecolare:453.51
Ref: TM-T6914
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SMI-16a
CAS:
- 587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (
Formula:C₁₃H₁₃NO₃S
Purezza:99.99%
Colore e forma:Solid
Peso molecolare:263.31
Ref: TM-T3989
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Momelotinib HCl
CAS:
- 1380317-28-1
Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
Formula:C₂₃H₂₄Cl₂N₆O₂
Colore e forma:Solid
Peso molecolare:487.38
Ref: TM-T70823
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(Z)-SMI-4a
CAS:
- 438190-29-5
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
Formula:C₁₁H₆F₃NO₂S
Purezza:97.66% - 99.93%
Colore e forma:Solid
Peso molecolare:273.23
Ref: TM-T3058
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Niclosamide sodium
CAS:
- 40321-86-6
Niclosamide (BAY2353) sodium: oral antihelminthic, STAT3 inhibitor (IC50 0.25 μM), anti-cancer, and DNA replication blocker.
Formula:C₁₃H₇Cl₂N₂NaO₄
Colore e forma:Solid
Peso molecolare:349.1
Ref: TM-T72519
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Oclacitinib
CAS:
- 1208319-26-9
Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000
Formula:C₁₅H₂₃N₅O₂S
Purezza:98% - 98.45%
Colore e forma:White To Off-White Solid
Peso molecolare:337.44
Ref: TM-T2012
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GS-829845
CAS:
- 1257705-09-1
GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life
Formula:C₁₇H₁₉N₅O₂S
Purezza:99.93%
Colore e forma:Solid
Peso molecolare:357.43
Ref: TM-T67905
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Osunprotafib
CAS:
- 2489404-97-7
Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.Cost-effective and quality-assured.
Formula:C₁₇H₂₄FN₃O₄S
Purezza:97.11% - 99.91%
Colore e forma:Solid
Peso molecolare:385.45
Ref: TM-T61699
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Golotimod
CAS:
- 229305-39-9
Golotimod (SCV 07) is an antimicrobial active dipeptide with immunomodulatory activity for the study of recurrent genital herpes simplex virus 2 infections.
Formula:C₁₆H₁₉N₃O₅
Purezza:99.88% - 99.98%
Colore e forma:Solid
Peso molecolare:333.34
Ref: TM-T11449L
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Cerdulatinib hydrochloride
CAS:
- 1369761-01-2
Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.
Formula:C₂₀H₂₈ClN₇O₃S
Purezza:99.85%
Colore e forma:Solid
Peso molecolare:482
Ref: TM-T6104