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Segnalazione JAK/STAT

Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 333 prodotti di "Segnalazione JAK/STAT"

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  • GDC-4379
    Targetmol
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    GDC-4379

    CAS:
    GDC-4379 is a JAK1 inhibitor that can be used to study asthma.
    Formula:C21H18ClF2N7O3
    Colore e forma:Solid
    Peso molecolare:489.86

    Ref: TM-T63280

  • JAK3-IN-12
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    JAK3-IN-12

    CAS:
    JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.
    Formula:C19H19N5O4S
    Colore e forma:Solid
    Peso molecolare:413.45

    Ref: TM-T62114

  • Peficitinib hydrobromide
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    Peficitinib hydrobromide

    CAS:
    Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.
    Formula:C18H23BrN4O2
    Colore e forma:Solid
    Peso molecolare:407.312

    Ref: TM-T33905

  • JAK-IN-10
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    JAK-IN-10

    CAS:
    <p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>
    Formula:C20H18FN5O3S
    Purezza:99.53%
    Colore e forma:Solid
    Peso molecolare:427.45

    Ref: TM-T13571

  • JAK3-IN-1
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    JAK3-IN-1

    CAS:
    JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.
    Formula:C26H30ClN7O2
    Colore e forma:Solid
    Peso molecolare:508.02

    Ref: TM-T15607

  • Povorcitinib
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    Povorcitinib

    CAS:
    Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).
    Formula:C23H22F5N7O
    Colore e forma:Solid
    Peso molecolare:507.469

    Ref: TM-T39113

  • SD-1029
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    SD-1029

    CAS:
    SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.
    Formula:C25H32Br2Cl2N2O3
    Colore e forma:Solid
    Peso molecolare:639.25

    Ref: TM-T24774

  • (2R,5S)-Ritlecitinib
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    (2R,5S)-Ritlecitinib

    CAS:
    (2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].
    Formula:C15H19N5O
    Colore e forma:Solid
    Peso molecolare:285.34

    Ref: TM-T60565

  • YM-341619
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    YM-341619

    CAS:
    YM-341619 (AS1617612), potent STAT6 inhibitor; IC50: 0.70 nM; hinders IL-4-induced Th2 in mice; may aid allergic disease research.
    Formula:C22H21F3N6O2
    Colore e forma:Solid
    Peso molecolare:458.44

    Ref: TM-T62860

  • TyK2-IN-2
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    TyK2-IN-2

    CAS:
    TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
    Formula:C16H18N6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:310.35

    Ref: TM-T13232

  • TUL01101
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    TUL01101

    CAS:
    TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.
    Formula:C22H25F2N5O2
    Colore e forma:Solid
    Peso molecolare:429.46

    Ref: TM-T73392

  • JAK-IN-20
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    JAK-IN-20

    CAS:
    JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.
    Formula:C28H30FN7O2
    Colore e forma:Solid
    Peso molecolare:515.58

    Ref: TM-T63581

  • JAK-IN-11
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    JAK-IN-11

    CAS:
    JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.
    Formula:C23H22FN5O4S
    Purezza:99.75%
    Colore e forma:Solid
    Peso molecolare:483.52

    Ref: TM-T12549

  • JAK-2/3-IN-2
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    JAK-2/3-IN-2

    CAS:
    JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).
    Formula:C19H19ClN2OS
    Colore e forma:Solid
    Peso molecolare:358.89

    Ref: TM-T61323

  • AZD-1897
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    AZD-1897

    CAS:
    AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.
    Formula:C18H23N3O3S
    Purezza:99.49%
    Colore e forma:Solid
    Peso molecolare:361.46

    Ref: TM-T71242

  • TP-5801
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    TP-5801

    CAS:
    TP-5801 is an orally active non-receptor tyrosine kinase (TNK1) inhibitor with an IC50 value of 1.40 nM and antitumor effects.
    Formula:C24H31BrN8O
    Colore e forma:Solid
    Peso molecolare:527.46

    Ref: TM-T63701

  • Stafia-1-dipivaloyloxymethyl ester
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    Stafia-1-dipivaloyloxymethyl ester

    CAS:
    Stafia-1 suppresses pSTAT5a in a dose-dependent manner (0-200 μM) without affecting pSTAT5b.
    Formula:C37H48FO13P
    Colore e forma:Solid
    Peso molecolare:750.74

    Ref: TM-T35917

  • MM-206
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    MM-206

    CAS:
    MM-206, a cell-permeable, non-cytotoxic naphthalene sulfonamide compound, it effectively inhibits STAT3 DNA-binding activity.
    Formula:C22H12F5NO3S2
    Colore e forma:Solid
    Peso molecolare:497.46

    Ref: TM-T28075

  • MC0704
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    MC0704

    MC0704: STAT3 inhibitor, IC50=2.13μM, promotes apoptosis & cell arrest, anti-breast cancer, for mTNBC research.
    Formula:C29H21BrN4O2
    Colore e forma:Solid
    Peso molecolare:537.41

    Ref: TM-T73501

  • XZH-5
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    XZH-5

    CAS:
    XZH-5 is an inhibitor of STAT3.
    Formula:C22H25F6N5O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:537.46

    Ref: TM-T26340