CymitQuimica logo
Segnalazione JAK/STAT

Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 322 prodotti di "Segnalazione JAK/STAT"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • Lepzacitinib
    Targetmol
    + Info

    Lepzacitinib

    CAS:
    <p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>
    Formula:C18H21N5O3
    Purezza:99.85%
    Colore e forma:Solid
    Peso molecolare:355.39

    Ref: TM-T78207

  • PM-43I
    Targetmol
    + Info

    PM-43I

    CAS:
    <p>PM-43I is a potent inhibitor of both STAT5- and STAT6-dependent allergic airway disease in mice.</p>
    Formula:C38H50F2N3O10P
    Colore e forma:Solid
    Peso molecolare:777.79

    Ref: TM-T70333

  • JAK-IN-26
    Targetmol
    + Info

    JAK-IN-26

    CAS:
    <p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>
    Formula:C22H24N6O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:420.46

    Ref: TM-T78189

  • TCS 21311
    Targetmol
    + Info

    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purezza:99.39% - ≥98%
    Colore e forma:Solid
    Peso molecolare:526.51

    Ref: TM-T17019

  • STAT3-IN-14
    Targetmol
    + Info

    STAT3-IN-14

    CAS:
    <p>STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 can directly bind to the hinge region of STAT3 .</p>
    Formula:C14H10O5
    Colore e forma:Solid
    Peso molecolare:258.23

    Ref: TM-T73070

  • Pim-1 kinase inhibitor 5
    Targetmol
    + Info

    Pim-1 kinase inhibitor 5

    CAS:
    <p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>
    Formula:C22H13Cl2N3O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:406.26

    Ref: TM-T78980

  • JAK-IN-24
    Targetmol
    + Info

    JAK-IN-24

    CAS:
    <p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>
    Formula:C20H25N5O2
    Colore e forma:Solid
    Peso molecolare:367.44

    Ref: TM-T73330

  • JAK kinase-IN-1
    Targetmol
    + Info

    JAK kinase-IN-1

    CAS:
    <p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>
    Formula:C17H19F2N7OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:407.44

    Ref: TM-T79807

  • PIM1-IN-4
    Targetmol
    + Info

    PIM1-IN-4

    CAS:
    <p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>
    Formula:C27H25BrCl2CuN6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:663.88

    Ref: TM-T73247

  • JAK-IN-1
    Targetmol
    + Info

    JAK-IN-1

    CAS:
    <p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>
    Formula:C20H24N6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:380.44

    Ref: TM-T11703

  • GNE-955
    Targetmol
    + Info

    GNE-955

    CAS:
    <p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>
    Formula:C22H24N8O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:416.48

    Ref: TM-T15406

  • PIM1-IN-1
    Targetmol
    + Info

    PIM1-IN-1

    CAS:
    <p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>
    Formula:C25H30N8O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:474.56

    Ref: TM-T12474

  • Tubulin/JAK2-IN-1
    Targetmol
    + Info

    Tubulin/JAK2-IN-1

    CAS:
    <p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>
    Formula:C22H20N6O3
    Colore e forma:Solid
    Peso molecolare:416.43

    Ref: TM-T80921

  • Ginsenoside Rk1
    Targetmol
    + Info

    Ginsenoside Rk1

    CAS:
    <p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>
    Formula:C42H70O12
    Purezza:98.46% - 99.13%
    Colore e forma:Solid
    Peso molecolare:767

    Ref: TM-T4S1499

  • Upadacitinib tartrate
    Targetmol
    + Info

    Upadacitinib tartrate

    CAS:
    <p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>
    Formula:C21H33F3N6O11
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:602.521

    Ref: TM-T7503L

  • JAK-IN-25
    Targetmol
    + Info

    JAK-IN-25

    CAS:
    <p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>
    Formula:C19H17N5O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:379.37

    Ref: TM-T78175

  • Tyk2-IN-9
    Targetmol
    + Info

    Tyk2-IN-9

    CAS:
    <p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>
    Formula:C20H17N9
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:383.41

    Ref: TM-T13237

  • JAK-IN-4
    Targetmol
    + Info

    JAK-IN-4

    CAS:
    <p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>
    Formula:C18H21N4Na2O6P
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:466.341

    Ref: TM-T11705

  • Nezulcitinib
    Targetmol
    + Info

    Nezulcitinib

    CAS:
    <p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>
    Formula:C30H37N7O2
    Colore e forma:Solid
    Peso molecolare:527.66

    Ref: TM-T63709

  • JAK2-IN-4
    Targetmol
    + Info

    JAK2-IN-4

    CAS:
    JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
    Formula:C23H27N5O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:469.56

    Ref: TM-T11708