JNK
Le JNK (c-Jun N-terminal kinases) sono un sottogruppo della famiglia MAPK che rispondono a stimoli di stress, come citochine, radiazioni ultraviolette e shock termico, e sono coinvolte nel controllo dell'apoptosi, dell'infiammazione e delle risposte immunitarie. La segnalazione JNK è cruciale per la regolazione delle risposte cellulari allo stress ed è stata implicata in varie malattie, tra cui disturbi neurodegenerativi, cancro e condizioni infiammatorie. Presso CymitQuimica, offriamo una gamma di modulatori della via JNK per supportare la tua ricerca sulla segnalazione dello stress, l'apoptosi e la patologia delle malattie.
Trovati 101 prodotti di "JNK"
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Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purezza:99.45%Colore e forma:SolidPeso molecolare:212.2Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formula:C21H23F3N6O2Purezza:98.66% - 99.28%Colore e forma:SolidPeso molecolare:448.44SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formula:C5H3N5O2S3Purezza:98.39%Colore e forma:SolidPeso molecolare:261.3JNK-IN-13
CAS:<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Formula:C13H7ClN4SPurezza:98.74%Colore e forma:SolidPeso molecolare:286.74Metacetamol
CAS:Metacetamol, a non-toxic acetaminophen derivative, is an OTC analgesic/antipyretic and synthesis intermediate.Formula:C8H9NO2Purezza:99.76% - 99.90%Colore e forma:Physical Description Light Gray Solid (Ntp 1992)Peso molecolare:151.16Chloramphenicol
CAS:<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formula:C11H12Cl2N2O5Purezza:99.6% - 99.84%Colore e forma:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecolare:323.13Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurezza:99% - 99.99%Colore e forma:Off-White To Yellow SolidPeso molecolare:414.77NBDHEX
CAS:NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Formula:C12H15N3O4SPurezza:97.38%Colore e forma:SolidPeso molecolare:297.33Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formula:C17H16F6N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:378.31Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurezza:99.79% - 99.84%Colore e forma:SolidPeso molecolare:291.37JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formula:C120H213F3N48O28Purezza:98%Colore e forma:SolidPeso molecolare:2833.28JNK-IN-18
JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).Colore e forma:Odour SolidJNK-1-IN-3
CAS:JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.Formula:C19H17FN4O3Purezza:97.551%Colore e forma:SolidPeso molecolare:368.36OVA-E1 peptide
CAS:OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.Formula:C47H76N10O14Colore e forma:SolidPeso molecolare:1005.181AS601245.2TFA (345987-15-7 free base)
CAS:AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formula:C24H18F6N6O4SPurezza:98%Colore e forma:SoildPeso molecolare:600.50L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formula:C164H286N66O40Purezza:98%Colore e forma:SolidPeso molecolare:3822.44PROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Formula:C35H32BrN9O6Colore e forma:SolidPeso molecolare:754.589JNK2-IN-1
JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α andFormula:C30H26N4O5Purezza:98%Colore e forma:SolidPeso molecolare:522.55SP 600125, negative control
CAS:<p>SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125.</p>Formula:C15H10N2OPurezza:≥98%Colore e forma:SolidPeso molecolare:234.25n-Butyl α-D-fructofuranoside
CAS:N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.Formula:C10H20O6Purezza:98%Colore e forma:SolidPeso molecolare:236.26BRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Colore e forma:Odour SolidJNK-IN-12
JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptideFormula:C56H82N16O7Purezza:98%Colore e forma:SolidPeso molecolare:1091.35MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Colore e forma:Odour SolidJNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formula:C32H30FN7O3Colore e forma:SolidPeso molecolare:579.62D-JNKI-1
CAS:D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.Formula:C164H286N66O40Purezza:98%Colore e forma:SolidPeso molecolare:3822.44IQ-1S
CAS:IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.Formula:C15H8N3NaOColore e forma:SolidPeso molecolare:269.23JNK-IN-14
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.Formula:C27H31N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:521.63Vacquinol-1
CAS:Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formula:C21H21ClN2OPurezza:99.92%Colore e forma:SolidPeso molecolare:352.86CC-401
CAS:<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Formula:C22H24N6OPurezza:98%Colore e forma:SolidPeso molecolare:388.47D-JBD19
CAS:D-JBD19 is a non-permeable peptide with neuroprotective effects.Formula:C99H164N32O28Purezza:98%Colore e forma:SolidPeso molecolare:2250.597Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidMAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidJNK-1-IN-2
"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values ofFormula:C16H20BrN5OPurezza:98%Colore e forma:SolidPeso molecolare:378.27JIP-1(153-163)
CAS:Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.Formula:C61H104N20O14Purezza:98%Colore e forma:SolidPeso molecolare:1341.6OVA-E1 peptide TFA
CAS:<p>OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.</p>Formula:C49H77F3N10O16Purezza:98%Colore e forma:SolidPeso molecolare:1119.19JNK3 inhibitor-7
Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.Formula:C32H31N7O3Colore e forma:SolidPeso molecolare:561.63JNK1 Protein, Human, Recombinant (GST)
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.Colore e forma:Lyophilized PowderPeso molecolare:75 kDa (predicted); 65 kDa (reducing conditions)Ezatiostat
CAS:Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.Formula:C27H35N3O6SPurezza:97.95%Colore e forma:SolidPeso molecolare:529.65JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Formula:C63H108N20O16Purezza:92.89%Colore e forma:SolidPeso molecolare:1401.65Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:316.35Ro 31-8220
CAS:Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Formula:C25H23N5O2SColore e forma:SolidPeso molecolare:457.55Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formula:C26H45NO6SPurezza:99.53% - 99.86%Colore e forma:SolidPeso molecolare:499.7CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formula:C22H25ClN6OPurezza:99.71% - ≥95%Colore e forma:SolidPeso molecolare:424.93Actein
CAS:Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formula:C37H56O11Purezza:≥98%Colore e forma:Brown PowderPeso molecolare:676.83Anisomycin
CAS:Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.Formula:C14H19NO4Purezza:98.33% - 99.81%Colore e forma:White Crystalline SolidPeso molecolare:265.3Bentamapimod
CAS:<p>Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.</p>Formula:C25H23N5O2SPurezza:97.04% - 99.92%Colore e forma:SolidPeso molecolare:457.55Guggulsterone
CAS:<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Formula:C21H28O2Purezza:99.4% - 99.8%Colore e forma:Light Yellow PowderPeso molecolare:312.45JNK Inhibitor VIII
CAS:<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Formula:C18H20N4O4Purezza:98.93%Colore e forma:SolidPeso molecolare:356.38Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Formula:C25H23N5O2S·CH4O3SPurezza:98.79% - 99.02%Colore e forma:SolidPeso molecolare:553.65TOMATIDINE HYDROCHLORIDE
CAS:<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Formula:C27H46ClNO2Purezza:99.75% - ≥95%Colore e forma:SolidPeso molecolare:452.11
