Proteasi/Proteasoma
Gli inibitori delle proteasi e del proteasoma sono composti che bloccano l'attività delle proteasi e del proteasoma, che sono coinvolti nella degradazione e nel turnover delle proteine. Questi inibitori sono fondamentali per studiare la regolazione dell'omeostasi proteica, il controllo del ciclo cellulare e l'apoptosi. Gli inibitori delle proteasi e del proteasoma vengono anche utilizzati nel trattamento di malattie come il cancro, dove la degradazione anomala delle proteine svolge un ruolo nella progressione della malattia. Inibendo le proteasi o il proteasoma, questi composti possono indurre la morte cellulare nelle cellule tumorali e sono strumenti critici sia per la ricerca di base che per lo sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle proteasi e del proteasoma di alta qualità per supportare la tua ricerca in biochimica, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Proteasi/Proteasoma"
- Acetil-CoA carbossilasi(36 prodotti)
- Cisteina proteasi(110 prodotti)
- DPP-4(24 prodotti)
- Glutaminasi(44 prodotti)
- Proteasi HIV(496 prodotti)
- PAI-1(26 prodotti)
- Inibitori della proteasi(50 prodotti)
- Ricettore attivato dalla proteasi(54 prodotti)
- Proteasoma(87 prodotti)
- Proteasi serina(51 prodotti)
- p97(15 prodotti)
Mostrare 3 più sottocategorie
Trovati 990 prodotti di "Proteasi/Proteasoma"
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Tyrosinase-IN-35
CAS:Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.40RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formula:C17H12ClN3OS3Colore e forma:SolidPeso molecolare:405.95TG-2-IN-4
CAS:TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Formula:C34H40N6O5Colore e forma:SolidPeso molecolare:612.72SMCypI C31
SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).Formula:C27H30N4O2SColore e forma:SolidPeso molecolare:474.62Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Formula:C21H14ClF3N4SColore e forma:SolidPeso molecolare:446.88Freselestat
CAS:Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.Formula:C23H28N6O4Colore e forma:SolidPeso molecolare:452.51MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Formula:C20H31ClN4O7Colore e forma:SolidPeso molecolare:474.936UK-370106
CAS:UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-Formula:C35H44N2O5Purezza:98%Colore e forma:SolidPeso molecolare:572.73Ciluprevir
CAS:Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.Formula:C40H50N6O8SPurezza:98%Colore e forma:SolidPeso molecolare:774.93PNU-248686A
CAS:PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).Formula:C22H18ClNaO5S2Purezza:98%Colore e forma:SolidPeso molecolare:484.95Piceid 6″-O-azelaic acid ester
Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.Formula:C24H36O10Colore e forma:SolidPeso molecolare:484.54GSK-2878175
CAS:GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C27H23BClFN2O6SPurezza:98%Colore e forma:SolidPeso molecolare:568.81Kallikrein-IN-1
CAS:Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formula:C28H26FN5O4Colore e forma:SolidPeso molecolare:515.54Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Formula:C30H33F4N5O3Colore e forma:SolidPeso molecolare:587.61(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Formula:C22H30N6OSColore e forma:SolidPeso molecolare:426.578Narlaprevir
CAS:Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.Formula:C36H61N5O7SPurezza:98%Colore e forma:SolidPeso molecolare:707.96TMPRSS6-IN-1 TFA
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.Formula:C35H41F3N8O6S2Colore e forma:SolidPeso molecolare:790.875BI-1915
CAS:BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.
Formula:C21H37N5O3Colore e forma:SolidPeso molecolare:407.55Plasma kallikrein-IN-2
Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.Formula:C28H24ClF3N8O3Colore e forma:SolidPeso molecolare:612.99Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formula:C28H21F3N6OSColore e forma:SolidPeso molecolare:546.57SD-2590 HCl
CAS:SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.Formula:C22H26ClF3N2O7SPurezza:98%Colore e forma:SolidPeso molecolare:554.96Isobutylamido thiazolyl resorcinol
CAS:Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.Formula:C13H14N2O3SColore e forma:SolidPeso molecolare:278.33HCV-IN-38
Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.Formula:C22H24ClF3N4O4Colore e forma:SolidPeso molecolare:500.93-Aminobenzene-1,2-diol
CAS:3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Formula:C6H7NO2Colore e forma:SolidPeso molecolare:125.13HCV NS5B polymerase-IN-2
CAS:HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.Formula:C26H24N2O4Colore e forma:SolidPeso molecolare:428.48RDN2150
CAS:RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69Formula:C28H29ClN8O4Colore e forma:SolidPeso molecolare:577.03UK 356618
CAS:UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).
Formula:C34H43N3O4Purezza:98%Colore e forma:SolidPeso molecolare:557.72GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Formula:C27H27BF2N2O6SColore e forma:SolidPeso molecolare:556.39(1R,3S)-THCCA-Asn
(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.Formula:C24H24N4O6Colore e forma:SolidPeso molecolare:464.47RBx-0597
CAS:RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Formula:C19H20F2N4O2Colore e forma:SolidPeso molecolare:374.384Tilpisertib fosmecarbil
CAS:Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Formula:C35H36ClN8O7PColore e forma:SolidPeso molecolare:747.14Marizomib
CAS:Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formula:C15H20ClNO4Purezza:98.03% - 99.41%Colore e forma:SolidPeso molecolare:313.78RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formula:C27H24F6N4O4SColore e forma:SolidPeso molecolare:614.56Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Formula:C23H30N6O5Colore e forma:SolidPeso molecolare:457.03Anti-infective agent 10
CAS:Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.Formula:C26H25N3O7SColore e forma:SolidPeso molecolare:523.56DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Formula:C17H14F3N3O2SColore e forma:SolidPeso molecolare:381.372SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Formula:C24H21N3O2Colore e forma:SolidPeso molecolare:383.44Valopicitabine
CAS:Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronicFormula:C15H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:356.37Cyclophilin inhibitor 1
CAS:Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Formula:C31H39N5O7Purezza:98%Colore e forma:SolidPeso molecolare:593.67ABT-072
CAS:ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.Formula:C24H27N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:469.55Cathepsin C-IN-5
CAS:Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.
Formula:C21H17ClN6OSColore e forma:SolidPeso molecolare:436.92HCV-IN-7
CAS:HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Formula:C40H48N8O6SPurezza:98%Colore e forma:SolidPeso molecolare:768.92Idraparinux Na
CAS:Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa InhibitorFormula:C38H55Na9O49S7Colore e forma:SolidPeso molecolare:1727.14Odiparcil
CAS:Odiparcil is an orally active beta-d-thioxyloside analog.Formula:C15H16O6SPurezza:98%Colore e forma:SolidPeso molecolare:324.35GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.Formula:C26H25FN4OSColore e forma:SolidPeso molecolare:460.57BAY-7598
CAS:BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).Formula:C28H31N3O6Purezza:98%Colore e forma:SolidPeso molecolare:505.56GW311616 hydrochloride
CAS:GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formula:C19H32ClN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:433.99AMG-222 tosylate
CAS:AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.Formula:C39H47N9O6SColore e forma:SolidPeso molecolare:769.91Faldaprevir
CAS:Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Formula:C40H49BrN6O9SPurezza:99.04% - 99.19%Colore e forma:SolidPeso molecolare:869.82BI-1942
CAS:BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.Formula:C24H26N4O4Colore e forma:SolidPeso molecolare:434.488Valopicitabine dihydrochloride
CAS:Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C15H25ClN4O6Colore e forma:SolidPeso molecolare:392.84Antiplatelet agent 3
CAS:Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Formula:C38H32N2O5Colore e forma:SolidPeso molecolare:596.671Plodicitinib
CAS:Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Formula:C19H22FN7O2Colore e forma:SolidPeso molecolare:399.422Dup-714
CAS:Dup-714 is a thrombin inhibitor.Formula:C21H33BN6O5Purezza:98%Colore e forma:SolidPeso molecolare:460.33Zetomipzomib
CAS:KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Formula:C30H42N4O8Colore e forma:SolidPeso molecolare:586.68Deleobuvir
CAS:Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.Formula:C34H33BrN6O3Colore e forma:SolidPeso molecolare:653.57GW311616
CAS:GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formula:C19H31N3O4SColore e forma:SolidPeso molecolare:397.53TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formula:C19H14BrClN4O2SColore e forma:SolidPeso molecolare:477.762Napsagatran hydrate
CAS:Napsagatran hydrate is a novel and specific inhibitor of thrombin.Formula:C26H36N6O7SPurezza:98%Colore e forma:SolidPeso molecolare:576.66ZINC09518833
CAS:ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Formula:C24H25N3O5Colore e forma:SolidPeso molecolare:435.47Tyrosinase-IN-37
CAS:Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.Formula:C12H12N6SColore e forma:SolidPeso molecolare:272.33BMT-052
CAS:BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).Formula:C30H17D9F4N6O5Purezza:98%Colore e forma:SolidPeso molecolare:635.61SSR-182289A (Free)
CAS:SSR-182289A (Free) is a thrombin inhibitor.Formula:C30H33F2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:597.68CM-352
CAS:CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.Formula:C24H29N3O6SPurezza:97.24%Colore e forma:SolidPeso molecolare:487.57Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formula:C22H27F8N5O9Colore e forma:SolidPeso molecolare:657.47RXP03
CAS:RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Formula:C39H43N4O6PColore e forma:SolidPeso molecolare:694.76Faldaprevir sodium
CAS:Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.Formula:C40H48BrN6NaO9SColore e forma:SolidPeso molecolare:891.81Monosodium 2-sulfoterephthalate
CAS:Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.
Formula:C8H5NaO7SColore e forma:SolidPeso molecolare:268.176Pyridoxatin
CAS:Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.Formula:C15H21NO3Colore e forma:SolidPeso molecolare:263.33PLGLAG
CAS:PLGLAG is a peptide chain that acts as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the PLGLAG linker are primarily sensitive to MMP-2 and MMP-9 in vivo. PLGLAG is applicable in cancer research.Formula:C24H42N6O7Colore e forma:SolidPeso molecolare:526.63MMP-13-IN-1
CAS:MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].Formula:C19H16F3N3O3Colore e forma:SolidPeso molecolare:391.34Beclabuvir
CAS:Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Formula:C36H45N5O5SPurezza:99.87% - 99.93%Colore e forma:SolidPeso molecolare:659.84NAPAP
CAS:NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Formula:C27H31N5O4SColore e forma:SolidPeso molecolare:521.63Feniralstat
CAS:Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Formula:C26H25F2N5O4Purezza:99.52%Colore e forma:SolidPeso molecolare:509.51AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Formula:C18H27N3O3Colore e forma:SolidPeso molecolare:333.43JBIR-22
CAS:JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.Formula:C23H33NO6Colore e forma:SolidPeso molecolare:419.51JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Formula:C37H33ClFN3O4Purezza:98.48% - 99.68%Colore e forma:SolidPeso molecolare:638.13Ref: TM-T27696
1mg296,00€5mg718,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€1mL*10mM (DMSO)1.108,00€IDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formula:C25H35N6O9PSPurezza:97.15%Colore e forma:SolidPeso molecolare:626.62MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formula:C17H24F3N3O4Purezza:99.27%Colore e forma:SolidPeso molecolare:391.39Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Formula:C38H55N5O9SPurezza:97.41%Colore e forma:SolidPeso molecolare:757.94PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Formula:C11H8FNO2SPurezza:98.63% - ≥95%Colore e forma:SolidPeso molecolare:237.25Sebetralstat
CAS:Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.
Formula:C26H26FN5O4Purezza:99.85%Colore e forma:SolidPeso molecolare:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Formula:C37H48N6O5S2Purezza:≥98%Colore e forma:SolidPeso molecolare:720.9442ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formula:C19H35N3O4SPurezza:98%Colore e forma:White PowderPeso molecolare:401.56IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formula:C24H29Cl2F3N8O3Colore e forma:SolidPeso molecolare:605.44ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Formula:C24H32KN3O8SColore e forma:SolidPeso molecolare:561.69MMP13-IN-2
CAS:MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Formula:C24H19FN6O4SColore e forma:SolidPeso molecolare:506.51Oxindole
CAS:Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Formula:C8H7NOPurezza:99.34%Colore e forma:Off-White Crystalline PowderPeso molecolare:133.15Butabindide oxalate
CAS:CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitorFormula:C19H27N3O6Purezza:98%Colore e forma:SolidPeso molecolare:393.43Davelizomib
CAS:Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Formula:C21H26BF2N3O7Purezza:98%Colore e forma:SolidPeso molecolare:481.25
