Proteasi/Proteasoma
Gli inibitori delle proteasi e del proteasoma sono composti che bloccano l'attività delle proteasi e del proteasoma, che sono coinvolti nella degradazione e nel turnover delle proteine. Questi inibitori sono fondamentali per studiare la regolazione dell'omeostasi proteica, il controllo del ciclo cellulare e l'apoptosi. Gli inibitori delle proteasi e del proteasoma vengono anche utilizzati nel trattamento di malattie come il cancro, dove la degradazione anomala delle proteine svolge un ruolo nella progressione della malattia. Inibendo le proteasi o il proteasoma, questi composti possono indurre la morte cellulare nelle cellule tumorali e sono strumenti critici sia per la ricerca di base che per lo sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle proteasi e del proteasoma di alta qualità per supportare la tua ricerca in biochimica, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Proteasi/Proteasoma"
- Acetil-CoA carbossilasi(36 prodotti)
- Cisteina proteasi(110 prodotti)
- DPP-4(21 prodotti)
- Glutaminasi(45 prodotti)
- Proteasi HIV(508 prodotti)
- PAI-1(26 prodotti)
- Inibitori della proteasi(50 prodotti)
- Ricettore attivato dalla proteasi(54 prodotti)
- Proteasoma(95 prodotti)
- Proteasi serina(55 prodotti)
- p97(15 prodotti)
Mostrare 3 più sottocategorie
Trovati 1082 prodotti di "Proteasi/Proteasoma"
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Pyrithione cadmium
CAS:Pyrithione cadmium suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinaseFormula:C10H8CdN2O2S2Colore e forma:SolidPeso molecolare:364.73I 432
CAS:I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM).Formula:C33H35Cl2F6N5O7SColore e forma:SolidPeso molecolare:830.62AGG-523
CAS:AGG-523, an aggrecanase inhibitor, may slow cartilage wear after joint injury by reducing ARG-aggrecan in rats.Formula:C28H29FN2O4Colore e forma:SolidPeso molecolare:476.54ABT-518
CAS:ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis.Formula:C21H22F3NO8SColore e forma:SolidPeso molecolare:505.46ACH-806
CAS:ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.Formula:C19H20F3N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:411.44HCV-IN-3
CAS:HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor (IC50: 20 μM; Kd: 29 μM).Formula:C13H11F2NOPurezza:98%Colore e forma:SolidPeso molecolare:235.23Plasma kallikrein-IN-3
CAS:Plasma kallikrein-IN-3 is a potent inhibitor (IC50: 0.15 μM) used in hereditary angioedema and diabetic eye disease research.Formula:C20H23N5O2Colore e forma:SolidPeso molecolare:365.43Elastase-IN-1
CAS:Elastase-IN-1 (Compound Q11) is a non-toxic elastase inhibitor with an IC 50 of 0.897 μM [1].Formula:C17H12N4O3Colore e forma:SolidPeso molecolare:320.3MK-2048
CAS:MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.Formula:C21H21ClFN5O4Purezza:98%Colore e forma:SolidPeso molecolare:461.87AZD-1236
CAS:AZD1236 is a selective inhibitor for human MMP-9/MMP-12, less effective in rodents, and reduces lung injury and inflammation.Formula:C15H19ClN4O5SColore e forma:SolidPeso molecolare:402.85Butabindide
CAS:Butabindide (UCL-1397) selectively inhibits TPP II, protecting CCK-8, with Ki of 10 μM (TPP I) and 7 nM (TPP II).Formula:C17H25N3O2Colore e forma:SolidPeso molecolare:303.4GM 1489
CAS:GM 1489 is an MMP inhibitor, effective against MMP-1, -2, -3, -8, -9, reduces cancer cell invasion, and prevents ear thickening in mice.Formula:C27H33N3O4Colore e forma:SolidPeso molecolare:463.57Cysteine Protease inhibitor
CAS:Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine ProteaseFormula:C18H14N4OPurezza:98%Colore e forma:SolidPeso molecolare:302.33GSK2793660 HCl
CAS:GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.Formula:C22H32ClN3O3Colore e forma:SolidPeso molecolare:421.96GSK2793660 free base
CAS:GSK-2793660, a cathepsin C inhibitor, may treat cystic fibrosis and related lung conditions.Formula:C22H31N3O3Colore e forma:SolidPeso molecolare:385.5THDP-17
CAS:THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Formula:C12H16N2SPurezza:98%Colore e forma:SolidPeso molecolare:220.33Garvagliptin
CAS:Garvagliptin has antidiabetic activity.Formula:C18H23F2N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:399.46(Rac)-Tanomastat
CAS:Tanomastat (BAY 12-9566) is an oral biphenyl MMP inhibitor; blocks MMP-2, -3, -9, -13, with anti-invasive and anti-metastatic properties.Formula:C23H19ClO3SColore e forma:SolidPeso molecolare:410.91DPP-IV-IN-1
CAS:DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).Formula:C11H18FN3O2Purezza:98%Colore e forma:SolidPeso molecolare:243.28SP-Chymostatin B
CAS:SP-Chymostatin B inhibits proteases like chymotrypsin and papain; less effective on human elastase; works at 100-200 μg/ml.Formula:C30H41N7O6Purezza:98%Colore e forma:SolidPeso molecolare:595.69Cysteine protease inhibitor-2
CAS:Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.Formula:C13H5N5OPurezza:98%Colore e forma:SolidPeso molecolare:247.21ZD8321
CAS:<p>ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).</p>Formula:C18H28F3N3O5Purezza:98%Colore e forma:SolidPeso molecolare:423.43Proteasome-IN-1
CAS:Proteasome-IN-1 is an inhibitor of proteasome.Formula:C42H35N5O3Purezza:98%Colore e forma:SolidPeso molecolare:657.76A-933548
CAS:A-933548: potent calpain inhibitor, selective vs. cathepsins, stable, effective in cell assays.Formula:C25H21N5O3Purezza:98%Colore e forma:SolidPeso molecolare:439.47Antiviral agent 30
CAS:Antiviral Agent 30 (Example 118) is an active compound against HCV and RSV with an inhibitory concentration (IC 50) of greater than 25μM [1].Formula:C21H32N2O3SColore e forma:SolidPeso molecolare:392.56TAPI-1
CAS:TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.Formula:C26H37N5O5Purezza:≥95%Colore e forma:SolidPeso molecolare:499.6ABT-770
CAS:ABT-770: an orally potent and selective MMP inhibitor, shown to reduce tumor growth in animal models.Formula:C22H22F3N3O6Colore e forma:SolidPeso molecolare:481.42Gü1303
CAS:Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).Formula:C20H22N4O3Colore e forma:SolidPeso molecolare:366.41GS-9256
CAS:GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1].Formula:C46H56ClF2N6O8PSPurezza:98%Colore e forma:SolidPeso molecolare:957.46Z-LLF-CHO
CAS:Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.Formula:C29H39N3O5Purezza:98%Colore e forma:SolidPeso molecolare:509.64MMP13-IN-4
CAS:MMP13-IN-4 (compound 13) is a potent, selective MMP-13 inhibitor with an IC50 of 14.6 μM, implicated in the pathology of osteoarthritis (OA) [1].Formula:C21H17BrN4O5Purezza:98%Colore e forma:SolidPeso molecolare:485.29ND-322 HCl
CAS:ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.Formula:C15H16ClNO3S2Purezza:99.49%Colore e forma:SolidPeso molecolare:357.88Ref: TM-T28145
1mg160,00€5mg354,00€10mg518,00€25mg822,00€50mg1.103,00€100mg1.491,00€1mL*10mM (DMSO)369,00€(S)-BI-1001
CAS:(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).Formula:C19H15BrClNO3Purezza:98%Colore e forma:SolidPeso molecolare:420.68PF-00356231 hydrochloride
CAS:PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.Formula:C25H21ClN2O3SPurezza:98.39%Colore e forma:SolidPeso molecolare:464.96Ref: TM-T12414
1mg71,00€5mg187,00€10mg300,00€25mg490,00€50mg678,00€100mg900,00€500mgPrezzo su richiestaTyrosinase-IN-1
CAS:Tyrosinase-IN-1: potent inhibitor for skin-whitening & food preservation with uses in cosmetics & medicine.Formula:C10H9N3O2S2Colore e forma:SolidPeso molecolare:267.33OM-189
CAS:OM-189 is a selective inhibitor of synthetic thrombin.Formula:C24H36N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:488.65NNGH
CAS:NNGH is a matrix metalloproteinase 3 (MMP-3) inhibitor with anticancer activity that counteracts the inhibitory effects of E2 and DHT on RANKL membrane-binding.Formula:C13H20N2O5SPurezza:98.41%Colore e forma:SolidPeso molecolare:316.37Navuridine
CAS:Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.Formula:C9H11N5O4Purezza:99.83%Colore e forma:SolidPeso molecolare:253.22Ref: TM-T21474
5mg48,00€10mg71,00€25mg131,00€50mg188,00€100mg298,00€500mg1.216,00€1mL*10mM (DMSO)52,00€ZM223 hydrochloride (2031177-48-5 free base)
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.Formula:C23H18ClF3N4O2S2Purezza:98%Colore e forma:SolidPeso molecolare:538.99Adafosbuvir PM
CAS:Adafosbuvir PM (AL-335 PM) is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.Formula:C10H13FN2O6Purezza:98.39%Colore e forma:SolidPeso molecolare:276.22Calpain Inhibitor XII
CAS:<p>Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.</p>Formula:C26H34N4O5Colore e forma:SolidPeso molecolare:482.57Flovagatran
CAS:Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Formula:C27H36BN3O7Purezza:99.56%Colore e forma:SolidPeso molecolare:525.4RO-9187
CAS:RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).Formula:C9H12N6O5Purezza:98%Colore e forma:SolidPeso molecolare:284.23BR351
CAS:BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).Formula:C20H25FN2O5SPurezza:98%Colore e forma:SolidPeso molecolare:424.492-MPPA
CAS:2-MPPA (GPI-5693) is a GCP II inhibitor and NAALADase inhibitor, used in research on neurodegenerative diseases.Formula:C8H14O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:206.26Ref: TM-T22497
1mg49,00€5mg104,00€10mg169,00€25mg378,00€50mg655,00€100mg1.169,00€200mg1.586,00€1mL*10mM (DMSO)115,00€Cofrogliptin
CAS:Cofrogliptin (HSK7653) is a DPP-4 inhibitor with hypoglycemic effects, which can be used to study type 2 diabetes (T2D).Formula:C18H19F5N4O3SColore e forma:SolidPeso molecolare:466.43Gemigliptin Tartrate(911637-19-9 free base)
CAS:Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).Formula:C22H25F8N5O8Purezza:>99.99%Colore e forma:SolidPeso molecolare:639.45Tanomastat
CAS:Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor.Formula:C23H19ClO3SPurezza:98%Colore e forma:SolidPeso molecolare:410.91Gosogliptin
CAS:Gosogliptin is a potent, orally active, highly selective, reversible and competitive inhibitor of DPP-4, increasing the level of intestinal GLP-1 and GIP.Formula:C17H24F2N6OPurezza:99.74%Colore e forma:SolidPeso molecolare:366.41Tyrosinase-IN-4
CAS:<p>Tyrosinase-IN-4, a potent inhibitor, has uses in skin-whitening, food preservation, cosmetics, agriculture, and medicine.</p>Formula:C15H9ClO3Colore e forma:SolidPeso molecolare:272.68
