Cellule staminali e Derivati
Gli inibitori delle cellule staminali sono composti che bersagliano specificamente le vie di segnalazione e le proteine coinvolte nel mantenimento, nella differenziazione e nella proliferazione delle cellule staminali. Questi inibitori sono cruciali per comprendere la biologia delle cellule staminali e per sviluppare strategie per manipolare le cellule staminali a fini terapeutici, come la medicina rigenerativa e il trattamento del cancro. Controllando il destino delle cellule staminali, questi inibitori possono aiutare a guidare la differenziazione delle cellule staminali in tipi cellulari specifici o a prevenire una crescita cellulare indesiderata. Presso CymitQuimica, offriamo una selezione di inibitori delle cellule staminali di alta qualità per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e medicina rigenerativa.
Sottocategorie di "Cellule staminali e Derivati"
- Gamma-secretasi(59 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Via di segnalazione Hippo(6 prodotti)
- JAK(245 prodotti)
- Proteina Porcupine(9 prodotti)
- ROCK(70 prodotti)
- STAT(98 prodotti)
- Cellule staminali(486 prodotti)
- TGF-beta/Smad(58 prodotti)
- Wnt/beta-catenina(66 prodotti)
Mostrare 2 più sottocategorie
Trovati 695 prodotti di "Cellule staminali e Derivati"
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MRT-83
CAS:<p>MRT-83 is a potent Smo antagonist.</p>Formula:C31H30N4O5Purezza:99.81%Colore e forma:SolidPeso molecolare:538.59WDR5-IN-6
CAS:<p>WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6</p>Formula:C13H8Cl2N2O2SPurezza:99.69%Colore e forma:SoildPeso molecolare:327.19CB-103
CAS:<p>CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.</p>Formula:C15H18N2OPurezza:99.44%Colore e forma:SolidPeso molecolare:242.32N-(3-Aminopropyl)cyclohexylamine
CAS:<p>N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.</p>Formula:C9H20N2Purezza:98.05% - 98.82%Colore e forma:Pale Yellow Clear LiquidPeso molecolare:156.2685Rovalpituzumab
CAS:<p>Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.</p>Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.02 kDaGolidocitinib
CAS:<p>Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).</p>Formula:C25H31N9O2Purezza:98.87% - 99.88%Colore e forma:SolidPeso molecolare:489.57Nefopam hydrochloride
CAS:<p>Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.</p>Formula:C17H20ClNOPurezza:99.32% - 99.85%Colore e forma:SolidPeso molecolare:289.8JAK2 Inhibitor V
CAS:<p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>Formula:C23H24N2OPurezza:98.36% - 99.15%Colore e forma:SolidPeso molecolare:344.45Silmitasertib sodium salt
CAS:<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formula:C19H11ClN3NaO2Purezza:99.49% - 99.62%Colore e forma:SolidPeso molecolare:371.75KY1220
CAS:<p>KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.</p>Formula:C14H10N4O3SPurezza:99.9%Colore e forma:SolidPeso molecolare:314.32NMS-P715
CAS:<p>NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).</p>Formula:C35H39F3N8O3Purezza:99.84%Colore e forma:SolidPeso molecolare:676.73JW74
CAS:<p>JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).</p>Formula:C24H20N6O2SPurezza:95.00%Colore e forma:SolidPeso molecolare:456.52Demcizumab
CAS:<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.34 kDaCWP232228
CAS:<p>CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.</p>Formula:C33H34N7Na2O7PPurezza:98.87%Colore e forma:SolidPeso molecolare:717.63Ilginatinib maleate
CAS:<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formula:C25H24FN7O4Purezza:99.74% - 99.82%Colore e forma:SolidPeso molecolare:505.5BRD0705
CAS:<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formula:C20H23N3OPurezza:99.01%Colore e forma:SolidPeso molecolare:321.42Ilginatinib hydrochloride
CAS:<p>Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formula:C21H21ClFN7Purezza:99.55%Colore e forma:SolidPeso molecolare:425.89TAK-901
CAS:<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formula:C28H32N4O3SPurezza:99.02% - 99.59%Colore e forma:SolidPeso molecolare:504.64Nimucitinib
CAS:<p>Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.</p>Formula:C25H26F2N6O2Purezza:98.71%Colore e forma:SoildPeso molecolare:480.51ROCK inhibitor-2
CAS:<p>ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).</p>Formula:C21H20N2O2Purezza:99.85%Colore e forma:SolidPeso molecolare:332.4Delgocitinib
CAS:<p>Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.</p>Formula:C16H18N6OPurezza:99.95%Colore e forma:SolidPeso molecolare:310.35NGP555
CAS:<p>NGP555 is a modulator of γ-secretase.</p>Formula:C23H23FN4SPurezza:99.86%Colore e forma:SolidPeso molecolare:406.52Ilginatinib
CAS:<p>Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formula:C21H20FN7Purezza:98.4% - 99.01%Colore e forma:SolidPeso molecolare:389.43Brontictuzumab
CAS:<p>Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.</p>Purezza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Colore e forma:LiquidGSK-3 inhibitor 4
CAS:<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formula:C22H15F2N5OPurezza:99.41%Colore e forma:SoildPeso molecolare:403.38Sonidegib diphosphate
CAS:<p>Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.</p>Formula:C26H32F3N3O11P2Purezza:99.48% - >99.99%Colore e forma:SolidPeso molecolare:681.49CCT251545
CAS:<p>CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).</p>Formula:C23H24ClN5OPurezza:98.2% - 98.69%Colore e forma:SolidPeso molecolare:421.92Ponsegromab
CAS:<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:146.08 kDaNetarsudil Dihydrochloride
CAS:<p>Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.</p>Formula:C28H29Cl2N3O3Purezza:99.94% - 99.98%Colore e forma:SolidPeso molecolare:526.45IK-930
CAS:<p>IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.</p>Formula:C19H19F3N4O2SPurezza:99.89%Colore e forma:SoildPeso molecolare:424.44Cyanoacetohydrazide
CAS:<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formula:C3H5N3OPurezza:99.78%Colore e forma:Stout Prisms From Alcohol Slightly Brown PowderPeso molecolare:99.09TNIK-IN-5
CAS:<p>TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.</p>Formula:C22H17N3O3Purezza:99.58%Colore e forma:SolidPeso molecolare:371.39BML-286
CAS:<p>BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.</p>Formula:C22H18N2O4Purezza:98.44%Colore e forma:SolidPeso molecolare:374.39E 2012
CAS:<p>E2012 is a γ-secretase modulator (GSM).</p>Formula:C25H26FN3O2Purezza:99.18%Colore e forma:SolidPeso molecolare:419.49Gusacitinib
CAS:<p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>Formula:C24H28N8O2Purezza:98.06% - 99.94%Colore e forma:SolidPeso molecolare:460.53Brepocitinib P-Tosylate
CAS:<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Formula:C25H29F2N7O4SPurezza:99.82% - 99.97%Colore e forma:SolidPeso molecolare:561.6Garetosmab
CAS:<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:146 kDaSTAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formula:C16H15NO3SColore e forma:SolidPeso molecolare:301.36Pumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formula:C17H20N8O2SPurezza:99.94%Colore e forma:SoildPeso molecolare:400.46Axltide
CAS:<p>Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.</p>Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77JAK-IN-33
<p>JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].</p>Purezza:98%Colore e forma:Odour SolidSPL-707
CAS:<p>SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).</p>Formula:C27H28FN5O4Purezza:98%Colore e forma:SolidPeso molecolare:505.54Ac-GpYLPQTV-NH2 acetate
<p>Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.</p>Formula:C38H60N9O14P·xC2H4O2Colore e forma:SolidPeso molecolare:897.91 (free base)LSKL TFA
CAS:<p>LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.</p>Formula:C23H43F3N6O7Purezza:99.33%Colore e forma:SolidPeso molecolare:572.62STAT3-IN-37
CAS:<p>STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.</p>Formula:C23H25Cl2N5O2Colore e forma:SolidPeso molecolare:474.38GSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formula:C15H12N4O2SColore e forma:SolidPeso molecolare:312.35PSEN1-IN-2
<p>PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.</p>Formula:C20H18ClFN2O3SColore e forma:SolidPeso molecolare:420.88GSK-3β inhibitor 14
CAS:<p>GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.</p>Formula:C17H17NOSPurezza:99.97%Colore e forma:SolidPeso molecolare:283.39γ-Secretase modulator 10
CAS:<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Formula:C25H23F3N4O2Colore e forma:SolidPeso molecolare:468.48GSK-3β inhibitor 22
CAS:<p>GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.</p>Formula:C18H12F3N3O2S2Colore e forma:SolidPeso molecolare:423.43Anticancer agent 259
<p>Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.</p>Formula:C30H26N2O2Colore e forma:SolidPeso molecolare:446.54CCT 031374 hydrobromide
CAS:<p>CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.</p>Formula:C23H20BrN3OPurezza:99.50%Colore e forma:SolidPeso molecolare:434.33β-catenin modulator IIa-661
CAS:<p>β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.</p>Formula:C19H23ClN2O3SPurezza:99.58%Colore e forma:SoildPeso molecolare:394.92Tyk2-IN-22
CAS:<p>Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.</p>Formula:C16H16ClN5O2Colore e forma:SolidPeso molecolare:345.78LX-7101 hydrochloride
CAS:<p>LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.</p>Formula:C23H29N7O3xHClPurezza:98.96%Colore e forma:SolidPeso molecolare:487.99pan-TEAD-IN-1
CAS:<p>pan-TEAD-IN-1 (Compound 3) is an orally active pan-inhibitor of TEAD, disrupting its interaction with coactivators YAP/TAZ by targeting the palmitoylation site of TEAD. This inhibition leads to the downregulation of oncogene transcription, such as Ctgf and Cyr61, within the Hippo signaling pathway. Demonstrating outstanding efficacy, pan-TEAD-IN-1 has an IC50 of 0.36 nM for luciferase and 1.52 nM for H226 cells, along with favorable pharmacokinetic properties (AUC0–∞= 228.7 μg/mL·min, T1/2= 183.9 min). The compound significantly inhibits tumor growth in xenograft models of TEAD-dependent cancers, indicating its potential for research in these cancer types.</p>Formula:C19H16F3NOColore e forma:SolidPeso molecolare:331.33F7H
CAS:<p>F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.</p>Formula:C24H18FN3O2S2Purezza:99.85%Colore e forma:SoildPeso molecolare:463.55GSK3a-IN-38
CAS:<p>GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.</p>Formula:C18H20N4OPurezza:99.75%Colore e forma:SoildPeso molecolare:308.38HAT-SIL-TG-1&AT
<p>HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.</p>Formula:C60H69N17O11SColore e forma:SolidPeso molecolare:1236.36JAK-IN-15
CAS:<p>JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).</p>Formula:C22H23FN4O3SColore e forma:SolidPeso molecolare:442.51BMS-906024
CAS:<p>BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.</p>Formula:C26H26F6N4O3Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:556.5WAY-656935
CAS:<p>WAY-656935 inhibits ROCK.</p>Formula:C20H28ClN3O3SPurezza:98.1%Colore e forma:SolidPeso molecolare:425.97TBCA
CAS:<p>TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.</p>Formula:C9H4Br4O2Purezza:99.3%Colore e forma:SolidPeso molecolare:463.74SJ988497
CAS:<p>SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.</p>Formula:C36H36N10O5Colore e forma:SolidPeso molecolare:688.74RBPJ Inhibitor-1
CAS:<p>RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell</p>Formula:C17H14FN3O2Purezza:99.58%Colore e forma:SoildPeso molecolare:311.31VT104
CAS:<p>VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research.Cost-effective and quality-assured.</p>Formula:C25H19F3N2OPurezza:99.42% - 99.5%Colore e forma:SolidPeso molecolare:420.43STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formula:C19H16N2O4SColore e forma:SolidPeso molecolare:368.41ALK5-IN-83
<p>ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.</p>Formula:C20H23N7O2SColore e forma:SolidPeso molecolare:425.51Rilogrotug
<p>Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Colore e forma:Odour LiquidJAK2-IN-6
CAS:<p>JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.</p>Formula:C14H10ClN3OS2Purezza:99.64%Colore e forma:SolidPeso molecolare:335.83Foxy-5 acetate
<p>Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.</p>Formula:C28H46N6O14S2Purezza:98%Colore e forma:SolidPeso molecolare:754.83YW2036
CAS:<p>YW2036 is an inhibitor of Wnt signaling pathway.</p>Formula:C20H16N4OPurezza:99.94%Colore e forma:SoildPeso molecolare:328.37PROTAC YAP degrader-1
<p>PROTAC YAP degrader-1, a targeted proteolysis promoting chimeric molecule, both degrades the YAP protein and inhibits its nuclear localization. This compound is formulated with Demethyl-NSC682769 as the target protein ligand, and utilizes (R,S,R)-AHPC-PEG2-C2-boc, which is the E3 ubiquitin ligase ligand + Linker conjugate. The linker incorporated in the design is Acid-PEG2-C2-Boc.</p>Formula:C56H62N6O9SColore e forma:SolidPeso molecolare:995.19JAK-2/3-IN-1
CAS:<p>JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.</p>Formula:C20H12ClN3OColore e forma:SolidPeso molecolare:345.79Wnt/β-catenin agonist 2
CAS:<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Formula:C13H12N4O3Purezza:99.35%Colore e forma:SolidPeso molecolare:272.26RhoA-ROCK-IN-1
<p>RhoA-ROCK-IN-1 (Compound b19) is an inhibitor of the RhoA/ROCK pathway. It significantly inhibits cell proliferation, migration, and invasion, while promoting cell apoptosis (apoptosis). RhoA-ROCK-IN-1 exhibits strong anticancer activities by inhibiting the RhoA/ROCK pathway.</p>Formula:C24H23N3O4SColore e forma:SolidPeso molecolare:449.52Disitertide acetate
<p>Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.</p>Formula:C70H113N17O24S2Purezza:95.11%Colore e forma:SoildPeso molecolare:1640.88Emugrobart
<p>Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidCasein kinase 1δ-IN-7
CAS:<p>Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C17H14N4O2SPurezza:98.6%Colore e forma:SolidPeso molecolare:338.38TYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Colore e forma:Odour SolidCasein kinase 1δ-IN-8
CAS:<p>Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.</p>Formula:C19H14FN5OSPurezza:99.66%Colore e forma:SolidPeso molecolare:379.41LP-922056
CAS:<p>LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.</p>Formula:C11H9ClN2O2S2Purezza:99.84%Colore e forma:SolidPeso molecolare:300.78SJ10542
CAS:<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95MSC-1254
<p>MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.</p>Formula:C25H22F2N4O4SColore e forma:SolidPeso molecolare:512.53MSC-5046
<p>MSC-5046 is a selective inhibitor of TEAD1.</p>Formula:C24H18F3N5O3Colore e forma:SolidPeso molecolare:481.43CSNK2-IN-2
<p>CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.</p>Formula:C25H30FN9OColore e forma:SolidPeso molecolare:491.56SJ1008030 formic
<p>SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an</p>Formula:C43H45N13O9SPurezza:98%Colore e forma:SolidPeso molecolare:919.96Jagged-1 (188-204)
CAS:<p>Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.</p>Formula:C93H127N25O26S3Purezza:98%Colore e forma:SolidPeso molecolare:2107.4JAK1/TYK2-IN-1
CAS:<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Formula:C18H20F3N7OColore e forma:SolidPeso molecolare:407.401YAP-TEAD-IN-3
CAS:<p>YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferation</p>Formula:C27H26ClF2N3O4Purezza:97.55% - 98.71%Colore e forma:SoildPeso molecolare:529.96Povorcitinib phosphate
CAS:<p>Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.</p>Formula:C23H25F5N7O5PPurezza:99.57%Colore e forma:SolidPeso molecolare:605.45Casein kinase 1δ-IN-3
CAS:<p>Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.</p>Formula:C17H16N2O2SPurezza:98.94%Colore e forma:SoildPeso molecolare:312.39AS2553627
CAS:<p>AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.</p>Formula:C18H19N5OColore e forma:SolidPeso molecolare:321.38STAT3 HiBiT degrader 1
CAS:<p>STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.</p>Formula:C58H63F4N10O14PSColore e forma:SolidPeso molecolare:1263.21ABC99
CAS:<p>ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.</p>Formula:C22H21ClN4O5Purezza:99.89%Colore e forma:SoildPeso molecolare:456.88Cirevetmab
CAS:<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Colore e forma:LiquidAPTSTAT3-9R acetate
<p>APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity.</p>Formula:C225H334N80O53Purezza:98%Colore e forma:SolidPeso molecolare:5007.56FRM-024
CAS:<p>FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of</p>Formula:C22H22ClN5O2Colore e forma:SolidPeso molecolare:423.9Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS:<p>Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.</p>Formula:C88H138N20O34P2Purezza:98%Colore e forma:SolidPeso molecolare:2082.1GSK-3 inhibitor 3
CAS:<p>GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively</p>Formula:C23H15FN6OPurezza:99.89%Colore e forma:SoildPeso molecolare:410.4CK1-IN-3
CAS:<p>WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.</p>Formula:C17H16N2O3SPurezza:99.18%Colore e forma:SolidPeso molecolare:328.39GSK3β inhibitor II
CAS:<p>GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).</p>Formula:C14H10IN3OSPurezza:99.48%Colore e forma:SolidPeso molecolare:395.22YAP/TEAD-IN-1
<p>YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.</p>Formula:C32H30N8OColore e forma:SolidPeso molecolare:542.634SAHM1
CAS:<p>Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.</p>Formula:C94H162N36O23SPurezza:98%Colore e forma:SolidPeso molecolare:2196.58(R)-Lisofylline
CAS:<p>(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).</p>Formula:C13H20N4O3Purezza:99.50%Colore e forma:SolidPeso molecolare:280.32ROCK2-IN-9
<p>ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.</p>Formula:C28H30N8O2Colore e forma:SolidPeso molecolare:510.59Navicixizumab
CAS:<p>Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.</p>Colore e forma:LiquidGSK-3β inhibitor 1
CAS:<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formula:C14H10N2OPurezza:99.40%Colore e forma:SolidPeso molecolare:222.24Lerdelimumab
CAS:<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Colore e forma:LiquidSTAT3-IN-39
CAS:<p>STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.</p>Formula:C20H17F3N2O3SColore e forma:SolidPeso molecolare:422.42BAY 593
CAS:<p>BAY 593 functions as an inhibitor of geranylgeranyltransferase-I (GGTase-I), effectively preventing the activation of Rho-GTPases and consequently inactivating YAP1/TAZ signaling pathways. It has been shown to inhibit tumor growth dose-dependently in xenograft mouse models, exhibiting IC50 values of 38.4 nM in MT-1080 cells and 564 nM in MDA-MB-231 cells, as well as in PXF 541 xenografts.</p>Formula:C26H32ClF3N2O3Colore e forma:SolidPeso molecolare:512.99LH168
<p>LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.</p>Formula:C29H31F3N6O2SColore e forma:SolidPeso molecolare:584.66HC-258
CAS:<p>HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.</p>Formula:C20H24N2O2Colore e forma:SolidPeso molecolare:324.42Super-TDU (1-31) (TFA)
<p>Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.</p>Formula:C141H218N40O48·C2HF3O2Colore e forma:SolidPeso molecolare:3355.5CK2-IN-14
<p>CK2-IN-14 (Compound 10b) is an inhibitor of cyclin-dependent kinase 2α with an IC50 of 36.7 nM. It effectively hinders the growth of cancer cell lines 786-O and U937, with GI50 values of 7.3 μM and 7.5 μM, respectively.</p>Formula:C19H20ClN5SColore e forma:SolidPeso molecolare:385.91GKI-1 HCl
<p>GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.</p>Formula:C15H13Cl2N3Purezza:98.51%Colore e forma:SoildPeso molecolare:306.19Casein kinase 1δ-IN-6
CAS:<p>CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.</p>Formula:C16H10ClF3N2OSPurezza:99%Colore e forma:SoildPeso molecolare:370.78JI069
CAS:<p>JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.</p>Formula:C15H12Cl2N2O4SPurezza:98.01%Colore e forma:SolidPeso molecolare:387.24Linavonkibart
CAS:<p>Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.</p>Purezza:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Colore e forma:LiquidJAK-IN-29
<p>JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].</p>Formula:C17H14ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:355.78TEAD-IN-19
<p>TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.</p>Colore e forma:Odour SolidDBL-6-13
<p>DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.</p>Formula:C25H38N4O3Colore e forma:SolidPeso molecolare:442.59Ac-ESMD-CHO
CAS:<p>Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (</p>Formula:C19H30N4O10SPurezza:98%Colore e forma:SolidPeso molecolare:506.53Akt/ROCK-IN-1
<p>Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively.</p>Formula:C21H19BrF2N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:509.37FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidEpigenetics Compound Library
<p>Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new</p>Colore e forma:Odour SolidGSK3-IN-1
CAS:<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formula:C14H10ClN3OSPurezza:99.66%Colore e forma:SolidPeso molecolare:303.77MR24
<p>MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.</p>Formula:C26H29ClN6O3Peso molecolare:508.19897WDR5 ligand 2
CAS:<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formula:C29H31F3N4O4Colore e forma:SolidPeso molecolare:556.576Wnt/β-catenin agonist 3
CAS:<p>Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.</p>Formula:C16H15ClN4O2Purezza:99.52%Colore e forma:SolidPeso molecolare:330.77Wnt/Hedgehog/Notch Compound Library
<p>A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidTEAD-IN-16
<p>TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.</p>Formula:C16H14F3NO3Peso molecolare:325.09258Tubastatin
CAS:<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Formula:C21H22N2O2Purezza:98.23%Colore e forma:SolidPeso molecolare:334.41Notch 1 TFA
<p>Notch 1 TFA encodes a member of the NOTCH family of proteins.</p>Formula:C64H98N15F3O25S3Purezza:98%Colore e forma:SolidPeso molecolare:1614.815β-Cholanic acid
CAS:<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formula:C24H40O2Purezza:98.91% - 99.89%Colore e forma:SoildPeso molecolare:360.57Plant 14-3-3-IN-1
<p>Plant 14-3-3-IN-1 (Compound 2) is an inhibitor of the Arabidopsis thaliana 14-3-3 protein, with an IC50 of 1.21 μM. It exhibits varying inhibitory activity against different 14-3-3 isoforms and promotes the closure of leaf stomata.</p>Formula:C22H19NO7SPeso molecolare:441.08822JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidWnt pathway inhibitor 3
CAS:<p>Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies</p>Formula:C21H17BrN2O5Purezza:99.69%Colore e forma:SoildPeso molecolare:457.27NIBR-LTSi
<p>NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.</p>Formula:C18H20N4OPurezza:99.87%Colore e forma:SolidPeso molecolare:308.38STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formula:C22H14N4O3Purezza:99.61%Colore e forma:SolidPeso molecolare:382.37DC-TEADin02
CAS:<p>DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.</p>Formula:C19H17NO2SPurezza:99.83%Colore e forma:SoildPeso molecolare:323.41Fresolimumab
CAS:<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:144.4 kDaS-Ruxolitinib
CAS:<p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>Formula:C17H18N6Purezza:98%Colore e forma:SolidPeso molecolare:306.37YAP-TEAD-IN-1 acetate
<p>YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.</p>Formula:C95H148ClN23O23S2Purezza:98.11% - 99.57%Colore e forma:SoildPeso molecolare:2079.92Ripasudil free base
CAS:<p>Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.</p>Formula:C15H18FN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:323.39WAY-297174
CAS:<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Formula:C11H12N2O2S2Purezza:99.53%Colore e forma:SoildPeso molecolare:268.36Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurezza:99.79% - 99.84%Colore e forma:SolidPeso molecolare:291.37Sotatercept
CAS:<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Purezza:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Colore e forma:LiquidTyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Colore e forma:Odour SolidWIC1
CAS:<p>2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.</p>Formula:C22H23N3O3Purezza:99.82%Colore e forma:SoildPeso molecolare:377.44Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidGSK3-IN-4
CAS:<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Formula:C18H20N4OPurezza:98.33%Colore e forma:SoildPeso molecolare:308.38Deuruxolitinib
CAS:<p>Deuruxolitinib functions as an inhibitor of JAK1/2.</p>Formula:C17H18N6Colore e forma:SolidPeso molecolare:314.41MR44397
<p>MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.</p>Formula:C23H26N4O2SColore e forma:SolidPeso molecolare:422.54JAK2-IN-10
CAS:<p>JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.</p>Formula:C33H33D3FN9O2Colore e forma:SolidPeso molecolare:612.71TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formula:C23H21FN4O2Colore e forma:SolidPeso molecolare:404.16485JAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Colore e forma:Odour SolidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:<p>SLLK is a control peptide for LSKL.</p>Formula:C21H41N5O6Purezza:98%Colore e forma:SolidPeso molecolare:459.58JAK1/STAT3-IN-1
<p>JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).</p>Formula:C30H33FN4O3SColore e forma:SolidPeso molecolare:548.67CIA-1 (Free base)
CAS:<p>CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.</p>Formula:C17H19N3O2SPurezza:99%Colore e forma:SolidPeso molecolare:329.42SJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formula:C42H43N13O7SColore e forma:SolidPeso molecolare:873.94PSEN1-IN-1
<p>PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50</p>Formula:C20H19ClF3NO3SColore e forma:SolidPeso molecolare:445.881(R),2(S)-epoxy Cannabidiol
CAS:<p>1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.</p>Formula:C21H30O3Colore e forma:SolidPeso molecolare:330.46Foxy-5 Ammonium Salt
<p>Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.</p>Formula:C26H46N7O12S2Purezza:97.70%Colore e forma:SolidPeso molecolare:712.26Carboxylesterase-IN-2
CAS:<p>Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.</p>Formula:C13H12N4OSPurezza:99.92%Colore e forma:SoildPeso molecolare:272.33TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Formula:C27H32N6O2Colore e forma:SolidPeso molecolare:472.582PROTAC TYK2 degradation agent1
CAS:<p>PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.</p>Formula:C55H69N13O7SPurezza:98%Colore e forma:SolidPeso molecolare:1056.28MeBIO
CAS:<p>MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.</p>Formula:C17H12BrN3O2Purezza:99.64%Colore e forma:SolidPeso molecolare:370.2YAP-IN-1
<p>YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.</p>Colore e forma:Odour SolidJAK/HDAC-IN-4
<p>JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.</p>Formula:C30H32N8O5SColore e forma:SolidPeso molecolare:616.69CBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Formula:C18H20ClN3OColore e forma:SolidPeso molecolare:329.82YAP/TAZ inhibitor-4
<p>YAP/TAZ Inhibitor-4 (Compound 45) acts as an inhibitor of YAP/TAZ, exhibiting inhibitory activity on TEAD transcriptional activation by preventing the interaction between YAP or TAZ and TEAD.</p>Formula:C28H28F3N3O3Colore e forma:SolidPeso molecolare:511.54P17 Peptide
CAS:<p>P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.</p>Formula:C95H139N27O21Colore e forma:SolidPeso molecolare:1995.29IWP-3
CAS:<p>IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].</p>Formula:C22H17FN4O2S3Purezza:98%Colore e forma:SolidPeso molecolare:484.59Anti-GPC3 Antibody (4L576)
<p>Anti-GPC3 Antibody (4L576) is an antibody targeting GPC3. Anti-GPC3 Antibody (4L576) can be used in ELISA, WB, IF.</p>Colore e forma:Odour LiquidAnti-5T4/TPBG Antibody (9P872)
<p>Anti-5T4/TPBG Antibody (9P872) is an antibody targeting 5T4/TPBG. Anti-5T4/TPBG Antibody (9P872) can be used in ELISA, FCM.</p>Colore e forma:Odour LiquidAnti-NANOG Antibody (1M448)
<p>Anti-NANOG Antibody (1M448) is a Mouse antibody targeting NANOG. Anti-NANOG Antibody (1M448) can be used in ELISA, WB, ICC, IF, FCM.</p>Purezza:>95%Colore e forma:Odour LiquidLegumain inhibitor 1
CAS:<p>Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.</p>Formula:C23H25N5O4SPurezza:98.14%Colore e forma:SolidPeso molecolare:467.54Anti-SOST Antibody (3R170)
<p>Anti-SOST Antibody (3R170) is an antibody targeting SOST. Anti-SOST Antibody (3R170) can be used in ELISA, IHC.</p>Colore e forma:Odour LiquidDTP3
CAS:<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Formula:C26H35N7O5Colore e forma:SolidPeso molecolare:525.6YAP/TAZ inhibitor-1
CAS:<p>YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.</p>Formula:C33H39N3O5S2Purezza:99.72%Colore e forma:SolidPeso molecolare:621.81Stafib-1
CAS:<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Formula:C26H24N2O11P2Purezza:97.18%Colore e forma:SolidPeso molecolare:602.42PF-5006739
CAS:<p>PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.</p>Formula:C22H22FN7OPurezza:98%Colore e forma:SolidPeso molecolare:419.45γ-secretase modulator 3
CAS:<p>Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.</p>Formula:C24H23FN4OSPurezza:98%Colore e forma:SolidPeso molecolare:434.53Bintrafusp alfa
CAS:<p>Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.</p>Purezza:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Colore e forma:LiquidEnoticumab
CAS:<p>Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.</p>Purezza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Colore e forma:LiquidIlunocitinib
CAS:<p>Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.</p>Formula:C17H17N7O2SPurezza:99.88%Colore e forma:SolidPeso molecolare:383.43Belumosudil mesylate
CAS:<p>Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.</p>Formula:C27H28N6O5SPurezza:98.73%Colore e forma:SolidPeso molecolare:548.61Ceftriaxone Sodium
CAS:<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formula:C18H17N8NaO7S3Colore e forma:SolidPeso molecolare:576.562Itacitinib adipate
CAS:<p>Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.</p>Formula:C32H33F4N9O5Colore e forma:SolidPeso molecolare:699.66Ifidancitinib
CAS:<p>Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.</p>Formula:C20H18FN5O3Purezza:98.05%Colore e forma:SolidPeso molecolare:395.39SGC-CK2-1
CAS:<p>SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.</p>Formula:C20H21N7OPurezza:99.41%Colore e forma:SolidPeso molecolare:375.43Atinvicitinib
CAS:<p>Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.</p>Formula:C16H17FN6O3Purezza:99.36%Colore e forma:SolidPeso molecolare:360.35GSK269962A hydrochloride
CAS:<p>GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.</p>Formula:C29H31ClN8O5Colore e forma:SolidPeso molecolare:607.06Cotosudil
CAS:<p>Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.</p>Formula:C16H21N3O2SPurezza:98.41%Colore e forma:SolidPeso molecolare:319.42IBS008738
CAS:<p>IBS008738 is a TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription.</p>Formula:C22H22N4O2Purezza:99.44%Colore e forma:SolidPeso molecolare:374.44CHZ868
CAS:<p>CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.</p>Formula:C22H19F2N5O2Purezza:99.38%Colore e forma:SolidPeso molecolare:423.42Verosudil
CAS:<p>Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.</p>Formula:C17H17N3O2SPurezza:99.72%Colore e forma:SolidPeso molecolare:327.4Porcn-IN-1
CAS:<p>Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).</p>Formula:C25H19FN4OPurezza:99.15%Colore e forma:SolidPeso molecolare:410.44Ruxolitinib phosphate
CAS:<p>Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.</p>Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36
