Ubiquitinazione

VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM …

DBeQ(JRF-12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.

DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 …

P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of …

USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).

FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). …

IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.

USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM …

USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).

DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).

Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.

MLN4924 is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).

HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).

USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).

DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific …

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 …

NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 …

WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).

ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for …

USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).

EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction …

COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited …

NAE-IN-M22 is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits …

XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing …

Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.

SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).

ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent …

FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds …

IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination …

TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 …

C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for …

MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase.

TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold …

B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S …

ML240 is a selective, ATP-competitive p97 inhibitor.

Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 …

ML241 is a potent and selective inhibitors of p97 ATPase.

NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of …

TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin …

LDN-91946 is an effective, selective, and uncompetitive inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki: 2.8 …

HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx …

IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with …

GNE-6776 is a selective USP7 inhibitor.

Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 …

CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).

SMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the …

PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.

P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also …

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.

GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of …

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.

ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) …

LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .

TAK-981 is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.

ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and …