Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1492 prodotti di "Autofagia"
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PHA-665752
CAS:PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.Formula:C32H34Cl2N4O4SPurezza:97.05% - 98.82%Colore e forma:SolidPeso molecolare:641.61Regorafenib mesylate
CAS:Regorafenib mesylate is an oral multi-kinase inhibitor targeting VEGFR, PDGFRβ, Kit, RET, Raf-1 with strong anti-tumor and anti-angiogenic effects.Formula:C22H19ClF4N4O6SColore e forma:SolidPeso molecolare:578.92Tepotinib hydrochloride(1 : x)
CAS:Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14Formula:C29H29ClN6O2Purezza:99.81%Colore e forma:SolidPeso molecolare:529.04Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formula:C19H18BrN3OPurezza:98.32% - 99.98%Colore e forma:SolidPeso molecolare:384.27Ref: TM-T6300
2mg42,00€5mg60,00€10mg92,00€25mg188,00€50mg324,00€100mg505,00€200mg710,00€1mL*10mM (DMSO)66,00€MLN9708 analogues
CAS:MLN2238 inhibits 20S proteasome's β5 site (Ki50=0.93 nM, IC50=3.4 nM), active form of Ixazomib Citrate in solutions/plasma.Formula:C20H23BCl2N2O9Purezza:98.24% - 99.23%Colore e forma:SolidPeso molecolare:517.12Ref: TM-T2016
5mg50,00€10mg66,00€25mg96,00€50mg131,00€100mg215,00€200mg319,00€500mg535,00€1mL*10mM (DMSO)52,00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurezza:98.3% - 99.46%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:407.5E-64
CAS:E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.Formula:C15H27N5O5Purezza:98% - 99.95%Colore e forma:White SolidPeso molecolare:357.41Ref: TM-T6037
2mg37,00€5mg50,00€10mg79,00€25mg140,00€50mg225,00€100mg335,00€500mg790,00€1mL*10mM (DMSO)51,00€Paeonol
CAS:Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.Formula:C9H10O3Purezza:98.55% - 99.56%Colore e forma:White To Beige Crystalline PowderPeso molecolare:166.17Kaempferol
CAS:<p>Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ.</p>Formula:C15H10O6Purezza:98% - 99.41%Colore e forma:Yellow Needles From Alcohol And Water SolidPeso molecolare:286.24Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purezza:98.39% - 98.43%Colore e forma:SolidPeso molecolare:319.36Ref: TM-T6945
1mg49,00€2mg67,00€5mg110,00€10mg192,00€25mg429,00€50mg628,00€100mg893,00€500mg1.791,00€1mL*10mM (DMSO)110,00€UM-164
CAS:<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formula:C30H31F3N8O3SPurezza:98.72% - 99.52%Colore e forma:SolidPeso molecolare:640.68Valinomycin
CAS:Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes ParkinFormula:C54H90N6O18Purezza:95.37% - 97.16%Colore e forma:White SolidPeso molecolare:1111.32Rottlerin
CAS:Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.Formula:C30H28O8Purezza:97.41% - 99.44%Colore e forma:Orange To Brown PowderPeso molecolare:516.54Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H15Cl3N2OS·HNO3Purezza:98.66% - 99.65%Colore e forma:SolidPeso molecolare:500.78Eupatilin
CAS:Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.Formula:C18H16O7Purezza:98.53% - 99%Colore e forma:SolidPeso molecolare:344.32Rosiglitazone hydrochloride
CAS:Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.Formula:C18H19N3O3S·HClPurezza:99.63% - 99.79%Colore e forma:SolidPeso molecolare:393.89Olaparib
CAS:View and buy Olaparib from TargetMol.Olaparib is a small molecule inhibitor of PARP1/PARP2.Cited in 10 publications.Formula:C24H23FN4O3Purezza:98% - >99.99%Colore e forma:SolidPeso molecolare:434.46Azithromycin
CAS:Azithromycin (CP 62993) is a macrolide antibiotic that primarily targets the 50S subunit of bacterial ribosomes. High-Quality, Low-Cost!Formula:C38H72N2O12Purezza:99.9% - 99.97%Colore e forma:White To Off-White Solid CrystallinePeso molecolare:748.98Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurezza:99.33% - 99.79%Colore e forma:SolidPeso molecolare:181.21LYN-1604
CAS:<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>Formula:C33H43Cl2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:584.62Tropifexor
CAS:<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Formula:C29H25F4N3O5SPurezza:99.3% - 99.85%Colore e forma:SolidPeso molecolare:603.58Ref: TM-T4379
1mg87,00€5mg166,00€10mg248,00€25mg437,00€50mg665,00€100mg1.008,00€200mg1.520,00€500mg2.252,00€Sevelamer hydrochloride
CAS:<p>Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption</p>Formula:(C3H7N·C3H5ClO·HCl)xPurezza:98%Colore e forma:SolidPeso molecolare:186.08Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formula:C22H18FN7OPurezza:98% - 99.39%Colore e forma:SolidPeso molecolare:415.42Ref: TM-T1894
5mg35,00€10mg50,00€25mg74,00€50mg93,00€100mg108,00€200mg140,00€500mg225,00€1mL*10mM (DMSO)52,00€Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purezza:97.1% - 99.33%Colore e forma:SolidPeso molecolare:558.70PATULIN
CAS:Patulin (Claviform) is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.Formula:C7H6O4Purezza:99.91% - 99.98%Colore e forma:Compact Prisms Or Thick Plates From Ether Or Chloroform White CrystallinePeso molecolare:154.12Panobinostat
CAS:<p>Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity.</p>Formula:C21H23N3O2Purezza:97.2% - 99.81%Colore e forma:Yellow SolidPeso molecolare:349.43Retro-2
CAS:<p>Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, it protects HeLa cells against Ricin, Stx1 and Stx2.</p>Formula:C19H16N2OSPurezza:98.15%Colore e forma:SolidPeso molecolare:320.41Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Formula:C26H46N2OPurezza:97.78% - 98%Colore e forma:SolidPeso molecolare:402.66Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formula:C21H22Cl2FN5OPurezza:99% - 99.87%Colore e forma:SolidPeso molecolare:450.34Ref: TM-T1661
2mgPrezzo su richiesta5mg34,00€10mg52,00€25mg58,00€50mg67,00€100mg93,00€500mg156,00€1mL*10mM (DMSO)52,00€IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurezza:99.31%Colore e forma:SolidPeso molecolare:482.51SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formula:C19H12Cl2N2O2Purezza:98.9% - 99.13%Colore e forma:SolidPeso molecolare:371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€TG101209
CAS:TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formula:C26H35N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:509.67Berberine hydrogen sulphate
CAS:Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Formula:C20H19NO8SPurezza:99% - 99.82%Colore e forma:Yellow Crystals Off-White To Yellow PowderPeso molecolare:433.43Galangin
CAS:Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.Formula:C15H10O5Purezza:98.24% - 99.93%Colore e forma:Yellowish Needle-Like CrystalPeso molecolare:270.24Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurezza:99.33%Colore e forma:SolidPeso molecolare:369.48Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurezza:98% - 99.45%Colore e forma:SolidPeso molecolare:393.49Ref: TM-T1825
1mg38,00€2mg49,00€5mg70,00€10mg88,00€25mg164,00€50mg224,00€100mg393,00€1mL*10mM (DMSO)70,00€JNJ-42165279
CAS:JNJ-42165279 selectively inactivates FAAH without notably affecting other enzymes, ion channels, receptors, or CYPs/hERG at 10 μM.Formula:C18H17ClF2N4O3Purezza:99.67% - 99.88%Colore e forma:SolidPeso molecolare:410.8Ref: TM-T3215
2mg46,00€5mg65,00€10mg96,00€25mg170,00€50mg246,00€100mg363,00€200mg512,00€1mL*10mM (DMSO)75,00€Purmorphamine
CAS:Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.Formula:C31H32N6O2Purezza:97.19% - 99.48%Colore e forma:Light Tan SolidPeso molecolare:520.62Ref: TM-T1810
1mg42,00€2mg52,00€5mg88,00€10mg106,00€25mg207,00€50mg264,00€100mg418,00€200mg615,00€1mL*10mM (DMSO)88,00€Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormula:C29H27F3N6OPurezza:98% - 99.60%Colore e forma:SolidPeso molecolare:532.56DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Formula:C22H20N4Purezza:98.93% - ≥95%Colore e forma:SolidPeso molecolare:340.42Ref: TM-T1969
2mg34,00€5mg52,00€10mg85,00€25mg152,00€50mg264,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)52,00€Vancomycin
CAS:Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibitingFormula:C66H75Cl2N9O24Purezza:98.76% - 99.52%Colore e forma:Almost White PowderPeso molecolare:1449.25Tacrolimus monohydrate
CAS:Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.Formula:C44H71NO13Purezza:97.07% - 98.05%Colore e forma:SolidPeso molecolare:822.05Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purezza:99.88%Colore e forma:White Crystal Or PowderPeso molecolare:182.17GSK621
CAS:GSK621 is a specific and potent AMPK activator.Formula:C26H20ClN3O5Purezza:97.02% - 97.05%Colore e forma:SolidPeso molecolare:489.91Ref: TM-T6854
1mg52,00€2mgPrezzo su richiesta5mg106,00€10mg180,00€25mg311,00€50mg502,00€100mg743,00€200mg1.026,00€BAY 11-7082
CAS:BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM).Formula:C10H9NO2SPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:207.25Ref: TM-T1902
5mg50,00€10mg57,00€25mg96,00€50mg170,00€100mg265,00€200mg399,00€500mg662,00€1mL*10mM (DMSO)52,00€TPEN
CAS:TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.Formula:C26H28N6Purezza:98% - 99.72%Colore e forma:White Crystalline PowderPeso molecolare:424.54Enalaprilat Dihydrate
CAS:Enalaprilat Dihydrate (MK-422 Dihydrate) （IC50=1.94 nM） is a potent angiotensin-converting enzyme (ACE) inhibitor.Formula:C18H24N2O5·2H2OPurezza:99.46% - 99.78%Colore e forma:SolidPeso molecolare:348.4Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purezza:99.11% - 99.63%Colore e forma:White PowderPeso molecolare:482.19Ref: TM-T6189
1g898,00€5mg51,00€10mg74,00€25mg127,00€50mg175,00€100mg273,00€200mg406,00€500mg662,00€1mL*10mM (DMSO)55,00€3BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purezza:97.76%Colore e forma:SolidPeso molecolare:327.33Ref: TM-T14033
1mg35,00€2mg47,00€5mg67,00€10mg97,00€25mg207,00€50mg329,00€100mg494,00€1mL*10mM (DMSO)74,00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82Ref: TM-T1792
5mg35,00€10mg51,00€25mg80,00€50mg96,00€100mg144,00€200mg185,00€500mg309,00€1mL*10mM (DMSO)57,00€
