Proteina G/GPCR

L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.

LP-533401 hydrochloride is a peripheral Tph inhibitor that does not cross the BBB and can be used to study periodontal disease and hepatic steatosis.

Clopidogrel thiolactone (2-oxoclopidogrel), a P2Y12 receptor inhibitor, is an antiplatelet aggregation compound.

ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.

(S)-Mirtazapine ((S)-Org3770) is a 5-HT2 receptor antagonist with pro-nociceptive effects that can be used to study depression.

Alfuzosin (SL 77499) is an alpha-1 adrenergic antagonist used to treat benign prostatic hypertrophy and urethral dysfunction.

Benzylthiouracil (6-Benzyl-2-thiouracil) induces ANCA-associated glomerulonephritis in Graves' disease patients and is used to study hyperthyroidism.

Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist for the study of systemic sclerosis.

CP-105696 is a potent and selective leukotriene B4 (LTB4) receptor antagonist for the study of allograft rejection.

(R)-Mirtazapine ((R)-Org3770) is a 5-HT3 receptor antagonist, a potential analgesic with anti-injury perception properties.

SID 7969543 is a selective SF-1 inhibitor with potential anticancer activity, inhibits SF-1-triggered luciferase expression and can be used for cancer research.

Citalopram (Lu 10-171), a serotonin and 5-HT reuptake inhibitor.Citalopram has antidepressant activity and may be used to study dementia.

<p>GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.</p>

WIN 51,708 is an antagonist of neurokinin-1 receptor.

Rotigotine (1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-) is an antiparkinson agent and dopamine receptor agonist.

Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).

(S)-Pramipexole-(N-Propyl-2,2,3,3,3-d5) Dihydrochloride is a deuterated compound of (S)-Pramipexole Dihydrochloride. (S)-Pramipexole Dihydrochloride has a CAS number of 104632-25-9. Pramipexole dihydrochloride could be used to treat Parkinson disease.

Hydroxyzine-d8 DiHCl is a deuterated compound of Hydroxyzine DiHCl. Hydroxyzine DiHCl has a CAS number of 2192-20-3.

R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.

Ropinirole, D2-like agonist, no D1 affinity, Ki 29 nM for D2, treats Parkinson's.

L-745870 is a D4 receptor antagonist that also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors.

SR59230A hydrochloride (SR59230A HCl) is a beta3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis.

PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a neuropeptide with 38 amino acid residues.

Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.

<p>Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.</p>

Buflomedil is a vasoactive compound. Buflomedil has been used for peripheral arterial diseases.

<p>Eptinezumab is a humanised monoclonal antibody targeting CGRP (calcitonin gene-related peptide), which prevents CGRP binding to its receptor, migraine.</p>

Mibavademab is a humanized anti-leptin receptor (LEPR) mAb under investigation for treating congenital leptin deficiency.

Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.

Tulobuterol is mainly used for the prevention and treatment of bronchial asthma, asthmatic bronchitis and chronic bronchitis. Research shows that it could inhibit rhinovirus infection in primary cultures of human tracheal epithelial cells.

Ziprasidone, an antipsychotic agent, functions as a dual antagonist of 5-HT (serotonin) and dopamine receptors.

Escitalopram (Seroplex), a serotonin inhibitor for depression, curbs alcohol intake and is favored over tricyclics for tardive dyskinesia.

Triflupromazine is a dopamine receptor D1/D2 antagonist and LHDA inhibitor that suppresses dopamine activity in (CNS)mental disorders, sedation, and antiemesis.

GLP-1 Receptormodulator 1 (Compound 7) is an effective positive allosteric modulator of the GLP-1 receptor. It is utilized in the research of obesity and type 2 diabetes.

Blontuvetmab (AT 004), a caninized CD20 monoclonal antibody, is utilized in the study of Canine B-cell lymphoma [1].

<p>PF-610355 is a long-acting and potent β2-adrenergic receptor agonist (EC50: 0.26 nM).PF-610355 can be used to study asthma and COPD.</p>

Metoxibutropate is a biochemical.

Risperidone Mesylate is a selective serotonin 5-HT2 receptor and dopamine D2 receptor blocker.

Uliledlimab, a humanized monoclonal antibody against CD73, reduces extracellular adenosine production and modulates immunosuppressive pathways.

Olopatadine is an antihistamine and anti-allergy medication for itchy eyes, also possibly treats red skin syndrome.

DL-Phenylephrine HCl is a selective agonist of the alpha1-adrenergic receptor.

Arazasetron is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27.

Methicillin: Narrow-spectrum beta-lactam, penicillin-type antibiotic for certain gram-positive bacterial infections.

N-Methyl amisulpride (Amisulpride impurity H) is a 5-HT7 receptor, D2 receptor, and D3 receptor antagonist used in the study of acute schizophrenia.

P2Y14R antagonist 1 (compound I-17) is a selective oral that inhibits inflammatory response in acute gouty arthritis the NLRP3/GSDMD y and cellular pyroptosis.

17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan

Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated IgG1 anti-OX40 monoclonal antibody indicated for atopic dermatitis (AD) research [1].

Fremanezumab (TEV-48125) is a humanised monoclonal antibody targeting CGRP, capable of neutralising human, mouse and rat CGRP, migraine.

Methaphenilene hydrochloride is an H1 receptor antagonist with antihistaminic and anticholinergic activity, in allergic inflammation and autonomic research.

GPR183-IN-1 (compound 15) is an effective orally active inhibitor of GPR183. It inhibits Ca2+ mobilization with an IC50 value of 39.97 nM. GPR183-IN-1 holds potential for research in cancer, autoimmune diseases, pain, and osteoporosis.

15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits.

Brexpiprazole D8 is a deuterium-modified partial agonist of 5-HT1A and dopamine receptors, with Ki values of 0.12 nM and 0.3 nM respectively.

Cinnarizine D8 is a deuterium-labeled Cinnarizine which is an antihistamine and a calcium channel blocker.

Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .

Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor.

Amitriptyline-d6 Hydrochloride is a deuterated compound of Amitriptyline Hydrochloride. Amitriptyline Hydrochloride has a CAS number of 549-18-8. Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.

Mianserin-d3 is a deuterated compound of Mianserin. Mianserin has a CAS number of 24219-97-4. Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family. Mianserin has antidepressant, antianxiety, antiemetic, hypotrophic, hypnotic and antihistamine effects, and can be used as a combination of norepinephrine and specific serotonin to treat depression.

Atenolol Hydrochloride is a selective antagonist of ß1 receptor.

Roxatidine acetate: anti-ulcer, blocks histamine, reduces acid. Safer at lower doses.

Ciproxifan (FUB-359) is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist (IC50: 3.1 μM).

MK-447 is a nonsteroidal antiinflammatory agent.

Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour

5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.

Amidephrine is an adrenergic agent.

Caerulein, desulfated (FI-6934, desulfated) is a desulfated compound formed after caerulein hydrolysis, a neuropeptide with lower smooth muscle activity.

Isoproterenol sulfate anhydrous is a useful alkaloid. It is used for biological research.

7-Desmethyl-3-hydroxyagomelatine, less active than parent drug Agomelatine, is a melatonergic agonist and 5-HT2C antagonist.

<p>Ketanserinol is a metabolite of the antihypertensive drug ketanserin, which blocks 5-HT2 receptors to treat protamine-induced pulmonary hypertension.</p>

Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.

Compound AMTHAMINE DIHYDROBROMIDE is a useful organic compound for research related to life sciences.

6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.

Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine.

Dehydroabiethylamine (NSC-2955) boosts liver CYP2B, blocks PDKs & cholesterol transport, and has anti-tumor effects.

Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neuron blockers exhibiting sympathomimetic effects similar to those of bromobenzamine and guanethidine in various animal models, particularly in cats. These compounds inhibit the release of norepinephrine during neural stimulation and enhance the responsiveness of smooth muscle to epinephrine and norepinephrine. Notably, bethanidine sulfate increases the pressor response to tyramine, although this effect diminishes with higher doses. Unlike guanethidine, bethanidine sulfate does not deplete pressor amines in the iris of cats following administration. Additionally, it temporarily suppresses autonomic cholinergic mechanisms and can cause transient neuromuscular paralysis at large doses, contrasting its long-term adrenergic neuron blocking effects.

ICI-118551 Hydrochloride (ICI-118,551) is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.

<p>Itopride HCl combats dyspepsia and GERD, inhibiting AChE and blocking D2 receptors.</p>