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Proteina G/GPCR

Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

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Trovati 5378 prodotti di "Proteina G/GPCR"

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  • Logo CymitQuimica
    Targetmol
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    Adenosine receptor agonist 1

    <p>Compound 6m, an A3 adenosine receptor (AR) partial agonist, exhibits a K i value of 6.7 nM as an adenosine receptor agonist.</p>
    Formula:C12H14ClN5O2Se
    Colore e forma:Solid
    Peso molecolare:374.68

    Ref: TM-T89890

  • HTR2A antagonist 1
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    HTR2A antagonist 1

    <p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>
    Formula:C35H43Cl2F2N5O4
    Colore e forma:Solid
    Peso molecolare:706.65

    Ref: TM-T204966

  • SBI-810
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    SBI-810

    CAS:
    <p>SBI-810 is a functional selective β-arrestin-biased allosteric modulator of the neurotensin receptor 1 (NTSR1). In the presence of the endogenous ligand neurotensin (NT), SBI-810 regulates NTSR1 signaling through a G protein-specific mechanism. It fully antagonizes NT-induced Gq activation and partially antagonizes NT-induced Gi1 activation, allowing NTSR1 to activate GoA and G12.</p>
    Formula:C27H34N4O2
    Colore e forma:Solid
    Peso molecolare:446.59

    Ref: TM-T203513

  • 4-P-PDOT
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    4-P-PDOT

    CAS:
    <p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>
    Formula:C19H21NO
    Purezza:99.91%
    Colore e forma:Solid
    Peso molecolare:279.38

    Ref: TM-T14042

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    MAO-B-IN-3

    <p>MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki</p>
    Formula:C24H25N3O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:387.47

    Ref: TM-T78648

  • Jmv 167
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    Jmv 167

    CAS:
    <p>Jmv 167 is an antagonist of the Cholecystokinin receptor.</p>
    Formula:C51H68N8O14S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1049.21

    Ref: TM-T24202

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    GRL093-22

    <p>GRL093-22 is an effective and selective inhibitor of G protein-coupled receptor kinases (GRK), with IC50 values of 60 nM for GRK5 and 40 nM for GRK6. It shows potential for research in heart failure and multiple myeloma.</p>
    Formula:C33H29FN6O3
    Colore e forma:Solid
    Peso molecolare:576.62

    Ref: TM-T203092

  • Losulazine
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    Losulazine

    CAS:
    <p>Losulazine: a new antihypertensive, requires functional sympathetic nervous system; mechanism undefined.</p>
    Formula:C27H22F4N4O3S
    Purezza:98.83%
    Colore e forma:Solid
    Peso molecolare:558.55

    Ref: TM-T68095

  • AL 34662
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    AL 34662

    CAS:
    <p>AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also a</p>
    Formula:C10H13N3O
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:191.23

    Ref: TM-T22029

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    TGR5 agonist 7

    <p>TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.</p>
    Formula:C37H59N2NaO9S
    Colore e forma:Solid
    Peso molecolare:730.93

    Ref: TM-T203565

  • Casopitant
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    Casopitant

    CAS:
    <p>Casopitant (GW679769) is an orally active neurokinin-1 (NK1) receptor antagonist, researched for its potential use in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).</p>
    Formula:C30H35F7N4O2
    Colore e forma:Solid
    Peso molecolare:616.61

    Ref: TM-T203625

  • β-MSH, human
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    β-MSH, human

    CAS:
    <p>beta-MSH, human is an endogenous peptide hormone and neurotransmitter by POMC, an agonist of MC4-R (melanocortin 4 receptor).</p>
    Formula:C118H174N34O35S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:2660.92

    Ref: TM-TP1004

  • 4-Hydroxy MPT
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    4-Hydroxy MPT

    CAS:
    <p>4-Hydroxy MPT (4-OH-MPT) is a serotonin-active compound that acts as an agonist for 5-HT2A and 5-HT2B receptors, with EC50 values of 3.82 nM and 3.4 nM, respectively.</p>
    Formula:C14H20N2O
    Colore e forma:Solid
    Peso molecolare:232.32

    Ref: TM-T203446

  • PSB 0777 ammonium salt
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    PSB 0777 ammonium salt

    CAS:
    <p>adenosine A2A receptor full agonist</p>
    Formula:C18H24N6O7S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:500.55

    Ref: TM-T23196

  • CB2R probe 1
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    CB2R probe 1

    CAS:
    <p>CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) of</p>
    Formula:C36H42N4O4
    Colore e forma:Solid
    Peso molecolare:594.74

    Ref: TM-T74604

  • Torososide B
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    Torososide B

    CAS:
    <p>Torososide B is an anti-allergic compound that inhibits leukotriene release from calcium ionophore A-stimulated rat peritoneal mast cells.</p>
    Formula:C40H52O25
    Colore e forma:Solid
    Peso molecolare:932.83

    Ref: TM-T203084

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    Targetmol
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    V1a/V2 antagonist 1

    <p>V1a/V2 antagonist 1 (Compound 18j) is an orally active dual-target antagonist of V1a and V2 receptors, exhibiting high binding affinity toward these receptors [Ki values are hV1a: 0.13 nM, hV2: 0.53 nM, and mV1a: 0.5 nM; IC50 for hV1a is 2.2 nM]. This compound can inhibit oxytocin-induced scratching behavior in mice.</p>
    Formula:C25H26ClN5O3
    Colore e forma:Solid
    Peso molecolare:479.96

    Ref: TM-T203525

  • [Deamino-Pen1,Val4,D-Arg8]-vasopressin
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    [Deamino-Pen1,Val4,D-Arg8]-vasopressin

    CAS:
    <p>[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an antagonist of arginine-vasopressin (AVP).</p>
    Formula:C48H69N13O11S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1068.27

    Ref: TM-T83501

  • Lanepitant 2HCl
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    Lanepitant 2HCl

    CAS:
    Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist that can be used to study painful neuropathy-like disorders such as migraine.
    Formula:C33H47Cl2N5O3
    Purezza:98.67%
    Colore e forma:Solid
    Peso molecolare:632.66

    Ref: TM-T25616

  • ADTN
    Targetmol
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    ADTN

    CAS:
    <p>ADTN is an agonist of the dopamine receptor.</p>
    Formula:C10H13NO2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:179.22

    Ref: TM-T23643