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Proteina G/GPCR

Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

Mostrare 18 più sottocategorie

Trovati 5745 prodotti di "Proteina G/GPCR"

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  • KFM19
    Targetmol
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    KFM19

    CAS:
    KFM19 is a potent and selective adenosine receptor (A1-receptor) antagonist (IC50 : 50 nM) for the study of neurological disorders.
    Formula:C16H22N4O3
    Purezza:98.62%
    Colore e forma:Solid
    Peso molecolare:318.37

    Ref: TM-T15655

  • PZ-1190
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    PZ-1190

    CAS:
    <p>PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].</p>
    Formula:C27H30N4O2S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:506.68

    Ref: TM-T81336

  • ASP6432
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    ASP6432

    CAS:
    ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
    Formula:C26H32KN4O6S2
    Colore e forma:Solid
    Peso molecolare:599.78

    Ref: TM-T14335

  • Ono-RS 347
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    Ono-RS 347

    CAS:
    Ono-RS 347 is a leukotriene antagonists with the activity of SRS-A antagonist.
    Formula:C26H25N5O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:471.51

    Ref: TM-T28253

  • JTE-952
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    JTE-952

    CAS:
    <p>JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.</p>
    Formula:C30H34N2O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:518.6

    Ref: TM-T11729

  • β3-AR agonist 1
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    β3-AR agonist 1

    CAS:
    β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/
    Formula:C22H28N4O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:444.55

    Ref: TM-T10523

  • Dersalazine sodium
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    Dersalazine sodium

    CAS:
    Dersalazine, potential ulcerative colitis drug, inhibits PAF & TNFα, reduces inflammation and MPO activity in rats.
    Formula:C35H32N6NaO4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:623.669

    Ref: TM-T27150

  • Orvepitant maleate
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    Orvepitant maleate

    CAS:
    <p>Orvepitant maleate, a selective NK-1 receptor antagonist (pKi 10.2), may treat depression and CRC; crosses the blood-brain barrier.</p>
    Formula:C35H39F7N4O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:744.7

    Ref: TM-T16406

  • SB 258719
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    SB 258719

    CAS:
    SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
    Formula:C18H30N2O2S
    Purezza:99.73%
    Colore e forma:Solid
    Peso molecolare:338.51

    Ref: TM-T12855

  • TGR5 agonist 3
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    TGR5 agonist 3

    CAS:
    Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].
    Formula:C28H48O5
    Colore e forma:Solid
    Peso molecolare:464.68

    Ref: TM-T79424

  • Prostaglandin E2 Ethanolamide
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    Prostaglandin E2 Ethanolamide

    CAS:
    Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].
    Formula:C22H37NO5
    Colore e forma:Solid
    Peso molecolare:395.54

    Ref: TM-T84584

  • tetranor-PGFM
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    tetranor-PGFM

    CAS:
    Tetranor-PGFM, the principal urinary metabolite of PGF2α, is excreted at rates of 7-13 µg per day in healthy females and 11-59 µg per 24 hours in healthy males. During pregnancy, female urinary levels of tetranor-PGFM increase 2 to 5-fold, returning to normal shortly after childbirth.
    Formula:C16H26O7
    Colore e forma:Solid
    Peso molecolare:330.4

    Ref: TM-T84618

  • RU-SKI 43
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    RU-SKI 43

    CAS:
    RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.
    Formula:C22H30N2O2S
    Purezza:99.85%
    Colore e forma:Solid
    Peso molecolare:386.55

    Ref: TM-T12797

  • OMDM-5
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    OMDM-5

    CAS:
    OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).
    Formula:C26H44N2O3
    Purezza:99.73%
    Colore e forma:Solid
    Peso molecolare:432.64

    Ref: TM-T12306

  • 2-O-Ethyl PAF C-16
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    2-O-Ethyl PAF C-16

    CAS:
    2-O-Ethyl PAF C-16, a homolog of Platelet-activating Factor (PAF) and competitive ligand for the Platelet-activating Factor Receptor (PAFR), inhibits the binding of PAF antagonist WEB 2086 to PAFR with an IC50 of 21 nM [1].
    Formula:C26H56NO6P
    Colore e forma:Solid
    Peso molecolare:509.709

    Ref: TM-T84613

  • APJ receptor agonist 6
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    APJ receptor agonist 6

    CAS:
    APJ receptor agonist 6 is a potent agonist of the APJ (apelin receptor) (Ki: 0.059 μM). (EC50: 6.22 μM).
    Formula:C29H34FN3O5
    Colore e forma:Solid
    Peso molecolare:523.6

    Ref: TM-T63669

  • Epinephrine HCl
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    Epinephrine HCl

    CAS:
    <p>Epinephrine HCl is a hormone and neurotransmitter secreted by the adrenal medulla, agonist of α-adrenergic and β-adrenergic receptor.</p>
    Formula:C9H14ClNO3
    Purezza:99.48%
    Colore e forma:Solid
    Peso molecolare:219.67

    Ref: TM-T84869

  • GYKI-46903 HCl
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    GYKI-46903 HCl

    CAS:
    GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.
    Formula:C17H21ClFNO2
    Colore e forma:Solid
    Peso molecolare:325.81

    Ref: TM-T32033

  • L 662025
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    L 662025

    CAS:
    L 662025 is a PAF receptor antagonist.
    Formula:C23H27N3O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:441.48

    Ref: TM-T24315

  • AL 8810 methyl ester
    Targetmol
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    AL 8810 methyl ester

    CAS:
    AL 8810 methyl ester, a prostaglandin F(2α) analog and receptor agonist, competitively antagonizes FP receptor agonist Fluprostenol effects. It lacks significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines [1].
    Formula:C25H33FO4
    Colore e forma:Solid
    Peso molecolare:416.53

    Ref: TM-T84517