Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(993 prodotti)
- Recettore dell'adenosina(246 prodotti)
- Recettore adrenergico(3.004 prodotti)
- Recettore della bombesina(33 prodotti)
- Recettore della bradichinina(59 prodotti)
- CXCR(153 prodotti)
- CaSR(33 prodotti)
- Recettore dei cannabinoidi(212 prodotti)
- Recettore della dopamina(433 prodotti)
- Recettore dell'endotelina(79 prodotti)
- Recettore GNRH(77 prodotti)
- GPCR19(32 prodotti)
- GRK(32 prodotti)
- GTPase(22 prodotti)
- Recettore del glucagone(182 prodotti)
- Proteina Hedgehog/Smoothened(47 prodotti)
- Recettore dell'istamina(381 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(26 prodotti)
- Recettore OX(41 prodotti)
- Recettore degli oppioidi(310 prodotti)
- PAFR(12 prodotti)
- PKA(51 prodotti)
- Recettore S1P(18 prodotti)
- SGLT(31 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 18 più sottocategorie
Trovati 5745 prodotti di "Proteina G/GPCR"
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Monlunabant
CAS:<p>Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].</p>Formula:C26H22ClF3N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:591.00MRS2905 trisodium
CAS:<p>MRS2905 (α,β-Methylene-2-thio-UDP) trisodium is a selective P2Y14R agonist with an EC50 of 0.92 nM. It shows no activity on UDP-activated P2Y6 receptors or other P2Y receptors.</p>Formula:C10H13N2Na3O10P2SColore e forma:SolidPeso molecolare:484.199EP4 receptor agonist 3
CAS:<p>EP4 receptor agonist 3 is an activator of the EP4 receptor and is useful for research in the DSS-induced colitis mouse model.</p>Formula:C21H27F2NO4Colore e forma:SolidPeso molecolare:395.44Cloprostenol
CAS:Cloprostenol is a synthetic prostaglandin and PGF2α analogue used in animals to terminate pregnancy and induce corpus luteum dissolution.Formula:C22H29ClO6Purezza:99.81%Colore e forma:Clear Colorless To Light Yellowish LiquidPeso molecolare:424.92SGLT inhibitor-1
CAS:SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).Formula:C24H27FO8Purezza:98%Colore e forma:SolidPeso molecolare:462.46KMN-80
CAS:<p>KMN-80 is a potent, selective EP4 agonist with IC50 3 nM, spurring osteoblast differentiation, and showing in vivo bone repair efficacy.</p>Formula:C21H33NO4Colore e forma:SolidPeso molecolare:363.49CP-481715
CAS:CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Formula:C26H31FN4O4Colore e forma:SolidPeso molecolare:482.55TAK-637
CAS:TAK-637 is a tachykinin 1 (NK1) receptor antagonist.Formula:C30H25F6N3O2Purezza:98%Colore e forma:SolidPeso molecolare:573.53BMS-986120
CAS:BMS-986120: Oral, reversible PAR4 antagonist. IC50: 9.5 nM (human), 2.1 nM (monkey). Potent, selective antiplatelet.Formula:C23H23N5O5S2Colore e forma:SolidPeso molecolare:513.59MK-8825
CAS:MK-8825 is a CGRP receptor antagonist.Formula:C31H30F2N6O3Colore e forma:SolidPeso molecolare:572.61FK-3657
CAS:FK-3657 is a non-peptide antagonist of bradykinin (BK)-B2 receptor.Formula:C30H27Cl2N5O4Colore e forma:SolidPeso molecolare:592.47Netupitant metabolite Monohydroxy Netupitant
CAS:Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.Formula:C30H32F6N4O2Purezza:98%Colore e forma:SolidPeso molecolare:594.59BI-44370
CAS:BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.Formula:C35H47N5O6Colore e forma:SolidPeso molecolare:633.78Delmadinone acetate
CAS:<p>Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.</p>Formula:C23H27ClO4Colore e forma:SolidPeso molecolare:402.911(S)-Praziquantel
CAS:(S)-Praziquantel is the inactive isomer of R-praziquantel.Formula:C19H24N2O2Colore e forma:SolidPeso molecolare:312.406Fasitibant
CAS:<p>Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.</p>Formula:C36H49Cl2N6O6SColore e forma:SolidPeso molecolare:764.78CVT-5440
CAS:CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.Formula:C27H28N6O5Colore e forma:SolidPeso molecolare:516.55(Rac)-BI 703704
CAS:(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).Formula:C32H37N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:559.72CCR7 Ligand 1
CAS:CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.Formula:C22H29N5O5SColore e forma:SolidPeso molecolare:475.56LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Formula:C32H39N3O·HCl·xH2OColore e forma:SolidIci D1542
CAS:Ici D1542: potent TXS inhibitor & TXA2 receptor antagonist, effective thromboxane blocker in vitro.Formula:C25H30N2O7Purezza:98%Colore e forma:SolidPeso molecolare:470.51TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Formula:C36H46N4O4SColore e forma:SolidPeso molecolare:630.84Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Formula:C19H17NNaO7Purezza:98%Colore e forma:SolidPeso molecolare:394.335DMPX
CAS:DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.Formula:C10H10N4O2Colore e forma:SolidPeso molecolare:218.212LPA2 antagonist 5
CAS:LPA2 antagonist 5 (EX1) functions as an antagonist of LPA2, with an IC50 value of 4.05 nM.Formula:C17H17F3N2O5Colore e forma:SolidPeso molecolare:386.323LY 292728
CAS:LY 292728 is a highly potent antagonist of leukotriene B4 receptor.Formula:C34H29FO9Purezza:98%Colore e forma:SolidPeso molecolare:600.59GLP-1R agonist 8
CAS:<p>GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).</p>Formula:C33H32N4O5Colore e forma:SolidPeso molecolare:564.63PF-00446687
CAS:PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).Formula:C28H36F2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:470.59BI 703704
CAS:<p>BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].</p>Formula:C32H37N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:559.72Henagliflozin
CAS:Henagliflozin (SHR3824): an oral, selective SGLT2 inhibitor, weak on SGLT1.Formula:C22H24ClFO7Colore e forma:SolidPeso molecolare:454.87GHSR-1a agonist-1
CAS:<p>GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a) with an EC50 of 0.49 nM. It effectively stimulates the release of endogenous growth hormone by activating GHSR-1a. Doses as low as 0.1 mg/kg (administered orally) can increase body weight and length in 4-week-old rats. GHSR-1a agonist-1 is applicable in research on pediatric growth and developmental delays.</p>Formula:C30H37N5O4Colore e forma:SolidPeso molecolare:531.646SCH-900822
CAS:SCH-900822 is a potent and selective glucagon receptor antagonist.Formula:C34H43Cl2N7O2Colore e forma:SolidPeso molecolare:652.66Revexepride
CAS:Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formula:C21H32ClN3O4Purezza:98%Colore e forma:SolidPeso molecolare:425.95CI-988
CAS:CCK2 (CCK-B) receptor antagonistFormula:C35H42N4O6Purezza:98%Colore e forma:SolidPeso molecolare:614.73SSR-241586
CAS:SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.Formula:C32H42Cl2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:601.61Mesulergine hydrochloride
CAS:5-HT2A and 2C receptor antagonistFormula:C18H27ClN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:398.95ADORA2A/PDE4D-IN-1
CAS:<p>ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.</p>Formula:C14H11N5Colore e forma:SolidPeso molecolare:249.271S1P1 agonist 5
Selective oral S1P1 agonist 5 inhibits lymphocyte drainage, potential for MS research.Formula:C23H24ClN2NaO4Colore e forma:SolidPeso molecolare:450.895-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formula:C23H29ClN6O2Colore e forma:SolidPeso molecolare:456.97Bometolol Hydrochloride
CAS:<p>Bometolol Hydrochloride is a beta-adrenergic blocking compound used for the treatment of cardiovascular disease.</p>Formula:C25H33ClN2O7Purezza:98%Colore e forma:SolidPeso molecolare:508.99BRD50837
CAS:BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).Formula:C26H32ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.07TGR5 Receptor Agonist 3
CAS:TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.Formula:C29H27N3O6Colore e forma:SolidPeso molecolare:513.54BRL-37344
CAS:<p>BRL-37344 is a selective β3-adrenergic receptor agonist. It significantly reduces the body weight of obese mice.</p>Formula:C19H22ClNO4Colore e forma:SolidPeso molecolare:363.84L-365260 hemihydrate
L-365260 hemihydrate: selective oral CCK-B/gastrin blocker, Ki=1.9/2.0 nM, competes with guinea pig receptors.Formula:C24H24N4O3Colore e forma:SolidPeso molecolare:407.47CCR4 antagonist 2
CAS:CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits TregFormula:C26H28Cl2N6OPurezza:98%Colore e forma:SolidPeso molecolare:511.45(E/Z)-Ozagrel sodium
CAS:(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is a mixture of the EZ isomers of Ozagrel (sodium). It acts as a thromboxane A2 (TXA2) synthase inhibitor. As an antiplatelet agent, Ozagrel (sodium) selectively inhibits human platelet aggregation, with an IC50 of 53.12 μM.Formula:C13H11N2NaO2Colore e forma:SolidPeso molecolare:250.228CP-865569
CAS:CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.Formula:C22H26ClFN2O5SColore e forma:SolidPeso molecolare:484.969Sulprostone
CAS:EP3 and EP1 receptor agonistFormula:C23H31NO7SPurezza:98%Colore e forma:White To Off-White SolidPeso molecolare:465.56MRGPRX1 agonist 3
Compound 1f, a potent MRGPRX1 agonist, has an EC50 of 0.22 μM, useful for neuropathic pain studies.Formula:C14H11FN2OSColore e forma:SolidPeso molecolare:274.31H3R antagonist 5
CAS:<p>H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.</p>Formula:C23H32N2O4Colore e forma:SolidPeso molecolare:400.511MDA7
CAS:<p>MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.</p>Formula:C22H25NO2Colore e forma:SolidPeso molecolare:335.439Anthrotainin
CAS:Anthrotainin is a tetracyclic compound that acts as an inhibitor of the binding of P substance (substance P), with an IC50 of 3 μM.Formula:C20H17NO9Colore e forma:SolidPeso molecolare:415.35Ro4368554
CAS:<p>Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.</p>Formula:C19H21N3O2SColore e forma:SolidPeso molecolare:355.454H1R ligand-1
CAS:<p>H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.</p>Formula:C19H23NOColore e forma:SolidPeso molecolare:281.3925-IAI hydrochloride
CAS:<p>5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.</p>Formula:C9H11ClINColore e forma:SolidPeso molecolare:295.548Taprostene
CAS:Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.Formula:C24H30O5Colore e forma:SolidPeso molecolare:398.49EP4 receptor antagonist 7
CAS:<p>EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4, with an IC50 of 1.1 nM. This compound inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 of 0.9 nM. In RAW 264.7 macrophages, it reduces the expression of PGE2-induced IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C motif) ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase 1 (Arg1) mRNA. In the CT26 mouse colon cancer model, EP4 receptor antagonist 7, combined with an anti-PD-1 antibody, inhibits tumor growth and enhances CD8+ T cell infiltration into the tumor.</p>Formula:C24H18F3N3O3Colore e forma:SolidPeso molecolare:453.413Gemilukast
CAS:<p>Gemilukast (ONO-6950) is a cysteinyl leukotriene 1 and 2 receptor inhibitor that inhibits bronchoconstriction and is used in the treatment of asthma.</p>Formula:C36H37F2NO5Purezza:98.27% - 99.5%Colore e forma:SolidPeso molecolare:601.68BI-113823
CAS:<p>BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. It alleviates mechanical hyperalgesia induced by complete Freund's adjuvant in rats. BI-113823 is applicable for research on chronic inflammatory pain.</p>Formula:C26H44N4O5SColore e forma:SolidPeso molecolare:524.716Zaladenant
CAS:<p>Zaladenant is an adenosine receptor antagonist with antitumor properties.</p>Formula:C19H15F3N6OColore e forma:SolidPeso molecolare:400.357D3/5-HT receptor modulator-1
CAS:D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.Formula:C24H29N3O2Colore e forma:SolidPeso molecolare:391.50625B-NBOH hydrochloride
CAS:<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Formula:C17H21BrClNO3Colore e forma:SolidPeso molecolare:402.711LY3154207
CAS:LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.Formula:C24H29Cl2NO3Colore e forma:SolidPeso molecolare:450.45-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formula:C33H38N4O3SColore e forma:SolidPeso molecolare:570.74PSB 36
CAS:A1 adenosine receptor antagonistFormula:C21H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:386.49SSR 146977
CAS:NK3 receptor antagonistFormula:C35H42Cl2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:621.64(Rac)-Nebivolol
CAS:(Rac)-Nebivolol, a racemic β1-adrenergic blocker (IC50=0.8 nM), has vasodilatory properties and mitigates ethanol-induced cardiac harm.Formula:C22H25F2NO4Colore e forma:SolidPeso molecolare:405.435-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.Formula:C14H18Cl2N4Colore e forma:SolidPeso molecolare:313.23Macitentan (n-butyl analogue)
CAS:Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.Formula:C20H21Br2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:587.29Y1 receptor antagonist 1
CAS:Y1 receptor antagonist 1 is an antagonist of neuropeptide Y1 receptor.Formula:C28H33N5O3Purezza:98.17%Colore e forma:SolidPeso molecolare:487.59CI-624
CAS:CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.Formula:C8H8N2SColore e forma:SolidPeso molecolare:164.228AFP-07 free acid
CAS:AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.Formula:C22H30F2O5Purezza:98%Colore e forma:SolidPeso molecolare:412.47(R)-BAY-899
(R)-BAY-899: R-isomer, selective LH-R antagonist, effective on hLH (IC50: 185 nM) and rLH (IC50: 46 nM), orally active.Formula:C25H19F2N5O2Colore e forma:SolidPeso molecolare:459.45Kendomycin
CAS:Kendomycin is a proteasome inhibitor and endothelin receptor antagonist. It induces apoptosis in lymphoma.Formula:C29H42O6Colore e forma:SolidPeso molecolare:486.64GAT564
GAT564, an allosteric CB1R modulator, shows EC50s of 87 nM (cAMP) & 320 nM (β-arrestin2) and lowers IOP effectively in glaucoma mice.Formula:C20H16N2O2SColore e forma:SolidPeso molecolare:348.42A1/A3 AR antagonist 1
<p>Compound 10 is a potent dual A1/A3 AR antagonist, with Ki values of 37.6 nM (hA1), 25.4 nM (hA3), and 1.47 nM (rA1), studied in renal, lung, and Alzheimer's.</p>Formula:C24H18N2O3SColore e forma:SolidPeso molecolare:414.48DM-4111
CAS:<p>DM-4111, one of the primary monohydroxy metabolites of Tolvaptan, is an effective vasopressin V2 receptor (vasopressin V2 receptor) inhibitor. By inhibiting water reabsorption in renal tubules, it facilitates the excretion of electrolyte-free water. DM-4111 holds potential for research in cardiovascular diseases.</p>Formula:C26H25ClN2O4Colore e forma:SolidPeso molecolare:464.94PD 140376
CAS:PD 140376: Selective CCK-B/gastrin receptor antagonist radioligand for guinea pig stomach & brain.Formula:C33H40N4O5Purezza:98%Colore e forma:SolidPeso molecolare:572.69CHF-6366
CAS:<p>CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.</p>Formula:C42H48N6O8Colore e forma:SolidPeso molecolare:764.87Vofopitant dihydrochloride
CAS:Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.Formula:C21H25Cl2F3N6OPurezza:98.99%Colore e forma:SolidPeso molecolare:505.36AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Formula:C30H41FN2O6Purezza:98.32% - 99.63%Colore e forma:SolidPeso molecolare:544.65Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Formula:C27H45NO7Purezza:99.86%Colore e forma:SolidPeso molecolare:495.65SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Formula:C26H32N2O4Purezza:99.22%Colore e forma:SolidPeso molecolare:436.54SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Formula:C32H33ClN4O3Purezza:97.82% - 98.99%Colore e forma:SolidPeso molecolare:557.08BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Formula:C34H51N5O7Purezza:98.81%Colore e forma:SolidPeso molecolare:641.8AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formula:C32H38F2N2O5S2Purezza:98.1%Colore e forma:SolidPeso molecolare:632.78Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Formula:C36H45F4N3O5Purezza:97.35% - 98.23%Colore e forma:SolidPeso molecolare:675.75BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Formula:C27H23N5O5S2Purezza:98.43% - 99.26%Colore e forma:SolidPeso molecolare:561.63Vofopitant
CAS:Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).Formula:C21H23F3N6OPurezza:97.86%Colore e forma:SolidPeso molecolare:432.44PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Formula:C25H27FN6O2Purezza:99.9%Colore e forma:SolidPeso molecolare:462.52LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Formula:C26H23Cl2N3O2Purezza:99.21%Colore e forma:SolidPeso molecolare:480.39Rolapitant hydrochloride
CAS:Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.Formula:C25H27ClF6N2O2Purezza:98.35% - 99.79%Colore e forma:SolidPeso molecolare:536.94ML-00253764 hydrochloride
CAS:ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).Formula:C18H19BrClFN2OColore e forma:SolidPeso molecolare:413.71Pumosetrag Hydrochloride
CAS:Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.Formula:C15H18ClN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:339.84Protease-Activated Receptor-4
CAS:Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.Formula:C33H46N8O7Purezza:98%Colore e forma:SolidPeso molecolare:666.77JMV 2959
CAS:JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).Formula:C30H32N6O2Colore e forma:SolidPeso molecolare:508.61CYM 9484
CAS:CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.Formula:C27H31N3O3S2Colore e forma:SolidPeso molecolare:509.68BIBP3226 TFA
CAS:BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).Formula:C29H32F3N5O5Colore e forma:SolidPeso molecolare:587.59SB-399885 hydrochloride
CAS:SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.Formula:C18H22Cl3N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:482.81HOKU-81
CAS:HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.Formula:C12H18ClNO2Colore e forma:SolidPeso molecolare:243.73Beraprost sodium
CAS:Beraprost sodium is a stable and orally active prodrug of PGI2.Formula:C24H29NaO5Colore e forma:SolidPeso molecolare:420.481SHA 68
CAS:SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.Formula:C26H24FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:445.49SR 146131
CAS:SR 146131 is a potent and selective agonist of the nonpeptide receptor.Formula:C32H36ClN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:610.16ML-290
CAS:ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.Formula:C24H21F3N2O5SColore e forma:SolidPeso molecolare:506.497-Desmethyl-agomelatine
CAS:7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.Formula:C14H15NO2Colore e forma:SolidPeso molecolare:229.27Arotinolol
CAS:Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.Formula:C15H21N3O2S3Colore e forma:White SolidPeso molecolare:371.54SKF 89748
CAS:SKF 89748 is an agonists of alpha 1-adrenoceptor.Formula:C12H17NOSPurezza:98%Colore e forma:SolidPeso molecolare:223.33Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Colore e forma:Odour Liquid1-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Formula:C21H41O7PColore e forma:SolidPeso molecolare:436.523-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Formula:C7H9NOColore e forma:SolidPeso molecolare:123.155Desmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Formula:C20H30Cl2N4OPurezza:98%Colore e forma:SolidPeso molecolare:413.38GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Colore e forma:Odour LiquidPatecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purezza:98%Colore e forma:LiquidRef: TM-T81538
Prodotto fuori produzioneAmelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Formula:C33H34N2O5Purezza:98%Colore e forma:SolidPeso molecolare:538.631-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
CAS:1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T65156 and the CAS number is 24155-42-8.Formula:C11H10Cl2N2OColore e forma:SolidPeso molecolare:257.116-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Formula:C10H9Cl2NOColore e forma:SolidPeso molecolare:230.09(Rac)-Zevaquenabant
CAS:(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.Formula:C25H21ClF3N5O2SColore e forma:SolidPeso molecolare:547.98Goserelin acetate(65807-02-5 Free base)
<p>Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>Purezza:99.77%Colore e forma:Odour Solid(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Formula:C6H13Cl2N3Colore e forma:SolidPeso molecolare:198.09Vornorexant
CAS:Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.Formula:C23H22FN7O2Colore e forma:SolidPeso molecolare:447.474TAK-683
CAS:TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.Formula:C64H83N17O13Purezza:98%Colore e forma:SolidPeso molecolare:1298.45BRL 15572
CAS:BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.Formula:C25H27ClN2OColore e forma:SolidPeso molecolare:406.954-Hydroxypropranolol hydrochloride
CAS:4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).Formula:C16H22ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:311.8Picumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Formula:C21H29Cl2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:426.38BX471 hydrochloride
CAS:BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.Formula:C21H25Cl2FN4O3Purezza:98%Colore e forma:SolidPeso molecolare:471.35dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Formula:C37H39NO4Colore e forma:SolidPeso molecolare:561.71CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Formula:C19H20N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:356.44Sarizotan
CAS:Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.Formula:C22H21FN2OColore e forma:SolidPeso molecolare:348.421Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Formula:C16H25N3O·xClHPurezza:99.25%Colore e forma:SoildTAK-448
CAS:TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.Formula:C58H80N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1225.364-Hydroxyatomoxetine
CAS:4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.Formula:C17H21NO2Purezza:98%Colore e forma:SolidPeso molecolare:271.35Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Formula:C24H25FO5SPurezza:98%Colore e forma:SolidPeso molecolare:448.54Ref: TM-T10669
Prodotto fuori produzione2-Methyl-5-HT hydrochloride
CAS:2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formula:C11H15ClN2OPurezza:98%Colore e forma:SolidPeso molecolare:226.7Ref: TM-T10075L2
Prodotto fuori produzioneAM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formula:C24H20N2OPurezza:99.37%Colore e forma:SolidPeso molecolare:352.43Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purezza:99.99%Colore e forma:Fine Yellow PowderPeso molecolare:388.37Flumexadol
CAS:Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.Formula:C11H12F3NOPurezza:98%Colore e forma:SolidPeso molecolare:231.21GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Formula:C24H33NO3SPurezza:98%Colore e forma:SolidPeso molecolare:415.59Ref: TM-T27431
Prodotto fuori produzioneMEN11467
CAS:MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.Formula:C38H40N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:600.75SB251023
CAS:SB251023 is an agonist of β3-adrenoceptor.Formula:C28H34NO6PColore e forma:SolidPeso molecolare:511.55Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Formula:C38H40N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:600.75Imetit dihydrobromide
CAS:Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).Formula:C6H12Br2N4SPurezza:98%Colore e forma:SolidPeso molecolare:332.06AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purezza:99.58%Colore e forma:SolidPeso molecolare:436.63S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Formula:C25H26F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:445.47Dimethandrolone Undecanoate
CAS:Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.Formula:C31H50O3Purezza:99.65% - >99.99%Colore e forma:SolidPeso molecolare:470.73Ref: TM-T27176
Prodotto fuori produzione2-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Formula:C8H8N2O3SColore e forma:LiquidPeso molecolare:212.23
