Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(939 prodotti)
- Recettore dell'adenosina(242 prodotti)
- Recettore adrenergico(2.945 prodotti)
- Recettore della bombesina(30 prodotti)
- Recettore della bradichinina(59 prodotti)
- CXCR(148 prodotti)
- CaSR(32 prodotti)
- Recettore dei cannabinoidi(195 prodotti)
- Recettore della dopamina(407 prodotti)
- Recettore dell'endotelina(76 prodotti)
- Recettore GNRH(73 prodotti)
- GPCR19(31 prodotti)
- GRK(31 prodotti)
- GTPase(21 prodotti)
- Recettore del glucagone(165 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Recettore dell'istamina(358 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(24 prodotti)
- Recettore OX(40 prodotti)
- Recettore degli oppioidi(297 prodotti)
- PAFR(11 prodotti)
- PKA(48 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(30 prodotti)
- Recettore Sigma(46 prodotti)
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Trovati 5352 prodotti di "Proteina G/GPCR"
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GLP-1R agonist 8
CAS:<p>GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).</p>Formula:C33H32N4O5Colore e forma:SolidPeso molecolare:564.63Aclidinium
CAS:<p>Aclidinium, a dual-action compound, serves as a long-acting muscarinic antagonist and a β2-adrenoceptor (β2-AR) agonist, exhibiting bronchodilator properties. It effectively reduces lung hyperinflation, enhances lung function, and prolongs exercise endurance time. This compound is commonly utilized in studies focusing on chronic obstructive pulmonary disease (COPD).</p>Formula:C26H30NO4S2Colore e forma:SolidPeso molecolare:484.65Henagliflozin
CAS:<p>Henagliflozin (SHR3824): an oral, selective SGLT2 inhibitor, weak on SGLT1.</p>Formula:C22H24ClFO7Colore e forma:SolidPeso molecolare:454.87GHSR-1a agonist-1
CAS:<p>GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a) with an EC50 of 0.49 nM. It effectively stimulates the release of endogenous growth hormone by activating GHSR-1a. Doses as low as 0.1 mg/kg (administered orally) can increase body weight and length in 4-week-old rats. GHSR-1a agonist-1 is applicable in research on pediatric growth and developmental delays.</p>Formula:C30H37N5O4Colore e forma:SolidPeso molecolare:531.646SCH-900822
CAS:<p>SCH-900822 is a potent and selective glucagon receptor antagonist.</p>Formula:C34H43Cl2N7O2Colore e forma:SolidPeso molecolare:652.66NBI 35965 hydrochloride
CAS:<p>NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].</p>Formula:C21H23Cl3N4Colore e forma:SolidPeso molecolare:437.79ADORA2A/PDE4D-IN-1
CAS:<p>ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.</p>Formula:C14H11N5Colore e forma:SolidPeso molecolare:249.271BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Formula:C26H32ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.07(2R,3S)-Azelaprag
CAS:<p>(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist</p>Formula:C25H29N7O4SPurezza:97.47% - >99.99%Colore e forma:SoildPeso molecolare:523.61Ersentilide
CAS:<p>Ersentilide, a benzamide derivative, functions as both a β1-adrenergic receptor antagonist and an Ikr blocker. It has demonstrated efficacy in animal models of cardiac arrhythmias.</p>Formula:C21H26N4O5SColore e forma:SolidPeso molecolare:446.52Protease-Activated Receptor-1 antagonist 1
<p>Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.</p>Formula:C25H24F2N2O3Colore e forma:SolidPeso molecolare:438.47GLP-1 receptor agonist 11
CAS:<p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>Formula:C31H31ClFN3O4Colore e forma:SolidPeso molecolare:564.05L-365260 hemihydrate
<p>L-365260 hemihydrate: selective oral CCK-B/gastrin blocker, Ki=1.9/2.0 nM, competes with guinea pig receptors.</p>Formula:C24H24N4O3Colore e forma:SolidPeso molecolare:407.47(R)-MrgprX2 antagonist-3
CAS:<p>(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.</p>Formula:C16H20FN3O2SPeso molecolare:337.41AA 497 (Free Base)
CAS:<p>AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.</p>Formula:C14H21NO3Purezza:98%Colore e forma:SolidPeso molecolare:251.32Protease-Activated Receptor-1 antagonist 2
<p>Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.</p>Colore e forma:SolidRBM10-8
CAS:<p>RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.</p>Formula:C17H36NO5PColore e forma:SolidPeso molecolare:365.45(E/Z)-Ozagrel sodium
CAS:<p>(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is a mixture of the EZ isomers of Ozagrel (sodium). It acts as a thromboxane A2 (TXA2) synthase inhibitor. As an antiplatelet agent, Ozagrel (sodium) selectively inhibits human platelet aggregation, with an IC50 of 53.12 μM.</p>Formula:C13H11N2NaO2Colore e forma:SolidPeso molecolare:250.228NK1 receptor antagonist 2
CAS:<p>NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.</p>Formula:C31H35F7N4O2Colore e forma:SolidPeso molecolare:628.62APJ receptor agonist 3
CAS:<p>APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.</p>Formula:C26H29ClN4O5Colore e forma:SolidPeso molecolare:512.98MDA7
CAS:<p>MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.</p>Formula:C22H25NO2Colore e forma:SolidPeso molecolare:335.439MK-8318
CAS:<p>MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).</p>Formula:C27H26F4N2O5Purezza:98%Colore e forma:SolidPeso molecolare:534.5ASN-1377642
CAS:<p>ASN-1377642 is an NK1 receptor antagonist with a Ki value of 251 nM. It demonstrates antitumor activity in breast cancer cells with high expression of NK1R-Tr.</p>Formula:C21H16ClN5OSColore e forma:SolidPeso molecolare:421.90Leukotriene F4
CAS:<p>LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.</p>Formula:C28H44N2O8SColore e forma:SolidPeso molecolare:568.72Ro-24-4736
CAS:<p>Ro 24-4736 is an effective and selective platelet-activating factor antagonist.</p>Formula:C31H20ClN5OSPurezza:98%Colore e forma:SolidPeso molecolare:546.04BAY-3153
CAS:<p>BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .</p>Formula:C25H29Cl2N3O4Colore e forma:SolidPeso molecolare:506.42Ophiobolin C
CAS:<p>inhibitor of human CCR5 binding to HIV-1 gp120</p>Formula:C25H38O3Purezza:98%Colore e forma:SolidPeso molecolare:386.57Tonapofylline
CAS:<p>Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.</p>Formula:C22H32N4O4Purezza:98.57%Colore e forma:SolidPeso molecolare:416.51MRGPRX1 agonist 4
<p>Potent, oral MRGPRX1 agonist 4 modulates receptor positively (EC50: 0.1 μM) and reduces mice's thermal allergy response.</p>Formula:C23H17Cl2F3N2O2SColore e forma:SolidPeso molecolare:513.36Nipradolol
CAS:<p>Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.</p>Formula:C15H22N2O6Colore e forma:SolidPeso molecolare:326.35ASP-2205
CAS:<p>ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.</p>Formula:C19H28N2OColore e forma:SolidPeso molecolare:300.44YM-31636 free base
CAS:<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formula:C14H11N3SColore e forma:SolidPeso molecolare:253.32CBR Agonist-2
<p>CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.</p>Formula:C27H27FN4OColore e forma:SolidPeso molecolare:442.53Dopamine D3 receptor antagonist-1
<p>Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeutic</p>Formula:C31H35Cl2N3O3Colore e forma:SolidPeso molecolare:568.53MDA77
CAS:<p>MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.</p>Formula:C21H23N3O3Colore e forma:SolidPeso molecolare:365.43UR-AK49
CAS:<p>UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.</p>Formula:C16H27N5OColore e forma:SolidPeso molecolare:305.42D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Formula:C21H25F2NO2Colore e forma:SolidPeso molecolare:361.43PD 136450
CAS:<p>PD-136,450: partial stomach secretory agonist, full pancreas agonist in rats; potential acid-reducing drug, adjuvant for gastrin-sensitive tumors.</p>Formula:C35H40N4O6Purezza:98%Colore e forma:SolidPeso molecolare:612.72FR-145715
CAS:<p>FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.</p>Formula:C16H21N5O2SColore e forma:SolidPeso molecolare:347.44Macitentan (n-butyl analogue)
CAS:<p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>Formula:C20H21Br2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:587.29Butopamine hydrochloride
CAS:<p>Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.</p>Formula:C18H24ClNO3Colore e forma:SolidPeso molecolare:337.84Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Formula:C27H29N5OColore e forma:SolidPeso molecolare:439.55(±)-Penbutolol
CAS:<p>(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.</p>Formula:C18H29NO2Colore e forma:SolidPeso molecolare:291.43(S)-Butaprost free acid
CAS:<p>(S)-Butaprost (free acid) is a potent and highly selective EP2 receptor agonist[1].</p>Formula:C23H38O5Colore e forma:SolidPeso molecolare:394.54BW A868C
CAS:BW A868C is a potent, selective PGD2 antagonist and a BW245C analogue, inert to other prostaglandin receptors.Formula:C25H37N3O5Colore e forma:SolidPeso molecolare:459.58TAAR1 agonist 2
CAS:<p>TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.</p>Formula:C9H11NOColore e forma:SolidPeso molecolare:149.19Danavorexton
CAS:<p>Danavorexton is an orexin receptor agonist.</p>Formula:C21H32N2O5SColore e forma:SolidPeso molecolare:424.55CP-481715
CAS:<p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>Formula:C26H31FN4O4Colore e forma:SolidPeso molecolare:482.55Setomagpran
CAS:<p>Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.</p>Formula:C22H19Cl2F6N5OColore e forma:SolidPeso molecolare:554.316SphK1-IN-1
<p>SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.</p>Formula:C22H22N6O2Colore e forma:SolidPeso molecolare:402.45Metrazoline
CAS:<p>Metrazoline (o-Methyl-tracizoline) acts as a ligand for adrenergic receptors (low affinity) and imidazoline I2 receptors.</p>Formula:C14H16N2O4Colore e forma:SolidPeso molecolare:276.288MRT-92
CAS:<p>MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.</p>Formula:C33H34N4O5Colore e forma:SolidPeso molecolare:566.65CP-608039
CAS:<p>CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.</p>Formula:C23H25ClN8O5Colore e forma:SolidPeso molecolare:528.95Enprostil
CAS:<p>Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.</p>Formula:C23H28O6Purezza:98%Colore e forma:SolidPeso molecolare:400.46Cicaprost
CAS:<p>Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.</p>Formula:C22H30O5Colore e forma:SolidPeso molecolare:374.47Nedocromil sodium
CAS:<p>Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.</p>Formula:C19H17NNaO7Purezza:98%Colore e forma:SolidPeso molecolare:394.335CB1/2 agonist 1
<p>Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.</p>Formula:C21H24BrFN2O2Colore e forma:SolidPeso molecolare:435.33Tofogliflozin
CAS:<p>Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).</p>Formula:C22H26O6Purezza:98%Colore e forma:SolidPeso molecolare:386.44SB 224289
CAS:<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formula:C32H32N4O3Purezza:98%Colore e forma:SolidPeso molecolare:520.62SAR-150640
CAS:<p>SAR-150640, a selective β3-adrenergic receptor agonist, prevents an increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis.</p>Formula:C25H35ClN2O7SColore e forma:SolidPeso molecolare:543.07NK-1 Antagonist 1
CAS:<p>NK-1 Antagonist 1 is a NK-1 receptor antagonist.</p>Formula:C25H23F6N5O2Purezza:98%Colore e forma:SolidPeso molecolare:539.47BAY-899
CAS:<p>BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.</p>Formula:C25H19F2N5O2Purezza:98%Colore e forma:SolidPeso molecolare:459.45Lp(a)-IN-8
CAS:<p>LPA2 antagonist 3 (compound 15) serves as an Lp(a) antagonist. Lp(a) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD).</p>Formula:C21H40Cl2N4O5Colore e forma:SolidPeso molecolare:499.472THRX-194556
CAS:<p>THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.</p>Formula:C28H41N5O5SColore e forma:SolidPeso molecolare:559.721GPBAR1-IN-3
CAS:<p>GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].</p>Formula:C21H23NO2Colore e forma:SolidPeso molecolare:321.41INCB-9471 dihydrochloride
CAS:<p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.</p>Formula:C30H42Cl2F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:632.59Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formula:C24H28F3N3O2Colore e forma:SolidPeso molecolare:447.49LX2761
CAS:<p>LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.</p>Formula:C32H47N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:601.80Becondogrel
CAS:<p>Becondogrel (2-Oxoclopidogrel) is a metabolite of Clopidogrel. It irreversibly inhibits the P2Y12 receptor, thereby preventing platelet aggregation and thrombosis.</p>Formula:C16H16ClNO3SColore e forma:SolidPeso molecolare:337.821CB2 receptor antagonist 1
CAS:<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Formula:C28H47NO3Colore e forma:SolidPeso molecolare:445.68SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Formula:C19H31ClN2O2SColore e forma:SolidPeso molecolare:386.98MF-592
CAS:<p>MF-592: EP4 receptor antagonist, hEP4 IC50 3 nM, hWB IC50 78 nM, great oral PK, rat arthritis ED50 0.1 mg/kg/day, promising for development.</p>Formula:C34H33Cl2N3O6SColore e forma:SolidPeso molecolare:682.61SGLT1/2-IN-1
CAS:<p>SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor.</p>Formula:C25H28O8Colore e forma:SolidPeso molecolare:456.48MRS2279 diammonium
CAS:<p>MRS2279 diammonium, a P2Y1 antagonist with K i 2.5 nM, IC 50 51.6 nM, blocks ADP-induced platelet aggregation, pK b 8.05.</p>Formula:C13H24ClN7O8P2Colore e forma:SolidPeso molecolare:503.77CCR1 antagonist 13
CAS:<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Formula:C25H27ClFN3O4Colore e forma:SolidPeso molecolare:487.95AL 6598
CAS:<p>AL 6598, a prodrug of PGD2 agonist AL 6556, reduces IOP by 53% at 1μg twice daily in monkeys; binds DP receptors with Ki of 3.2μM.</p>Formula:C23H39ClO5Colore e forma:SolidPeso molecolare:431.01LJ-4517
<p>LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.</p>Formula:C19H21N5O3SColore e forma:SolidPeso molecolare:399.47SSTR5 antagonist 6
CAS:<p>SSTR5 antagonist 6, an orally active antagonist specific to the somatostatin receptor subtype 5 (SSTR5), exhibits an IC50 value of 24 nM. This compound is utilized in researching type 2 diabetes [1].</p>Formula:C22H28ClN3O4Colore e forma:SolidPeso molecolare:433.93Leukotriene B4 dimethyl amide
CAS:<p>LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).</p>Formula:C22H37NO3Colore e forma:SolidPeso molecolare:363.53Aplaviroc
CAS:<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Formula:C33H43N3O6Purezza:97.98% - 98.26%Colore e forma:SolidPeso molecolare:577.71MRS4833
CAS:<p>MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.</p>Formula:C30H24F3NO3Colore e forma:SolidPeso molecolare:503.51Fosrolapitant
CAS:<p>Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.</p>Formula:C27H29F6N2O8PColore e forma:SolidPeso molecolare:654.49MrgprX2 antagonist-7
<p>MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.</p>Formula:C24H22ClF3N6O3Colore e forma:SolidPeso molecolare:534.92BMS-986104
CAS:<p>BMS-986104 is an effective selective modulator of the S1P1 receptor. It demonstrates efficacy in the mouse EAE model, comparable to that of FTY720. Furthermore, BMS-986104 shows promising remyelination properties in three-dimensional brain cell cultures subjected to lysophosphatidylcholine (LPC)-induced demyelination.</p>Formula:C22H35NOColore e forma:SolidPeso molecolare:329.52D1R antagonist 1
CAS:<p>Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].</p>Formula:C22H26BrNO4Purezza:98%Colore e forma:SolidPeso molecolare:448.35LB-102
CAS:<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formula:C18H29N3O4SColore e forma:SolidPeso molecolare:383.51L-657926
CAS:<p>L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.</p>Formula:C21H19ClFNO2Colore e forma:SolidPeso molecolare:371.832DA-302168S
CAS:<p>DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.</p>Formula:C33H24ClF2N3O5Colore e forma:SolidPeso molecolare:616.011LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Formula:C26H23Cl2N3O2Purezza:99.21%Colore e forma:SolidPeso molecolare:480.39Vofopitant dihydrochloride
CAS:<p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>Formula:C21H25Cl2F3N6OPurezza:98.99%Colore e forma:SolidPeso molecolare:505.36SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Formula:C26H32N2O4Purezza:99.22%Colore e forma:SolidPeso molecolare:436.54Vofopitant
CAS:<p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>Formula:C21H23F3N6OPurezza:97.86%Colore e forma:SolidPeso molecolare:432.44Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Formula:C36H45F4N3O5Purezza:97.35% - 98.23%Colore e forma:SolidPeso molecolare:675.75BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Formula:C27H23N5O5S2Purezza:98.43% - 99.26%Colore e forma:SolidPeso molecolare:561.63AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formula:C32H38F2N2O5S2Purezza:98.1%Colore e forma:SolidPeso molecolare:632.78PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Formula:C25H27FN6O2Purezza:99.9%Colore e forma:SolidPeso molecolare:462.52AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Formula:C30H41FN2O6Purezza:98.32% - 99.63%Colore e forma:SolidPeso molecolare:544.65BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Formula:C34H51N5O7Purezza:98.81%Colore e forma:SolidPeso molecolare:641.8SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Formula:C32H33ClN4O3Purezza:97.82% - 98.99%Colore e forma:SolidPeso molecolare:557.08Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Formula:C27H45NO7Purezza:99.86%Colore e forma:SolidPeso molecolare:495.65Rolapitant hydrochloride
CAS:<p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>Formula:C25H27ClF6N2O2Purezza:98.35% - 99.79%Colore e forma:SolidPeso molecolare:536.94Beraprost sodium
CAS:<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>Formula:C24H29NaO5Colore e forma:SolidPeso molecolare:420.481Metipranolol hydrochloride
CAS:<p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>Formula:C17H28ClNO4Purezza:98%Colore e forma:SolidPeso molecolare:345.867-Desmethyl-agomelatine
CAS:<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Formula:C14H15NO2Colore e forma:SolidPeso molecolare:229.27SB-399885 hydrochloride
CAS:<p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>Formula:C18H22Cl3N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:482.81ML-00253764 hydrochloride
CAS:<p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>Formula:C18H19BrClFN2OColore e forma:SolidPeso molecolare:413.71SHA 68
CAS:<p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>Formula:C26H24FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:445.49CYM 9484
CAS:<p>CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.</p>Formula:C27H31N3O3S2Colore e forma:SolidPeso molecolare:509.68Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Formula:C33H46N8O7Purezza:98%Colore e forma:SolidPeso molecolare:666.77Arotinolol
CAS:<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Formula:C15H21N3O2S3Colore e forma:White SolidPeso molecolare:371.54ML-290
CAS:<p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>Formula:C24H21F3N2O5SColore e forma:SolidPeso molecolare:506.49SR 146131
CAS:<p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>Formula:C32H36ClN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:610.16(Rac)-Rotigotine hydrochloride
CAS:<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Formula:C19H26ClNOSColore e forma:SolidPeso molecolare:351.93HOKU-81
CAS:<p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>Formula:C12H18ClNO2Colore e forma:SolidPeso molecolare:243.73BIBP3226 TFA
CAS:<p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>Formula:C29H32F3N5O5Colore e forma:SolidPeso molecolare:587.59Pumosetrag Hydrochloride
CAS:<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Formula:C15H18ClN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:339.84JMV 2959
CAS:<p>JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).</p>Formula:C30H32N6O2Colore e forma:SolidPeso molecolare:508.61Vornorexant
CAS:<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>Formula:C23H22FN7O2Colore e forma:SolidPeso molecolare:447.4743-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Formula:C7H9NOColore e forma:SolidPeso molecolare:123.1554-Hydroxypropranolol hydrochloride
CAS:<p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>Formula:C16H22ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:311.81-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Formula:C21H41O7PColore e forma:SolidPeso molecolare:436.52Sarizotan
CAS:<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Formula:C22H21FN2OColore e forma:SolidPeso molecolare:348.421dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Formula:C37H39NO4Colore e forma:SolidPeso molecolare:561.71Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Formula:C16H25N3O·xClHPurezza:99.25%Colore e forma:Soild(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Formula:C25H21ClF3N5O2SColore e forma:SolidPeso molecolare:547.98BRL 15572
CAS:<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Formula:C25H27ClN2OColore e forma:SolidPeso molecolare:406.95Goserelin acetate(65807-02-5 Free base)
<p>Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>Purezza:99.77%Colore e forma:Odour SolidDesmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Formula:C20H30Cl2N4OPurezza:98%Colore e forma:SolidPeso molecolare:413.38Picumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Formula:C21H29Cl2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:426.38Amelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Formula:C33H34N2O5Purezza:98%Colore e forma:SolidPeso molecolare:538.634-Hydroxyatomoxetine
CAS:<p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>Formula:C17H21NO2Purezza:98%Colore e forma:SolidPeso molecolare:271.35BX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Formula:C21H25Cl2FN4O3Purezza:98%Colore e forma:SolidPeso molecolare:471.35(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Formula:C6H13Cl2N3Colore e forma:SolidPeso molecolare:198.09CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Formula:C19H20N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:356.44Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Colore e forma:Odour LiquidTAK-683
CAS:<p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>Formula:C64H83N17O13Purezza:98%Colore e forma:SolidPeso molecolare:1298.45TAK-448
CAS:<p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>Formula:C58H80N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1225.36Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purezza:98%Colore e forma:LiquidRef: TM-T81538
Prodotto fuori produzioneCanagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Formula:C24H25FO5SPurezza:98%Colore e forma:SolidPeso molecolare:448.54Ref: TM-T10669
Prodotto fuori produzione2-Methyl-5-HT hydrochloride
CAS:<p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Formula:C11H15ClN2OPurezza:98%Colore e forma:SolidPeso molecolare:226.7Ref: TM-T10075L2
Prodotto fuori produzioneAM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formula:C24H20N2OPurezza:99.37%Colore e forma:SolidPeso molecolare:352.43Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purezza:99.99%Colore e forma:Fine Yellow PowderPeso molecolare:388.37MEN11467
CAS:<p>MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.</p>Formula:C38H40N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:600.75Flumexadol
CAS:<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Formula:C11H12F3NOPurezza:98%Colore e forma:SolidPeso molecolare:231.212-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Formula:C23H38O4Purezza:95%Colore e forma:LiquidPeso molecolare:378.55Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Formula:C38H40N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:600.75GR 218,231
CAS:<p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>Formula:C24H33NO3SPurezza:98%Colore e forma:SolidPeso molecolare:415.59Ref: TM-T27431
Prodotto fuori produzioneImetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Formula:C6H12Br2N4SPurezza:98%Colore e forma:SolidPeso molecolare:332.06AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purezza:99.58%Colore e forma:SolidPeso molecolare:436.63S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Formula:C25H26F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:445.47Dimethandrolone Undecanoate
CAS:<p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>Formula:C31H50O3Purezza:99.65% - >99.99%Colore e forma:SolidPeso molecolare:470.73Ref: TM-T27176
Prodotto fuori produzione2-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Formula:C8H8N2O3SColore e forma:LiquidPeso molecolare:212.23
