Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(939 prodotti)
- Recettore dell'adenosina(242 prodotti)
- Recettore adrenergico(2.943 prodotti)
- Recettore della bombesina(30 prodotti)
- Recettore della bradichinina(59 prodotti)
- CXCR(148 prodotti)
- CaSR(32 prodotti)
- Recettore dei cannabinoidi(196 prodotti)
- Recettore della dopamina(407 prodotti)
- Recettore dell'endotelina(76 prodotti)
- Recettore GNRH(69 prodotti)
- GPCR19(31 prodotti)
- GRK(31 prodotti)
- GTPase(21 prodotti)
- Recettore del glucagone(164 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Recettore dell'istamina(358 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(24 prodotti)
- Recettore OX(40 prodotti)
- Recettore degli oppioidi(297 prodotti)
- PAFR(11 prodotti)
- PKA(48 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(30 prodotti)
- Recettore Sigma(46 prodotti)
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Trovati 5337 prodotti di "Proteina G/GPCR"
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SEP-363856 mesylate
CAS:<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formula:C10H17NO4S2Colore e forma:SolidPeso molecolare:279.38TAK-024
CAS:TAK-024 is an inhibitor of platelet(IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively).Formula:C27H34N10O6Purezza:98%Colore e forma:SolidPeso molecolare:594.62Ro4368554
CAS:<p>Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.</p>Formula:C19H21N3O2SColore e forma:SolidPeso molecolare:355.454Sulamserod hydrochloride
CAS:<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formula:C19H29Cl2N3O5SColore e forma:SolidPeso molecolare:482.42Rivenprost
CAS:<p>Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.</p>Formula:C24H34O6SColore e forma:SolidPeso molecolare:450.59RTIOXA-43
CAS:<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Formula:C37H37N5O5SPurezza:99.17%Colore e forma:SolidPeso molecolare:663.79GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Formula:C15H15N5Colore e forma:SolidPeso molecolare:265.313PD 136450
CAS:<p>PD-136,450: partial stomach secretory agonist, full pancreas agonist in rats; potential acid-reducing drug, adjuvant for gastrin-sensitive tumors.</p>Formula:C35H40N4O6Purezza:98%Colore e forma:SolidPeso molecolare:612.72LY3154207
CAS:<p>LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.</p>Formula:C24H29Cl2NO3Colore e forma:SolidPeso molecolare:450.4BAY-899
CAS:<p>BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.</p>Formula:C25H19F2N5O2Purezza:98%Colore e forma:SolidPeso molecolare:459.4525B-NBOH hydrochloride
CAS:<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Formula:C17H21BrClNO3Colore e forma:SolidPeso molecolare:402.711(S)-Butaprost free acid
CAS:<p>(S)-Butaprost (free acid) is a potent and highly selective EP2 receptor agonist[1].</p>Formula:C23H38O5Colore e forma:SolidPeso molecolare:394.54SGL5213
CAS:<p>SGL5213 is a potent oral SGLT1 inhibitor (IC50: 29 nM) with potential for treating type 2 diabetes.</p>Formula:C37H55N3O8Purezza:98%Colore e forma:SolidPeso molecolare:669.85D3/5-HT receptor modulator-1
CAS:<p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>Formula:C24H29N3O2Colore e forma:SolidPeso molecolare:391.506Zaladenant
CAS:<p>Zaladenant is an adenosine receptor antagonist with antitumor properties.</p>Formula:C19H15F3N6OColore e forma:SolidPeso molecolare:400.357Taprostene
CAS:<p>Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.</p>Formula:C24H30O5Colore e forma:SolidPeso molecolare:398.49Neflumozide
CAS:<p>Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.</p>Formula:C22H23FN4O2Colore e forma:SolidPeso molecolare:394.44Sigma-2 Radioligand 2
CAS:<p>Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).</p>Formula:C23H28FN3O3Colore e forma:SolidPeso molecolare:413.49Elsovaptan
CAS:<p>Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.</p>Formula:C19H20ClN5O2Colore e forma:SolidPeso molecolare:385.847BI-113823
CAS:<p>BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. It alleviates mechanical hyperalgesia induced by complete Freund's adjuvant in rats. BI-113823 is applicable for research on chronic inflammatory pain.</p>Formula:C26H44N4O5SColore e forma:SolidPeso molecolare:524.716SAR-114137
CAS:<p>SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.</p>Formula:C25H34N4O7SPurezza:99.09% - 99.91%Colore e forma:SolidPeso molecolare:534.63LB-102
CAS:<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formula:C18H29N3O4SColore e forma:SolidPeso molecolare:383.51Bzo-poxizid
CAS:<p>Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.</p>Formula:C20H21N3O2Colore e forma:SolidPeso molecolare:335.40Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Formula:C27H29N5OColore e forma:SolidPeso molecolare:439.55Protease-Activated Receptor-1 antagonist 1
<p>Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.</p>Formula:C25H24F2N2O3Colore e forma:SolidPeso molecolare:438.47Atumelnant
CAS:<p>Atumelnant (CRN04894) is an MC2R antagonist used in the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).</p>Formula:C33H42F3N5O3Purezza:98.41%Colore e forma:SolidPeso molecolare:613.71LY210073
CAS:<p>LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).</p>Formula:C30H28O8Purezza:98%Colore e forma:SolidPeso molecolare:516.54ATX inhibitor 27
CAS:<p>ATX inhibitor 27 (Compound 31) is an ATX inhibitor. It demonstrates IC50 values of 13 nM against human autotaxin (hATX) and 23 nM against lysophosphatidylcholine (LPC). By inhibiting the ATX enzyme, ATX inhibitor 27 reduces LPA levels in the body. This compound is applicable in research related to ATX-LPA-associated conditions such as inflammation, neurodegenerative disorders, and cancer.</p>Formula:C26H26ClN5O3Colore e forma:SolidPeso molecolare:491.97Gemilukast
CAS:<p>Gemilukast (ONO-6950) is a cysteinyl leukotriene 1 and 2 receptor inhibitor that inhibits bronchoconstriction and is used in the treatment of asthma.</p>Formula:C36H37F2NO5Purezza:98.27% - 99.5%Colore e forma:SolidPeso molecolare:601.68TAK-637
CAS:<p>TAK-637 is a tachykinin 1 (NK1) receptor antagonist.</p>Formula:C30H25F6N3O2Purezza:98%Colore e forma:SolidPeso molecolare:573.53CB1/2 receptor-1
CAS:<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Formula:C33H48O2Colore e forma:SolidPeso molecolare:476.73PD 135158
CAS:<p>PD 135158 is a CCK2 receptor antagonist.</p>Formula:C42H61N5O11Purezza:98%Colore e forma:SolidPeso molecolare:811.96AM9405
<p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>Formula:C24H33BrN2O2Purezza:98%Colore e forma:SolidPeso molecolare:461.44KAG-308
CAS:<p>KAG-308: selective EP4 agonist; Ki: 2.57 nM, EC50: 17 nM; suppresses colitis, promotes mucosal healing, inhibits TNF-α.</p>Formula:C24H30F2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:460.52Tipelukast
CAS:<p>Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.</p>Formula:C29H38O7SPurezza:>99.99%Colore e forma:SolidPeso molecolare:530.67Delmadinone acetate
CAS:<p>Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.</p>Formula:C23H27ClO4Colore e forma:SolidPeso molecolare:402.911BI-685509
CAS:<p>BI-685509: potent, oral sGC activator, boosts cGMP, enhances NO pathways, for CKD/DKD research.</p>Formula:C34H38N4O5Colore e forma:SolidPeso molecolare:582.69SphK1-IN-1
<p>SphK1-IN-1: SphK1 ATPase inhibitor, IC50=2.48 μM, potential for cancer research.</p>Formula:C22H22N6O2Colore e forma:SolidPeso molecolare:402.45MRGPRX2 modulator-1
CAS:<p>MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].</p>Formula:C20H19F6N5OColore e forma:SolidPeso molecolare:459.39YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Formula:C35H36N4O6SColore e forma:SolidPeso molecolare:640.749S1PR1 agonist 2
CAS:<p>S1PR1 agonist 2 is potent for autoimmune research (from WO2021175225A1).</p>Formula:C25H25N5O4Colore e forma:SolidPeso molecolare:459.50BI 703704
CAS:<p>BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].</p>Formula:C32H37N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:559.72Butaprost
CAS:<p>Butaprost: EP2 receptor agonist, EC50=33 nM, Ki=2.4 μM (murine), reduces fibrosis via TGF-β/Smad2.</p>Formula:C24H40O5Purezza:98%Colore e forma:SolidPeso molecolare:408.57Vibegron
CAS:<p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>Formula:C26H28N4O3Colore e forma:SolidPeso molecolare:444.53Pareptide monohydrochloride
CAS:<p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>Formula:C14H27ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:334.84Setomagpran
CAS:<p>Setomagpran is an antagonist of the mas-related G protein-coupled receptor (MRGPR) and possesses anti-inflammatory properties.</p>Formula:C22H19Cl2F6N5OColore e forma:SolidPeso molecolare:554.316EP4 receptor agonist 3
CAS:<p>EP4 receptor agonist 3 is an activator of the EP4 receptor and is useful for research in the DSS-induced colitis mouse model.</p>Formula:C21H27F2NO4Colore e forma:SolidPeso molecolare:395.44YM158 free base
CAS:<p>YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87).</p>Formula:C32H33ClN6O5S2Purezza:98%Colore e forma:SolidPeso molecolare:681.22CVT-5440
CAS:<p>CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.</p>Formula:C27H28N6O5Colore e forma:SolidPeso molecolare:516.55K-8794
CAS:<p>K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.</p>Formula:C36H38N6O6SColore e forma:SolidPeso molecolare:682.789RS 12254
CAS:<p>RS 12254 is a dopamine agonist and antihypertensive agent.</p>Formula:C28H40N2O4Purezza:98%Colore e forma:SolidPeso molecolare:468.63RBM10-8
CAS:<p>RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.</p>Formula:C17H36NO5PColore e forma:SolidPeso molecolare:365.45Sigma-1 receptor antagonist 6
CAS:<p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>Formula:C32H34N6Colore e forma:SolidPeso molecolare:502.65Macitentan (n-butyl analogue)
CAS:<p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>Formula:C20H21Br2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:587.29Inupadenant HCl
CAS:<p>Inupadenant (EOS-850) is a selective A2a receptor antagonist, targeting immunosuppression in tumors.</p>Formula:C25H27ClF2N8O4S2Colore e forma:SolidPeso molecolare:641.115-HT7R antagonist 1
<p>5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.</p>Formula:C14H18Cl2N4Colore e forma:SolidPeso molecolare:313.23Opipramol dihydrochloride
CAS:<p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>Formula:C23H31Cl2N3OColore e forma:SolidPeso molecolare:436.418LX2761
CAS:<p>LX2761 is a stable inhibitor for SGLT1/2 with IC50s of 2.2/2.7 nM; it targets SGLT1 in the GI tract.</p>Formula:C32H47N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:601.80SSTR5 antagonist 2 TFA
CAS:<p>Potent, oral SSTR5 antagonist 2 TFA may treat type 2 diabetes.</p>Formula:C34H36F4N2O7Purezza:98%Colore e forma:SolidPeso molecolare:660.65SSR 146977
CAS:<p>NK3 receptor antagonist</p>Formula:C35H42Cl2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:621.64Thielavin B
CAS:<p>Thielavin B, from Thielavia terricola, inhibits prostaglandin E2 synthesis and reduces rat oedema.</p>Formula:C31H34O10Colore e forma:SolidPeso molecolare:566.6IMP-1575
CAS:<p>IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.</p>Formula:C19H25N3OSPeso molecolare:343.49R-96544 hydrochloride
CAS:<p>5-HT2 receptor antagonist</p>Formula:C22H29NO3Purezza:98%Colore e forma:SolidPeso molecolare:355.47H3R antagonist 1
CAS:<p>H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).</p>Formula:C19H23N3O3Colore e forma:SolidPeso molecolare:341.4Aplaviroc
CAS:<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Formula:C33H43N3O6Purezza:97.98% - 98.26%Colore e forma:SolidPeso molecolare:577.71IRL 2500
CAS:<p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>Formula:C36H35N3O4Purezza:99.36%Colore e forma:White Crystalline SolidPeso molecolare:573.68CP-481715
CAS:<p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>Formula:C26H31FN4O4Colore e forma:SolidPeso molecolare:482.555-HT6R/MAO-B modulator 1
<p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>Formula:C33H38N4O3SColore e forma:SolidPeso molecolare:570.74MDMB-FUBICA
CAS:<p>MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.</p>Formula:C23H25FN2O3Colore e forma:SolidPeso molecolare:396.455(R)-MrgprX2 antagonist-3
CAS:<p>(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.</p>Formula:C16H20FN3O2SPeso molecolare:337.41Pexacerfont
CAS:<p>Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).</p>Formula:C18H24N6OPurezza:99.77%Colore e forma:SolidPeso molecolare:340.42AMG-369
CAS:<p>AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.</p>Formula:C26H22FN3O2SPurezza:98.04% - 98.92%Colore e forma:SolidPeso molecolare:459.54NMDAR antagonist 5
CAS:<p>NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.</p>Formula:C17H21N3Colore e forma:SolidPeso molecolare:267.369PAR4 antagonist 3
CAS:<p>PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.</p>Formula:C22H16FN3O5SPeso molecolare:453.44S1P1 agonist 4
CAS:<p>S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating</p>Formula:C24H31NO3Colore e forma:SolidPeso molecolare:381.51PF-9404C
CAS:<p>PF-9404C: S-S diastereoisomer, beta-blocker with vasodilation, boosts cyclic GMP in rat aorta cells from 3 to 53 pmol/mg protein.</p>Formula:C16H25N3O9Purezza:98%Colore e forma:SolidPeso molecolare:403.38Remlifanserin
CAS:<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Formula:C24H29F2N3O2Colore e forma:SolidPeso molecolare:429.50Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Formula:C21H30N2O5SColore e forma:SolidPeso molecolare:422.538VGD071
CAS:<p>VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer.</p>Formula:C32H41N3O4S2Colore e forma:SolidPeso molecolare:595.82SR 140333
CAS:<p>SR 140333 is a NK1 receptor antagonist.</p>Formula:C37H45Cl3N2O2Purezza:98%Colore e forma:SolidPeso molecolare:656.12Ersentilide
CAS:<p>Ersentilide, a benzamide derivative, functions as both a β1-adrenergic receptor antagonist and an Ikr blocker. It has demonstrated efficacy in animal models of cardiac arrhythmias.</p>Formula:C21H26N4O5SColore e forma:SolidPeso molecolare:446.52Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formula:C24H28F3N3O2Colore e forma:SolidPeso molecolare:447.49Nolpitantium besilate
CAS:<p>Nolpitantium besilate is a neurokinin-1 receptor antagonist.</p>Formula:C43H50Cl2N2O5SColore e forma:SolidPeso molecolare:777.84MDA7
CAS:<p>MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.</p>Formula:C22H25NO2Colore e forma:SolidPeso molecolare:335.439Lp(a)-IN-8
CAS:<p>LPA2 antagonist 3 (compound 15) serves as an Lp(a) antagonist. Lp(a) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD).</p>Formula:C21H40Cl2N4O5Colore e forma:SolidPeso molecolare:499.472Cloprostenol
CAS:<p>Cloprostenol is a synthetic prostaglandin and PGF2α analogue used in animals to terminate pregnancy and induce corpus luteum dissolution.</p>Formula:C22H29ClO6Purezza:99.81%Colore e forma:Clear Colorless To Light Yellowish LiquidPeso molecolare:424.925-HT2A/5-HT2C inverse agonist 1
CAS:<p>5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.</p>Formula:C24H35N5O2Colore e forma:SolidPeso molecolare:425.57TAAR1 agonist 2
CAS:<p>TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.</p>Formula:C9H11NOColore e forma:SolidPeso molecolare:149.19(S)-Bucindolol
CAS:(S)-Bucindolol is an enantiomer of bucindolol, specifically a β1-adrenergic receptor antagonist. It is primarily utilized in research related to heart failure.Formula:C22H25N3O2Colore e forma:SolidPeso molecolare:363.45SB 224289
CAS:<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formula:C32H32N4O3Purezza:98%Colore e forma:SolidPeso molecolare:520.625-HT1A modulator 4
CAS:<p>5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.</p>Formula:C9H14N4Colore e forma:SolidPeso molecolare:178.234BNS808
CAS:<p>BNS808 is an orally active, selective CB1R antagonist with an IC50 of 0.8 nM, demonstrating significant selectivity for CB2R and minimal brain penetration. It is being studied for the treatment of obesity and related metabolic complications, such as metabolic dysfunction-associated steatotic liver disease (MASLD). BNS808 reduces drug exposure to the central nervous system, enhancing safety, and minimizes drug interactions through high plasma protein binding.</p>Formula:C25H20Cl3N3O3SColore e forma:SolidPeso molecolare:548.869U91356
CAS:<p>U91356 is an agonist of the dopamine receptors.</p>Formula:C13H17N3OPurezza:98%Colore e forma:SolidPeso molecolare:231.29Udifitimod
CAS:<p>Udifitimod (BMS-986166) is a potent, selective, and orally active modulator of the S1P1R receptor, showing potential for research in autoimmune diseases.</p>Formula:C25H33NO2Colore e forma:SolidPeso molecolare:379.54TM38837
CAS:<p>CB1 antagonist 4 is an inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. It can reduce body weight, improve plasma inflammatory markers, and enhance glucose homeostasis [1].</p>Formula:C27H20Cl2F3N7OColore e forma:SolidPeso molecolare:586.40Leukotriene F4
CAS:<p>LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.</p>Formula:C28H44N2O8SColore e forma:SolidPeso molecolare:568.72AFP-07
CAS:<p>AFP-07 is a highly selective and potent agonist. It was used for the prostacyclin receptor.</p>Formula:C22H29F2NaO5Purezza:98%Colore e forma:SolidPeso molecolare:434.45Befiradol hydrochloride
CAS:<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Formula:C20H23Cl2F2N3OPurezza:99.1%Colore e forma:SolidPeso molecolare:430.32CCR1 antagonist 13
CAS:<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Formula:C25H27ClFN3O4Colore e forma:SolidPeso molecolare:487.95SGLT inhibitor-1
CAS:<p>SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).</p>Formula:C24H27FO8Purezza:98%Colore e forma:SolidPeso molecolare:462.46DA-302168S
CAS:<p>DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.</p>Formula:C33H24ClF2N3O5Colore e forma:SolidPeso molecolare:616.011MRGPRX1 agonist 3
<p>Compound 1f, a potent MRGPRX1 agonist, has an EC50 of 0.22 μM, useful for neuropathic pain studies.</p>Formula:C14H11FN2OSColore e forma:SolidPeso molecolare:274.31MED 27
CAS:<p>MED 27 is an inhibitor of thromboxane synthase and thromboxane A2 receptors. It effectively inhibits rat platelet aggregation at doses significantly lower than those required for acetylsalicylic acid.</p>Formula:C24H25N5O5Colore e forma:SolidPeso molecolare:463.49AAZ-A 154 mesylate
CAS:<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Formula:C15H24N2O4SColore e forma:SolidPeso molecolare:328.43BMS-986120
CAS:BMS-986120: Oral, reversible PAR4 antagonist. IC50: 9.5 nM (human), 2.1 nM (monkey). Potent, selective antiplatelet.Formula:C23H23N5O5S2Colore e forma:SolidPeso molecolare:513.59INCB-9471 dihydrochloride
CAS:<p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.</p>Formula:C30H42Cl2F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:632.59AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formula:C14H20N2OColore e forma:SolidPeso molecolare:232.32VA012
CAS:<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formula:C21H19N3Colore e forma:SolidPeso molecolare:313.40YGZ-331
CAS:<p>YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.</p>Formula:C19H23N5O4Colore e forma:SolidPeso molecolare:385.42BAY 38-7271
CAS:<p>BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).</p>Formula:C20H21F3O5SPurezza:98%Colore e forma:SolidPeso molecolare:430.44AAZ-A 154 benzoate
CAS:<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formula:C21H26N2O3Colore e forma:SolidPeso molecolare:354.44Iralukast (CGP 45715A)
CAS:<p>Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.</p>Formula:C38H37F3O8SColore e forma:SolidPeso molecolare:710.76GPR27 agonist-1
CAS:<p>GPR27 agonist-1 (compound I) is a selective agonist for GPR27 with a pEC50 value of 6.34.</p>Formula:C19H14Cl2N2O3SColore e forma:SolidPeso molecolare:421.30CHF-6366
CAS:<p>CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.</p>Formula:C42H48N6O8Colore e forma:SolidPeso molecolare:764.87TAAR1 agonist 3
CAS:<p>TAAR1 agonist 3 is a potent agonist of Trace Amine-Associated Receptor 1 (TAAR1) with a pEC50 value of 7.6. Additionally, it acts as a full agonist at the α2AR with a pEC50 of 6. TAAR1 agonist 3 is utilized in the research of neuropsychiatric disorders.</p>Formula:C10H13NOColore e forma:SolidPeso molecolare:163.22PD 140376
CAS:<p>PD 140376: Selective CCK-B/gastrin receptor antagonist radioligand for guinea pig stomach & brain.</p>Formula:C33H40N4O5Purezza:98%Colore e forma:SolidPeso molecolare:572.69TAK-661
CAS:<p>TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.</p>Formula:C13H21N5O3SColore e forma:SolidPeso molecolare:327.40Serlopitant
CAS:<p>Serlopitant is a selective antagonist of Neurokinin-1 (NK-1) receptor.</p>Formula:C29H28F7NO2Colore e forma:SolidPeso molecolare:555.53NCATS-SM4420
CAS:<p>NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.</p>Formula:C31H27N3O5Colore e forma:SolidPeso molecolare:521.56Toladryl
CAS:<p>Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.</p>Formula:C18H23NOColore e forma:SolidPeso molecolare:269.38(2R,3S)-Azelaprag
CAS:<p>(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist</p>Formula:C25H29N7O4SPurezza:97.47% - >99.99%Colore e forma:SoildPeso molecolare:523.61Leukotriene B4 dimethyl amide
CAS:<p>LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).</p>Formula:C22H37NO3Colore e forma:SolidPeso molecolare:363.53Rodatristat
CAS:<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Formula:C27H27ClF3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:561.98Abarelix acetate
CAS:<p>Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.</p>Formula:C72H95ClN14O14·xC2H4O2Colore e forma:SolidPeso molecolare:1476.142,3-dinor-11β-Prostaglandin F2α
CAS:<p>2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where</p>Formula:C18H30O5Colore e forma:SolidPeso molecolare:326.43Mafoprazine
CAS:<p>Mafoprazine, a phenylpiperazine derivative, exhibits varying affinities for neuronal receptors, primarily exerting its antipsychotic effects through blocking D2 receptors and enhancing α-adrenergic activity. It also increases the activity of dopamine metabolites.</p>Formula:C22H28FN3O3Colore e forma:SolidPeso molecolare:401.47DM-4111
CAS:<p>DM-4111, one of the primary monohydroxy metabolites of Tolvaptan, is an effective vasopressin V2 receptor (vasopressin V2 receptor) inhibitor. By inhibiting water reabsorption in renal tubules, it facilitates the excretion of electrolyte-free water. DM-4111 holds potential for research in cardiovascular diseases.</p>Formula:C26H25ClN2O4Colore e forma:SolidPeso molecolare:464.94(E/Z)-Ozagrel sodium
CAS:<p>(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is a mixture of the EZ isomers of Ozagrel (sodium). It acts as a thromboxane A2 (TXA2) synthase inhibitor. As an antiplatelet agent, Ozagrel (sodium) selectively inhibits human platelet aggregation, with an IC50 of 53.12 μM.</p>Formula:C13H11N2NaO2Colore e forma:SolidPeso molecolare:250.228AM8936
<p>AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.</p>Formula:C25H33NO3Colore e forma:SolidPeso molecolare:395.53TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Formula:C36H46N4O4SColore e forma:SolidPeso molecolare:630.84MK-3207
CAS:<p>MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.</p>Formula:C31H29F2N5O3Colore e forma:SolidPeso molecolare:557.59CBR Agonist-1
<p>CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.</p>Formula:C27H27FN4OColore e forma:SolidPeso molecolare:442.53WIN 66306
CAS:<p>WIN 66306: Cyclic heptapeptide, blocks NK1/NK2 receptors, inhibits substance P-triggered contractions in guinea pig ileum.</p>Formula:C41H52N8O9Colore e forma:SolidPeso molecolare:800.9RF9 hydrochloride
<p>RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist that acts on hNPFF1R (Ki: 58 nM) and hNPFF2R (Ki: 7 nM).</p>Formula:C26H39ClN6O3Colore e forma:SolidPeso molecolare:519.088 Hydroxy PIPAT oxalate
CAS:<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Formula:C18H24INO5Colore e forma:SolidPeso molecolare:461.29LY 245769
CAS:<p>LY 245769 is an inhibitor of leukotriene E4 (LTE4).</p>Formula:C25H33F3N8OSPurezza:98%Colore e forma:SolidPeso molecolare:550.64Pentacosafluorotridecanoic Acid
CAS:<p>Pentacosafluorotridecanoic Acid (PFTrDA) is a perfluoroalkyl substance (PFAS) that exhibits various biological impacts across different species. In zebrafish embryos, exposure to PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, at concentrations of 0.1 and 0.3 mg/L. At a dosage of 10 mg/kg, PFTrDA reduces serum testosterone and luteinizing hormone levels, as well as palmitic acid, linoleic acid, and oleic acid levels in the testicular interstitial cells of late adolescent rats. In humans, maternal plasma levels of PFTrDA during pregnancy are positively correlated with the development of eczema in female infants (but not male infants), and PFTrDA levels are higher in the livers of cancerous humans compared to non-cancerous ones. Additionally, PFTrDA is found in marine mammals.</p>Formula:C13HF25O2Colore e forma:SolidPeso molecolare:664.11PF-4693627
CAS:<p>PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).</p>Formula:C26H29Cl2N3O3Purezza:98%Colore e forma:SolidPeso molecolare:502.43SJPYT-310
CAS:<p>SJPYT-310 is a selective PXR antagonist, exhibiting no noticeable cytotoxicity.</p>Formula:C27H36N4O3Colore e forma:SolidPeso molecolare:464.6Zafirlukast metabolite M1
CAS:<p>Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.</p>Formula:C25H25N3O4SColore e forma:SolidPeso molecolare:463.549Acyline
CAS:<p>Acyline, a GnRH antagonist, suppresses gonadotropins and testosterone in animals and maintains the effect for 2 weeks in men with one dose.</p>Formula:C80H102ClN15O14Colore e forma:SolidPeso molecolare:1533.21PF-06372222
CAS:<p>PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.</p>Formula:C26H28F3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:515.53MRS2179 tetrasodium hydrate
<p>MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.</p>Formula:C11H15N5Na4O10P2Colore e forma:SolidPeso molecolare:576.21(-)-5-HT2C agonist-3
CAS:<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Formula:C19H23ClFNO2Colore e forma:SolidPeso molecolare:351.84CB2R/5-HT1AR agonist 1
CAS:<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Formula:C24H33NO3Colore e forma:SolidPeso molecolare:383.52Cicaprost
CAS:<p>Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.</p>Formula:C22H30O5Colore e forma:SolidPeso molecolare:374.47AAZ-A 154 hydrochloride
CAS:<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Formula:C14H21ClN2OColore e forma:SolidPeso molecolare:268.78Nocloprost
CAS:<p>Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.</p>Formula:C22H37ClO4Colore e forma:SolidPeso molecolare:400.98CCR1 antagonist 11 hydrochloride
<p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>Colore e forma:SolidUTPγS trisodium salt
CAS:<p>P2Y2 and P2Y4 receptor agonist</p>Formula:C9H12N2Na3O14P3SPurezza:98%Colore e forma:SolidPeso molecolare:566.15Beloxepin
CAS:<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Formula:C19H21NO2Purezza:98%Colore e forma:SolidPeso molecolare:295.38CP-199330
CAS:<p>CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.</p>Formula:C28H24ClF3N2O6SColore e forma:SolidPeso molecolare:609.01L-365260 hemihydrate
<p>L-365260 hemihydrate: selective oral CCK-B/gastrin blocker, Ki=1.9/2.0 nM, competes with guinea pig receptors.</p>Formula:C24H24N4O3Colore e forma:SolidPeso molecolare:407.47Cendifensine
CAS:<p>Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).</p>Formula:C14H17Cl2NOColore e forma:SolidPeso molecolare:286.197K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Formula:C51H56Cl2N8O4Colore e forma:SolidPeso molecolare:915.95SSTR5 antagonist 2 hydrochloride
<p>SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.</p>Formula:C32H36ClFN2O5Colore e forma:SolidPeso molecolare:583.09Taranabant
CAS:<p>Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.</p>Formula:C27H25ClF3N3O2Purezza:99.06% - 99.06%Colore e forma:SolidPeso molecolare:515.96(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Formula:C19H24N2O2Colore e forma:SolidPeso molecolare:312.406AA 497 (Free Base)
CAS:<p>AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.</p>Formula:C14H21NO3Purezza:98%Colore e forma:SolidPeso molecolare:251.32MSX-3
CAS:<p>MSX-3 is an antagonist of the A2A adenosine receptor and a prodrug of MSX-2.</p>Formula:C21H23N4Na2O7PPurezza:98%Colore e forma:SolidPeso molecolare:520.389BRL-37344
CAS:<p>BRL-37344 is a selective β3-adrenergic receptor agonist. It significantly reduces the body weight of obese mice.</p>Formula:C19H22ClNO4Colore e forma:SolidPeso molecolare:363.84APJ receptor agonist 3
CAS:<p>APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.</p>Formula:C26H29ClN4O5Colore e forma:SolidPeso molecolare:512.98CP-608039
CAS:<p>CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.</p>Formula:C23H25ClN8O5Colore e forma:SolidPeso molecolare:528.95BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Formula:C26H32ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.07BIIE-0246 HCl
CAS:<p>BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.</p>Formula:C49H59Cl2N11O6Colore e forma:SolidPeso molecolare:968.97Netupitant metabolite Monohydroxy Netupitant
CAS:<p>Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.</p>Formula:C30H32F6N4O2Purezza:98%Colore e forma:SolidPeso molecolare:594.59Disulergine
CAS:<p>Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.</p>Formula:C17H24N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:348.465-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formula:C23H29ClN6O2Colore e forma:SolidPeso molecolare:456.97H3R antagonist 2
<p>Compound 23: H3R antagonist with 170 nM Ki; inhibits AChE, BChE, hMAO B; IC50s: 180, 880, 775 nM; anti-pain, memory boost; crosses BBB. [1]</p>Formula:C24H29NO3Colore e forma:SolidPeso molecolare:379.49BI-44370
CAS:<p>BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.</p>Formula:C35H47N5O6Colore e forma:SolidPeso molecolare:633.78S1P1 agonist 5
<p>Selective oral S1P1 agonist 5 inhibits lymphocyte drainage, potential for MS research.</p>Formula:C23H24ClN2NaO4Colore e forma:SolidPeso molecolare:450.89Mesulergine hydrochloride
CAS:<p>5-HT2A and 2C receptor antagonist</p>Formula:C18H27ClN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:398.95Lisuride
CAS:<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Formula:C20H26N4OColore e forma:SolidPeso molecolare:338.45BMS-741672
CAS:<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Formula:C25H33F3N6O2Colore e forma:SolidPeso molecolare:506.56CB2 receptor antagonist 1
CAS:<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Formula:C28H47NO3Colore e forma:SolidPeso molecolare:445.68Enprostil
CAS:<p>Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.</p>Formula:C23H28O6Purezza:98%Colore e forma:SolidPeso molecolare:400.46Burapitant
CAS:<p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>Formula:C31H35Cl2F6N3O3Purezza:>99.99% - >99.99%Colore e forma:SolidPeso molecolare:682.52SSR-241586
CAS:<p>SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.</p>Formula:C32H42Cl2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:601.61LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Formula:C32H39N3O·HCl·xH2OColore e forma:SolidKendomycin
CAS:<p>Kendomycin is a proteasome inhibitor and endothelin receptor antagonist. It induces apoptosis in lymphoma.</p>Formula:C29H42O6Colore e forma:SolidPeso molecolare:486.64(R)-BAY-899
<p>(R)-BAY-899: R-isomer, selective LH-R antagonist, effective on hLH (IC50: 185 nM) and rLH (IC50: 46 nM), orally active.</p>Formula:C25H19F2N5O2Colore e forma:SolidPeso molecolare:459.45CI-988
CAS:<p>CCK2 (CCK-B) receptor antagonist</p>Formula:C35H42N4O6Purezza:98%Colore e forma:SolidPeso molecolare:614.73RS 61756-007
CAS:<p>RS 61756-007 is a selective thromboxane receptor (TP) agonist.</p>Formula:C23H28O5Purezza:98%Colore e forma:SolidPeso molecolare:384.47Danavorexton
CAS:<p>Danavorexton is an orexin receptor agonist.</p>Formula:C21H32N2O5SColore e forma:SolidPeso molecolare:424.55SCH-900822
CAS:<p>SCH-900822 is a potent and selective glucagon receptor antagonist.</p>Formula:C34H43Cl2N7O2Colore e forma:SolidPeso molecolare:652.66GHSR-1a agonist-1
CAS:<p>GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a) with an EC50 of 0.49 nM. It effectively stimulates the release of endogenous growth hormone by activating GHSR-1a. Doses as low as 0.1 mg/kg (administered orally) can increase body weight and length in 4-week-old rats. GHSR-1a agonist-1 is applicable in research on pediatric growth and developmental delays.</p>Formula:C30H37N5O4Colore e forma:SolidPeso molecolare:531.646Terguride
CAS:<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Formula:C20H28N4OColore e forma:SolidPeso molecolare:340.46NK1 receptor antagonist 2
CAS:<p>NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.</p>Formula:C31H35F7N4O2Colore e forma:SolidPeso molecolare:628.62CCR7 Ligand 1
CAS:<p>CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.</p>Formula:C22H29N5O5SColore e forma:SolidPeso molecolare:475.56Rodatristat ethyl
CAS:<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formula:C29H31ClF3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:590.04Nipradolol
CAS:<p>Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.</p>Formula:C15H22N2O6Colore e forma:SolidPeso molecolare:326.355-HT7R antagonist 3
CAS:<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Formula:C30H33FN4O3Colore e forma:SolidPeso molecolare:516.61Becondogrel
CAS:<p>Becondogrel (2-Oxoclopidogrel) is a metabolite of Clopidogrel. It irreversibly inhibits the P2Y12 receptor, thereby preventing platelet aggregation and thrombosis.</p>Formula:C16H16ClNO3SColore e forma:SolidPeso molecolare:337.821YM-49598 iodide
CAS:<p>YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.</p>Formula:C36H45Cl2IN2O2Colore e forma:SolidPeso molecolare:735.57YM-31636 free base
CAS:<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formula:C14H11N3SColore e forma:SolidPeso molecolare:253.32PF-07054894
CAS:<p>PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.</p>Formula:C24H30N6O4Colore e forma:SolidPeso molecolare:466.53Henagliflozin
CAS:<p>Henagliflozin (SHR3824): an oral, selective SGLT2 inhibitor, weak on SGLT1.</p>Formula:C22H24ClFO7Colore e forma:SolidPeso molecolare:454.87UMB24
CAS:<p>UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.</p>Formula:C17H21N3Colore e forma:SolidPeso molecolare:267.37Mrgx2 antagonist-3
CAS:<p>Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.</p>Formula:C15H15F2N3OColore e forma:SolidPeso molecolare:291.301'-Naphthoyl-2-methylindole
CAS:<p>1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.</p>Formula:C20H15NOColore e forma:SolidPeso molecolare:285.34
