Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(939 prodotti)
- Recettore dell'adenosina(242 prodotti)
- Recettore adrenergico(2.943 prodotti)
- Recettore della bombesina(30 prodotti)
- Recettore della bradichinina(59 prodotti)
- CXCR(148 prodotti)
- CaSR(32 prodotti)
- Recettore dei cannabinoidi(196 prodotti)
- Recettore della dopamina(407 prodotti)
- Recettore dell'endotelina(76 prodotti)
- Recettore GNRH(69 prodotti)
- GPCR19(31 prodotti)
- GRK(31 prodotti)
- GTPase(21 prodotti)
- Recettore del glucagone(164 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Recettore dell'istamina(358 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(24 prodotti)
- Recettore OX(40 prodotti)
- Recettore degli oppioidi(297 prodotti)
- PAFR(11 prodotti)
- PKA(48 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(30 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 18 più sottocategorie
Trovati 5337 prodotti di "Proteina G/GPCR"
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Rivenprost
CAS:<p>Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.</p>Formula:C24H34O6SColore e forma:SolidPeso molecolare:450.59Merigolix
CAS:<p>Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .</p>Formula:C36H35F7N4O6Colore e forma:SolidPeso molecolare:752.68MK-0812
CAS:<p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>Formula:C24H34F3N3O3Purezza:98%Colore e forma:SolidPeso molecolare:469.54CB1/2 receptor-1
CAS:<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Formula:C33H48O2Colore e forma:SolidPeso molecolare:476.73(2R,3S)-Azelaprag
CAS:<p>(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist</p>Formula:C25H29N7O4SPurezza:97.47% - >99.99%Colore e forma:SoildPeso molecolare:523.61Taprostene
CAS:<p>Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.</p>Formula:C24H30O5Colore e forma:SolidPeso molecolare:398.49(R)-BAY-899
<p>(R)-BAY-899: R-isomer, selective LH-R antagonist, effective on hLH (IC50: 185 nM) and rLH (IC50: 46 nM), orally active.</p>Formula:C25H19F2N5O2Colore e forma:SolidPeso molecolare:459.45YM-31636 free base
CAS:<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formula:C14H11N3SColore e forma:SolidPeso molecolare:253.32Org-6906
CAS:<p>DCB-3503, a tylophorine analog, may treat cancer and suppress immunity by blocking protein synthesis and modulating HSC70's ATPase activity.</p>Formula:C13H16ClNPurezza:98%Colore e forma:SolidPeso molecolare:221.73(S)-Butaprost free acid
CAS:<p>(S)-Butaprost (free acid) is a potent and highly selective EP2 receptor agonist[1].</p>Formula:C23H38O5Colore e forma:SolidPeso molecolare:394.54AFP-07 free acid
CAS:<p>AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.</p>Formula:C22H30F2O5Purezza:98%Colore e forma:SolidPeso molecolare:412.47AAZ-A 154 benzoate
CAS:<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formula:C21H26N2O3Colore e forma:SolidPeso molecolare:354.44CCG258208
CAS:<p>GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>Formula:C24H25FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:452.48CI-624
CAS:<p>CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.</p>Formula:C8H8N2SColore e forma:SolidPeso molecolare:164.228PAR-2-IN-2
CAS:<p>PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.</p>Formula:C25H20F3N5O2Colore e forma:SolidPeso molecolare:479.454MDMB-FUBICA
CAS:<p>MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.</p>Formula:C23H25FN2O3Colore e forma:SolidPeso molecolare:396.455SphK2-IN-2
<p>SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).</p>Formula:C21H25ClN10OColore e forma:SolidPeso molecolare:468.941'-Naphthoyl-2-methylindole
CAS:<p>1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.</p>Formula:C20H15NOColore e forma:SolidPeso molecolare:285.34SSR-241586
CAS:<p>SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.</p>Formula:C32H42Cl2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:601.61FDU-PB-22
CAS:<p>FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.</p>Formula:C26H18FNO2Colore e forma:SolidPeso molecolare:395.43MrgprX2 antagonist-7
<p>MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.</p>Formula:C24H22ClF3N6O3Colore e forma:SolidPeso molecolare:534.92H3R antagonist 1
CAS:<p>H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).</p>Formula:C19H23N3O3Colore e forma:SolidPeso molecolare:341.4CB2 receptor antagonist 1
CAS:<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Formula:C28H47NO3Colore e forma:SolidPeso molecolare:445.68Netupitant metabolite Monohydroxy Netupitant
CAS:<p>Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.</p>Formula:C30H32F6N4O2Purezza:98%Colore e forma:SolidPeso molecolare:594.59ASN-1377642
CAS:<p>ASN-1377642 is an NK1 receptor antagonist with a Ki value of 251 nM. It demonstrates antitumor activity in breast cancer cells with high expression of NK1R-Tr.</p>Formula:C21H16ClN5OSColore e forma:SolidPeso molecolare:421.90Neladenoson
CAS:<p>Neladenoson is an effective and selective agonist of the Adenosine A1 Receptor (A1R). EGFR-IN-162 shows potential for research in heart failure.</p>Formula:C29H24ClN5O2S2Colore e forma:SolidPeso molecolare:574.12TM38837
CAS:<p>CB1 antagonist 4 is an inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. It can reduce body weight, improve plasma inflammatory markers, and enhance glucose homeostasis [1].</p>Formula:C27H20Cl2F3N7OColore e forma:SolidPeso molecolare:586.40WIN 62577
CAS:<p>WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.</p>Formula:C29H31N3OColore e forma:SolidPeso molecolare:437.576PF-00446687
CAS:<p>PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).</p>Formula:C28H36F2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:470.59MDA77
CAS:<p>MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.</p>Formula:C21H23N3O3Colore e forma:SolidPeso molecolare:365.43PD 140376
CAS:<p>PD 140376: Selective CCK-B/gastrin receptor antagonist radioligand for guinea pig stomach & brain.</p>Formula:C33H40N4O5Purezza:98%Colore e forma:SolidPeso molecolare:572.69CHF-6366
CAS:<p>CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.</p>Formula:C42H48N6O8Colore e forma:SolidPeso molecolare:764.87Delmadinone acetate
CAS:<p>Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.</p>Formula:C23H27ClO4Colore e forma:SolidPeso molecolare:402.911Mafoprazine
CAS:<p>Mafoprazine, a phenylpiperazine derivative, exhibits varying affinities for neuronal receptors, primarily exerting its antipsychotic effects through blocking D2 receptors and enhancing α-adrenergic activity. It also increases the activity of dopamine metabolites.</p>Formula:C22H28FN3O3Colore e forma:SolidPeso molecolare:401.47Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Formula:C27H29N5OColore e forma:SolidPeso molecolare:439.55TAAR1 agonist 3
CAS:<p>TAAR1 agonist 3 is a potent agonist of Trace Amine-Associated Receptor 1 (TAAR1) with a pEC50 value of 7.6. Additionally, it acts as a full agonist at the α2AR with a pEC50 of 6. TAAR1 agonist 3 is utilized in the research of neuropsychiatric disorders.</p>Formula:C10H13NOColore e forma:SolidPeso molecolare:163.22Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formula:C24H28F3N3O2Colore e forma:SolidPeso molecolare:447.49UR-AK49
CAS:<p>UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.</p>Formula:C16H27N5OColore e forma:SolidPeso molecolare:305.42Elsovaptan
CAS:<p>Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.</p>Formula:C19H20ClN5O2Colore e forma:SolidPeso molecolare:385.847YGZ-331
CAS:<p>YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.</p>Formula:C19H23N5O4Colore e forma:SolidPeso molecolare:385.42BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Formula:C26H32ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.07Bzo-poxizid
CAS:<p>Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.</p>Formula:C20H21N3O2Colore e forma:SolidPeso molecolare:335.40PGDM
CAS:<p>PGD2 is involved in allergy, asthma, sleep, temperature regulation, inhibits clotting, and relaxes blood vessels; PGDM, its metabolite, is a biomarker.</p>Formula:C16H24O7Colore e forma:SolidPeso molecolare:328.36Y1 receptor antagonist 1
CAS:<p>Y1 receptor antagonist 1 is an antagonist of neuropeptide Y1 receptor.</p>Formula:C28H33N5O3Purezza:98.17%Colore e forma:SolidPeso molecolare:487.59LB-102
CAS:<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formula:C18H29N3O4SColore e forma:SolidPeso molecolare:383.51Nedemelteon
CAS:<p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>Formula:C15H18N2O2Colore e forma:SolidPeso molecolare:258.32VA012
CAS:<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formula:C21H19N3Colore e forma:SolidPeso molecolare:313.405-HT2A/5-HT2C inverse agonist 1
CAS:<p>5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.</p>Formula:C24H35N5O2Colore e forma:SolidPeso molecolare:425.575-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Formula:C21H26N6SColore e forma:SolidPeso molecolare:394.54Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Formula:C23H16D2F4N4O2Purezza:98.89%Colore e forma:SolidPeso molecolare:460.42FR-145715
CAS:<p>FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.</p>Formula:C16H21N5O2SColore e forma:SolidPeso molecolare:347.44PD 135158
CAS:<p>PD 135158 is a CCK2 receptor antagonist.</p>Formula:C42H61N5O11Purezza:98%Colore e forma:SolidPeso molecolare:811.96R-96544 hydrochloride
CAS:<p>5-HT2 receptor antagonist</p>Formula:C22H29NO3Purezza:98%Colore e forma:SolidPeso molecolare:355.47A3AR antagonist 5
CAS:<p>A3AR antagonist 5 (Compound 16) acts as a selective antagonist for the human adenosine A3 receptor (human adenosine A3 receptor), with an affinity expressed as a pC value of 4.542 μM.</p>Formula:C18H16N2O2SColore e forma:SolidPeso molecolare:324.40SphK2-IN-1
CAS:<p>SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.</p>Formula:C23H22ClF3N8OColore e forma:SolidPeso molecolare:518.92CM699
CAS:<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Formula:C24H29N3O2Colore e forma:SolidPeso molecolare:391.51ATL444
CAS:<p>ATL444 is an adenosine receptor antagonist with affinity (Ki values) for rA1AR, rA2AAR, rA2BAR, and rA3AR of 7.0, 2.5, 61.8, and >1000 nM, respectively.</p>Formula:C17H19N5OColore e forma:SolidPeso molecolare:309.37PD 136450
CAS:<p>PD-136,450: partial stomach secretory agonist, full pancreas agonist in rats; potential acid-reducing drug, adjuvant for gastrin-sensitive tumors.</p>Formula:C35H40N4O6Purezza:98%Colore e forma:SolidPeso molecolare:612.72R-137696
CAS:<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Formula:C17H23N3O2Colore e forma:SolidPeso molecolare:301.38APJ receptor agonist 8
CAS:<p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>Formula:C24H27N7O5SPurezza:98.31% - 99.60%Colore e forma:SolidPeso molecolare:525.58SSTR4 agonist 4
CAS:<p>SSTR4 agonist 4, potent in pain research, shows promise in rodent pain models, with potential for Alzheimer's due to hippocampus activity.</p>Formula:C19H26N4OColore e forma:SolidPeso molecolare:326.44(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Formula:C19H24N2O2Colore e forma:SolidPeso molecolare:312.406LY 245769
CAS:<p>LY 245769 is an inhibitor of leukotriene E4 (LTE4).</p>Formula:C25H33F3N8OSPurezza:98%Colore e forma:SolidPeso molecolare:550.64Flucopride
CAS:<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Formula:C22H33FN2O2Colore e forma:SolidPeso molecolare:376.51(1R,2S,3R)-Aprepitant
CAS:<p>(1R,2S,3R)-Aprepitant (Compound ent-4) is a competitive antagonist of the human neurokinin-1 (NK-1) receptor. It holds potential for research in the treatment of nausea and vomiting related to cancer or postoperative conditions.</p>Formula:C23H21F7N4O3Colore e forma:SolidPeso molecolare:534.427Sulprostone
CAS:<p>EP3 and EP1 receptor agonist</p>Formula:C23H31NO7SPurezza:98%Colore e forma:White To Off-White SolidPeso molecolare:465.56GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Formula:C15H15N5Colore e forma:SolidPeso molecolare:265.313CS-0777
CAS:<p>CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).</p>Formula:C21H31N2O5PColore e forma:SolidPeso molecolare:422.45ATX inhibitor 27
CAS:<p>ATX inhibitor 27 (Compound 31) is an ATX inhibitor. It demonstrates IC50 values of 13 nM against human autotaxin (hATX) and 23 nM against lysophosphatidylcholine (LPC). By inhibiting the ATX enzyme, ATX inhibitor 27 reduces LPA levels in the body. This compound is applicable in research related to ATX-LPA-associated conditions such as inflammation, neurodegenerative disorders, and cancer.</p>Formula:C26H26ClN5O3Colore e forma:SolidPeso molecolare:491.97AGH-107
CAS:<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Formula:C13H12IN3Colore e forma:SolidPeso molecolare:337.16Macitentan (n-butyl analogue)
CAS:<p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>Formula:C20H21Br2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:587.29SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Formula:C32H33ClN4O3Purezza:97.82% - 98.99%Colore e forma:SolidPeso molecolare:557.08BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Formula:C27H23N5O5S2Purezza:98.43% - 99.26%Colore e forma:SolidPeso molecolare:561.63Vofopitant dihydrochloride
CAS:<p>Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.</p>Formula:C21H25Cl2F3N6OPurezza:98.99%Colore e forma:SolidPeso molecolare:505.36Vofopitant
CAS:<p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>Formula:C21H23F3N6OPurezza:97.86%Colore e forma:SolidPeso molecolare:432.44Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Formula:C27H45NO7Purezza:99.86%Colore e forma:SolidPeso molecolare:495.65AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formula:C32H38F2N2O5S2Purezza:98.1%Colore e forma:SolidPeso molecolare:632.78SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Formula:C26H32N2O4Purezza:99.22%Colore e forma:SolidPeso molecolare:436.54Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Formula:C36H45F4N3O5Purezza:97.35% - 98.23%Colore e forma:SolidPeso molecolare:675.75BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Formula:C34H51N5O7Purezza:98.81%Colore e forma:SolidPeso molecolare:641.8PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Formula:C25H27FN6O2Purezza:99.9%Colore e forma:SolidPeso molecolare:462.52LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Formula:C26H23Cl2N3O2Purezza:99.21%Colore e forma:SolidPeso molecolare:480.39AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Formula:C30H41FN2O6Purezza:98.32% - 99.63%Colore e forma:SolidPeso molecolare:544.65Rolapitant hydrochloride
CAS:<p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>Formula:C25H27ClF6N2O2Purezza:98.35% - 99.79%Colore e forma:SolidPeso molecolare:536.94SB-399885 hydrochloride
CAS:<p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>Formula:C18H22Cl3N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:482.81HOKU-81
CAS:<p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>Formula:C12H18ClNO2Colore e forma:SolidPeso molecolare:243.73CYM 9484
CAS:<p>CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.</p>Formula:C27H31N3O3S2Colore e forma:SolidPeso molecolare:509.68SR 146131
CAS:<p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>Formula:C32H36ClN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:610.16Pumosetrag Hydrochloride
CAS:<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Formula:C15H18ClN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:339.84ML-290
CAS:<p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>Formula:C24H21F3N2O5SColore e forma:SolidPeso molecolare:506.49ML-00253764 hydrochloride
CAS:<p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>Formula:C18H19BrClFN2OColore e forma:SolidPeso molecolare:413.71Beraprost sodium
CAS:<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>Formula:C24H29NaO5Colore e forma:SolidPeso molecolare:420.481SHA 68
CAS:<p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>Formula:C26H24FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:445.49Arotinolol
CAS:<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Formula:C15H21N3O2S3Colore e forma:White SolidPeso molecolare:371.547-Desmethyl-agomelatine
CAS:<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Formula:C14H15NO2Colore e forma:SolidPeso molecolare:229.27Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Formula:C33H46N8O7Purezza:98%Colore e forma:SolidPeso molecolare:666.77JMV 2959
CAS:<p>JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).</p>Formula:C30H32N6O2Colore e forma:SolidPeso molecolare:508.61BIBP3226 TFA
CAS:<p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>Formula:C29H32F3N5O5Colore e forma:SolidPeso molecolare:587.59(Rac)-Rotigotine hydrochloride
CAS:<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Formula:C19H26ClNOSColore e forma:SolidPeso molecolare:351.93Metipranolol hydrochloride
CAS:<p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>Formula:C17H28ClNO4Purezza:98%Colore e forma:SolidPeso molecolare:345.86Atenolol
CAS:<p>Atenolol (Tenormin) is a selective β1 receptor antagonist.</p>Formula:C14H22N2O3Purezza:99.07% - 99.95%Colore e forma:White Crystalline Powder SolidPeso molecolare:266.341-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Formula:C21H41O7PColore e forma:SolidPeso molecolare:436.52Vornorexant
CAS:<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>Formula:C23H22FN7O2Colore e forma:SolidPeso molecolare:447.474dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Formula:C37H39NO4Colore e forma:SolidPeso molecolare:561.714-Hydroxypropranolol hydrochloride
CAS:<p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>Formula:C16H22ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:311.8Desmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Formula:C20H30Cl2N4OPurezza:98%Colore e forma:SolidPeso molecolare:413.38(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Formula:C6H13Cl2N3Colore e forma:SolidPeso molecolare:198.09Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Formula:C16H25N3O·xClHPurezza:99.25%Colore e forma:SoildAmelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Formula:C33H34N2O5Purezza:98%Colore e forma:SolidPeso molecolare:538.63(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Formula:C25H21ClF3N5O2SColore e forma:SolidPeso molecolare:547.98Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purezza:98%Colore e forma:LiquidRef: TM-T81538
Prodotto fuori produzioneBX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Formula:C21H25Cl2FN4O3Purezza:98%Colore e forma:SolidPeso molecolare:471.353-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Formula:C7H9NOColore e forma:SolidPeso molecolare:123.155TAK-448
CAS:<p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>Formula:C58H80N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1225.36Sarizotan
CAS:<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Formula:C22H21FN2OColore e forma:SolidPeso molecolare:348.421Picumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Formula:C21H29Cl2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:426.38CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Formula:C19H20N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:356.444-Hydroxyatomoxetine
CAS:<p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>Formula:C17H21NO2Purezza:98%Colore e forma:SolidPeso molecolare:271.35BRL 15572
CAS:<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Formula:C25H27ClN2OColore e forma:SolidPeso molecolare:406.95TAK-683
CAS:<p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>Formula:C64H83N17O13Purezza:98%Colore e forma:SolidPeso molecolare:1298.45GRK2 Inhibitor
CAS:<p>GRK2 Inhibitor is an inhibitor of β-Adrenergic Receptor Kinase 1 (β ARK1).</p>Formula:C12H9NO6Colore e forma:SolidPeso molecolare:263.2Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Formula:C24H25FO5SPurezza:98%Colore e forma:SolidPeso molecolare:448.54Ref: TM-T10669
Prodotto fuori produzione2-Methyl-5-HT hydrochloride
CAS:<p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Formula:C11H15ClN2OPurezza:98%Colore e forma:SolidPeso molecolare:226.7Ref: TM-T10075L2
Prodotto fuori produzioneWIN 55,212-2 Mesylate
CAS:<p>WIN 55,212-2 Mesylate ((R)-(+)-WIN 55212) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. Cannabinoid analogue WIN 55,212-2 Mesylate exhibited a novel anticancer effect against human tumors.</p>Formula:C28H30N2O6SPurezza:98% - 99.71%Colore e forma:White To Off-White SolidPeso molecolare:522.61Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purezza:99.99%Colore e forma:Fine Yellow PowderPeso molecolare:388.37TFLLR-NH2 2TFA(197794-83-5(free base))
<p>TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).</p>Formula:C35H55F6N9O10Purezza:99.56%Colore e forma:SolidPeso molecolare:875.87AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formula:C24H20N2OPurezza:99.37%Colore e forma:SolidPeso molecolare:352.43Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Formula:C38H40N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:600.75Flumexadol
CAS:<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Formula:C11H12F3NOPurezza:98%Colore e forma:SolidPeso molecolare:231.21MEN11467
CAS:<p>MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.</p>Formula:C38H40N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:600.75Imetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Formula:C6H12Br2N4SPurezza:98%Colore e forma:SolidPeso molecolare:332.06GR 218,231
CAS:<p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>Formula:C24H33NO3SPurezza:98%Colore e forma:SolidPeso molecolare:415.59Ref: TM-T27431
Prodotto fuori produzione2-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Formula:C23H38O4Purezza:95%Colore e forma:LiquidPeso molecolare:378.55Ref: TM-T14011
Prodotto fuori produzioneAEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purezza:99.58%Colore e forma:SolidPeso molecolare:436.63S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Formula:C25H26F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:445.47Dimethandrolone Undecanoate
CAS:<p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>Formula:C31H50O3Purezza:99.65% - >99.99%Colore e forma:SolidPeso molecolare:470.73Ref: TM-T27176
Prodotto fuori produzione2-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Formula:C8H8N2O3SColore e forma:LiquidPeso molecolare:212.23
