Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(1.003 prodotti)
- Recettore dell'adenosina(247 prodotti)
- Recettore adrenergico(3.010 prodotti)
- Recettore della bombesina(33 prodotti)
- Recettore della bradichinina(60 prodotti)
- CXCR(153 prodotti)
- CaSR(33 prodotti)
- Recettore dei cannabinoidi(215 prodotti)
- Colecistochinina(1 prodotti)
- Recettore della dopamina(435 prodotti)
- Recettore dell'endotelina(83 prodotti)
- Recettore GNRH(82 prodotti)
- GPCR19(33 prodotti)
- GRK(32 prodotti)
- GTPase(22 prodotti)
- Recettore del glucagone(190 prodotti)
- Proteina Hedgehog/Smoothened(48 prodotti)
- Recettore dell'istamina(381 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(26 prodotti)
- Recettore OX(41 prodotti)
- Recettore degli oppioidi(321 prodotti)
- PAFR(13 prodotti)
- PKA(51 prodotti)
- Recettore S1P(18 prodotti)
- SGLT(31 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 19 più sottocategorie
Trovati 5838 prodotti di "Proteina G/GPCR"
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BAY-784
CAS:<p>BAY-784 is a gonadotropin-releasing hormone receptor (GnRH-R) antagonist (IC50s: 21 and 24 nM for human and rat GnRH-R).</p>Formula:C29H26ClF4N3O5S2Purezza:98%Colore e forma:SolidPeso molecolare:672.11NKP608
CAS:NKP608 is a NK-1 receptor antagonist with anticancer and anxiolytic activities.Formula:C31H24ClF6N3O2Purezza:99.88% - 99.88%Colore e forma:SolidPeso molecolare:619.99Dansyl-NECA
CAS:Dansyl-NECA is a selective agonist of fluorescent adenosine A1 receptor.Formula:C30H40N8O6SColore e forma:SolidPeso molecolare:640.75L-796568 free base
CAS:L-796568 is a potent β3 agonist for obesity with 600x selectivity over β1/β2 receptors (EC50: 3.6 nM).Formula:C31H27F3N4O3S2Colore e forma:SolidPeso molecolare:624.7SDZ-216525
CAS:SDZ-216525, a 5-HT1A receptor antagonist, inhibits the tracheal contractions induced both by NKA (10 nM-3 microM) and 5-HT (10 nM-10 microM) (n=4-10).Formula:C25H28N4O5SColore e forma:SolidPeso molecolare:496.58Indacaterol acetate
CAS:Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist.Formula:C26H32N2O5Colore e forma:SolidPeso molecolare:452.54RXFP1 receptor agonist-2
CAS:RXFP1 Receptor Agonist-2 (Example 124), an EC50 value of 1 nM [1].Formula:C33H32F7N3O5Colore e forma:SolidPeso molecolare:683.61Domesticine, (-)-
CAS:Domesticine, (-)- is an antagonist of alpha-1D-adrenoceptor.Formula:C19H19NO4Purezza:98%Colore e forma:SolidPeso molecolare:325.3615(S)-Fluprostenol isopropyl ester
CAS:15(S)-Fluprostenol isopropyl ester, an isomer of the prostaglandin F2α analog, fluprostenol isopropyl ester, serves as a possible prodrug to 15(S)-fluprostenol. It has the potential to act as an agonist at FP receptors, albeit with lower potency compared to the 15(R) epimer and the FP receptor agonist, fluprostenol. Additionally, it may be present as a potential impurity in commercial formulations of fluprostenol isopropyl ester.Formula:C26H35F3O6Colore e forma:SolidPeso molecolare:500.555CCR2 antagonist 4
CAS:<p>CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM</p>Formula:C21H21ClF3N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:439.86RR-RJW100
RR-RJW100: potent LRH-1 & SF-1 agonist; studies metabolic disorders, diabetes, liver disease, IBD.Formula:C28H34OColore e forma:SolidPeso molecolare:386.57Cipralisant maleate
CAS:Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.Formula:C18H24N2O4Colore e forma:SolidPeso molecolare:332.39FR-181877
CAS:FR-181877: nonprostanoid PGI2 agonist, ADP-induced platelet aggregation inhibitor (IC50=0.081μM), orally bioavailable (56%), long half-life (4.3h) in rats.Formula:C30H28N2O4Purezza:98%Colore e forma:SolidPeso molecolare:480.55Brilaroxazine
CAS:Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.Formula:C22H25Cl2N3O3Purezza:99.36%Colore e forma:SolidPeso molecolare:450.36APJ receptor agonist 5
CAS:Potent oral APJ agonist (EC 50:0.4 nM); improves cardiac function in HF, with good pharmacokinetics and safety.Formula:C26H29N3O6Colore e forma:SolidPeso molecolare:479.5211-keto Fluprostenol
CAS:11-Keto Fluprostenol, a potent analog of prostaglandin F2α (PGF2α), primarily interacts with the FP receptor. It is a structurally modified derivative of prostaglandin D2 (PGD2) designed to enhance its potency and extend its half-life. The compound is produced by oxidizing fluprostenol at the C-11 position, which results in 11-keto fluprostenol. This modification allows 11-keto Fluprostenol to exhibit moderate affinity for the CRTH2/DP2 receptor, though it shows negligible activity at the DP1 receptor, distinguishing its action from that of PGD2.Formula:C23H27F3O6Colore e forma:SolidPeso molecolare:456.458Neladenoson dalanate
CAS:Neladenoson dalanate (BAY-1067197), an oral Adenosine A1 receptor partial agonist, is safe with good pharmacokinetics for chronic heart disease.Formula:C35H34ClN7O4S2Colore e forma:SolidPeso molecolare:716.27GSK494581A
CAS:GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Formula:C27H28F2N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:514.58Nolomirole HCl
CAS:<p>Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study</p>Formula:C19H28ClNO4Purezza:99.03% - >99.99%Colore e forma:SolidPeso molecolare:369.88MRS3558
CAS:MRS3558 is an agonist of A3 adenosine receptors.Formula:C20H20Cl2N6O3Colore e forma:SolidPeso molecolare:463.32VKGILS-NH2 TFA
CAS:<p>VKGILS-NH2 TFA, a non-impacting control peptide for PAR2 agonist SLIGKV-NH2, doesn't affect DNA synthesis.</p>Formula:C30H55F3N8O9Colore e forma:SolidPeso molecolare:728.8AR-08
CAS:<p>AR-08 is a potent α2-adrenergic receptor agonist for the study of ADHD and attention deficit.</p>Formula:C12H12N6Purezza:99.7%Colore e forma:SolidPeso molecolare:240.26mPGES1-IN-3
CAS:mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .Formula:C24H16ClF5N4O3Purezza:98%Colore e forma:SolidPeso molecolare:538.85PAC1R antagonist 1
CAS:<p>PAC1R antagonist 1 is a PAC1 receptor antagonist that inhibits the activation of peptides by pituitary adenylate cyclase and can be used to study tumours.</p>Formula:C17H17ClN6O2Purezza:98.43%Colore e forma:SolidPeso molecolare:372.81PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Formula:C25H36F3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:511.58KUC-7322
CAS:Ritobegron is used as a selective β3-adrenoceptor agonist and the prodrug of the active compound, KUC-7322.Formula:C21H27NO5Colore e forma:SolidPeso molecolare:373.44RS 17053 hydrochloride
CAS:RS 17053 hydrochloride: selective α1A adrenoceptor antagonist, pKi 9.1, pA2 9.8.Formula:C24H30Cl2N2O2Purezza:99.27%Colore e forma:SolidPeso molecolare:449.41UNC9994
CAS:UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.Formula:C21H22Cl2N2OSColore e forma:SolidPeso molecolare:421.38Ebrotidine
CAS:Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.Formula:C14H17BrN6O2S3Purezza:97.519%Colore e forma:SolidPeso molecolare:477.42Crisdesalazine
CAS:Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1).Formula:C16H14F3NO3Purezza:98.96%Colore e forma:SolidPeso molecolare:325.28BIM-23056 TFA
CAS:BIM 23056 TFA, a potent linear octapeptide antagonist of sst3 and sst5 somatostatin receptors, exhibits inhibition constants (K_i) of 10.8 for sst3 and 5.7 forFormula:C73H82F3N11O11Colore e forma:SolidPeso molecolare:1346.49BAY 60-2770
CAS:BAY 60-2770: oral sGC activator, NO-independent, antifibrotic, boosts sGC activity.Formula:C35H33F4NO5Colore e forma:SolidPeso molecolare:623.63PD 160170
CAS:neuropeptide Y1 receptor antagonistFormula:C18H17N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:371.41L 691678
CAS:L 691678 is a potent leukotriene biosynthesis inhibitor.Formula:C36H30IN5O5SPurezza:98%Colore e forma:SolidPeso molecolare:771.63Pronetalol
CAS:<p>Pronethalol ((±)-Pronethalol), a non-selective β-adrenergic antagonist, effectively inhibits Sox2 expression and offers protection against Digitalis-induced ventricular arrhythmias. Additionally, it can reverse such arrhythmias and limit the development of cerebral arteriovenous malformations (AVMs) [1] [2].</p>Formula:C15H19NOColore e forma:SolidPeso molecolare:229.32TASP0412098
CAS:TASP0412098 is a potent, selective CRTH2 antagonist with oral activity.Formula:C27H23ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:458.94Lidamidine
CAS:Lidamidine (Lidamidinum) is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscleFormula:C11H16N4OPurezza:99.98%Colore e forma:SolidPeso molecolare:220.27Z1078601926
CAS:Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1].Formula:C14H19FN2OColore e forma:SolidPeso molecolare:250.31Tradipitant
CAS:Tradipitant (VLY-686) is an antagonist of neurokinin-1.Formula:C28H16ClF6N5OPurezza:99.42%Colore e forma:SolidPeso molecolare:587.9(2R,3S)-E1R
CAS:(2R,3S)-E1R, an enantiomer of E1R, is a sigma-1 receptor modulator for treating cognitive disorders.Formula:C13H16N2O2Purezza:98%Colore e forma:SolidPeso molecolare:232.289-keto Fluprostenol
CAS:9-Keto Fluprostenol, a potent analog of prostaglandin E2 (PGE2), features structural modifications aimed at enhancing its half-life and potency. It derives from Fluprostenol, a thoroughly researched, potent analog of PGF2α, primarily interacting with the FP receptor. The creation of 9-Keto Fluprostenol through the oxidation at C-9 of Fluprostenol suggests a high affinity for EP receptors, potentially functioning as a PGE2 agonist.Formula:C23H27F3O6Colore e forma:SolidPeso molecolare:456.458L 659837
CAS:<p>L 659837 is an antagonist of ANC-2, lactam, and tackykinin.</p>Formula:C40H52N8O7SColore e forma:SolidPeso molecolare:788.96TRAP-6-IN-1
CAS:<p>TRAP-6-IN-1 inhibits collagen/TRAP-6, IC50: 17.12/11.88 μM, blocks platelet aggregation.</p>Formula:C18H20O3Colore e forma:SolidPeso molecolare:284.35ZINC49534341
CAS:ZINC49534341 is a potent MRGPRX2 antagonist, exhibiting a K_i (inhibition constant) of 32 nM [1].Formula:C12H9N3OS2Colore e forma:SolidPeso molecolare:275.35FTY720 (S)-Phosphate
CAS:FTY720 (S)-Phosphate is an active FTY720 derivative modulating S1P receptors, preventing lymphocyte egress, enhancing barrier integrity, aiding immune research.Formula:C19H34NO5PPurezza:99.37%Colore e forma:SolidPeso molecolare:387.45Droxicam
CAS:<p>Droxicam (Droxicamum) is a non-steroidal anti-inflammatory compound and can be used for research on the relief of inflammation and pain in musculoskeletal</p>Formula:C16H11N3O5SPurezza:99.04%Colore e forma:SolidPeso molecolare:357.34Orexin receptor modulator-1
CAS:Orexin Receptor Modulator-1 is a compound utilized in the study of various conditions including substance addiction, panic disorder, anxiety, post-traumaticFormula:C23H22ClF5N6OColore e forma:SolidPeso molecolare:528.915-HT3 antagonist 1
CAS:5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.Formula:C22H27N5OPurezza:98%Colore e forma:SolidPeso molecolare:377.48Fiboflapon sodium
CAS:Fiboflapon sodium, an oral 5-LOX-activating protein inhibitor, binds FLAP at 2.9 nM, inhibits LTB4 at 76 nM.Formula:C38H43N3NaO4SColore e forma:SolidPeso molecolare:660.83Prostaglandin F2α 1,9-lactone
CAS:Prostaglandin F2α (PGF2α) 1,9-lactone, a lipid-soluble internal ester of PGF2α, demonstrates resistance to hydrolysis by human plasma esterases, maintaining its structure even after 20 hours of incubation under physiological conditions. Unlike PGF2α, this compound exhibits minimal antifertility and vasoactivity.Formula:C20H32O4Colore e forma:SolidPeso molecolare:336.5
