Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(993 prodotti)
- Recettore dell'adenosina(246 prodotti)
- Recettore adrenergico(3.004 prodotti)
- Recettore della bombesina(33 prodotti)
- Recettore della bradichinina(59 prodotti)
- CXCR(153 prodotti)
- CaSR(33 prodotti)
- Recettore dei cannabinoidi(212 prodotti)
- Recettore della dopamina(433 prodotti)
- Recettore dell'endotelina(79 prodotti)
- Recettore GNRH(77 prodotti)
- GPCR19(32 prodotti)
- GRK(32 prodotti)
- GTPase(22 prodotti)
- Recettore del glucagone(182 prodotti)
- Proteina Hedgehog/Smoothened(47 prodotti)
- Recettore dell'istamina(381 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(26 prodotti)
- Recettore OX(41 prodotti)
- Recettore degli oppioidi(310 prodotti)
- PAFR(12 prodotti)
- PKA(51 prodotti)
- Recettore S1P(18 prodotti)
- SGLT(31 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 18 più sottocategorie
Trovati 5745 prodotti di "Proteina G/GPCR"
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ADORA2A/PDE4D-IN-1
CAS:<p>ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.</p>Formula:C14H11N5Colore e forma:SolidPeso molecolare:249.271Mesulergine hydrochloride
CAS:5-HT2A and 2C receptor antagonistFormula:C18H27ClN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:398.95SSR-241586
CAS:SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.Formula:C32H42Cl2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:601.61CI-988
CAS:CCK2 (CCK-B) receptor antagonistFormula:C35H42N4O6Purezza:98%Colore e forma:SolidPeso molecolare:614.73Leukotriene F4
CAS:LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.Formula:C28H44N2O8SColore e forma:SolidPeso molecolare:568.72Revexepride
CAS:Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formula:C21H32ClN3O4Purezza:98%Colore e forma:SolidPeso molecolare:425.95SCH-900822
CAS:SCH-900822 is a potent and selective glucagon receptor antagonist.Formula:C34H43Cl2N7O2Colore e forma:SolidPeso molecolare:652.66GHSR-1a agonist-1
CAS:<p>GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a) with an EC50 of 0.49 nM. It effectively stimulates the release of endogenous growth hormone by activating GHSR-1a. Doses as low as 0.1 mg/kg (administered orally) can increase body weight and length in 4-week-old rats. GHSR-1a agonist-1 is applicable in research on pediatric growth and developmental delays.</p>Formula:C30H37N5O4Colore e forma:SolidPeso molecolare:531.646Henagliflozin
CAS:Henagliflozin (SHR3824): an oral, selective SGLT2 inhibitor, weak on SGLT1.Formula:C22H24ClFO7Colore e forma:SolidPeso molecolare:454.87BI 703704
CAS:<p>BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].</p>Formula:C32H37N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:559.72PF-00446687
CAS:PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).Formula:C28H36F2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:470.59Aplaviroc
CAS:Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.Formula:C33H43N3O6Purezza:97.98% - 98.26%Colore e forma:SolidPeso molecolare:577.71GLP-1R agonist 8
CAS:<p>GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).</p>Formula:C33H32N4O5Colore e forma:SolidPeso molecolare:564.63Butaprost
CAS:Butaprost: EP2 receptor agonist, EC50=33 nM, Ki=2.4 μM (murine), reduces fibrosis via TGF-β/Smad2.Formula:C24H40O5Purezza:98%Colore e forma:SolidPeso molecolare:408.57P2Y14R antagonist 4
CAS:<p>Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) induced by LPS.</p>Formula:C27H27F3N2O4SColore e forma:SolidPeso molecolare:532.574LY 292728
CAS:LY 292728 is a highly potent antagonist of leukotriene B4 receptor.Formula:C34H29FO9Purezza:98%Colore e forma:SolidPeso molecolare:600.59LPA2 antagonist 5
CAS:LPA2 antagonist 5 (EX1) functions as an antagonist of LPA2, with an IC50 value of 4.05 nM.Formula:C17H17F3N2O5Colore e forma:SolidPeso molecolare:386.323DMPX
CAS:DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.Formula:C10H10N4O2Colore e forma:SolidPeso molecolare:218.212BMS-986104 HCl
CAS:BMS-986104 is a potent and selective S1P1 receptor modulator.Formula:C22H36ClNOPurezza:98%Colore e forma:SolidPeso molecolare:365.98MRS7799
CAS:<p>MRS7799 is a selective A3 Adenosine Receptor antagonist with Kd values of 0.55 nM for humans, 3.74 nM for mice, and 2.80 nM for rats. MRS7799 can be utilized in research related to neurodegenerative diseases, cancer, cardiac and cerebral ischemia, and autoimmune inflammatory diseases.</p>Formula:C22H18N4OSColore e forma:SolidPeso molecolare:386.47PD 136450
CAS:<p>PD-136,450: partial stomach secretory agonist, full pancreas agonist in rats; potential acid-reducing drug, adjuvant for gastrin-sensitive tumors.</p>Formula:C35H40N4O6Purezza:98%Colore e forma:SolidPeso molecolare:612.72Nedocromil sodium
CAS:Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.Formula:C19H17NNaO7Purezza:98%Colore e forma:SolidPeso molecolare:394.335IRL 2500
CAS:<p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>Formula:C36H35N3O4Purezza:99.36%Colore e forma:White Crystalline SolidPeso molecolare:573.68TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Formula:C36H46N4O4SColore e forma:SolidPeso molecolare:630.84(1R,2S,3R)-Aprepitant
CAS:<p>(1R,2S,3R)-Aprepitant (Compound ent-4) is a competitive antagonist of the human neurokinin-1 (NK-1) receptor. It holds potential for research in the treatment of nausea and vomiting related to cancer or postoperative conditions.</p>Formula:C23H21F7N4O3Colore e forma:SolidPeso molecolare:534.427Ici D1542
CAS:Ici D1542: potent TXS inhibitor & TXA2 receptor antagonist, effective thromboxane blocker in vitro.Formula:C25H30N2O7Purezza:98%Colore e forma:SolidPeso molecolare:470.51Abarelix acetate
CAS:Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.Formula:C72H95ClN14O14·xC2H4O2Colore e forma:SolidPeso molecolare:1476.14SR 140333
CAS:SR 140333 is a NK1 receptor antagonist.Formula:C37H45Cl3N2O2Purezza:98%Colore e forma:SolidPeso molecolare:656.12LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Formula:C32H39N3O·HCl·xH2OColore e forma:SolidBNS808
CAS:<p>BNS808 is an orally active, selective CB1R antagonist with an IC50 of 0.8 nM, demonstrating significant selectivity for CB2R and minimal brain penetration. It is being studied for the treatment of obesity and related metabolic complications, such as metabolic dysfunction-associated steatotic liver disease (MASLD). BNS808 reduces drug exposure to the central nervous system, enhancing safety, and minimizes drug interactions through high plasma protein binding.</p>Formula:C25H20Cl3N3O3SColore e forma:SolidPeso molecolare:548.869CCR7 Ligand 1
CAS:CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.Formula:C22H29N5O5SColore e forma:SolidPeso molecolare:475.56Pexacerfont
CAS:Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).Formula:C18H24N6OPurezza:99.77%Colore e forma:SolidPeso molecolare:340.42CB1/2 receptor-1
CAS:CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.Formula:C33H48O2Colore e forma:SolidPeso molecolare:476.73Bzo-poxizid
CAS:Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.Formula:C20H21N3O2Colore e forma:SolidPeso molecolare:335.40MED 27
CAS:<p>MED 27 is an inhibitor of thromboxane synthase and thromboxane A2 receptors. It effectively inhibits rat platelet aggregation at doses significantly lower than those required for acetylsalicylic acid.</p>Formula:C24H25N5O5Colore e forma:SolidPeso molecolare:463.49AAZ-A 154 mesylate
CAS:<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Formula:C15H24N2O4SColore e forma:SolidPeso molecolare:328.43LB-102
CAS:LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.Formula:C18H29N3O4SColore e forma:SolidPeso molecolare:383.51AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formula:C14H20N2OColore e forma:SolidPeso molecolare:232.32Sigma-2 Radioligand 2
CAS:Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).Formula:C23H28FN3O3Colore e forma:SolidPeso molecolare:413.49AAZ-A 154 benzoate
CAS:<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formula:C21H26N2O3Colore e forma:SolidPeso molecolare:354.44Protease-Activated Receptor-1 antagonist 3
PAR-1 antagonist 3: potent (IC50: 7 nM), binds hERG K+ channels (IC50: 9 μM).Formula:C30H34N4O3Colore e forma:SolidPeso molecolare:498.62BMS-741672
CAS:<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Formula:C25H33F3N6O2Colore e forma:SolidPeso molecolare:506.56NCATS-SM4420
CAS:<p>NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.</p>Formula:C31H27N3O5Colore e forma:SolidPeso molecolare:521.56Neflumozide
CAS:Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.Formula:C22H23FN4O2Colore e forma:SolidPeso molecolare:394.44Nedemelteon
CAS:<p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>Formula:C15H18N2O2Colore e forma:SolidPeso molecolare:258.32(Rac)-BI 703704
CAS:(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).Formula:C32H37N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:559.72Zafirlukast metabolite M1
CAS:<p>Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.</p>Formula:C25H25N3O4SColore e forma:SolidPeso molecolare:463.549CVT-5440
CAS:CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.Formula:C27H28N6O5Colore e forma:SolidPeso molecolare:516.55PF-06372222
CAS:<p>PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.</p>Formula:C26H28F3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:515.53Fasitibant
CAS:<p>Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.</p>Formula:C36H49Cl2N6O6SColore e forma:SolidPeso molecolare:764.78
