Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(1.024 prodotti)
- Recettore dell'adenosina(249 prodotti)
- Recettore adrenergico(3.030 prodotti)
- Recettore della bombesina(35 prodotti)
- Recettore della bradichinina(61 prodotti)
- CXCR(159 prodotti)
- CaSR(34 prodotti)
- Recettore dei cannabinoidi(217 prodotti)
- Colecistochinina(1 prodotti)
- Recettore della dopamina(443 prodotti)
- Recettore dell'endotelina(86 prodotti)
- Recettore GNRH(84 prodotti)
- GPCR19(33 prodotti)
- GRK(33 prodotti)
- GTPase(22 prodotti)
- Recettore del glucagone(196 prodotti)
- Proteina Hedgehog/Smoothened(49 prodotti)
- Recettore dell'istamina(385 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(26 prodotti)
- Recettore OX(42 prodotti)
- Recettore degli oppioidi(326 prodotti)
- PAFR(14 prodotti)
- PKA(54 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(31 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 19 più sottocategorie
Trovati 5981 prodotti di "Proteina G/GPCR"
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Propranolol hydrochloride
CAS:Propranolol hydrochloride is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverseFormula:C16H22ClNO2Purezza:99.94% - >99.99%Colore e forma:White Or Almost White Powder White PowderPeso molecolare:295.80HAEGTFTSD
CAS:HAEGTFTSD is GLP-1's initial segment; GLP-1 (7-36) amide, tied to food intake, stems from preproglucagon in L-cells.Formula:C40H57N11O17Purezza:98%Colore e forma:SolidPeso molecolare:963.94Adrenocorticotropic Hormone (ACTH) (1-39), rat
CAS:ACTH (1-39), rat: potent MC2 agonist, forms fragments in vitro, isolated by HPLC, characterized by amino acids and NH2-terminus.Formula:C210H315N57O57SPurezza:98%Colore e forma:SolidPeso molecolare:4582.23Neuropeptide S(Mouse)
CAS:Endogenous NPSR agonist, EC50 = 3 nM. Boosts Ca2+ levels, activity, wakefulness, reduces anxiety in mice.Formula:C93H156N34O27Purezza:98%Colore e forma:SolidPeso molecolare:2182.47Pasireotide L-aspartate salt
CAS:Pasireotide L-aspartate, a stable cyclohexapeptide, mimics somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).Formula:C62H73N11O13Purezza:98%Colore e forma:SolidPeso molecolare:1180.33Adrenomedullin (AM) (22-52), human
CAS:Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin.Formula:C159H252N46O48Purezza:98%Colore e forma:SolidPeso molecolare:3576.04Cholecystokinin (27-32)-amide
CAS:Cholecystokinin (27-32)-amide is a CCK receptor antagonist.Formula:C36H48N8O12S3Purezza:98%Colore e forma:SolidPeso molecolare:881.01Kisspeptin-54(human)
CAS:Endogenous ligand for KISS1 receptor; Ki values: rat 1.80 nM, human 1.45 nM. Inhibits tumor spread, stimulates gonadotropin release.Formula:C258H401N79O78Purezza:98%Colore e forma:SolidPeso molecolare:5857.49HDAC6-IN-49
HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.Colore e forma:Odour SolidMeluadrine tartrate
CAS:Meluadrine tartrate is an endogenous metabolite.Formula:C16H24ClNO8Purezza:98%Colore e forma:SolidPeso molecolare:393.822-Methyl-N,N-dimethyltryptamine
CAS:2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.Formula:C13H18N2Colore e forma:SolidPeso molecolare:202.3Ivabradine-d3 hydrochloride
CAS:Ivabradine HCl: novel If blocker, IC50 2.9 μM, slows heart rate; D3 version is deuterium labeled.Formula:C27H37ClN2O5Purezza:98%Colore e forma:SolidPeso molecolare:508.07HCGRP-(8-37)
CAS:Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonistFormula:C139H230N44O38Purezza:98%Colore e forma:SolidPeso molecolare:3125.59BAM(8-22)
CAS:Potent MRGPRX1 agonist peptide; first found in bovine adrenal glands. Non-opioid, lacking met-enkephalin motif. EC50: 8-150 nM.Formula:C91H127N25O23SPurezza:98%Colore e forma:SolidPeso molecolare:1971.22PACAP (6-38), human, ovine, rat
CAS:PACAP (6-38) in humans, sheep, rats: a strong inhibitor of PACAP 38, outperforms PACAP (6-27) in blocking PACAP-27-induced adenylate cyclase.Formula:C182H300N56O45SPurezza:98%Colore e forma:SolidPeso molecolare:4024.74Ramelteon metabolite M-II
CAS:Ramelteon M-II binds MT1/MT2 with IC50s: 208/1470 pM; it's the main metabolite and a melatonin receptor agonist.Formula:C16H21NO3Purezza:98%Colore e forma:SolidPeso molecolare:275.34PAR650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.Purezza:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:144.1 kDaCCG258208 hydrochloride
<p>GRKs-IN-1 HCl (14as) strongly inhibits GRK2 (IC50=130nM) & GRK5 (IC50=7.1μM), is a paroxetine derivative with 100x cardiac boost.</p>Colore e forma:SolidSubstance P (1-9)
CAS:Substance P (1-9), a nonapeptide, slows its own inactivation and stimulates neurons.Formula:C52H77N15O12Purezza:98%Colore e forma:SolidPeso molecolare:1104.26BA 1
CAS:Potent BB1, BB2, and BB3 agonist; IC50: 0.26, 1.55, 2.52 nM. Boosts glucose transport in myocytes, promotes cancer cell growth in vitro.Formula:C57H76N14O11Purezza:98%Colore e forma:SolidPeso molecolare:1133.3211-deoxy Prostaglandin E2
CAS:11-deoxy PGE2 is a synthetic PGE2 analog, a potent bronchoconstrictor, 5-30x stronger than PGF2α on human respiratory muscles.Formula:C20H32O4Colore e forma:SolidPeso molecolare:336.47(±)5(6)-EET
CAS:5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.Formula:C20H32O3Colore e forma:SolidPeso molecolare:320.473Cagrilintide acetate
.Cagrilintide is a long-acting amylin analog,treat diabetes and obesity by reducing appetite through activation of the AMY3R and calcitonin receptor.Formula:C196H316N54O61S2Purezza:99.88%Colore e forma:SolidPeso molecolare:4469.06CYM5442 hydrochloride
CAS:CYM 5442 HCl: potent, selective S1P1 agonist (EC50 = 1.35 nM), induces MAPK activation & lymphopenia, brain-penetrant.Formula:C23H28ClN3O4Colore e forma:SolidPeso molecolare:445.94ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
CAS:ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.Formula:C22H18N4O3Purezza:99.86%Colore e forma:SolidPeso molecolare:386.4Ref: TM-T9887
1mg101,00€5mg215,00€10mg323,00€25mg545,00€50mg735,00€100mg979,00€200mg1.320,00€1mL*10mM (DMSO)Prezzo su richiestaSenktide TFA
Senktide TFA is a potent and selective neurokinin 3 (NK3) receptor agonist with an EC50 of 0.5-3 nM, while showing significantly weaker activity on NK1 receptors (EC50=35 µM). It is a promising candidate for research in neurological disorders.Colore e forma:Odour SolidDexbrompheniramine
CAS:Dexbrompheniramine: oral H1 antagonist, antihistamine for hay fever and urticaria research.Formula:C16H19BrN2Colore e forma:SolidPeso molecolare:319.242-Furoyl-LIGRLO-amide
CAS:2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.Formula:C36H63N11O8Purezza:98%Colore e forma:SolidPeso molecolare:777.95P2Y6R antagonist 1
P2Y6R antagonist 1 (compound 5ab) is a selective, orally active antagonist of P2Y6R, featuring an IC50 value of 19.6 nM. This compound also exhibits anti-inflammatory properties.Colore e forma:Odour SolidNeuropeptide Y(29-64)
CAS:Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.Formula:C189H284N54O58SPurezza:98%Colore e forma:SolidPeso molecolare:4272.7Dulaglutide
CAS:Dulaglutide (LY2189265) is a GLP-1 receptor agonist for studying type 2 diabetes mellitus (T2DM).Colore e forma:SolidSibenadet hydrochloride
CAS:Sibenadet, a D2/beta2-agonist, is potential useful for the treatment of symptoms of chronic obstructive pulmonary disease.Formula:C22H29ClN2O5S2Colore e forma:SolidPeso molecolare:501.06IRL-1038
CAS:<p>ETB endothelin receptor antagonist</p>Formula:C68H92N14O15S2Purezza:98%Colore e forma:SolidPeso molecolare:1409.67Secretin (28-54), human TFA
Secretin (28-54), human TFA is a 27-amino acid peptide that works on the human Secretin receptor.Formula:C132H221N44F3O42Purezza:98%Colore e forma:SolidPeso molecolare:3153.48RF9 acetate
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.Formula:C28H42N6O5Purezza:99.77%Colore e forma:SolidPeso molecolare:542.67Ref: TM-T16738L
1mg65,00€5mg125,00€10mg182,00€25mg325,00€50mg467,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)167,00€SGLT1/2-IN-2
CAS:SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).Formula:C23H26F2O7Colore e forma:SolidPeso molecolare:452.451MK-7246 S enantiomer
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.Formula:C21H21FN2O4SPurezza:98%Colore e forma:SolidPeso molecolare:416.47P2Y14 antagonist 1
P2Y14 antagonist 1 (compound 45) is a highly selective and orally active P2Y14 receptor antagonist with an IC50 value of 0.70 nM. It demonstrates significant anti-inflammatory effects by effectively reducing pulmonary infiltration of immune cells and inflammatory responses through the inhibition of the NLRP3 signaling pathway. P2Y14 antagonist 1 is suitable for studying acute lung injury.Formula:C24H21N3O3Colore e forma:SolidPeso molecolare:399.442NTRC-824
CAS:NTRC-824: NTS2 antagonist, 150x more selective than NTS1; IC50: 38 nM, Ki: 202 nM; nonpeptide, neurotensin-like.Formula:C25H26F3N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:553.55Leukotriene B4 Ethanolamide
CAS:<p>LTB4 binds to BLT1 (high affinity) and BLT2. LTB4-EA, a metabolite, is a stronger BLT1 antagonist, suggesting anti-inflammatory properties.</p>Formula:C22H37NO4Colore e forma:SolidPeso molecolare:379.541GLP-1 receptor agonist 9 citrate
<p>GLP-1 receptor agonist 9 citrate is an agonist of GLP-1.</p>Formula:C38H39ClFN3O12Purezza:98.76%Colore e forma:SolidPeso molecolare:784.18(R)-V-0219 hydrochloride
(R)-V-0219 hydrochloride: Oral GLP-1R PAM, enantiomer of V-0219, triggers Ca2+ flux in hGLP-1R HEK cells.Formula:C20H26ClF3N4O2Colore e forma:SolidPeso molecolare:446.89SR 142948 dihydrochloride
SR 142948 dihydrochloride is a selective oral non-peptide NT antagonist, IC50 <4 nM, with brain penetration and potential for psychiatric research.Formula:C39H53Cl2N5O6Colore e forma:SolidPeso molecolare:758.77ANXA3 degrader 1
ANXA3 degrader 1 (Compound 18a5) is a highly selective ANXA3 degrader with activity against cancer cells. It demonstrates significant inhibitory effects in a triple-negative breast cancer (TNBC) tumor xenograft model, with a tumor growth inhibition (TGI) rate of 96%.Formula:C30H32N6O2S2Colore e forma:SolidPeso molecolare:572.74Pancreatic polypeptide TFA
Pancreatic polypeptide TFA acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.Colore e forma:Odour Solid(+)-Cloprostenol
CAS:(+)-Cloprostenol is a analogue of prostaglandin F2α (PGF2α), and is selective prostaglandin receptor agonistic.Formula:C22H29ClO6Purezza:98%Colore e forma:SolidPeso molecolare:424.92BMS-196085
CAS:BMS-196085 is an effective and selective human β( 3) All agonists of adrenergic receptors, in β( 1) Partial agonist activity was 45%.Formula:C24H26F2N2O5SColore e forma:SolidPeso molecolare:492.54GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].Formula:C19H16FN5O2Colore e forma:SolidPeso molecolare:365.36Cortagine
Potent CRF1 agonist, EC50 = 0.18 nM in rats. Exhibits in vivo anxiolytic and antidepressant effects; reduces mouse defensive behavior.Formula:C192H323N55O63SPurezza:98%Colore e forma:SolidPeso molecolare:4442.06Spns2-IN-2
Spns2-IN-2 (compound 3a) is an inhibitor of SPNS2.Formula:C22H30ClN3O2Colore e forma:SolidPeso molecolare:403.95
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