Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

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Trovati 5352 prodotti di "Proteina G/GPCR"

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SPN009
SPN009 (Sequence 3) is a GLP-1 receptor (GLP-1 Receptor) agonist, with an EC50 of 2.84 nM, and improves type 2 diabetes in DB/DB mouse models.
Formula:C₁₉₁H₂₉₉N₄₅O₅₉
Peso molecolare:4167.17798
Ref: TM-TP3525
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Leukotriene B4 Ethanolamide
CAS:
- 877459-63-7
LTB4 binds to BLT1 (high affinity) and BLT2. LTB4-EA, a metabolite, is a stronger BLT1 antagonist, suggesting anti-inflammatory properties.
Formula:C₂₂H₃₇NO₄
Colore e forma:Solid
Peso molecolare:379.541
Ref: TM-T37619
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Donitriptan hydrochloride
CAS:
- 170911-68-9
Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively
Formula:C₂₃H₂₆ClN₅O₂
Purezza:99.8% - 99.86%
Colore e forma:Solid
Peso molecolare:439.94
Ref: TM-T21666
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CI-988 hemihydrate
CI-988 hemihydrate (PD134308) is a potent and selective orally active CCK2R (cholecystokinin 2 receptor) antagonist, with an IC50 of 1.7 nM for mouse cortical CCK2. It is over 1600 times more selective for CCK2 than for CCK1 receptors. CI-988 hemihydrate exhibits anxiolytic and antitumor properties.
Formula:C₃₅H₄₂N₄O₆H₂O
Peso molecolare:632.321
Ref: TM-T208995
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Myristoylated ARF6 (2-13)
Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.
Formula:C₇₄H₁₂₈N₁₆O₁₈
Peso molecolare:1528.95925
Ref: TM-TP3490
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GUB03385
GUB03385 is a long-acting PrRP31 analogue and an effective dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM), with anti-obesity properties.
Formula:C₁₉₈H₃₂₂N₆₀O₅₂S
Peso molecolare:4404.41173
Ref: TM-TP3547
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[D-Phe12]-Bombesin
CAS:
- 108437-87-2
Bombesin receptor antagonist
Formula:C₇₄H₁₁₂N₂₂O₁₈S
Purezza:98%
Colore e forma:Solid
Peso molecolare:1629.88
Ref: TM-TP2239
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Neurokinin B
CAS:
- 86933-75-7
NKB, a tachykinin peptide, impacts human functions like gonadotropin-releasing hormone secretion.
Formula:C₅₅H₇₉N₁₃O₁₄S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:1210.42
Ref: TM-TP1363
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BPP-2
BPP-2 is a GHSR ligand containing the element F. By labeling BPP-2 with the isotope 18F, a PET probe targeting GHSR can be produced. The binding affinity (Ki) of 18F-BPP-2 for GHSR is 274 nM.
Formula:C₂₇H₂₈FN₅O₂
Peso molecolare:473.2227
Ref: TM-T209024
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Adenosine 2',5'-diphosphate sodium
CAS:
- 154146-84-6
Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.
Formula:C₁₀H₁₅N₅NaO₁₀P₂
Colore e forma:Solid
Peso molecolare:450.192
Ref: TM-T39025
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Methapyrilene hydrochloride
CAS:
- 135-23-9
Methapyrilene hydrochloride is a biochemical.
Formula:C₁₄H₂₀ClN₃S
Colore e forma:Liquid Solution) 5 5 (Ntp 1992)
Peso molecolare:297.85
Ref: TM-T33316
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IRL-1620
CAS:
- 142569-99-1
IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).
Formula:C₈₆H₁₁₇N₁₇O₂₇
Purezza:98%
Colore e forma:Solid
Peso molecolare:1820.974
Ref: TM-T15595
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Prazobind
CAS:
- 107021-36-3
Prazobind is a prazosinoid substance that blocks insulin stimulation of IP1 (inositol phosphate) accumulation and is an effective α1 adrenoceptor blocker.
Formula:C₂₃H₂₇N₅O₃
Colore e forma:Solid
Peso molecolare:421.501
Ref: TM-T35581
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α-CGRP, rat
CAS:
- 83651-90-5
Endogenous neuropeptide, potent vasodilator
Formula:C₁₆₂H₂₆₂N₅₀O₅₂S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:3806.25
Ref: TM-TP2233
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Peptide C105Y TFA
Peptide C105Y TFA is a cell-penetrating peptide synthesized based on the amino acid sequence of residues 359-374 of α1-antitrypsin. It enhances the gene expression of DNA nanoparticles.
Formula:C₉₇H₁₄₈N₂₀O₂₃S·xC₂HF₃O₂
Ref: TM-TP3340
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SB 216641
CAS:
- 170230-39-4
SB 216641 is a 5-HT (1B/1D) antagonist with anxiolytic activity for the study of anxiety disorders and depression.
Formula:C₂₈H₃₀N₄O₄
Purezza:98.09%
Colore e forma:Solid
Peso molecolare:486.56
Ref: TM-T85323
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hNTS1R agonist-1
Compound 10, an hNTS1R agonist-1, acts as a full agonist with a strong affinity for hNTS1R (K i: 6.9 nM), showing the ability to cross the blood-brain barrier (
Formula:C₃₇H₆₂N₁₀O₉
Purezza:98%
Colore e forma:Solid
Peso molecolare:790.95
Ref: TM-T78954
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{Val1}-Exendin-3/4
{Val1}- exendin-3/4 is the first n-terminal 1-28 residue of exendin-4 peptide.
Formula:NA
Purezza:98%
Colore e forma:Solid
Peso molecolare:3241.7
Ref: TM-TP1394
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Somatostatin 1-28 acetate
Somatostatin 1-28 acetate circulates in human plasma.
Purezza:99.22%
Colore e forma:Soild
Ref: TM-TP2124L
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Azaline B
CAS:
- 134457-28-6
Azaline B is an antagonist of the gonadotropin-releasing hormone (GnRH), with an IC50 of 1.37 nM. It is utilized in research related to pathologies associated with sex hormones, ovulation induction, and male contraception.
Formula:C₈₀H₁₀₂ClN₂₃O₁₂
Colore e forma:Solid
Peso molecolare:1613.27
Ref: TM-TP2707
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TRAP-5 amide
CAS:
- 141923-41-3
TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].
Formula:C₃₀H₅₁N₉O₆
Colore e forma:Solid
Peso molecolare:633.78
Ref: TM-T80111
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Chemerin-9 (149-157) TFA
Chemerin-9 (149-157) TFA is a peptide located at positions 149-157 of chemerin-9, acting as a ChemR23/CMKLR1 agonist.
Formula:C₅₆H₆₇F₃N₁₀O₁₅
Purezza:99.77%
Colore e forma:Solid
Peso molecolare:1177.18
Ref: TM-TP1435
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Xenopus orexin B
CAS:
- 254757-78-3
Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].
Formula:C₁₃₀H₂₁₉N₄₅O₄₀S₂
Colore e forma:Solid
Peso molecolare:3116.54
Ref: TM-TP2641
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[Pro34]Neuropeptide Y, porcine
CAS:
- 128768-54-7
[Pro34]Neuropeptide Y, porcine functions as a selective agonist for the NPY (Y1) receptor and induces vasoconstriction in the guinea pig's caval vein [1].
Formula:C₁₉₀H₂₈₆N₅₄O₅₆
Colore e forma:Solid
Peso molecolare:4222.63
Ref: TM-TP2523
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HL2-m5
CAS:
- 2130846-15-8
HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.
Formula:C₇₀H₁₀₁N₁₅O₂₄S₃
Colore e forma:Solid
Peso molecolare:1632.83
Ref: TM-TP3102
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SFNGGP-NH2
CAS:
- 261521-21-5
SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.
Formula:C₂₅H₃₆N₈O₈
Colore e forma:Solid
Peso molecolare:576.6
Ref: TM-T80234
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Parstatin(human) TFA
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].
Formula:C₁₉₃H₃₃₁F₃N₆₄O₅₅S₃
Colore e forma:Solid
Peso molecolare:4581.28
Ref: TM-T75873
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Tau conotoxin CnVA
CAS:
- 1436463-45-4
Tau conotoxin CnVA, a small peptide found in the venom of Conus consors (cone snail), is a member of the T1 cone snail peptide superfamily. It demonstrates high selectivity for the somatostatin sst3 receptor with a Ki value of 1.5 µM. Tau conotoxin CnVA is unique as the only known toxin interacting with this subfamily of G protein-coupled receptors (GPCR). This compound is useful for research related to diseases associated with the sst3 receptor, such as pancreatic cancer or pituitary adenomas.
Formula:C₇₂H₁₁₆N₂₄O₁₇S₄
Colore e forma:Solid
Peso molecolare:1718.1
Ref: TM-TP2735
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YFLLRNP
CAS:
- 149440-16-4
YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.
Formula:C₄₅H₆₇N₁₁O₁₀
Colore e forma:Solid
Peso molecolare:922.08
Ref: TM-T80235
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Protease-Activated Receptor-1, PAR-1 Agonist
CAS:
- 141136-85-8
Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.
Formula:C₃₅H₅₈N₁₀O₉
Colore e forma:Solid
Peso molecolare:762.91
Ref: TM-T38836
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BMS-753426
CAS:
- 1004536-52-0
BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Formula:C₂₅H₃₃F₃N₆O₂
Colore e forma:Solid
Peso molecolare:506.574
Ref: TM-T38397
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Methionyl-Lysyl-Bradykinin
CAS:
- 550-19-6
Methionyl-Lysyl-Bradykinin (Met-Lys-Bradykinin), a Bradykinin analogue, is a kinin [1] [2] .
Formula:C₆₁H₉₄N₁₈O₁₃S
Colore e forma:Solid
Peso molecolare:1319.58
Ref: TM-T76384
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CYN 154806
CAS:
- 183658-72-2
CYN 154806: potent sst2 antagonist; pIC50: 8.58 (sst2), 5.41 (sst1), 6.07 (sst3), 5.76 (sst4), 6.48 (sst5).
Formula:C₅₆H₆₈N₁₂O₁₄S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:1197.34
Ref: TM-TP1877
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Kisspeptin 13
CAS:
- 374675-18-0
Kisspeptin 13 activates GPR54 & GnRH receptors, boosts memory, and aids in Alzheimer's research.
Formula:C₇₈H₁₀₇N₂₁O₁₈
Colore e forma:Solid
Peso molecolare:1626.81
Ref: TM-T76339
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HAEGTFTSD
CAS:
- 926018-45-3
HAEGTFTSD is GLP-1's initial segment; GLP-1 (7-36) amide, tied to food intake, stems from preproglucagon in L-cells.
Formula:C₄₀H₅₇N₁₁O₁₇
Purezza:98%
Colore e forma:Solid
Peso molecolare:963.94
Ref: TM-TP1452
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Prostaglandin H1
CAS:
- 52589-22-7
Prostaglandin H1 is the cyclooxygenase metabolite of DGLA, a CRTh2 agonist and a precursor of a family of 1 anti-inflammatory prostaglandins.
Formula:C₂₀H₃₄O₅
Colore e forma:Solid
Peso molecolare:354.487
Ref: TM-T37328
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4-Chloromethamphetamine hydrochloride
CAS:
- 30572-91-9
4-Chloromethamphetamine hydrochloride is a novel psychoactive substance belonging to the amphetamine class.
Formula:C₁₀H₁₅Cl₂N
Colore e forma:Solid
Peso molecolare:220.14
Ref: TM-T203542
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M40
CAS:
- 143896-17-7
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat
Formula:C₉₄H₁₄₅N₂₃O₂₄
Purezza:98%
Colore e forma:Solid
Peso molecolare:1981.33
Ref: TM-TP1992
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Setmelanotide Acetate(920014-72-8 free base)
CAS:
- 2759937-80-7
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM
Formula:C₅₁H₇₂N₁₈O₁₁S₂
Purezza:99.71%
Colore e forma:Solid
Peso molecolare:1177.35
Ref: TM-T12882L
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Tezusomant
CAS:
- 2802416-72-2
Tezusomant is an antagonist of the growth hormone receptor (growth hormone receptor). It is being investigated for potential use in conditions like acromegaly, which are caused by excessive secretion of growth hormone.
Formula:C₁₂₀H₁₇₁N₂₃O₃₂S
Colore e forma:Solid
Peso molecolare:2479.84
Ref: TM-T207171
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(Ala13)-Apelin-13
CAS:
- 568565-11-7
(Ala13)-Apelin-13 is a useful organic compound for research related to life sciences. The catalog number is T35374 and the CAS number is 568565-11-7.
Formula:C₆₃H₁₀₇N₂₃O₁₆S
Purezza:98%
Colore e forma:Solid
Peso molecolare:1474.75
Ref: TM-T35374
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[Ala17]-MCH acetate
[Ala17]-MCH acetate is a selective ligand for MCHR1 with a Ki of 0.16 nM and Kd of 0.37 nM(Eu3+ chelate-labeled).
Formula:C₉₉H₁₅₉N₂₉O₂₈S₄
Purezza:98.92%
Colore e forma:Solid
Peso molecolare:2331.76
Ref: TM-TP1997L
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JKC363 TFA
JKC363 TFA is an MC4 receptor antagonist with 90x more affinity than MC3 (IC50: 0.5 nM vs 44.9 nM), blocks α-MSH's effect on TRH, and is anti-hyperalgesic.
Formula:C₇₁H₉₃F₃N₁₉O₁₈S₂
Colore e forma:Solid
Peso molecolare:1620.73
Ref: TM-T75850
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Imipramine N-oxide
CAS:
- 6829-98-7
Imipramine N-oxide is a tricyclic antidepressant (TCA) and imipramine analogue used to treat depression.
Formula:C₁₉H₂₄N₂O
Purezza:99.80%
Colore e forma:Solid
Peso molecolare:296.41
Ref: TM-T74205
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Picumeterol FA
picumeterol FA is a potent and selective β2-adrenergic receptor agonist.
Formula:C₂₂H₃₁Cl₂N₃O₄
Purezza:99.8%
Colore e forma:Soild
Peso molecolare:472.4
Ref: TM-T68129L1
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Galantide
CAS:
- 138579-66-5
Galantide is a reversible and non-specific antagonist of galanin receptor.
Formula:C₁₀₄H₁₅₁N₂₅O₂₆S
Purezza:98%
Colore e forma:White Lyophilised Solid
Peso molecolare:2199.53
Ref: TM-T15368
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B-Raf IN 14
CAS:
- 326918-98-3
B-Raf IN 14 is a BRAF inhibitor.
Formula:C₁₅H₁₄BrN₅O₃S
Purezza:98.32%
Colore e forma:Solid
Peso molecolare:424.27
Ref: TM-T72070
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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS:
- 211190-38-4
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtype
Formula:C₄₂H₆₃FN₁₂O₈
Colore e forma:Solid
Peso molecolare:883.02
Ref: TM-T80240
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NSC380324
NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.
Formula:C₃₁H₂₄N₄O₄
Colore e forma:Solid
Peso molecolare:516.55
Ref: TM-T205528
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4-fluoro MBZP
CAS:
- 144734-44-1
4-fluoro MBZP is a novel psychoactive substance in the phenylpiperazine class, utilized for studies on the 5-HT2 receptors in the central nervous system.
Formula:C₁₂H₁₇FN₂
Colore e forma:Solid
Peso molecolare:208.28
Ref: TM-T203276