Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(942 prodotti)
- Recettore dell'adenosina(242 prodotti)
- Recettore adrenergico(2.949 prodotti)
- Recettore della bombesina(30 prodotti)
- Recettore della bradichinina(59 prodotti)
- CXCR(149 prodotti)
- CaSR(32 prodotti)
- Recettore dei cannabinoidi(195 prodotti)
- Recettore della dopamina(410 prodotti)
- Recettore dell'endotelina(75 prodotti)
- Recettore GNRH(73 prodotti)
- GPCR19(31 prodotti)
- GRK(32 prodotti)
- GTPase(21 prodotti)
- Recettore del glucagone(166 prodotti)
- Proteina Hedgehog/Smoothened(45 prodotti)
- Recettore dell'istamina(359 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(24 prodotti)
- Recettore OX(40 prodotti)
- Recettore degli oppioidi(298 prodotti)
- PAFR(11 prodotti)
- PKA(49 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(30 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 18 più sottocategorie
Trovati 5378 prodotti di "Proteina G/GPCR"
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5-HT5AR/5-HT6R ligand-1
<p>5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, exhibiting high affinity for the 5-HT5A and 5-HT6 receptors with Ki values of 59 nM and 96 nM, respectively. It possesses some antiproliferative activity against tumor cells and can be utilized in cancer research.</p>Formula:C25H30N4O2SColore e forma:SolidPeso molecolare:450.6[Ala11,D-Leu15]-Orexin B(human)
CAS:<p>OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).</p>Formula:C120H206N44O35SPurezza:98%Colore e forma:SolidPeso molecolare:2857.28APJ receptor agonist 1
CAS:<p>Potent APJ-R agonist 1, biphenyl acid, EC50: 0.093 nM (human), 0.12 nM (rat), targets apelin-13, promising for heart failure study.</p>Formula:C31H26ClN3O3Colore e forma:SolidPeso molecolare:524.02Brexpiprazole S-oxide
CAS:<p>Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).</p>Formula:C25H27N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:449.57Lanepitant
CAS:<p>Lanepitant (LY303870) is a non-peptide neurokinin-1 (NK-1) antagonist with analgesic activity for the prevention of migraine.</p>Formula:C33H45N5O3Purezza:97.71%Colore e forma:SolidPeso molecolare:559.744-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Formula:C19H21NOPurezza:99.91%Colore e forma:SolidPeso molecolare:279.38MrgprX2 antagonist-4
CAS:<p>MrgprX2 antagonist-4, from patent US20210128561A1, inhibits MrgprX2 receptor; useful for skin inflammation studies.</p>Formula:C16H19N3OColore e forma:SolidPeso molecolare:269.348Calcitonin (8-32), salmon
CAS:Calcitonin (8-32), salmon: selective amylin receptor antagonist, regulates calcium/phosphorus, thyroid origin, 32-aa peptide.Formula:C119H198N36O37Purezza:98%Colore e forma:SolidPeso molecolare:2725.06rGHRH(1-29)NH2
RGHRH (1-29)NH2 is a synthetic peptide that stimulates the secretion of growth hormone (GH).Formula:C155H251N49O40SPurezza:98%Colore e forma:SolidPeso molecolare:3473.02β-MSH, human
CAS:<p>beta-MSH, human is an endogenous peptide hormone and neurotransmitter by POMC, an agonist of MC4-R (melanocortin 4 receptor).</p>Formula:C118H174N34O35SPurezza:98%Colore e forma:SolidPeso molecolare:2660.92REGN-7544
<p>REGN-7544 is a humanised monoclonal antibody targeting NPR1, which blocks and inhibits NPR1 to increase blood pressure, hypotensione.</p>Purezza:95%Colore e forma:Odour LiquidAnthramycin
CAS:<p>Anthramycin: a PBD family antibiotic with antitumor effects and CNS cholecystokinin antagonist properties in mice.</p>Formula:C16H17N3O4Colore e forma:SolidPeso molecolare:315.32CRSP-1
CAS:Central CT receptor agonist, 350x stronger than CT, no CGRP or adrenomedullin action, inhibits osteoclasts, affects rat feeding, body temp, and calcium.Formula:C175H294N54O49S5Purezza:98%Colore e forma:SolidPeso molecolare:4098.88AL 34662
CAS:<p>AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also a</p>Formula:C10H13N3OPurezza:99.77%Colore e forma:SolidPeso molecolare:191.23Sulamserod
CAS:<p>Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular related</p>Formula:C19H28ClN3O5SPurezza:98.76%Colore e forma:SolidPeso molecolare:445.96CTP-amiodarone
<p>CTP-amiodarone, a cellular-penetrating conjugate of myocardial cell-targeting peptide and Amiodarone, exhibits anti-arrhythmic activity by blocking Na+, K+, and Ca2+ channels as well as β-adrenergic receptors.</p>Formula:C97H131F3I2N20O25S2Colore e forma:SolidPeso molecolare:2352.13Lys-Bradykinin
CAS:<p>Endogenous bradykinin receptor agonist</p>Formula:C56H85N17O12Purezza:98%Colore e forma:SolidPeso molecolare:1188.38FR167344 free base
CAS:<p>FR167344 free base: oral, nonpeptide B2 bradykinin receptor antagonist, high-affinity (IC50: 65 nM), no B1 affinity.</p>Formula:C30H28BrCl2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:673.38Fluphenazine free base
CAS:<p>Flufenazine: antipsychotic for schizophrenia, blocks dopamine D2 receptors, reduces hallucinations and delusions.</p>Formula:C22H26F3N3OSColore e forma:SolidPeso molecolare:437.52Nemifitide diTFA
CAS:<p>Nemifitide diTFA is a synthetic pentapeptide with antidepressant properties, resembling MIF, that crosses the blood-brain barrier.</p>Formula:C37H45F7N10O10Purezza:99.78% - 99.84%Colore e forma:SolidPeso molecolare:922.8WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Formula:C19H17ClN2O2S2Purezza:97.92%Colore e forma:SolidPeso molecolare:404.93SB-206606
CAS:<p>SB-206606 is a novel, highly specific radioactive ligand for the β3-adrenergic receptor.</p>Formula:C19H22ClNO4Colore e forma:SolidPeso molecolare:363.838-iso-15-keto Prostaglandin F2α
CAS:<p>8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans.</p>Formula:C20H32O5Colore e forma:SolidPeso molecolare:352.471RAG8 peptide
RAG8 peptide is an antagonist of protease-activated receptor 4 (PAR 4), which inhibits late-stage platelet activation and reduces thrombosis without altering hemostasis or increasing bleeding risk. It is applicable in atherosclerosis research.Formula:C56H98N16O11Peso molecolare:1170.7601palm-PrRP31
palm-PrRP31 is a potent dual agonist for GPR10 (EC50=72 pM) and NPFF-R2. It activates downstream signaling pathways by binding to GPR10 and NPFF-R2 receptors, leading to reduced appetite and increased energy expenditure. palm-PrRP31 can be utilized to investigate its mechanism of action in the nervous system, thereby elucidating the complex biological processes involved in the regulation of appetite and energy expenditure.Formula:C176H282N56O43SPeso molecolare:3900.1322Big Gastrin I (human) TFA
<p>BigGastrinI, human (TFA), is a gastrointestinal hormone comprised of 34 amino acids. It can serve as a potential substance in the study of conditions such as cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological disorders, or cardiovascular diseases.</p>Formula:C178H252F3Peso molecolare:2446.96712CRF(6-33)(human)
CAS:<p>CRFBP inhibitor peptide; blocks CRF, reduces weight gain, boosts activity in obese rats.</p>Formula:C141H231N41O43SPurezza:98%Colore e forma:SolidPeso molecolare:3220.68Fasitibant chloride hydrochloride
CAS:Fasitibant chloride( MEN16132) is an effective and selective non-peptide antagonist of kinin B2 receptor.Formula:C36H50Cl4N6O6SColore e forma:SolidPeso molecolare:836.7Cyclic AC253
<p>Cyclic AC253 is an amylin receptor antagonist with an IC50 of 0.3 μM. It offers neuroprotective effects against Aβ toxicity and mitigates Aβ-induced impairments in hippocampal long-term potentiation. Additionally, Cyclic AC253 is capable of penetrating the blood-brain barrier.</p>Formula:C126H202N42O40S2Peso molecolare:3007.45049S1H
<p>S1H is an analog of human growth hormone (hGH) and acts as an antagonist to the human growth hormone receptor (hGHR). It inhibits the interaction between hGH and hGHR and prevents the phosphorylation of STAT5 in cells treated with hGH.</p>Formula:C94H141N23O27Peso molecolare:2024.03673Atrial Natriuretic Peptide (ANP) (1-28), rat
CAS:<p>Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.</p>Formula:C128H205N45O39S2Purezza:98%Colore e forma:SolidPeso molecolare:3062.41Alosetron
CAS:<p>Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.</p>Formula:C17H18N4OPurezza:98%Colore e forma:Crystalline PowderPeso molecolare:294.36palm11-PrRP31
<p>Palm11-PrRP31 is a lipid-modified analog of the endogenous appetite-suppressing neuropeptide (PrRP). It functions as a potent dual agonist for GPR10 (EC50 = 39 pM) and NPFF-R2. By mimicking the natural activity of PrRP, palm11-PrRP31 binds to these receptors to reduce food intake. It has potential applications as an anti-obesity agent and is useful in studying neuropeptide and receptor interactions.</p>Formula:C181H289N55O46SPeso molecolare:4001.16865MR33317
<p>MR33317 is an inhibitor of acetylcholinesterase with an IC50 value of 41 nM. Additionally, it acts as an agonist for brain 5-HT4 receptors.</p>Formula:C22H28ClN3O2Peso molecolare:401.187GRK2i
CAS:GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.Formula:C153H256N50O41SPurezza:98%Colore e forma:SolidPeso molecolare:3484.08RF9
CAS:<p>RF9 is an effective and selective antagonist of the Neuropeptide FF receptor (Kis: 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively).</p>Formula:C26H38N6O3Purezza:98%Colore e forma:SolidPeso molecolare:482.62OXA(17-33)
CAS:Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Formula:C79H125N23O22Purezza:98%Colore e forma:SolidPeso molecolare:1749RC-3095
CAS:<p>RC-3095, a selective GRPR antagonist, has been shown to have anti-inflammatory properties in different models of inflammation.</p>Formula:C56H79N15O9Purezza:98%Colore e forma:SolidPeso molecolare:1106.32Neocarzinostatin
CAS:<p>Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic.</p>Purezza:98%Colore e forma:SolidPeso molecolare:N/AM617
CAS:<p>Galanin GAL1 agonist, Ki: GAL1 0.23 nM, GAL2 5.71 nM; boosts rat appetite, lessens inflammation pain.</p>Formula:C112H161N29O28Purezza:98%Colore e forma:SolidPeso molecolare:2361.68CRF, bovine
CAS:CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.Formula:C206H340N60O63SPurezza:98%Colore e forma:SolidPeso molecolare:4697.34Relaxin H3 (human) TFA
Relaxin H3 (human) (TFA) is a relaxin peptide that exerts antifibrotic effects through the RXFP1 receptor.Formula:C237H374N70O69S6·xC2HF3O2JNJ-39933673
CAS:<p>JNJ-39933673 is a bio-active chemical.</p>Formula:C48H54F2N2O11Colore e forma:SolidPeso molecolare:872.96Tebufelone
CAS:<p>Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).</p>Formula:C20H28O2Purezza:99.32%Colore e forma:SolidPeso molecolare:300.44Zoliprofen
CAS:<p>Zoliprofen: potent, oral NSAID with anti-inflammatory, antipyretic, analgesic effects. Exceeds ibuprofen's efficacy in rats and rabbits.</p>Formula:C12H11NO3SPurezza:99.62%Colore e forma:SolidPeso molecolare:249.29GLP-1R agonist 20
<p>GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.</p>Formula:C31H30Cl2F2N4O5Peso molecolare:646.1561315(S)-15-methyl Prostaglandin F2α methyl ester
CAS:<p>15(S)-15-methyl Prostaglandin F2α methyl ester can be used in related research in the field of life sciences.</p>Formula:C22H38O5Colore e forma:SolidPeso molecolare:382.53(Iso)-Landipirdine
CAS:<p>(Iso)-Landipirdine((Iso)-RO5025181) is a selective and potent 5-HT6R antagonist.</p>Formula:C18H19FN2O3SPurezza:98.50%Colore e forma:SoildPeso molecolare:362.42Syk Inhibitor II hydrochloride
CAS:<p>Syk signaling is key in lupus. Syk inhibitors reduce inflammation and sepsis severity in FcgRIIb-/- mice, lowering cytokines and organ damage.</p>Formula:C14H16ClF3N6OPurezza:99.05%Colore e forma:SolidPeso molecolare:376.77SYD5115
<p>SYD5115 is an orally active TSH-R antagonist.</p>Formula:C22H32F2N4O3Peso molecolare:438.24425
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