Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

Mostrare 19 più sottocategorie

Trovati 5838 prodotti di "Proteina G/GPCR"

Purezza (%)

100

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MMC(TMZ)-TOC TFA
MMC(TMZ)-TOC TFA exhibits high binding affinity and selectivity for the somatostatin receptor subtype 2 (SSTR2). It targets the delivery of TMZ to SSTR2-positive tumor cells, making MMC(TMZ)-TOC TFA useful for cancer research.
Formula:C₇₄H₉₉F₃N₂₀O₂₁S₂
Colore e forma:Solid
Peso molecolare:1725.82
Ref: TM-T204151
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NTRC-824
CAS:
- 1623002-61-8
NTRC-824: NTS2 antagonist, 150x more selective than NTS1; IC50: 38 nM, Ki: 202 nM; nonpeptide, neurotensin-like.
Formula:C₂₅H₂₆F₃N₃O₆S
Purezza:98%
Colore e forma:Solid
Peso molecolare:553.55
Ref: TM-T16358
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Desglymidodrine
CAS:
- 3600-87-1
Desglymidodrine (ST 1059) is an α1-adrenoceptor agonist and vasoconstrictor, used in cardiovascular research and neurocardiogenic syncope studies.
Formula:C₁₀H₁₅NO₃
Purezza:99.56%
Colore e forma:Solid
Peso molecolare:197.23
Ref: TM-T31388L
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AZP-531
CAS:
- 1088543-62-7
Azp-531 is a disacylated ghrelin used to improve blood sugar control and weight loss.
Formula:C₄₀H₆₃N₁₅O₁₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:962.02
Ref: TM-TP1439
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TE-8105
TE-8105 is a GLP-1 receptor agonist that demonstrates prolonged and enhanced efficacy in models of diabetes, obesity, and non-alcoholic steatohepatitis (NASH).
Colore e forma:Odour Solid
Ref: TM-TP3839
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BIBP3226
CAS:
- 159013-54-4
BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor.
Formula:C₂₇H₃₁N₅O₃
Colore e forma:Solid
Peso molecolare:473.57
Ref: TM-T26801
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Stressin I
Potent CRF1 agonist; Ki: 1.5 nM (CRF1), 224 nM (CRF2). Boosts ACTH, enhances stool frequency after i.p. administration.
Formula:C₂₀₃H₃₃₇N₅₇O₅₆
Purezza:98%
Colore e forma:Solid
Peso molecolare:4472.24
Ref: TM-TP2125
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(±)5(6)-EET
CAS:
- 87173-80-6
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.
Formula:C₂₀H₃₂O₃
Colore e forma:Solid
Peso molecolare:320.473
Ref: TM-T36070
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α-CGRP(human)
CAS:
- 90954-53-3
Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
Formula:C₁₆₃H₂₆₇N₅₁O₄₉S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:3789.33
Ref: TM-TP2044
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GLP-1(28-36)amide acetate
GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.
Formula:C₅₆H₈₉N₁₅O₁₁
Purezza:99.9500%
Colore e forma:Solid
Peso molecolare:1148.4
Ref: TM-T37890L
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5-HT5AR/5-HT6R ligand-1
5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, exhibiting high affinity for the 5-HT5A and 5-HT6 receptors with Ki values of 59 nM and 96 nM, respectively. It possesses some antiproliferative activity against tumor cells and can be utilized in cancer research.
Formula:C₂₅H₃₀N₄O₂S
Colore e forma:Solid
Peso molecolare:450.6
Ref: TM-T205096
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5-OMe-UDP trisodium salt
CAS:
- 1207530-98-0
Potent P2Y6 agonist
Formula:C₁₀H₁₆N₂O₁₃P₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:434.19
Ref: TM-T22525
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GLP-1R agonist 14
CAS:
- 2758666-01-0
GLP-1R agonist 14, also known as Compound 14, is a potent agonist of the GLP-1 receptor, demonstrating an EC50 range of 0-20 nM against human GLP-1 [1].
Formula:C₄₅H₄₂F₂N₁₀O₅
Colore e forma:Solid
Peso molecolare:840.88
Ref: TM-T74608
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PD 144418 oxalate
CAS:
- 1794760-28-3
PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.
Formula:C₂₀H₂₄N₂O₅
Purezza:98.76%
Colore e forma:Solid
Peso molecolare:372.42
Ref: TM-T39211
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GLP-1 receptor agonist 9 citrate
GLP-1 receptor agonist 9 citrate is an agonist of GLP-1.
Formula:C₃₈H₃₉ClFN₃O₁₂
Purezza:98.76%
Colore e forma:Solid
Peso molecolare:784.18
Ref: TM-T9579L
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L-803087 TFA
CAS:
- 1786412-46-1
L-803087 TFA: potent sst4 agonist, Ki=0.7 nM, >280x selective vs other somatostatin receptors; boosts AMPA, heightens seizures.
Formula:C₂₇H₃₀F₅N₅O₅
Colore e forma:Solid
Peso molecolare:599.55
Ref: TM-T39207
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Neuromedin N
CAS:
- 92169-45-4
Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.
Formula:C₃₈H₆₃N₇O₈
Purezza:98%
Colore e forma:Solid
Peso molecolare:745.95
Ref: TM-TP1085
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Beraprost
CAS:
- 88430-50-6
Beraprost is a stable prostacyclin analog.
Formula:C₂₄H₃₀O₅
Colore e forma:Solid
Peso molecolare:398.49
Ref: TM-T30426
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Galanin (1-15) (porcine, rat)
CAS:
- 112747-70-3
N-terminal galanin fragment used to mediate central cardiovascular effects
Formula:C₇₂H₁₀₅N₁₉O₂₀
Purezza:98%
Colore e forma:Solid
Peso molecolare:1556.72
Ref: TM-TP2250
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MEN 11270
CAS:
- 235082-52-7
B2 bradykinin receptor peptide antagonist, pKi 10.3; improves hypotension, bronchoconstriction; B2-selective over 29 receptors/ion channels.
Formula:C₆₀H₉₀N₂₀O₁₁S
Purezza:98%
Colore e forma:Solid
Peso molecolare:1299.56
Ref: TM-TP1999
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Dipentylone hydrochloride
CAS:
- 17763-13-2
Dipentylone hydrochloride (Bk-dmbdp HCl) is a psychoactive synthetic cathinone and sympathomimetic stimulant. Its inhibitory activity towards the dopamine transporter (IC50=0.233µM) is tenfold higher than that towards NET and SERT, inhibiting dopamine uptake and stimulating locomotor activity in mice.
Formula:C₁₄H₂₀ClNO₃
Purezza:99.94%
Colore e forma:Solid
Peso molecolare:285.77
Ref: TM-T205977
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Apelin-36(human)
CAS:
- 252642-12-9
Endogenous APJ agonist, EC50=20nM, regulates cardiovascular function, fluid balance, and feeding; blocks certain HIV strains.
Formula:C₁₈₄H₂₉₇N₆₉O₄₃S
Purezza:98%
Colore e forma:Solid
Peso molecolare:4195.87
Ref: TM-TP2093
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Tiflucarbine
CAS:
- 89875-86-5
Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of soluble
Formula:C₁₆H₁₇FN₂S
Purezza:97.71%
Colore e forma:Solid
Peso molecolare:288.38
Ref: TM-T68162
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ACTH (1-17)
CAS:
- 7266-47-9
ACTH (1-17), a potent MC1 receptor agonist with a Ki of 0.21 nM, is a variant of corticotropin from the pituitary gland.
Formula:C₉₅H₁₄₅N₂₉O₂₃S
Purezza:98%
Colore e forma:Solid
Peso molecolare:2093.41
Ref: TM-TP1011
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SR 142948 dihydrochloride
SR 142948 dihydrochloride is a selective oral non-peptide NT antagonist, IC50 <4 nM, with brain penetration and potential for psychiatric research.
Formula:C₃₉H₅₃Cl₂N₅O₆
Colore e forma:Solid
Peso molecolare:758.77
Ref: TM-T73677
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Antisauvagine-30
CAS:
- 220673-95-0
CRF2 receptor antagonist; Kd 1.4 nM (mCRF2β), 153.6 nM (rCRF1). Blocks sauvagine-induced cAMP in cells & stress-related responses in mice.
Formula:C₁₆₁H₂₇₄N₄₈O₄₆S
Purezza:98%
Colore e forma:Solid
Peso molecolare:3650.29
Ref: TM-TP2091
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β-MSH, human
CAS:
- 17908-57-5
beta-MSH, human is an endogenous peptide hormone and neurotransmitter by POMC, an agonist of MC4-R (melanocortin 4 receptor).
Formula:C₁₁₈H₁₇₄N₃₄O₃₅S
Purezza:98%
Colore e forma:Solid
Peso molecolare:2660.92
Ref: TM-TP1004
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FSLLRY-NH2
CAS:
- 245329-02-6
PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.
Formula:C₃₉H₆₀N₁₀O₈
Purezza:98%
Colore e forma:Solid
Peso molecolare:796.97
Ref: TM-TP1904
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VU0453379 hydrochloride
VU0453379 hydrochloride: selective CNS-penetrant GLP-1R PAM, EC50 1.3 μM.
Formula:C₂₆H₃₅ClN₄O₂
Colore e forma:Solid
Peso molecolare:471.03
Ref: TM-T73840
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Clomipramine D3
CAS:
- 136765-29-2
Clomipramine D3 is deuterium-labeled Clomipramine, blocking serotonin, norepinephrine, dopamine transporters (Ki: 0.14, 54, 3 nM).
Formula:C₁₉H₂₃ClN₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:317.87
Ref: TM-T10842
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Hemopressin(human, mouse) TFA
CAS:
- 1431329-48-4
Hemopressin TFA: nonapeptide from hemoglobin, oral CB1 inverse agonist, eases inflammatory pain.
Formula:C₅₂H₈₀F₃N₁₃O₁₄
Purezza:98%
Colore e forma:Solid
Peso molecolare:1168.27
Ref: TM-T75799
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[D-Phe12]-Bombesin
CAS:
- 108437-87-2
Bombesin receptor antagonist
Formula:C₇₄H₁₁₂N₂₂O₁₈S
Purezza:98%
Colore e forma:Solid
Peso molecolare:1629.88
Ref: TM-TP2239
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5-HT6R antagonist 6
5-HT6R antagonist 6 (Compound PP15) exhibits high affinity and selectivity for the 5-HT6R receptor, with a Ki of 42 nM. It demonstrates weak antiproliferative activity on tumor cells and low toxicity toward normal cells. 5-HT6R antagonist 6 is applicable in tumor research.
Formula:C₂₄H₂₆N₄O₂S
Colore e forma:Solid
Peso molecolare:434.55
Ref: TM-T205194
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Neurokinin B
CAS:
- 86933-75-7
NKB, a tachykinin peptide, impacts human functions like gonadotropin-releasing hormone secretion.
Formula:C₅₅H₇₉N₁₃O₁₄S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:1210.42
Ref: TM-TP1363
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ONO-0300302
CAS:
- 856689-51-5
ONO-0300302: LPA1 antagonist, treats Benign Prostatic Hyperplasia, IC50 = 0.16 nM, reduces IUP in rats and dogs for 12h.
Formula:C₂₉H₃₅NO₅
Purezza:98%
Colore e forma:Solid
Peso molecolare:477.59
Ref: TM-T28245
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Lobeline sulfate
CAS:
- 134-64-5
Lobeline sulfate, an alkaloid like nicotine, aids in smoking cessation, insomnia, and respiratory issues. Less potent on nicotinic receptors.
Formula:C₂₂H₂₉NO₆S
Purezza:98%
Colore e forma:White Powder
Peso molecolare:435.54
Ref: TM-T22357
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Terazosin dimer impurity dihydrochloride
CAS:
- 1486464-41-8
Terazosin dimer impurity dihydrochloride is a chemical byproduct of the α1-antagonist Terazosin, derived from quinazoline.
Formula:C₂₄H₃₀Cl₂N₈O₄
Colore e forma:Solid
Peso molecolare:565.46
Ref: TM-T37817
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Thrombin Receptor Activator for Peptide 5 (TRAP-5)
CAS:
- 141685-53-2
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5), used in the research of coronary heart disease (CHD).
Formula:C₃₀H₅₀N₈O₇
Purezza:98%
Colore e forma:Solid
Peso molecolare:634.77
Ref: TM-T7496
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SB 201146
CAS:
- 141311-11-7
SB 201146 is a leukotriene B4 antagonist with high affinity.
Formula:C₃₀H₃₅LiN₂O₅S
Colore e forma:Solid
Peso molecolare:542.61
Ref: TM-T28667
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IRL-3630
CAS:
- 173189-01-0
IRL 3460 is an enantiomer.
Formula:C₃₁H₄₀N₄O₆S
Purezza:98%
Colore e forma:Solid
Peso molecolare:596.74
Ref: TM-T25541
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Methapyrilene hydrochloride
CAS:
- 135-23-9
Methapyrilene hydrochloride is a biochemical.
Formula:C₁₄H₂₀ClN₃S
Colore e forma:Liquid Solution) 5 5 (Ntp 1992)
Peso molecolare:297.85
Ref: TM-T33316
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IRL-1620
CAS:
- 142569-99-1
IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).
Formula:C₈₆H₁₁₇N₁₇O₂₇
Purezza:98%
Colore e forma:Solid
Peso molecolare:1820.974
Ref: TM-T15595
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Prazobind
CAS:
- 107021-36-3
Prazobind is a prazosinoid substance that blocks insulin stimulation of IP1 (inositol phosphate) accumulation and is an effective α1 adrenoceptor blocker.
Formula:C₂₃H₂₇N₅O₃
Colore e forma:Solid
Peso molecolare:421.501
Ref: TM-T35581
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α-CGRP, rat
CAS:
- 83651-90-5
Endogenous neuropeptide, potent vasodilator
Formula:C₁₆₂H₂₆₂N₅₀O₅₂S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:3806.25
Ref: TM-TP2233
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8-iso Prostaglandin A2
CAS:
- 474391-66-7
8-iso Prostaglandin A2 is an isoprostane produced by the nonenzymatic oxidation of arachidonic acid.
Formula:C₂₀H₃₀O₄
Colore e forma:Solid
Peso molecolare:334.45
Ref: TM-T36158
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Onvitrelin ucalontide
CAS:
- 1174415-90-7
Onvitrelin ucalontide is a LHRH analogue with anticancer effect; halts breast, ovarian, and prostate tumors in mice.
Formula:C₁₆₃H₂₄₃N₄₃O₃₂
Peso molecolare:3316.94
Ref: TM-T76558
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(±)14(15)-EpETE
CAS:
- 131339-24-7
(±)14(15)-EpETE is an intestinal microbial lipid metabolite that attenuates cisplatin chemotherapy-induced nausea in rats by inhibiting Substance P release.
Formula:C₂₀H₃₀O₃
Colore e forma:Solid
Peso molecolare:318.45
Ref: TM-T37234
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GFB-024
GFB-024 is a humanized antibody targeting CB1, which can be used to study obesity.
Colore e forma:Liquid
Peso molecolare:145.5kDa
Ref: TM-T77488
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Antibiotic Sch 60057
CAS:
- 203061-35-2
Antibiotic Sch 60057 is a useful organic compound for research related to life sciences. The catalog number is T125403 and the CAS number is 203061-35-2.
Formula:C₄₅H₈₄O₆
Colore e forma:Solid
Peso molecolare:721.161
Ref: TM-T125403
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Surfagon
CAS:
- 52435-06-0
Surfagon is an effective LHRH agonist.
Formula:C₅₆H₇₈N₁₆O₁₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:1167.34
Ref: TM-T26239