Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(1.025 prodotti)
- Recettore dell'adenosina(249 prodotti)
- Recettore adrenergico(3.030 prodotti)
- Recettore della bombesina(35 prodotti)
- Recettore della bradichinina(61 prodotti)
- CXCR(159 prodotti)
- CaSR(34 prodotti)
- Recettore dei cannabinoidi(217 prodotti)
- Colecistochinina(1 prodotti)
- Recettore della dopamina(445 prodotti)
- Recettore dell'endotelina(86 prodotti)
- Recettore GNRH(84 prodotti)
- GPCR19(33 prodotti)
- GRK(33 prodotti)
- GTPase(22 prodotti)
- Recettore del glucagone(196 prodotti)
- Proteina Hedgehog/Smoothened(49 prodotti)
- Recettore dell'istamina(385 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(26 prodotti)
- Recettore OX(42 prodotti)
- Recettore degli oppioidi(325 prodotti)
- PAFR(14 prodotti)
- PKA(58 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(31 prodotti)
- Recettore Sigma(46 prodotti)
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Trovati 5982 prodotti di "Proteina G/GPCR"
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HCGRP-(8-37) acetate
HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.
Formula:C141H234N44O40Purezza:99.29%Colore e forma:SolidPeso molecolare:3185.64Ibrolipim
CAS:Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
Formula:C19H20BrN2O4PPurezza:98.04%Colore e forma:SolidPeso molecolare:451.25Amitriptyline
CAS:Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.Formula:C20H23NPurezza:98.24% - 99.64%Colore e forma:Crystals SolidPeso molecolare:277.4Siramesine
CAS:Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potentFormula:C30H31FN2OPurezza:98%Colore e forma:SolidPeso molecolare:454.58[Sar9,Met(O2)11]-Substance P acetate
[Sar9,Met(O2)11]-Substance P acetate is an NK1 agonist, raising MAP and HR equally to septide but with unique timing and behaviors.Formula:C66H106N18O18SPurezza:>99.99%Colore e forma:SolidPeso molecolare:1471.75BD 1008 dihydrobromide
CAS:BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.
Formula:C15H24Br2Cl2N2Purezza:97.81%Colore e forma:SolidPeso molecolare:463.08Almotriptan
CAS:Almotriptan (LAS 31416), a triptan and 5-HT1B/1D agonist, treats migraines by constricting cranial vessels and altering blood flow.Formula:C17H25N3O2SPurezza:99.85%Colore e forma:Light Yellow Or White PowerPeso molecolare:335.46[Lys5,MeLeu9,Nle10]-NKA(4-10)
CAS:Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).Formula:C39H65N9O9Purezza:>99.99%Colore e forma:SolidPeso molecolare:803.99FAUC 346
CAS:FAUC 346 is a highly selective D3 partial agonist with EC50 of 1.5 nM.Formula:C24H29N3O2SPurezza:99.46%Colore e forma:SolidPeso molecolare:423.57Ref: TM-T9081
2mg34,00€5mg50,00€10mg77,00€25mg138,00€50mg224,00€100mg359,00€200mg490,00€1mL*10mM (DMSO)52,00€Neuropeptide S (Mouse) acetate
Neuropeptide S (Mouse) acetate is a bioactive peptide.Formula:C95H160N34O29Purezza:98.25%Colore e forma:SolidPeso molecolare:2242.5S26131
CAS:S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki ofFormula:C31H34N2O4Purezza:99.77%Colore e forma:SolidPeso molecolare:498.61PU02
CAS:PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.Formula:C16H12N4SPurezza:99.35%Colore e forma:SolidPeso molecolare:292.36MIPS521
CAS:MIPS521 ({2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone) is a positive allosteric modulator of the A1R.Formula:C19H10ClF6NOSPurezza:99.76%Colore e forma:SolidPeso molecolare:449.8Ref: TM-T9330
1mg35,00€2mg50,00€5mg74,00€10mg105,00€25mg178,00€50mg313,00€100mg485,00€1mL*10mM (DMSO)82,00€ML-178
CAS:ML-178: selective S1PR4 agonist, EC50 of 46 nM; inactive on other S1P receptors at 25 μM.Formula:C13H9Br2Cl2NO2Purezza:95.92%Colore e forma:SolidPeso molecolare:441.93ML417
CAS:ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).Formula:C22H25N3O3Purezza:98.4% - 99.42%Colore e forma:SolidPeso molecolare:379.45Rizatriptan benzoate
CAS:Rizatriptan benzoate (MK-462 Benzoate) selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraineFormula:C22H25N5O2Purezza:99% - 99.79%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:391.47Ref: TM-T1512
10mg47,00€25mg79,00€50mg126,00€100mg183,00€200mg273,00€500mg462,00€1mL*10mM (DMSO)50,00€SB 204741
CAS:SB 204741 is a selective 5-HT2B antagonist with high affinity and pKi value of 7.1.Formula:C14H14N4OSPurezza:99.83%Colore e forma:SolidPeso molecolare:286.35Ref: TM-T23312
1mg38,00€2mg50,00€5mg84,00€10mg119,00€25mg234,00€50mg439,00€100mg600,00€200mg837,00€1mL*10mM (DMSO)84,00€Istradefylline
CAS:Istradefylline (KW-6002)(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails.Formula:C20H24N4O4Purezza:98.18% - 99.95%Colore e forma:SolidPeso molecolare:384.43H4 Receptor antagonist 1
CAS:H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.Formula:C16H17ClN4OPurezza:98.81%Colore e forma:SolidPeso molecolare:316.791-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.
Formula:C13H13NO5Purezza:99.55%Colore e forma:SolidPeso molecolare:263.25AZD4635
CAS:AZD4635 (HTL1071) is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).Formula:C15H11ClFN5Purezza:99.15% - 99.90%Colore e forma:SolidPeso molecolare:315.73Ref: TM-T4265
1mg37,00€2mg52,00€5mg79,00€10mg116,00€25mg188,00€50mg296,00€100mg457,00€500mg1.008,00€1mL*10mM (DMSO)87,00€RVD-Hpα acetate(1193362-76-3 free base)
RVD-Hpα acetate is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist.Formula:C67H109N19O19Purezza:99.87%Colore e forma:SolidPeso molecolare:1484.71BIM-23190 aceate
BIM-23190 aceate, a somatostatin analog, a selective agonist of SSTR2 and SSTR5. BIM-23190 can be used in cancer and acromegaly studies.
Formula:C59H83N13O14S2Purezza:99.7%Colore e forma:SolidPeso molecolare:1262.5Trazodone
CAS:Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.Formula:C19H22ClN5OPurezza:99.79% - 99.92%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:371.86LP-211
CAS:LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.Formula:C30H34N4OPurezza:98.65%Colore e forma:SolidPeso molecolare:466.62Ref: TM-T5387
2mg44,00€5mg66,00€10mg90,00€25mg170,00€50mg289,00€100mg462,00€200mg658,00€1mL*10mM (DMSO)73,00€Montelukast
CAS:Montelukast (Singular), oral asthma med, linked to rare liver injury.Formula:C35H36ClNO3SPurezza:98.56% - >99.99%Colore e forma:SolidPeso molecolare:586.18Ramosetron hydrochloride
CAS:Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.Formula:C17H18ClN3OPurezza:99.95%Colore e forma:SolidPeso molecolare:315.8Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Formula:C13H12N2OPurezza:98.29% - 99.92%Colore e forma:Off-White SolidPeso molecolare:212.25(R)-Propranolol hydrochloride
CAS:(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol.Formula:C16H22ClNO2Purezza:98.63% - 99.01%Colore e forma:SolidPeso molecolare:295.8Capromorelin Tartrate
CAS:Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).Formula:C32H41N5O10Purezza:97.69%Colore e forma:SolidPeso molecolare:655.7Ref: TM-TQ0022
5mg39,00€10mg64,00€25mg126,00€50mg215,00€100mg319,00€200mg455,00€1mL*10mM (DMSO)52,00€Vanoxerine dihydrochloride
CAS:Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM)Formula:C28H34Cl2F2N2OPurezza:98.16% - 98.35%Colore e forma:White SolidPeso molecolare:523.49Pramipexole dihydrochloride hydrate
CAS:Pramipexole dihydrochloride hydrate (Mirapex) is a selective, blood-brain barrier-crossing D2 dopamine receptor agonist, and is used in the study of PD.Formula:C10H17N3S·2HCl·H2OPurezza:99.68%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:302.26Ref: TM-T6951
10mg47,00€25mg74,00€50mg119,00€100mg170,00€200mg255,00€500mg430,00€1mL*10mM (DMSO)47,00€Sultopride hydrochloride
CAS:Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist.Formula:C17H27ClN2O4SPurezza:≥95%Colore e forma:White Or Yellowish PowderPeso molecolare:390.93SHU 9119 acetate
SHU 9119 acetate: hMC3R & hMC4R antagonist, hMC5R partial agonist. IC50: MC3R 0.23nM, MC4R 0.06nM, MC5R 0.09nM.Formula:C56H75N15O11Purezza:99.8%Colore e forma:SolidPeso molecolare:1134.29TGR5 Receptor Agonist
CAS:TGR5 is a potent TGR5(GPCR19) agonist.Formula:C18H14Cl2N2O2Purezza:99.77% - ≥95%Colore e forma:SolidPeso molecolare:361.22Metoclopramide
CAS:Metoclopramide: dopamine D2 antagonist, treats nausea, vomiting, gastroparesis, GERD; safe for pregnancy.Formula:C14H22ClN3O2Purezza:99.75%Colore e forma:SolidPeso molecolare:299.80GR-73632
CAS:Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).Formula:C40H59N7O6SPurezza:99.68%Colore e forma:SolidPeso molecolare:766Naftopidil dihydrochloride
CAS:Naftopidil dihydrochloride (KT-611 2HCl) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.Formula:C24H28N2O3·2HClPurezza:99.76%Colore e forma:White SolidPeso molecolare:465.415-Iodotubercidin
CAS:5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM.
Formula:C11H13IN4O4Purezza:99.98%Colore e forma:Tan SolidPeso molecolare:392.15Zotepine
CAS:Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM,Formula:C18H18ClNOSPurezza:99.78%Colore e forma:SolidPeso molecolare:331.86Exo-1
CAS:Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, asFormula:C15H12FNO3Purezza:99.45%Colore e forma:SolidPeso molecolare:273.26Ref: TM-T9200
5mg52,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€200mg388,00€500mg642,00€1mL*10mM (DMSO)65,00€Mebhydrolin
CAS:Mebhydrolin (Mebhydroline) is a specific histamine H1 receptor antagonist.Formula:C19H20N2Purezza:99.3% - ≥98%Colore e forma:SolidPeso molecolare:276.38Fexofenadine
CAS:Fexofenadine, a non-sedating antihistamine, treats allergies like hay fever and urticaria.Formula:C32H39NO4Purezza:99.35%Colore e forma:White To Off-White SolidPeso molecolare:501.66Idalopirdine Hydrochloride
CAS:Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.
Formula:C20H20ClF5N2OPurezza:99.77%Colore e forma:SolidPeso molecolare:434.83Dimemorfan phosphate
CAS:Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Formula:C18H25N·H3O4PPurezza:99.65%Colore e forma:SolidPeso molecolare:353.4TG6-10-1
CAS:TG6-10-1 is an EP2 antagonist.Formula:C23H23F3N2O4Purezza:99.66% - ≥95%Colore e forma:SolidPeso molecolare:448.43BAR501
CAS:BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。Formula:C26H46O3Purezza:99.29% - 99.68%Colore e forma:SolidPeso molecolare:406.64ANP(1-28) Acetate (human, porcine)
CAS:Carperitide acetate: 28-amino acid hormone from human heart, counters cardiac injury/stretch, reduces endothelin-1.Formula:C129H207N45O41S3Purezza:98.24%Colore e forma:SolidPeso molecolare:3140.5Ref: TM-TP1220L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.388,00€100mg1.872,00€200mg2.527,00€ACTH 11-24 acetate(4237-93-8 free base)
CAS:ACTH 11-24 acetate is a cortisol-stimulating adrenocorticotrophin fragment and a competitive antagonist of ACTH 1-39 and 1-10.Formula:C79H138N24O18Purezza:>99.99%Colore e forma:SolidPeso molecolare:1712.12PEN (human) aceate
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.Formula:C99H163N27O34Purezza:99.25%Colore e forma:SolidPeso molecolare:2275.51
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