Proteina G/GPCR
Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.
Sottocategorie di "Proteina G/GPCR"
- recettore 5-HT(1.025 prodotti)
- Recettore dell'adenosina(249 prodotti)
- Recettore adrenergico(3.030 prodotti)
- Recettore della bombesina(35 prodotti)
- Recettore della bradichinina(61 prodotti)
- CXCR(159 prodotti)
- CaSR(34 prodotti)
- Recettore dei cannabinoidi(217 prodotti)
- Colecistochinina(1 prodotti)
- Recettore della dopamina(445 prodotti)
- Recettore dell'endotelina(86 prodotti)
- Recettore GNRH(84 prodotti)
- GPCR19(33 prodotti)
- GRK(33 prodotti)
- GTPase(22 prodotti)
- Recettore del glucagone(196 prodotti)
- Proteina Hedgehog/Smoothened(49 prodotti)
- Recettore dell'istamina(385 prodotti)
- Recettore LPA(21 prodotti)
- Recettore della melatonina(26 prodotti)
- Recettore OX(42 prodotti)
- Recettore degli oppioidi(325 prodotti)
- PAFR(14 prodotti)
- PKA(55 prodotti)
- Recettore S1P(17 prodotti)
- SGLT(31 prodotti)
- Recettore Sigma(46 prodotti)
Mostrare 19 più sottocategorie
Trovati 5985 prodotti di "Proteina G/GPCR"
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Endothelin-2 (49-69), human TFA
Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.Formula:C117H161N26F3O34S4Purezza:98%Colore e forma:SolidPeso molecolare:2660.94AA 497 HCl
CAS:AA 497, a beta-2 agonist, suppresses Ca spikes.Formula:C14H22ClNO3Colore e forma:SolidPeso molecolare:287.78Denrakibart
Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.Colore e forma:Odour LiquidCorazonin
CAS:Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.Formula:C62H83N17O19Colore e forma:SolidPeso molecolare:1370.42PSB-22269
PSB-22269 is identified as a GPR17 antagonist with a Ki value of 8.91 nM. It exhibits significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies indicate that the binding site of PSB-22269 includes positively charged arginine residues and a hydrophobic pocket. PSB-22269 promotes myelin regeneration strategies, offering potential for multiple sclerosis research.Formula:C26H21NO6Colore e forma:SolidPeso molecolare:443.45PD-149164
CAS:PD-149164 is an agonist of the CCK-A receptor.Formula:C33H38FN3O5Colore e forma:SolidPeso molecolare:575.67Cabergoline
CAS:Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.
Formula:C26H37N5O2Purezza:97.69% - 99.86%Colore e forma:White Crystalline SolidPeso molecolare:451.6MD01-67
CAS:MD01-67 is a macrocyclic compound selectively targeting the neurotensin 2 receptor (NTS2), with a Ki of 2.9 nM. It exhibits analgesic activity and reduces tactile hypersensitivity in rat models of acute, sustained, and chronic inflammatory pain.Formula:C37H58N8O8Colore e forma:SolidPeso molecolare:742.91Quinelorane
CAS:Quinelorane is dextrorotary isomer.Formula:C14H22N4Colore e forma:SolidPeso molecolare:246.35Azirkitug
Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidThielocin B1
CAS:Thielocin B1, a PAC3 inhibitor and novel PLA2 blocker, is derived from Thielavia terricola RF-143's culture.Formula:C53H58O17Colore e forma:SolidPeso molecolare:967.02Triamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Formula:C12H11N7Purezza:99.77%Colore e forma:Yellow Yellow SolidPeso molecolare:253.26[Des-His1,Glu9]-Glucagon amide
CAS:Glucagon blocker with pA2 of 7.2; no agonist effect. Boosts insulin; prevents glucagon-driven hyperglycemia in rabbits and diabetic rats.Formula:C148H221N41O47SPurezza:98%Colore e forma:SolidPeso molecolare:3358.68TGR5 agonist 6
CAS:Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.Formula:C42H48Cl2N6O6Colore e forma:SolidPeso molecolare:803.77CCR4 antagonist 3 hydrochloride
CAS:Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Formula:C24H27Cl2N7O·xHClColore e forma:Solidpalm11-PrRP31
Palm11-PrRP31 is a lipid-modified analog of the endogenous appetite-suppressing neuropeptide (PrRP). It functions as a potent dual agonist for GPR10 (EC50 = 39 pM) and NPFF-R2. By mimicking the natural activity of PrRP, palm11-PrRP31 binds to these receptors to reduce food intake. It has potential applications as an anti-obesity agent and is useful in studying neuropeptide and receptor interactions.
Formula:C181H289N55O46SPeso molecolare:4001.16865Vatinoxan
CAS:Vatinoxan is a peripheral α2 adrenoreceptor antagonist.Formula:C20H26N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:418.51BIBP3226
CAS:BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor.Formula:C27H31N5O3Colore e forma:SolidPeso molecolare:473.57SKF-83566 hydrochloride
CAS:SKF-83566 hydrochloride is a D1-like dopamine receptor antagonist, inhibiting dopamine transporters and mitigating GBP-induced CPP.Formula:C17H19BrClNOPurezza:99.27%Colore e forma:SoildPeso molecolare:368.69Rp-UTP-α-S tetrasodium
Rp-UTP-α-S (tetrasodium) is a nucleotide agonist of the purinergic P2Y2 and P2Y4 receptors. It can induce the accumulation of inositol phosphate in 1321N1 cells expressing P2Y2 or P2Y4, with EC50 values of 5.4 and 27 μM, respectively.Colore e forma:Odour SolidNPS ALX Compound 4a hydrochloride(1:1)
NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.Formula:C25H26ClN3O2SPurezza:99.84%Colore e forma:SoildPeso molecolare:468.01Ref: TM-T12262L1
1mg40,00€5mg88,00€10mg119,00€25mg198,00€50mg288,00€100mg393,00€200mg520,00€1mL*10mM (DMSO)97,00€Endolide F
Endolide F (Compound 2) is a proline-containing lactone that serves as a moderate antagonist of the arginine vasopressin V1A receptor.Formula:C25H32N4O6Peso molecolare:484.23218Berobenatide
CAS:Berobenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist.Colore e forma:SolidCholic Acid 7-sulfate
CAS:Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.Formula:C24H40O8SColore e forma:SolidPeso molecolare:488.64Ref: TM-T37854
1mgPrezzo su richiesta5mgPrezzo su richiesta10mgPrezzo su richiesta500µgPrezzo su richiestaA 77636 hydrochloride
CAS:A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM).
Formula:C20H28ClNO3Purezza:99.57%Colore e forma:SolidPeso molecolare:365.89Carazolol-d7
CAS:Carazolol-d7 is the deuterium-labeled isotope of Carazolol, commonly used in pharmacokinetic studies to investigate the metabolic pathways of Carazolol.Formula:C18H22N2O2Colore e forma:SolidPeso molecolare:305.42GW-328267
CAS:GW-328267 is an agonist of the adenosine A2 receptor.Formula:C21H26N10O4Colore e forma:SolidPeso molecolare:482.5Nolomirole
CAS:Nolomirole is a dopamine receptor agonist that reduces symptoms of congestive heart failure caused by monoclinine.Formula:C19H27NO4Colore e forma:SolidPeso molecolare:333.42LysoPalloT-NH-amide-C3-ph-m-O-C11
CAS:LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist of the GPR174 receptor with an EC50 value of 34 nM.Formula:C27H47N2O9PColore e forma:SolidPeso molecolare:574.64Pneumadin, rat
CAS:Rat Pneumadin (PNM), a decapeptide, stimulates AVP release, exerting strong antidiuretic effects in animals with an active AVP system.Formula:C47H74N12O15Purezza:98%Colore e forma:SolidPeso molecolare:1047.17817-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
CAS:Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
Formula:C26H36F3NO4Colore e forma:SolidPeso molecolare:483.572Khusimol
CAS:Khusimol is a vasopressin V1a receptors non-peptide ligand that acts by inhibiting the binding of vasopressin.Formula:C15H24OPurezza:98%Colore e forma:SolidPeso molecolare:220.35THX-B
CAS:THX-B, a potent non-peptidic p75 NTR antagonist, aids in researching diabetic kidney disease and neurodegenerative and inflammatory disorders.Formula:C16H24N6O4Colore e forma:SolidPeso molecolare:364.4Bradykinin (1-6)
CAS:Bradykinin (1-6) is a stable, CPY-cleaved metabolite that triggers pain, induces muscle contractions, and activates NO synthetase.Formula:C30H45N9O8Purezza:98%Colore e forma:SolidPeso molecolare:659.73HTL22562
CAS:HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.Formula:C40H49N11O5Colore e forma:SolidPeso molecolare:763.904N-desmethyl Zolmitriptan
CAS:DZT, an active metabolite of zolmitriptan, agonizes 5-HT1B/D receptors; contracts human cerebral arteries (EC50=100nM).Formula:C15H19N3O2Colore e forma:SolidPeso molecolare:273.33Cisapride hydrate
CAS:Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.Formula:C23H31ClFN3O5Purezza:98%Colore e forma:SolidPeso molecolare:483.96GLP-1R agonist 15
CAS:GLP-1R agonist 15 (Compound 101) is a GLP-1 receptor agonist [1] .Formula:C46H47FN8O7SColore e forma:SolidPeso molecolare:874.98Survodutide
CAS:Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptor (GLP Receptor) that reduces body weight in HbA1c16 diabetes.Formula:C192H289N47O61Purezza:99.83%Colore e forma:SolidPeso molecolare:4229.0957Betahistine mesylate
CAS:Betahistine mesylate (Extovyl), an H1 agonist and vasodilator, treats Meniere's disease and vascular headaches; risks with asthma/ulcers.
Formula:C8H12N2·2(CH4O3S)Purezza:98% - 99.85%Colore e forma:CoaPeso molecolare:328.4SB236057
CAS:SB236057: potent selective inverse agonist at 5-HT autoreceptors; increases brain 5-HT; teratogen causing musculoskeletal defects in rodents.Formula:C33H34N4O3Purezza:98%Colore e forma:SolidPeso molecolare:534.65Big Gastrin I (human) TFA
BigGastrinI, human (TFA), is a gastrointestinal hormone comprised of 34 amino acids. It can serve as a potential substance in the study of conditions such as cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological disorders, or cardiovascular diseases.Formula:C178H252F3Peso molecolare:2446.96712CB2 receptor antagonist 2
Compound 39, also known as CB2 receptor antagonist 2, is a potent CB2 antagonist exhibiting an IC50 of 0.33 μM.Colore e forma:Odour SolidRamelteon metabolite M-II
CAS:Ramelteon M-II binds MT1/MT2 with IC50s: 208/1470 pM; it's the main metabolite and a melatonin receptor agonist.Formula:C16H21NO3Purezza:98%Colore e forma:SolidPeso molecolare:275.34CB2 receptor agonist 2
CAS:CB2 receptor agonist 2 (ZINC72105556): potent, Ki=8.5 nM, high selectivity for CB2.
Formula:C30H36N2O4Purezza:99.75%Colore e forma:SolidPeso molecolare:488.62Ono 3708
CAS:Ono-3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo.Formula:C23H37NO4Purezza:98%Colore e forma:SolidPeso molecolare:391.5417-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
CAS:A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones
Formula:C24H33F3O5Colore e forma:SolidPeso molecolare:458.518(Iso)-WAY-260022
CAS:(Iso)-WAY-260022 ((Iso)-NRI-022) is a stereoisomer of WAY-260022, a norepinephrine reuptake inhibitor and selective inhibitor of 5-hydroxytryptamine and dopamine transport proteins.Formula:C21H31F3N2O2Purezza:97.68% - 99.36%Colore e forma:SoildPeso molecolare:400.48GLP-1R agonist 34
CAS:GLP-1R agonist 34 (Compound 1) is an orally active small molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R). It enhances insulin secretion, suppresses glucagon release, and slows gastric emptying, thereby effectively reducing blood glucose levels. GLP-1R agonist 34 holds potential for research into metabolic disorders such as type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).Formula:C50H50F2N10O5Colore e forma:SolidPeso molecolare:908.99Cannabigerorcin
CAS:Cannabigerorcin, a phytocannabinoid, serves as an analytical reference standard. It is designated for research and forensic applications.Formula:C17H24O2Colore e forma:SolidPeso molecolare:260.377
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