Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(144 prodotti)
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Trovati 1030 prodotti di "Segnalazione PI3K/Akt/mTOR"
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Lumretuzumab
CAS:<p>Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.</p>Purezza:95.3% (SDS-PAGE); 96.4% (SEC-HPLC) - 95.3% (SDS-PAGE); 96.4% (SEC-HPLC)Colore e forma:LiquidGSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Formula:C14H10N2OPurezza:99.40%Colore e forma:SolidPeso molecolare:222.24PROTAC PI3K/110β degrader-1
CAS:<p>PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.</p>Formula:C51H65N9O9SColore e forma:SolidPeso molecolare:980.18GSK-3 inhibitor 3
CAS:<p>GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively</p>Formula:C23H15FN6OPurezza:99.89%Colore e forma:SoildPeso molecolare:410.4AMX-818
<p>AMX-818 is a conditionally activated, masked T cell engager (TCE) that targets HER2. It demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines and can induce tumor regression in vivo. AMX-818 holds promise for research into HER2-positive solid tumors.</p>Colore e forma:Odour LiquidEGFRvIII peptide (PEPvIII)
CAS:<p>PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes.</p>Formula:C70H111N19O24SPurezza:98%Colore e forma:SolidPeso molecolare:1634.81EGFR-IN-162
<p>EGFR-IN-162 (compound 20) is an effective EGFR inhibitor that enhances both early and late apoptosis (EGFR) as well as necrosis (necrosis). It shows potential for use in breast cancer research.</p>Formula:C27H31N3O2Colore e forma:SolidPeso molecolare:429.241632B-(SP)
CAS:<p>Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)</p>Formula:C71H123N26O29PPurezza:98%Colore e forma:SolidPeso molecolare:1835.87mTOR inhibitor WYE-28
CAS:<p>Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).</p>Formula:C30H34N8O5Colore e forma:SolidPeso molecolare:586.653GSK-3 Inhibitor 5
CAS:<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formula:C9H6BrNOPurezza:99.58%Colore e forma:Off-White To Light Yellow Crystalline PowderPeso molecolare:224.05GSK251
CAS:<p>GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.</p>Formula:C29H37FN6O4SPurezza:99.8%Colore e forma:SolidPeso molecolare:584.71MS9427 TFA
<p>MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.</p>Formula:C50H59ClF4N8O14Colore e forma:SolidPeso molecolare:1107.5Pertuzumab
CAS:<p>Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2</p>Purezza:98.00%Colore e forma:LiquidPeso molecolare:148 kDaMS39N
CAS:<p>MS39N (compound 27) serves as the negative control for MS39, capable of binding to EGFR without causing its degradation.</p>Formula:C55H71ClFN9O7SPeso molecolare:1056.73Vislarafusp alfa
<p>Vislarafusp alfa is a humanized IgG1κ antibody that targets EGFR/CD47, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidAzerutamig
<p>Azerutamig is a dual-specificity antibody targeting KLRK1/ERBB2 of type (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3).</p>Colore e forma:Odour LiquidIHMT-PI3Kδ-372 S-isomer
CAS:<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Formula:C26H23F2N7O2Purezza:99.97%Colore e forma:SoildPeso molecolare:503.5EGFR WT/T790M/L858R-IN-1
EGFRWT/T790M/L858R-IN-1 (compound 10d) is a potent inhibitor of EGFR, demonstrating IC50 values of 0.097, 0.280, and 0.051 μM for EGFRWT, EGFRT790M, and EGFRL858R, respectively. This compound can be utilized in cancer research.Formula:C26H25Cl3N2O3Peso molecolare:518.09308Duvelisib (R enantiomer) hydrochloride
<p>Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.</p>Formula:C22H18Cl2N6OPurezza:99.88% - >99.99%Colore e forma:SoildPeso molecolare:453.32(S)-STX-478
CAS:(S)-STX-478 is the S-isomer of STX-478. STX-478 is a PI3Kα inhibitor with anticancer activity, inhibiting tumor growth.Formula:C16H12F5N5O2Colore e forma:SoildPeso molecolare:401.29EGFR ligand-11
CAS:<p>EGF Rligand-11, a target protein ligand for EGFR, is utilized in the synthesis of PROTAC MS154.</p>Formula:C25H29ClFN5O4Colore e forma:SolidPeso molecolare:517.98Varlitinib
CAS:Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Formula:C22H19ClN6O2SPurezza:99.7%Colore e forma:SolidPeso molecolare:466.94mTOR inhibitor 9c
CAS:<p>mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.</p>Formula:C21H22FN5O2SPurezza:99.23%Colore e forma:SoildPeso molecolare:427.5AMPK activator 15
<p>AP39 Prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. In hepatocytes, it induces ROS-dependent mild mitochondrial uncoupling, activates mitochondria-associated AMPK, and inhibits Palmitic acid (PA)-induced lipid accumulation.</p>Formula:C53H51BrNO10PSColore e forma:SolidPeso molecolare:1004.92BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formula:C21H16N2O6Colore e forma:SolidPeso molecolare:392.36SOS1/EGFR-IN-2
<p>SOS1/EGFR-IN-2 (Compound 4) functions as a dual inhibitor of SOS1 and EGFR, exhibiting IC50 values of 8.3 and 14.6 nM, respectively. It demonstrates significant antiproliferative effects on cancer cells harboring various KRAS mutations.</p>Formula:C25H29F3N4O3Colore e forma:SolidPeso molecolare:490.52EGFR-IN-148
<p>EGFR-IN-148 (compound 8c) is a potent EGFR inhibitor with an IC50 of 0.161 μM. It induces G1/S phase arrest and significantly enhances apoptosis in HepG2 cells.</p>Formula:C17H16N4O4SColore e forma:SolidPeso molecolare:372.398EGFR T790M/L858R-IN-9
<p>EGFRT790M/L858R-IN-9 (Compound 8) is an inhibitor targeting the EGFR-L858R/T790M mutations. It effectively inhibits the phosphorylation of the EGFR-L858R/T790M mutant kinase, demonstrating an IC50 value of 0.0064 µM. Additionally, EGFRT790M/L858R-IN-9 can suppress the proliferation of non-small cell lung cancer (NSCLC) cells, making it useful for cancer research.</p>Formula:C26H27N7O3SColore e forma:SolidPeso molecolare:517.603PI3Kγ ligand 1
CAS:<p>PI3Kγ ligand 1 serves as a PROTAC target protein ligand (Ligand for Target Protein for PROTAC).</p>Formula:C26H29N5O3SColore e forma:SolidPeso molecolare:491.61TX2-120-1
CAS:<p>TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.</p>Formula:C26H27N7O2Colore e forma:SolidPeso molecolare:469.54Caxmotabart
<p>Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.</p>Colore e forma:Odour LiquidCalotatug
<p>Calotatug is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidBI-4732
CAS:<p>DL-Homocystine is a mutagen secreted by F. nucleatum.</p>Formula:C32H36N10O2Purezza:98.88%Colore e forma:SolidPeso molecolare:592.69CZY43
<p>CZY43 is an HER3 degrader that effectively induces degradation of HER3 in breast cancer SKBR3 cells in a dose- and time-dependent manner. It efficiently inhibits HER3-dependent signaling and cancer cell growth, outperforming Bosutinib.</p>Formula:C42H53Cl2N5O3Colore e forma:SolidPeso molecolare:746.808EGFR/VEGFR2-IN-5
<p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>Formula:C17H15N7O5SColore e forma:SolidPeso molecolare:429.41JBJ-09-063 TFA
<p>JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.</p>Formula:C33H30F4N4O5SColore e forma:SolidPeso molecolare:670.672DII
<p>2DII is a potent and selective mTORC2 inhibitor. It specifically binds to the mSin1 PH domain, resulting in a decreased phosphorylation of AKT1.</p>Formula:C54H76ClN7O11SColore e forma:SolidPeso molecolare:1066.74Zenocutuzumab
CAS:<p>Zenocutuzumab (MCLA-128) is a humanized antibody targeting HER2, used for research on tumors driven by NRG1 gene rearrangement.</p>Purezza:97%Colore e forma:LiquidTilatamig
<p>Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.</p>Colore e forma:Odour LiquidDalmitamig
<p>Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.</p>Colore e forma:Odour LiquidEGFR T790M/L858R-IN-6
CAS:<p>EGFR T790M/L858R-IN-6 (compound 53), classified as a pyrimidine compound, serves as an effective inhibitor of EGFR T790M/L858R, demonstrating 90.88% inhibition of enzyme activity at a concentration of 0.05 μM [1].</p>Formula:C27H27N7O2Colore e forma:SolidPeso molecolare:481.55EGFR-IN-124
<p>EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.</p>Colore e forma:Odour SolidQL-IX-55
CAS:<p>QL-IX-55 has a wide range of applications in life science related research.</p>Formula:C24H14F4N4OColore e forma:SolidPeso molecolare:450.39Thioether-cyclized helix B peptide, CHBP TFA
<p>Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP.</p>Formula:C56H93N19O22S·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:1416.52 (free base)FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidUmbralisib R-enantiomer
CAS:<p>Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.</p>Formula:C31H24F3N5O3Purezza:97.34%Colore e forma:SolidPeso molecolare:571.55GSK-3β inhibitor 22
CAS:<p>GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.</p>Formula:C18H12F3N3O2S2Colore e forma:SolidPeso molecolare:423.43MCX 28
CAS:<p>MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.</p>Formula:C25H19N5O4S3Colore e forma:SolidPeso molecolare:549.64Wnt/β-catenin agonist 2
CAS:<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Formula:C13H12N4O3Purezza:99.35%Colore e forma:SolidPeso molecolare:272.26Simotinib hydrochloride
CAS:<p>Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.</p>Formula:C25H27Cl2FN4O4Colore e forma:SolidPeso molecolare:537.41RMC-6272
CAS:<p>RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.</p>Formula:C95H141FN6O27SColore e forma:SolidPeso molecolare:1850.25DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Colore e forma:Odour SolidTyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Colore e forma:Odour SolidEGFR-IN-140
<p>EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.</p>Formula:C27H37FN8O2Colore e forma:SolidPeso molecolare:524.633MELK-8a Dihydrochloride
<p>MELK-8a Dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T35342.</p>Purezza:98%Colore e forma:SolidJAK 3 inhibitor IV
CAS:<p>JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to</p>Formula:C16H19NOPurezza:98%Colore e forma:SolidPeso molecolare:241.33ErbB-2-binding peptide
CAS:<p>ErbB-2-binding peptide (HER2-binding peptide), a tumor-targeting peptide, holds potential for cancer research applications [1].</p>Formula:C43H60N8O11Colore e forma:SolidPeso molecolare:864.98MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Formula:C17H12BrN3O2Purezza:99.64%Colore e forma:SolidPeso molecolare:370.2EGFR-IN-129
<p>EGFR-IN-129 (Compound 10b) is an effective, selective EGFR inhibitor with an IC50 of 51.2 nM and demonstrates broad-spectrum antiproliferative activity against the NCI tumor panel.</p>Formula:C21H18N4O3SColore e forma:SolidPeso molecolare:406.46(R)-VX-984
CAS:<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formula:C23H21D2N7OPurezza:98%Colore e forma:SolidPeso molecolare:415.49GSK3β Inhibitor XI
CAS:<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Formula:C18H15N5O3Colore e forma:SolidPeso molecolare:349.35IC 86621
CAS:<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Formula:C12H15NO3Purezza:99.68%Colore e forma:SolidPeso molecolare:221.25Oritinib
CAS:<p>Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (</p>Formula:C31H37N7O2Purezza:99.62%Colore e forma:SoildPeso molecolare:539.67PROTAC EGFR degrader 10
CAS:<p>PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.</p>Formula:C49H65ClN10O7SColore e forma:SolidPeso molecolare:973.62PI3K-IN-46
CAS:<p>PI3K-IN-46 is a specific inhibitor of PI3Kγ.</p>Formula:C13H9N3OSPurezza:97.51%Colore e forma:SoildPeso molecolare:255.3ZLN 024 hydrochloride
CAS:<p>ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).</p>Formula:C13H14BrClN2OSPurezza:98.541%Colore e forma:SolidPeso molecolare:361.68MS9449
CAS:<p>MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.</p>Formula:C60H76ClFN10O8SPurezza:98%Colore e forma:SolidPeso molecolare:1151.82U3-1565
<p>U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.</p>Colore e forma:LiquidPeso molecolare:144.82 kDa (Predicted)GSK2292767 FA
<p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>Formula:C25H30N6O7SPurezza:99.52%Colore e forma:SoildPeso molecolare:558.61ARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purezza:99.75%Colore e forma:SoildPeso molecolare:319.40740 Y-P(TFA)
<p>740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.</p>Formula:C143H223F3N43O41PS3Purezza:98%Colore e forma:SolidPeso molecolare:3384.73bpV(pic) (potassium hydrate)
CAS:<p>bpV(pic) (potassium hydrate) can be used in related research in the field of life sciences. Its product number is T35630 and CAS number is 148556-27-8.</p>Formula:C6H8K2NO9VColore e forma:SolidPeso molecolare:367.266Etevritamab
CAS:<p>Etevritamab is a monoclonal antibody that targets CD3E/EGFR.</p>Colore e forma:LiquidCH7233163
<p>CH7233163 is a useful organic compound for research related to life sciences and the catalog number is T35334.</p>Purezza:98%Colore e forma:SolidNecitumumab
CAS:Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Purezza:97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.5 kDaHDS 029
CAS:<p>HDS 029 has a wide range of applications in life science related research.</p>Formula:C17H11ClFN5OColore e forma:SolidPeso molecolare:355.76PROTAC EGFR degrader 11
CAS:<p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>Formula:C49H64ClFN10O7SColore e forma:SolidPeso molecolare:991.61Self-assembling peptide pY1
<p>Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.</p>Formula:C104H125N24O29PColore e forma:SolidPeso molecolare:2206.22DSPE-PEG5000-GE11
<p>DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.</p>Colore e forma:Odour SolidmTOR inhibitor 9e
CAS:<p>mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.</p>Formula:C22H23N5O2SPurezza:98.84%Colore e forma:SoildPeso molecolare:421.52EGFR-IN-22
CAS:<p>EGFR-IN-22: potent for EGFR (IC50: 4.91 nM) & L858R/T790M/C797S mutation (IC50: 0.54 nM).</p>Formula:C38H47BrFN10O2PColore e forma:SolidPeso molecolare:805.72Inetetamab
<p>Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.</p>Purezza:96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Colore e forma:Odour LiquidAnti-Phospho-EGFR (Tyr1068) Antibody (3Q245)
<p>Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) is an antibody targeting Phospho-EGFR (Tyr1068). Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) can be used in ELISA, WB.</p>Colore e forma:Odour LiquidAnti-EGFR Antibody (3B845)
<p>Anti-EGFR Antibody (3B845) is an antibody targeting EGFR. Anti-EGFR Antibody (3B845) can be used in ELISA, WB, IHC.</p>Colore e forma:Odour LiquidAnti-Phospho-EGFR (Tyr1092) Antibody (9I899)
<p>Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.</p>Colore e forma:Odour LiquidAnti-EGFR Antibody (9S619)
<p>Anti-EGFR Antibody (9S619) is an antibody targeting EGFR. Anti-EGFR Antibody (9S619) can be used in ELISA, IHC, FCM.</p>Colore e forma:Odour LiquidAnti-EGFR Antibody (7X976)
<p>Anti-EGFR Antibody (7X976) is an antibody targeting EGFR. Anti-EGFR Antibody (7X976) can be used in ELISA, WB, IHC, IF, FCM.</p>Colore e forma:Odour LiquidPF-06843195
CAS:<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Formula:C20H25F3N8O4Purezza:98.01%Colore e forma:SolidPeso molecolare:498.46RMC-5552
CAS:<p>RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.</p>Formula:C93H136N10O24Colore e forma:SolidPeso molecolare:1778.16BI-4142
CAS:<p>BI-4142 is a HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.</p>Formula:C28H27N9O2Purezza:97.21% - 98.09%Colore e forma:SolidPeso molecolare:521.57Tucatinib hemiethanolate
CAS:<p>Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.</p>Formula:C54H54N16O5Purezza:99.76%Colore e forma:SolidPeso molecolare:1007.11Erlotinib-d6
CAS:<p>Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .</p>Formula:C22H23N3O4Purezza:98%Colore e forma:SolidPeso molecolare:399.47(3S,4S)-PF-06459988
CAS:<p>(3S, 4S)-PF-06459988, a less active S enantiomer, specifically inhibits T790M mutant EGFR with high selectivity.</p>Formula:C19H22ClN7O3Colore e forma:SolidPeso molecolare:431.88EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Colore e forma:Lyophilized PowderPeso molecolare:69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Colore e forma:Lyophilized PowderPeso molecolare:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 60-78 kDa based on Tris-Bis PAGE result.EGFRVIII Protein, Human, Recombinant (His & Avi)
<p>The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.</p>Colore e forma:Lyophilized PowderPeso molecolare:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Colore e forma:Lyophilized PowderPeso molecolare:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Formula:C35H58N6O9Purezza:98.59%Colore e forma:SolidPeso molecolare:706.87EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
<p>EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-120 kDa based on Tris-Bis PAGE result.EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
<p>EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:60-90 KDa (reducing condition)EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
<p>The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.</p>Colore e forma:Lyophilized PowderPeso molecolare:41.6 kDa (predicted)EGFR vIII Protein, Human, Recombinant (His)
<p>EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:61-75 Kda (reducing condition)EGFR Protein, Human, Recombinant (His & Avi)
<p>EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag.Colore e forma:Lyophilized PowderPeso molecolare:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.Kinetin triphosphate tetrasodium
<p>Kinetin triphosphate tetrasodium is salt form of Kinetin triphosphate KTP, an ATP analog that enhances activity of Parkinson's disease-associated mutant PINK1.</p>Formula:C15H16N5Na4O14P3Purezza:96.80%Colore e forma:SoildPeso molecolare:675.19Brivanib
CAS:<p>Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against</p>Formula:C19H19FN4O3Purezza:98.87%Colore e forma:SolidPeso molecolare:370.38EGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Colore e forma:Lyophilized PowderPeso molecolare:90-120 KDa (reducing condition)PI3K-IN-30
CAS:<p>PI3K-IN-30 (compound 6d) 是一种 PI3K 的有效抑制剂，能够作用于 PI3Kα (IC50: 5.1 nM)、PI3Kβ (IC50: 136 nM)、PI3Kγ (IC50: 30.7 nM) 和 PI3Kδ (IC50: 8.9 nM)。</p>Formula:C20H25F2N7O3Colore e forma:SolidPeso molecolare:449.45AV-412 free base
CAS:<p>AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).</p>Formula:C27H28ClFN6OColore e forma:SolidPeso molecolare:507PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Formula:C15H9ClN2O2S3Purezza:98%Colore e forma:SolidPeso molecolare:380.89Osimertinib dimesylate
CAS:Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formula:C30H41N7O8S2Purezza:98%Colore e forma:SolidPeso molecolare:691.82Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formula:C18H22FN9O2Purezza:99.89%Colore e forma:SolidPeso molecolare:415.42Neratinib maleate
CAS:Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.Formula:C34H33ClN6O7Purezza:99.99%Colore e forma:SolidPeso molecolare:673.11Rociletinib hydrobromide
CAS:Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).Formula:C27H29BrF3N7O3Purezza:98%Colore e forma:SolidPeso molecolare:636.46Rilematovir
CAS:<p>Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.</p>Formula:C21H20ClF3N4O3SPurezza:99.82%Colore e forma:SolidPeso molecolare:500.92Ceftriaxone Sodium
CAS:<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formula:C18H17N8NaO7S3Colore e forma:SolidPeso molecolare:576.562AMA-37
CAS:<p>AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.</p>Formula:C17H17NO3Purezza:98%Colore e forma:SolidPeso molecolare:283.32Tyrphostin 8
CAS:<p>Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein</p>Formula:C10H6N2OPurezza:99.86%Colore e forma:SolidPeso molecolare:170.17Anti-EGFR Monoclonal Antibody-Biotin
Antibody Type: Rabbit Monoclonal<br> Application: FCM<br> Reactivity: HumanPurezza:> 95% as determined by SDS-PAGE.Colore e forma:LiquidPeso molecolare:150 kDaAnti-EGFR Monoclonal Antibody
<p>Antibody Type: Rabbit Monoclonal<br><br>Application: FCM<br><br>Reactivity: Human</p>Purezza:> 95% as determined by SDS-PAGE.Colore e forma:LiquidPeso molecolare:150 kDaTX1-85-1
CAS:<p>TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.</p>Formula:C32H36N8O3Purezza:98.12% - 98.12%Colore e forma:SolidPeso molecolare:580.68Sulforaphene
CAS:<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Formula:C6H9NOS2Purezza:97.55% - 99.19%Colore e forma:Slightly Yellowish LiquidPeso molecolare:175.27Tyrphostin B44, (+) enantiomer
CAS:<p>Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)</p>Formula:C18H16N2O3Purezza:97.18%Colore e forma:SolidPeso molecolare:308.33GSK2334470
CAS:<p>GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.</p>Formula:C25H34N8OPurezza:99.57% - 99.87%Colore e forma:SolidPeso molecolare:462.59GNE-317
CAS:<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Formula:C19H22N6O3SPurezza:98.42% - 99.54%Colore e forma:SolidPeso molecolare:414.48RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formula:C17H20N4O2Purezza:99.30%Colore e forma:SolidPeso molecolare:312.37Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Formula:C23H27N5O5SPurezza:97.69% - 99.25%Colore e forma:SolidPeso molecolare:485.56TGX-221
CAS:<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formula:C21H24N4O2Purezza:99.68% - >99.99%Colore e forma:SolidPeso molecolare:364.44PD-161570
CAS:<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formula:C26H35Cl2N7OPurezza:99.92%Colore e forma:SolidPeso molecolare:532.51AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H15ClIN3O2Purezza:98.64%Colore e forma:SolidPeso molecolare:443.66Trastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Purezza:97.1% (SDS-PAGE); 99.2% (SEC-HPLC) - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Colore e forma:LiquidPeso molecolare:Approximately 145.53 kDaOlafertinib
CAS:<p>Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.</p>Formula:C29H28F2N6O2Purezza:98.62% - 99.706%Colore e forma:SolidPeso molecolare:530.57IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formula:C22H20FN3O2Purezza:99.42% - >99.99%Colore e forma:SolidPeso molecolare:377.41AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Formula:C22H24N4O4Purezza:99.79% - 99.95%Colore e forma:SolidPeso molecolare:408.45AEE788
CAS:<p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>Formula:C27H32N6Purezza:98% - >99.99%Colore e forma:SolidPeso molecolare:440.58Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formula:C15H12O5Purezza:98.76% - >99.99%Colore e forma:SolidPeso molecolare:272.25BI-4020
CAS:<p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>Formula:C30H38N8O2Purezza:97.21% - >99.99%Colore e forma:SolidPeso molecolare:542.68Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formula:C13H14N6OPurezza:98.21% - 99.69%Colore e forma:SolidPeso molecolare:270.29(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formula:C29H35ClFN7O3Purezza:99.64%Colore e forma:SolidPeso molecolare:584.08KU-0063794
CAS:<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Formula:C25H31N5O4Purezza:98.21% - >99.99%Colore e forma:SolidPeso molecolare:465.54Saracatinib
CAS:<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Formula:C27H32ClN5O5Purezza:98% - 99.63%Colore e forma:SolidPeso molecolare:542.03Tuxobertinib
CAS:<p>Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.</p>Formula:C29H29ClN6O4Purezza:99.22%Colore e forma:SolidPeso molecolare:561.03GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurezza:98.86%Colore e forma:SolidPeso molecolare:337.36YKL-05-099
CAS:<p>YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 and SIK3.Cost-effective and quality-assured.</p>Formula:C32H34ClN7O3Purezza:99.57% - 99.66%Colore e forma:SolidPeso molecolare:600.11WS6
CAS:<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formula:C29H31F3N6O3Purezza:97.65% - 99.95%Colore e forma:SolidPeso molecolare:568.59PKI-166 hydrochloride
CAS:<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Formula:C20H19ClN4OColore e forma:SolidPeso molecolare:366.85Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Formula:C23H20FN7OPurezza:97.96%Colore e forma:SolidPeso molecolare:429.45NRC-2694
CAS:<p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>Formula:C24H26N4O3Purezza:99.90%Colore e forma:SolidPeso molecolare:418.49AR-A014418
CAS:<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formula:C12H12N4O4SPurezza:>99.99% - ≥95%Colore e forma:SolidPeso molecolare:308.31GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formula:C18H22N8O2Purezza:99.72% - 99.87%Colore e forma:SolidPeso molecolare:382.42YKL-06-061
CAS:<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Formula:C30H37N7O2Purezza:99.52% - 99.79%Colore e forma:SolidPeso molecolare:527.66CL-387785
CAS:<p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>Formula:C18H13BrN4OPurezza:99.56% - 99.62%Colore e forma:SolidPeso molecolare:381.23TAS0728
CAS:<p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>Formula:C26H32N8O3Purezza:97.78%Colore e forma:SolidPeso molecolare:504.58WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purezza:97.93% - 99.94%Colore e forma:SolidPeso molecolare:569.58Mutant EGFR inhibitor
CAS:<p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>Formula:C27H30ClN7O2Purezza:98% - 99.75%Colore e forma:SolidPeso molecolare:520.03HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formula:C29H34ClN7OPurezza:99.75% - >99.99%Colore e forma:SolidPeso molecolare:532.08Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formula:C29H32N6O8Colore e forma:SolidPeso molecolare:592.6KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purezza:98.06%Colore e forma:SolidPeso molecolare:360.19NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formula:C20H14F3N3SPurezza:99.84% - 99.9%Colore e forma:SolidPeso molecolare:385.41KI8751
CAS:<p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>Formula:C24H18F3N3O4Purezza:99.22% - 99.9%Colore e forma:SolidPeso molecolare:469.41Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formula:C25H24N4O2Purezza:98.19% - 98.75%Colore e forma:Orange SolidPeso molecolare:412.48RG13022
CAS:<p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>Formula:C16H14N2O2Purezza:98.38%Colore e forma:SolidPeso molecolare:266.29JCN037
CAS:<p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>Formula:C16H11BrFN3O2Purezza:99.5%Colore e forma:SolidPeso molecolare:376.18GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formula:C17H20N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.44NU 7026
CAS:<p>NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition</p>Formula:C17H15NO3Purezza:99.51% - >99.99%Colore e forma:SolidPeso molecolare:281.31Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Formula:C28H31F3N8O2Purezza:99.87%Colore e forma:SolidPeso molecolare:568.59PF-6274484
CAS:<p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>Formula:C18H14ClFN4O2Purezza:97.71%Colore e forma:SolidPeso molecolare:372.78ARN-3236
CAS:<p>ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM</p>Formula:C19H16N2O2SPurezza:98.89% - 99.7%Colore e forma:SolidPeso molecolare:336.41ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formula:C19H21F2N7O2Purezza:98.29% - 99.95%Colore e forma:White PowderPeso molecolare:417.41MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Formula:C18H16N2O2Purezza:99.66%Colore e forma:SolidPeso molecolare:292.33Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Formula:C30H29ClN6O3Purezza:96.17% - 99.85%Colore e forma:SolidPeso molecolare:557.04KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurezza:97.14% - 98.99%Colore e forma:Tan SolidPeso molecolare:327.18CC-115 hydrochloride
CAS:<p>CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.</p>Formula:C16H17ClN8OColore e forma:SolidPeso molecolare:372.82PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formula:C22H24N2O3Purezza:98.92%Colore e forma:SolidPeso molecolare:364.44AZD8931 diFuMaric acid
CAS:<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Formula:C31H33ClFN5O11Purezza:99.92%Colore e forma:SolidPeso molecolare:706.1AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Formula:C16H12N2O3Purezza:98.69%Colore e forma:SolidPeso molecolare:280.28Dorsomorphin
CAS:<p>Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.</p>Formula:C24H25N5OPurezza:98% - 99.06%Colore e forma:SolidPeso molecolare:399.49Idelalisib
CAS:<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formula:C22H18FN7OPurezza:98% - 99.39%Colore e forma:SolidPeso molecolare:415.42BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formula:C28H25F3N6O2Purezza:95.74% - 99.51%Colore e forma:SolidPeso molecolare:534.53UCB9608
CAS:<p>UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.</p>Formula:C20H26N8O2Purezza:97.53% - 99.59%Colore e forma:SolidPeso molecolare:410.47AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formula:C22H28FN9O3SPurezza:≥98%Colore e forma:SolidPeso molecolare:517.58Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purezza:98.3% - 99.33%Colore e forma:SolidPeso molecolare:607.62Torin 2
CAS:<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formula:C24H15F3N4OPurezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:432.4Dacomitinib
CAS:<p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>Formula:C24H25ClFN5O2Purezza:99.4% - 99.72%Colore e forma:SolidPeso molecolare:469.94HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formula:C26H28N8OPurezza:98.38% - 99.70%Colore e forma:SolidPeso molecolare:468.55AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formula:C16H18N2OPurezza:98.12%Colore e forma:SolidPeso molecolare:254.33TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formula:C10H10N2O2SPurezza:97.13% - 99.61%Colore e forma:White SolidPeso molecolare:222.26Taselisib
CAS:<p>Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.</p>Formula:C24H28N8O2Purezza:99.62% - 99.79%Colore e forma:SolidPeso molecolare:460.53ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Formula:C19H16BrFN6O2Purezza:99.12%Colore e forma:SolidPeso molecolare:459.27Tyrphostin AG30
CAS:<p>Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.</p>Formula:C10H7NO4Purezza:99.02%Colore e forma:SolidPeso molecolare:205.174-Chloro-2'-bromoacetophenone
CAS:<p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>Formula:C8H6BrClOPurezza:98.34% - 99.41%Colore e forma:White To Beige SolidPeso molecolare:233.49PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Formula:C11H9N5Purezza:98.61%Colore e forma:Whit To Off-White SolidPeso molecolare:211.22PP2
CAS:<p>PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.</p>Formula:C15H16ClN5Purezza:98% - 98.21%Colore e forma:White SolidPeso molecolare:301.77Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formula:C29H31Cl2FN4OColore e forma:SolidPeso molecolare:541.49WHI-P180
CAS:<p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>Formula:C16H15N3O3Purezza:99.21%Colore e forma:SolidPeso molecolare:297.31Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Formula:C21H25F3N6O2Purezza:99.88%Colore e forma:SolidPeso molecolare:450.46WHI-P154
CAS:<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formula:C16H14BrN3O3Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:376.2SU5204
CAS:<p>SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and</p>Formula:C17H15NO2Purezza:99.46%Colore e forma:SolidPeso molecolare:265.31AMG319
CAS:<p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.</p>Formula:C21H16FN7Purezza:98.9% - 99.24%Colore e forma:Crystalline SolidPeso molecolare:385.4PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS:<p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>Formula:C18H21Cl3N4OPurezza:99.5%Colore e forma:SolidPeso molecolare:415.75
