Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(145 prodotti)
Mostrare 2 più sottocategorie
Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"
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Saracatinib
CAS:<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Formula:C27H32ClN5O5Purezza:98% - 99.63%Colore e forma:SolidPeso molecolare:542.03AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Formula:C22H28FN9O3SPurezza:≥98%Colore e forma:SolidPeso molecolare:517.58Mutant EGFR inhibitor
CAS:<p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>Formula:C27H30ClN7O2Purezza:98% - 99.75%Colore e forma:SolidPeso molecolare:520.03YKL-06-061
CAS:<p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>Formula:C30H37N7O2Purezza:99.52% - 99.79%Colore e forma:SolidPeso molecolare:527.66YKL-05-099
CAS:<p>YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 and SIK3.Cost-effective and quality-assured.</p>Formula:C32H34ClN7O3Purezza:99.57% - 99.66%Colore e forma:SolidPeso molecolare:600.11HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formula:C29H34ClN7OPurezza:99.75% - >99.99%Colore e forma:SolidPeso molecolare:532.08CL-387785
CAS:<p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>Formula:C18H13BrN4OPurezza:99.56% - 99.62%Colore e forma:SolidPeso molecolare:381.23WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purezza:97.93% - 99.94%Colore e forma:SolidPeso molecolare:569.58UCB9608
CAS:<p>UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.</p>Formula:C20H26N8O2Purezza:97.53% - 99.59%Colore e forma:SolidPeso molecolare:410.47Buformin hydrochloride
CAS:<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>Formula:C6H16ClN5Purezza:97.83%Colore e forma:SolidPeso molecolare:193.68JCN037
CAS:<p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>Formula:C16H11BrFN3O2Purezza:99.5%Colore e forma:SolidPeso molecolare:376.18GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Formula:C17H20N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.44KI8751
CAS:<p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>Formula:C24H18F3N3O4Purezza:99.22% - 99.9%Colore e forma:SolidPeso molecolare:469.41KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purezza:98.06%Colore e forma:SolidPeso molecolare:360.19TAS0728
CAS:<p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>Formula:C26H32N8O3Purezza:97.78%Colore e forma:SolidPeso molecolare:504.58Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formula:C29H32N6O8Colore e forma:SolidPeso molecolare:592.6Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Formula:C30H24N8O2Purezza:99.04% - 99.28%Colore e forma:SolidPeso molecolare:528.56Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formula:C25H24N4O2Purezza:98.19% - 98.75%Colore e forma:Orange SolidPeso molecolare:412.48RG13022
CAS:<p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>Formula:C16H14N2O2Purezza:98.38%Colore e forma:SolidPeso molecolare:266.29NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFormula:C17H15NO3Purezza:99.51% - >99.99%Colore e forma:SolidPeso molecolare:281.31Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Formula:C28H31F3N8O2Purezza:99.87%Colore e forma:SolidPeso molecolare:568.59MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Formula:C18H16N2O2Purezza:99.66%Colore e forma:SolidPeso molecolare:292.33PF-6274484
CAS:<p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>Formula:C18H14ClFN4O2Purezza:97.71%Colore e forma:SolidPeso molecolare:372.78ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formula:C19H21F2N7O2Purezza:98.29% - 99.95%Colore e forma:White PowderPeso molecolare:417.41BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formula:C28H25F3N6O2Purezza:95.74% - 99.51%Colore e forma:SolidPeso molecolare:534.53KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formula:C16H11BrN2OPurezza:97.14% - 98.99%Colore e forma:Tan SolidPeso molecolare:327.18CC-115 hydrochloride
CAS:<p>CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.</p>Formula:C16H17ClN8OColore e forma:SolidPeso molecolare:372.82Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Formula:C30H29ClN6O3Purezza:96.17% - 99.85%Colore e forma:SolidPeso molecolare:557.04AZD8931 diFuMaric acid
CAS:<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Formula:C31H33ClFN5O11Purezza:99.92%Colore e forma:SolidPeso molecolare:706.1NRC-2694 hydrochloride
CAS:<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formula:C24H27ClN4O3Colore e forma:SolidPeso molecolare:454.95Idelalisib
CAS:<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formula:C22H18FN7OPurezza:98% - 99.39%Colore e forma:SolidPeso molecolare:415.42PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Formula:C22H24N2O3Purezza:98.92%Colore e forma:SolidPeso molecolare:364.44NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Formula:C20H14F3N3SPurezza:99.84% - 99.9%Colore e forma:SolidPeso molecolare:385.41ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formula:C23H25NO·HClPurezza:98.05%Colore e forma:SolidPeso molecolare:367.91WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Formula:C25H29ClN6O3Purezza:99.65% - >99.99%Colore e forma:SolidPeso molecolare:496.99TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formula:C10H10N2O2SPurezza:97.13% - 99.61%Colore e forma:White SolidPeso molecolare:222.26AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Formula:C16H12N2O3Purezza:98.69%Colore e forma:SolidPeso molecolare:280.28Torin 2
CAS:<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Formula:C24H15F3N4OPurezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:432.4HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Formula:C26H28N8OPurezza:98.38% - 99.70%Colore e forma:SolidPeso molecolare:468.55AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formula:C16H18N2OPurezza:98.12%Colore e forma:SolidPeso molecolare:254.33Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purezza:98.3% - 99.33%Colore e forma:SolidPeso molecolare:607.62Dacomitinib
CAS:<p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>Formula:C24H25ClFN5O2Purezza:99.4% - 99.72%Colore e forma:SolidPeso molecolare:469.94Tyrphostin AG30
CAS:<p>Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.</p>Formula:C10H7NO4Purezza:99.02%Colore e forma:SolidPeso molecolare:205.17PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Formula:C11H9N5Purezza:98.61%Colore e forma:Whit To Off-White SolidPeso molecolare:211.22Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formula:C29H31Cl2FN4OColore e forma:SolidPeso molecolare:541.49ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Formula:C19H16BrFN6O2Purezza:99.12%Colore e forma:SolidPeso molecolare:459.27KU-57788
CAS:<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Formula:C25H19NO3SPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:413.49Taselisib
CAS:<p>Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.</p>Formula:C24H28N8O2Purezza:99.62% - 99.79%Colore e forma:SolidPeso molecolare:460.53WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purezza:99.21%Colore e forma:SolidPeso molecolare:297.314-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Formula:C8H6BrClOPurezza:98.34% - 99.41%Colore e forma:White To Beige SolidPeso molecolare:233.49
