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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • A 1070722
    Targetmol
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    A 1070722

    CAS:
    A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.
    Formula:C17H13F3N4O2
    Purezza:99.9%
    Colore e forma:Solid
    Peso molecolare:362.31

    Ref: TM-T10202

  • Alpelisib hydrochloride
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    Alpelisib hydrochloride

    CAS:
    <p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>
    Formula:C19H23ClF3N5O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:477.93

    Ref: TM-T14191

  • PI3K/mTOR Inhibitor-12
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    PI3K/mTOR Inhibitor-12

    CAS:
    PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.
    Formula:C27H27F2N9O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:611.62

    Ref: TM-T72374

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Formula:C22H23BrFN5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:488.35

    Ref: TM-T79124

  • PI5P4K-β-IN-1
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    PI5P4K-β-IN-1

    CAS:
    <p>PI5P4K-β-IN-1 (compound vs1) is a potent PI5P4K-β inhibitor with an IC50 of 0.80 μM [1].</p>
    Formula:C23H17Cl2N3O2
    Colore e forma:Solid
    Peso molecolare:438.31

    Ref: TM-T81465

  • Labuxtinib
    Targetmol
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    Labuxtinib

    CAS:
    <p>Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].</p>
    Formula:C20H16FN5O2
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:377.37

    Ref: TM-T79851

  • (Rac)-BRD0705
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    (Rac)-BRD0705

    CAS:
    <p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>
    Formula:C20H23N3O
    Purezza:99.7%
    Colore e forma:Solid
    Peso molecolare:321.42

    Ref: TM-T12664

  • Lifirafenib
    Targetmol
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    Lifirafenib

    CAS:
    Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant
    Formula:C25H17F3N4O3
    Purezza:97.99% - 98%
    Colore e forma:Solid
    Peso molecolare:478.42

    Ref: TM-T22272

  • DNA-PK-IN-10
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    DNA-PK-IN-10

    CAS:
    DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].
    Formula:C25H28N6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:444.53

    Ref: TM-T79165

  • BEBT-109
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    BEBT-109

    CAS:
    BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.
    Formula:C27H32N8O3
    Purezza:97.26%
    Colore e forma:Solid
    Peso molecolare:516.6

    Ref: TM-T80643

  • Nazartinib S-enantiomer
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    Nazartinib S-enantiomer

    CAS:
    Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.
    Formula:C26H31ClN6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:495.02

    Ref: TM-T11156

  • PI5P4Kα-IN-1
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    PI5P4Kα-IN-1

    CAS:
    <p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>
    Formula:C20H17N3O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:363.43

    Ref: TM-T78178

  • EGFR-IN-29
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    EGFR-IN-29

    CAS:
    EGFR-IN-29 is a potent EGFR inhibitor.
    Formula:C36H46BrN8O2P
    Colore e forma:Solid
    Peso molecolare:733.68

    Ref: TM-T73106

  • GNE-490
    Targetmol
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    GNE-490

    CAS:
    GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.
    Formula:C18H22N6O2S
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:386.47

    Ref: TM-T22339

  • PT-65
    Targetmol
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    PT-65

    CAS:
    <p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>
    Formula:C51H63N13O12S
    Colore e forma:Solid
    Peso molecolare:1082.19

    Ref: TM-T84913

  • Antitrypanosomal agent 14
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    Antitrypanosomal agent 14

    CAS:
    Antitrypanosomal agent 14 (Compound 1), a potent T.
    Formula:C14H23N3OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:281.42

    Ref: TM-T79254

  • HER2-IN-5
    Targetmol
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Formula:C27H33N7O3
    Colore e forma:Solid
    Peso molecolare:503.6

    Ref: TM-T63432

  • mTOR inhibitor-11
    Targetmol
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    mTOR inhibitor-11

    CAS:
    <p>mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.</p>
    Formula:C21H26N6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:394.47

    Ref: TM-T79211

  • HKI-357
    Targetmol
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    HKI-357

    CAS:
    <p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>
    Formula:C31H29ClFN5O3
    Purezza:99.91%
    Colore e forma:Solid
    Peso molecolare:574.05

    Ref: TM-T11569

  • SAR502250
    Targetmol
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    SAR502250

    CAS:
    SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.
    Formula:C19H18FN5O2
    Colore e forma:Solid
    Peso molecolare:367.38

    Ref: TM-T35560