Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(145 prodotti)
Mostrare 2 più sottocategorie
Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"
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EGFR-IN-1
CAS:<p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>Formula:C28H30N6O4Purezza:98%Colore e forma:SolidPeso molecolare:514.58PF-06459988
CAS:PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Formula:C19H22ClN7O3Purezza:98%Colore e forma:SolidPeso molecolare:431.88PI3Kδ-IN-17
CAS:<p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>Formula:C23H24F3N7O2Purezza:98%Colore e forma:SolidPeso molecolare:487.48mTOR inhibitor 9b
CAS:<p>mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR</p>Formula:C21H23N5O2SPurezza:99.52%Colore e forma:SoildPeso molecolare:409.5mTOR inhibitor 9d
CAS:<p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>Formula:C21H23N5O3SPurezza:99.08%Colore e forma:SoildPeso molecolare:425.5T-00127_HEV1
CAS:<p>T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).</p>Formula:C22H29N5O3Purezza:99.89%Colore e forma:SolidPeso molecolare:411.5MSC2360844
CAS:<p>MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).</p>Formula:C26H27FN4O5SPurezza:99.54% - 99.9%Colore e forma:SolidPeso molecolare:526.58EGFR-IN-71
CAS:<p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>Formula:C16H9ClIN3Colore e forma:SolidPeso molecolare:405.62PI3K/mTOR Inhibitor-7
CAS:<p>Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.</p>Formula:C29H33N9O4Colore e forma:SolidPeso molecolare:571.63EGFR-IN-36
CAS:<p>EGFR-IN-36 inhibits EGFR, HER2, & mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>Formula:C26H25ClN6O2Colore e forma:SolidPeso molecolare:488.97BX-320
CAS:<p>BX-320, a PDK1 inhibitor (IC50=30nM), selectively blocks Akt/p70S6K1 phosphorylation, induces apoptosis, and inhibits cancer cell growth.</p>Formula:C23H31BrN8O3Colore e forma:SolidPeso molecolare:547.45PI3K/mTOR Inhibitor-5
CAS:PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.Formula:C32H40N10O3Colore e forma:SolidPeso molecolare:612.73PI3K/mTOR Inhibitor-14
CAS:<p>PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and</p>Formula:C28H30N8O3SPurezza:98%Colore e forma:SolidPeso molecolare:558.66PI3Kδ-IN-1
CAS:<p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>Formula:C22H20F3N7O2Purezza:99.85%Colore e forma:SolidPeso molecolare:471.44LDHA/PDKs-IN-2
CAS:<p>Compound 20k is a dual LDHA/PDKs inhibitor; IC50: 0.7/1.6 μM. It boosts O2 use, cuts lactate, and slows A549 cancer cell growth (EC50: 15.7 μM).</p>Formula:C17H20N2O5Colore e forma:SolidPeso molecolare:332.35mTOR inhibitor-11
CAS:<p>mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.</p>Formula:C21H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:394.47EGFR-IN-32
CAS:<p>EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)</p>Formula:C31H34N6O3Colore e forma:SolidPeso molecolare:538.64MTI-31
CAS:<p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.</p>Formula:C26H30N6O3Purezza:99.97%Colore e forma:SolidPeso molecolare:474.55SU-11752
CAS:<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Formula:C26H27N3O5SColore e forma:SolidPeso molecolare:493.57ZLN024
CAS:<p>ZLN024 is an activator of AMPK allosteric.</p>Formula:C13H13BrN2OSPurezza:99.751%Colore e forma:SolidPeso molecolare:325.22
