Reagenti sintetici

<p>Applications A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.<br>References Yamada, Y. et al.: Horm. Metab. Res., 40, 539 (2008); Kopelman, P. et al.: Int. J. Obes., 31, 494 (2007); Kopelman, P. et al.: Obesity, 18, 108 (2010);<br></p>

<p>Applications 4-(Trifluoromethyl)benzyl Bromide is a useful building block. It is used in the synthesis of 1-(Substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles with antiviral activities.It is also used to prepare 2-[(4-diarylmethoxy)phenyl]benzimidazoles as potent inhibitors of hepatitis C virus NS5B polymerase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Porcari, A., et al.: J. Med. Chem., 41, 1252 (1998); Ishida, T., et al.: Bioorg. Med. Chem. Lett., 16, 1859 (2006)<br></p>

<p>Applications N-(2-Carboxy-2-hydroxycaproyl)hydrazobenzene is an impurity in the synthesis of pheylbutazone (P319570) derivatives.<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>

<p>Applications Iodine is used in ionic liquids in the preparation of dye-sensitized solar cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, P. et al.: J. Phys. Chem. B, 107, 13280 (2003); Kubo, W. et al.: J. Phys. Chem. B. 105, 12809 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>

<p>Applications Carveol, is a constituent of spearmint essential oil in the form of cis-(−)-carveol. It can be used as a fragrance ingredient, and as a flavor additive in the food industry. It is also found that its alpha-trans-dihydroxy derivative, possesses potent antiparkinsonian activity in animal models.<br>References Bhatia, S. P., et al.: Food and chemical Toxic., 46 Suppl, 11(11), S88 (2008); Ardashov, O. V., et al.: J. Med. Chem., 54(11), 3866 (2011);<br></p>

<p>Applications Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.<br>References Cook, P., James, I.: New England J. Med. 305, 1560 (1981); DeNoble, V., et al.: Pharmacol. Biochem. Be., 24, 1123 (1986)<br></p>

<p>Applications GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.<br>References Metcalf, B., et al.: ACS Med. Chem., 8, 321-326 (2017); Li, Q., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, E689-E696 (2017)<br></p>

<p>Applications Floctafenine is an nonsteroidal antiinflammatory drug (NSAID) used in inflammatory disorders.<br>References Tawakkol, M., et al.: Pharmazie, 36, 163 (1981), Sandouk, P., et al.: Ther. Drug Monit., 17, 544 (1995), Moussa, B., et al.: J. Pharm. Biomed. Anal., 23, 1045 (2000),<br></p>

<p>Applications Deuterated Tolterodine (T535800), a muscarinic receptor antagonist. Used in the treatment of urinary incontinence.<br>References Nilvebrant, L., et al.: Life Sci., 60, 1129 (1997), Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997), Brynne, N., et al.: Int. J. Clin. Pharmacol. Ther., 35, 287 (1997)<br></p>

<p>Stability Light Sensitive, Moisture Sensitive<br>Applications Mercury(II) thiocyanate (cas# 592-85-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Phosphoric Acid is used in various chemical processes as a phosphorylating compound. It is involved in the hydrolysis via phosphorylation of nanocrystals to obtain high-aspect-ratio cellulose nanocrystals. Also used in the synthesis of lithium-ion cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Camarero E. et al.: Biomacromol., 14, 1223 (2013); Meligrana, G. et al.: J. Power. Sources., 160, 516 (2006);<br></p>

<p>Stability Desiccate and Store at -20°C<br>Applications Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Ph<br>References Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem &amp; Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991)<br></p>

<p>Stability Hygroscopic<br>Applications (S)-3-Aminoazepan-2-one hydrochloride (cas# 26081-07-2) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications An antibacterial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Applications Potassium Hydroxide is inorganic compound and strong base with many applications. It is used in the production of biodiesel. Potassium Hydroxide is also used in the manufacture of soaps.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nadarajan, R., Ismail, R.: J. Surfactants Deterg., 14, 463 (2011); Hajek, M., et al.: Fuel, 96, 85 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamm, J.J., et al.: J. Am. Acad. Dermatol., 6, 652 (1982), Warrel, R.P., et al.: Leukemia, 8, 929 (1994), Sasai, Y., et al.: J. Neurol., 249, 41 (2002),<br></p>

<p>Applications An oral angiogenesis inhibitor targeting VEGFR and PDGFR.<br>References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),<br></p>

<p>Applications Potassium Bisnonafluoro-1-butanesulfonimidate (cas# 129135-87-1) is a useful research chemical.<br></p>

<p>Applications A novel nonsteroidal FXR nuclear receptor agonist.<br>References Makishima, M., et al.: Science, 284, 1362 (1999), Wang, H., et al.: Mol. Cell, 3, 543 (1999), Zhang, Y., et al.: J. Biol. Chem., 276, 43018 (2001), Carlton, V.E., et al.: Nat. Genet., 34, 91 (2003),<br></p>

<p>Applications Intermediate of Nafamostat mesilate (N210000).<br>References Rahimian, M., et al.: Biochemistry, 48, 1573 (2009),<br></p>

<p>Applications Lanreotide Acetate is a drug used in the control and prevention of glycemia and hypoglycemic brain damage without surgery in patients diagnosed with congenital hyperinsulinism. It improves outcomes in patients suffering from acromegalyresulting from invasive pituitary macroadenoma.<br>References Kuehnen, P. et al.: Horm. Res. Paediat., 78, 106 (2012); Li, Z. et al.: J. Int. Med. Res., 40, 517 (2012);<br></p>

<p>Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.<br>References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications 5-Amino-1-pentanol is an aliphatic amino alcohol with potential plasma lipid-lowering properties. 5-Amino-1-pentanol and other amino alcohols are used as emulsifying agents in dry-cleaning soaps, wax removers, cosmetics, paints and insecticides.<br>References Bondesson, G. et al.: Acta Pharm. Suec., 11, 417 (1974); Scheers, E.M. et al.: ALTA Alt. Lab. Anim., 30,309 (2002);<br></p>

<p>Applications rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.<br>References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),<br></p>

<p>Applications 1,3-Dihydroxyacetone Dimer is used in the synthesis of dihydropyrimidine calcium channel blockers. Also used in the preparation of a new antineoplastic and antifilarial agents as anticancer agents.<br>References Atwal, K. et al., J. Med. Chem., 33, 1510 (1990); Ram, S. et al.: J. Med. Chem., 35, 539 (1992);<br></p>

<p>Applications (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, L., et al.: Tetrahedron Lett., 58, 1644 (2017); Ju, X., et al.: Org. Process Res. Dev., 18, 827 (2014)<br></p>

<p>Applications 2-Fluoro-3-methoxyphenylboronic acid<br></p>

<p>Applications An acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Potassium Thiocyanate has been used as a catalyst in a one-pot reaction of dialkyl acetylenedicarboxylates with indane-1,3-dione. Potassium Thiocyanate has been used as a selective bacterial inhibitor to create ESS-3 broth to allow co-​enrichment of the target pathogens and suppress growth of some non-​target pathogens<br>References Hassanabadi, A., Zhiani, R., et. al.: J. Chem. Res., 37, 458 (2013); Zhang, Q., et. al.: Plant. Biotech., 29, 103 (2012)<br></p>

<p>Applications 5-Chloro-1-Indanone is used as a reagent in the synthesis of novel tricyclic pyrazoles as CB1 and CB2 cannabinoid receptors. Also used in he synthesis of heteroarylmethylidene cubstituted compounds as selective inhibitors of aldosterone synthase.<br>References Ulmschneider, S. et al.: J. Med. Chem., 48, 1563 (2005); Ulmschneider, S. et al.: J. Med. Chem., 48, 1563 (2005);<br></p>

<p>Applications Diethyl Pyrocarbonate is used as a reagents for the comparative pharmacokinectic study of quinic acid as a potent drug candidate for prostrate cancer. Also used in the study of the critical modulating role of histidine imidazole ring on the amyloidogenicity of insulin.<br>References Yang, X., et al.: J. Biochem., 157, 45 92015); Inbathamizh, L., et al.: Asian J. Pharm. Clin. Res., 6, 106 (2013)<br></p>

<p>Applications Vanadyl Meso-Tetraphenylporphine (1-3% Chlorin) (cas# 14705-63-6) is a useful research chemical.<br></p>

<p>Applications An antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>

<p>Applications 1,8-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities.<br>References Barasch, D., et al.: Eur. J. Med. Chem., 34, 597 (1999)<br></p>

<p>Applications 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.<br>References Richter, J., et al.: J. Am. Chem. Soc., 129, 12857 (2007); Yeung, B., et al.: J. Med. Chem., 53, 5155 (2010);<br></p>

<p>Applications Sodium azide is commonly used as a preservative in aqueous laboratory reagents and biological samples. Sodium azide’s toxicity can be attributed to its role as a reversible inhibitor of mitochondrial respiration and insulin secretion in human pancreatic cells. Acts as a catalyst for: Oxidative decarboxylation &amp; Michael addition reactions.Used as a reagent for synthesis of Blue fluorescent copolymers; Metal phosphonates &amp; Arenes via aminations. Actively involved in regioselective synthesis of prianosin B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, S. &amp; Lamm, S.: Int. J. Toxicol., 22, 175 (2003); Misler, S., et al.: Pflügers Archiv., 421, 289 (1992)<br></p>

<p>Applications Octapeptide analog of Somatostatin. A gastric antisecretory agent. Used in treatment of acromegaly.<br>References Bauer, W., et al.: Life Sci., 31, 1133 (1982), Plewe, G., et al.: Lancet, 2, 782 (1984), Kraenzlin, M.E., et al.: Experientia, 41, 738 (1985), del Pozo, E., et al.: Acta Endocrinol., 111, 433 (1986),<br></p>

<p>Applications BAY-876 is a potent glucose transporter 1 (GLUT 1) selective small molecular inhibitor that showed good metabolic stability in vitro and high oral bioavailability in vivo.<br>References Siebeneicher, H., et al.: ChemMedChem, 11, 2261 (2016)<br></p>

<p>Applications Calcium Hydroxide is used in the preparation of highly substituted hydroxyapatite. Also used in the preparation of nanofillers like hydroxyapatite.<br>References Cho, J. et al.: J. Biomed. Mat. Res., 102, 455 (2014); Palacios, J. et al.: Polym. Eng. Sci., 53, 1414 (2013);<br></p>

<p>Applications 1,1-Bis(4-hydroxyphenyl)-2-phenyl-1-butene (cas# 91221-46-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Gabexate mesylate is used in combination with somatostatin and octreotide in the treatment of severe acute pancreatitis in elderly patients.<br>References Li, X., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 3719 (2014); Wei, Q., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 5346 (2014)<br></p>

<p>Applications Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.<br>References Laufer, S.A., et al.: J. Med. Chem., 37, 1894 (1994), Tries, S., et al.: Inflamm. Res., 51, 135 (2002), Moreau, M., et al.: J. Vet. Pharmacol. Ther., 28, 81 (2005),<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Stability Shock Sensitive<br>Applications 2,2-Diphenyl-1-picrylhydrazyl is a stable free radical molecule most commonly used as a tool to monitor chemical reactions involving radicals, most notably in antioxidant assay.<br>References Suzhukim K., et al.: J. Org. Chem., 78, 2301 (2013); Chen, Z., et al.: Food. Chem., 138, 414 (2013); Chatterjee, S ., et al.: Advan. BIo. Res., 3, 109 (2012);<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.<br>References Harada, H., et al.: Bioorg. Med. Chem., 9, 2709 (2001); Tully, D., et al.: Bioorg. Med. Chem. Lett., 16, 5112 (2006)<br></p>

<p>Applications Trimethylamine is used as a reagent in the synthesis of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism. L-Carnitine is required for the transport of fatty acids through the inner mitochondrial membrane and is synthetized primarily in the liver and kidney.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004); Wu, J., et al.: Faming Zhuanli Shenqing. CN 104030934 A 20140910. Sep 10, 2014<br></p>

<p>Applications 2-​Methoxy-​4-​methylphenol is used in treating inflammatory disorder, by inhibiting IL-6 expression and other expressions and activating nirp3 inflammasome in cells. Also used as one of the substances for the mechanism-based QSAR modelling of skin sensitization.<br>References Ka, Shuk M., et al.: Taiwan. (2015), TW I498114 B 20150901, Dearden, J. C., et al.: Chem. Res. Toxicol., 28, 1975 (2015)<br></p>

<p>Applications 3-Hydroxytetradecanoic Acid Methyl Ester is used in the preparation of (S)-3-hydroxytetradecanoic acid and synthesis of unnatural analogs of lipid A containing the (S)-acid.<br>References Gouteux, B., et al.: Environ. Sci. Technol., 39, 1448 (2005), Esteve-Turrillas, F., et al.: J. Agric. Food Chem., 56, 1797 (2008),<br></p>

<p>Applications A caffeine metabolite which showed high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.<br>References Buchanan, C., et al.: J. Sci. Food Agric., 71, 459 (1996), Andreasen, M., et al.: J. Agric. Food Chem., 49, 5679 (2001), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008),<br></p>

<p>Applications N-Isopropylbenzylamine, can be used as an intermediate in the synthesis of pharmaceutical compounds,and as a precursor to the manufacture of some drugs. Due to it’s similarity in appearance and physical properties to methamphetamine, it has been recently come under consideration of DEA.<br></p>

<p>Stability Moisture Sensitive<br>Applications Hexahydro-1,3-isobenzofurandione is used in the synthesis of hypotensive agents, pyridazinones. Also used in the synthesis of selective PDE4 inhibitors.<br>References Curran, W. et al.: J. Med. Chem., 17, 273 (1974); Van der Mey, M. et al.: J. Med. Chem., 44, 2511 (2001);<br></p>

<p>Applications Used in the one-pot synthesis of 2-aminobenzimidazoles.<br>References Artman, G.D., et al.: Tetrahedron Lett., 51, 5319 (2010),<br></p>

<p>Applications It is a designer drug which acts as a phosphodiesterase inhibitor. It is a structural analogue of Sidenafil (Viagra), which has been detected in numerous different brands of supposedly ”herbal” aphrodisiac products sold to boost libido and alleviate erectile dysfunction.<br>References Brock, G., et al.: Drugs Today, 36, 125 (2000), Rosen, R., et al.: Am. J. Cardiol., 92, 9 (2003), Shimizu-Albergine, M., et al.: J. Neurosci., 23, 6452 (2003), Venhuis, B.J., et al.: Forensic Sci. International., 177, 25 (2008),<br></p>

<p>Applications Mercury(II) Chloride is used to produce amalgamated aluminium which is used as reducing agent. Mercury(II) Chloride is also used as a catalyst for the conversion of acetylene to vinyl chloride.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diuguid, L., et al.: J. Am. Chem. Soc., 12,3527 (1941);<br></p>

<p>Applications Used for preparation of hydrophilic polymers for biomedical devices.<br>References Delbressine, L., et al.: Xenobiotica, 11, 241 (1981), Gerberick, G., et al.: Toxicol. Sci., 97, 417 (2007),<br></p>

<p>Applications 1,3-Diaminopropane is a common chemical reagent, used in the synthesis of 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors applied in the treatment of Alzheimer’s disease. Also used in the synthesis of thrombosis inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spilovska, K. et al.: Molecules, 18, 2397 (2013); Smith, S. et al.: Blood, 120, 5103 (2012);<br></p>

<p>Applications A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.<br>References Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010); Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010); Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008); Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011);<br></p>

<p>Stability Moisture and Temperature Sensitive<br>Applications An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B.<br>References Baji, H., et al,: Eur. J. Med. Chem., 30, 617 (1995), Vaaje-Kolstad, G., et al.: J. Biol. Chem., 279, 3612 (2004), Perreira, M., et al.: Bioorg. Med. Chem., 14, 837 (2006).<br></p>

<p>Stability Very Hygroscopic<br>Applications Potassium trifluoroacetate (cas# 2923-16-2) is a useful research chemical.<br></p>

<p>Applications An impurity of the anti-convulsant (S)-Pregabalin (P704790).<br>References Lin, S. et al.: J. Liq. Chrom. Rel. Technol., 19, 2699 (1996); Sripathi, S. et al.: ARKIVOC, 10, 266 (2010);<br></p>

<p>Applications Tropolone is found in many natural compounds. It is an inhibitor of grape polyphenol oxidase (PPO).<br>References Nunez-Delicado, E., et al.: J. Agric. Food Chem., 53, 6087 (2005); Okumura, S., et al.: Food Sci Technol Res., 17, 251 (2011);<br></p>

<p>Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>

<p>Applications Copper(II) carbonate dihydroxide is commonly used as an impregnant in activated carbons for respiratory filters. Copper(II) carbonate dihydroxide is also used to form a protective layer around the corrosion sites of electrodes to prevent them from further corrosion.<br>References Mattsson, E. &amp; Fredriksson, A.: Brit. Corr. J., 3, 246 (1968); Smith, J., et al.: J. Coll. Inter. Sci., 337, 313 (2009)<br></p>

<p>Applications D,L-2-Amino-3-phosphonopropionic acid is a phosphonate substituted derivative of Aspartic acid (A788955) and is a known antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.<br>References Hedberg, T. &amp; Stanton, P.: Eur. J. Pharma., 310, 19 (1996); Saugstad, J., et al.: Eur. J. Pharm.: Mol. Pharm., 289, 395 (1995); Schoepp, D., et al.: Mol. Pharm., 38, 222 (1990)<br></p>

<p>Applications Palladium(II) Acetylacetonate is an active anticancer agent. Exhibits growth inhibitory effect more than cisplatin in several cancer cells and treatment with Palladium(II) Acetylacetonate inhibits H460 cells. Palladium(II) Acetylacetonate is a catalyst for various organic transformations.<br>References Wang, Y., et al.: J. Med. Chem., 56, 9601 (2013); Fang, W., et al.: Small, 8, 3816 (2012); Yao, H., et al.: ACS Catalysis, 7, 5456 (2017)<br></p>

<p>Applications Xenon Difluoride is a fluorination agent used in gas chromatography.<br>References Zhu, M. et al.: J. Micromech. Microeng., 27, 125007 (2017);<br></p>

<p>Applications 5-Carboxyfluorescein is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent. Dyes and metabolites.<br>References Theisen, P., et al.: Tetrahedron Lett., 33, 5033 (1992); Mattingly, P.: Bioconjgate Chem., 3, 430 (1992); Bertrand, R., et al.: Biochemistry, 34, 9500 (1995);<br></p>

<p>Applications 5-Hydroxymethyl-2-furoylglycine can be used as analyte for analytical and biological studies of determination of metabolites of 5-​hydroxymethylfurfural in human urine after oral application.<br>References Hardt-Stremayr, M., et al.: J Sep Sci., 36, 670-676 (2013)<br></p>

<p>Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. &amp; Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>

<p>Applications Sodium Iodide is used in the synthesis of dye-sensitized solar cells. Also used in the preparation of propargylamines as inhibitors of lysine specific. demethylase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zalas, M. et al.: Electrochem. Acta., 108, 736 (2013); Schmitt, M. et al.: J. Med. Chem., 56, 7334 (2013);<br></p>

<p>Applications Anticholinergic.<br>References Umetzu, T., et al.: Eur. J. Pharmacol., 64, 69 (1980),<br></p>

<p>Applications (R)-(-)-2-Amino-1-butanol (cas# 5856-63-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.<br>References Seymour, P.A., et al.: Prog. Clin. Biol. Res., 361, 453 (1990), Evans, S.M., et al.: J. Pharmacol. Exp. Ther., 271, 683 (1994),<br></p>