Reagenti sintetici

<p>Stability Light Sensitive<br>Applications (1,1'-Bis(diphenylphosphino)ferrocene)dichloropalladium-dichloromethane is used in the preparation of imidazoles, benzimidazoles, and tetrahydropyrimidines.<br>References Geden, J. et al.: J. Org. Chem., 78, 4158 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Bis(tributylammonium) Pyrophosphate is an phosphorylating reagent used in the synthesis of phosphorylated deoxynucleosides.<br>References Santner, T. et al.: Bioorg. Med. Chem, 20, 2416 (2012); Sun, D. et al.: ChemMedChem, 4, 1649 (2009)<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.<br>References Scouten, W.H, et al.: Ann. N.Y. Acad. Sci., 750, 391 (1995); Mikulec, L.J. et al.: J. Biomed. Mat. Res., 32, 203 (1996);<br></p>

<p>Applications Furyl Hydroxymethyl Ketone is a reagent in the preparation of 3-iodocoumarins. Also used in the preparation of quinoxalines generally used in dyes and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reddy, M. et al.: J. Org. Chem., 78, 5878 (2013); Cho, C. et al.: J. Mol. Catal. A. Chem., 276, 205 (2007);<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.<br>References Harada, H., et al.: Bioorg. Med. Chem., 9, 2709 (2001); Tully, D., et al.: Bioorg. Med. Chem. Lett., 16, 5112 (2006)<br></p>

<p>Applications Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-binding inhibitor of Eg5 that prevents mitotic progression.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DeBonis, S. et al.: J. Med. Chem., 51, 1115 (2008); Chadwick, D.J. et al.: J. Chem. Soc. Perk. Trans. Org. Bio-Org. Chem., 1, 102 (1983);<br></p>

<p>Applications (R)-(+)-α-Methylbenzylamine (cas# 3886-69-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Magnesium Monoperoxyphthalic Acid Hexahydrate is used as an oxidant in various synthetic reactions. For example: it is a mild and efficient oxidant for the synthesis of selenones which are useful synthetic intermediates in the synthesis of different heterocyclic compounds.<br>References Temperini, A., et al.: Beilstein J. Org. Chem., 10, 1267 (2014); Salvador, J.A.R., et al.: Beilstein J. Org. Chem., 8, 164 (2012); Carvalho, J.F.S., et al.: Tetrahedron, 65, 2773 (2009)<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>

<p>Applications VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.<br>References Loo, T. et al.: Biochem. Pharm., 86, 612 (2013); McPhail, G.. et al.: Drugs. Future., 37, 717 (2012);<br></p>

<p>Applications A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ.<br>References Rose, W.C. et al.: Cancer Res., 61, 7507 (2001); Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2005); Pellicano, F. et al.: Blood, 114, 4186 (2009);<br></p>

<p>Applications A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrska, B. et al.: Zagadnien Nauk Sadowych 81, 101 (2010); Cervo, L. et al.: Pharmacol Biochem Be 82, 727 (2005)<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Applications An aromatase inhibitor. Also blocks adrenal steroidogenesis.<br>References Santen, R.J. and Misbin, R.I.: Pharmacotherapy, 1, 95 (1981), Havlin, K.A. and Trump, D.L.: Cancer Threat. Res., 39, 83 (1988)<br></p>

<p>Applications β-Methylphenethylamine is a positional isomer of Amphetamine (HCl: A634240), and as a result, has been classified as a doping agent by the World-Anti Doping Agency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cho?bi?ski, P., et al.: Anal. Bioanal. Chem., No vol. given, 1 (2014); Cohen, P., et al.: New Engl. J. Med., 370, 1277 (2014); Pawar, R., et al.: J. Pharm. Biomed. Anal., 88, 457 (2014); Vaclavik, L., et al.: Anal. Chim. Acta, 810, 45 (2014)<br></p>

<p>Stability Freezer at -20°C<br>Applications A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.<br>References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)<br></p>

<p>Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.<br>References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)<br></p>

<p>Applications Dibutyltin(IV) Oxide is used in studies pertaining to discovering novel antitumor agents. Antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boualam, M. et al.: App. Organometal. Chem., 6, 197 (1992); Hadi, S. et al.: Ori. J. Chem., 26, 775 (2010); Hadi, S. et al.: Modern. App. Sci., 3, 12 (2009);<br></p>

<p>Applications A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.<br>References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),<br></p>

<p>Applications Tropolone is found in many natural compounds. It is an inhibitor of grape polyphenol oxidase (PPO).<br>References Nunez-Delicado, E., et al.: J. Agric. Food Chem., 53, 6087 (2005); Okumura, S., et al.: Food Sci Technol Res., 17, 251 (2011);<br></p>

<p>Applications Synthetic analog of Vasopressin with antidiuretic activity and decreased pressor effects. Improves hemostatsis by increasing plasma levels of von Willebrand factor, factor VIII and tissue plasminogen activator. Antidiuretic; hemostatic.<br>References Mannucci, P.M., et al.: Blood, 90 2515 (1997), Kaufmann, J. E., et al.: Haemostasis, 1, 682 (2003),<br></p>

<p>Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>

<p>Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.<br>References Kopetz,S., et al.: N. Engl., 381, 1632-1643<br></p>

<p>Applications BENZAMIDINE (cas# 618-39-3) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Methylbutyl Chloroformate is an ester of chloroformic acid and is used as an intermediate in the synthetic preparation of pharmaceutical goods and inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dupuy, W.E., et al.: J. Chem. Soc. Phy. Org. Chem., 1, 74 (1973);<br></p>

<p>Applications Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.<br>References Walker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)<br></p>

<p>Applications Fmoc-L-2-nitrophenylalanine<br></p>

<p>Applications Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase.<br>References Arch. Biochem. Biophys., 221, 593 (1983), Clin. Biochem., 17, 3 (1984), Trends Bio. Sci., 9, 32, (1984), J. Biol. Chem., 260, 15873-15879 (1985), FEBS, 1985, 28 (1986)<br></p>

<p>Stability -200C<br>Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.<br>References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),<br></p>

<p>Applications (R)-2-Aminobutyramide Hydrochloride is used as a reagent in the synthesis of a new class of 2-[(arylalkyl)amino]alkanamide derivatives which have anticonvulsant activity.<br>References Pevarello, P., et al.: J. Med. Chem., 41, 579 (1998)<br></p>

<p>Applications (-)-Dihydroquinine, is a dihydro derivative of Quinine (Q694000), having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties.<br>References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983); Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994);<br></p>

<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>

<p>Applications Palladium(II) Acetylacetonate is an active anticancer agent. Exhibits growth inhibitory effect more than cisplatin in several cancer cells and treatment with Palladium(II) Acetylacetonate inhibits H460 cells. Palladium(II) Acetylacetonate is a catalyst for various organic transformations.<br>References Wang, Y., et al.: J. Med. Chem., 56, 9601 (2013); Fang, W., et al.: Small, 8, 3816 (2012); Yao, H., et al.: ACS Catalysis, 7, 5456 (2017)<br></p>

<p>Applications Potassium Thiocyanate has been used as a catalyst in a one-pot reaction of dialkyl acetylenedicarboxylates with indane-1,3-dione. Potassium Thiocyanate has been used as a selective bacterial inhibitor to create ESS-3 broth to allow co-​enrichment of the target pathogens and suppress growth of some non-​target pathogens<br>References Hassanabadi, A., Zhiani, R., et. al.: J. Chem. Res., 37, 458 (2013); Zhang, Q., et. al.: Plant. Biotech., 29, 103 (2012)<br></p>

<p>Applications A useful phase transfer catalyst.<br></p>

<p>Applications The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.<br>References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Methanesulfonic acid is a strong acid and is an important intermediate in the cycling process of sulfur in the environment. Methanesulfonic acid is an oxidation product of Dimethyl sulfide (T348000), and is also used as a sole source of carbon and energy for some gram-negative methylotropic bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References de Marco, P., et al.: J. Bacteriol., 181, 2244 (1999); Kolaitis, L., et al.: Env. Sci. Tech., 23, 236 (1989); Saltzman, E., et al.: Geophys. Res. Lett., 12, 437 (1985)<br></p>

<p>Applications The S-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>

<p>Applications Carveol, is a constituent of spearmint essential oil in the form of cis-(−)-carveol. It can be used as a fragrance ingredient, and as a flavor additive in the food industry. It is also found that its alpha-trans-dihydroxy derivative, possesses potent antiparkinsonian activity in animal models.<br>References Bhatia, S. P., et al.: Food and chemical Toxic., 46 Suppl, 11(11), S88 (2008); Ardashov, O. V., et al.: J. Med. Chem., 54(11), 3866 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications (-)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid is a chiral NMR solvating agent used for determining the enantiomeric purity and absolute configuration of β-amino acids. It is also used as a solvating agent in the chiral NMR discrimination of pyrrolidines.<br>References Wenzel, T.J., et al.: Tetrahedron-Assymetr., 20, 2052 (2009); Lovely, A.E., et al.: Chirality, 20, 370 (2008); Li, R., et al.: Fenxi Ceshi Xuebao, 26, 305 (2007); Lovely, A.E., et al.: Tetrahedron-Assymetr., 17, 2642 (2006)<br></p>

<p>Applications L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.<br>References (1) Knabl, J., et al.: Nature. 451, 330 (2008) (2) Johnston, G.A.R., et al.: Curr. Pharm. Design, 11, 1867 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>

<p>Applications An acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Barium chloride dihydrate is used in the synthesis of 2R, 3S-Dihydroxy-4-oxo-butanoic Acid (D450800).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Potassium Hexacyanoferrate(III) is used in the synthesis of nanocomposite photoadducts.<br>References Rather, M. et al.: Synth. Metal., 179, 60 (2013);<br></p>

<p>Impurity Flucytosine EP Impurity A<br>Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);<br></p>

<p>Applications (-)-Perillyl Alcohol is a monoterpene that induces apoptosis in colon tumor cells. Also, it is used in preparation of terpene-vanilloid conjugates as anti-inflammatory agents.<br>References Young, Sherri C., et al.: U.S. Pat. Appl. Publ., (2020);<br></p>

<p>Applications Lead(II) Nitrate, is toxic, an oxidising agent, and is categorized as probably carcinogenic to humans . It is shown to inhibit bacterial oxidation of ferrous iron in sulfate-rich systems. Other Lead(II) Nitrate applications include use as a heat stabilizer in nylon and polyesters, as a coating for photothermographic paper, and in rodenticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hongmei, w., et al.: J Hazard. Mat., 244, 718 (2013); Greenwoos, N. N., et al.: 388 (1997); Pauley, J. L., et al.: J. Amer. Chem. Soci., 76 (16), 4220 (1954);<br></p>

<p>Applications 3-Mercaptopropionic Acid (cas# 107-96-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications A bisphosphonate antiresorptive agent; bone resorption inhibitor.<br>References Coukell, A.J., et al.: Drugs Aging, 12, 149 (1998), McTavish, D., et al.: Drugs, 41, 289 (1991), Sissons, C.H., et al.: Oral Microbiol. Immunol., 15, 317 (2000), Chen, J.X., et al.: J. Cell Physiol., 186, 116 (2001),<br></p>

<p>Applications A primary Prostaglandin; easily crystallized from purified biological extracts. Vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anggard, S., et al.: J. Biol. Chem., 239, 4097 (1964), Wooster, D.L., et al.: J. Am. Med. Assoc., 245, 1846 (1981), Linet, O.I., et al.: N. Engl. J. Med., 334, 873 (1996),<br></p>

<p>Applications Heparan Sulfate is a linear polysaccharide in which the backbone is composed of repeating sulfated disaccharide units. Heparan Sulfate is found in the extracellular matrix and on the surfaces of animal cells. It has numerous important biological activities associated with its interaction with diverse proteins. Heparan is used as an anticoagulant drug.<br>References Capila, I., Linhardt, R.: Angew. Chem. Int. Ed., 41, 390 (2002); Rabenstein, D.: Nat. Prod. Rep., 19, 312 (2002);<br></p>

<p>Applications Trimethylamine is used as a reagent in the synthesis of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism. L-Carnitine is required for the transport of fatty acids through the inner mitochondrial membrane and is synthetized primarily in the liver and kidney.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004); Wu, J., et al.: Faming Zhuanli Shenqing. CN 104030934 A 20140910. Sep 10, 2014<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of sesame lignans (sesamin, sesamolin). Inhibits colonic cancer cell growth by inducing cell cycle arrest and apoptosis. Possible relationship between exposure and reduced risk of breast cancer.<br>References Ayella, A. et al.: Nut. Res., 30, 762 (2010); Pianjing, P. et al.: J. Agric. Food Chem., 59, 212 (2011); Buck, K. et al.: Am. J. Clinic. Nut., 92, 141 (2010);<br></p>

<p>Applications An enantiomer of Atracurium Besylate (A794500). A neuromuscular blocking agent. It could be used in liver transplant patient with safety.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hughes, R., et al.: Br. J. Anaesth., 53, 31 (1981), Basta, S.J., et al.: Anesth. Analog., 61, 723 (1982), Neill, E.A., et al.: Xenobiotica, 12, 203 (1982), Bangsbo, J., et al.: J. Physiol., 422, 539 (1990),<br></p>

<p>Applications Magnesium Chloride Hexahydrate is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.<br>References Cook, P., James, I.: New England J. Med. 305, 1560 (1981); DeNoble, V., et al.: Pharmacol. Biochem. Be., 24, 1123 (1986)<br></p>

<p>Applications Carmofur is a derivative of fluorouracil (F596002) an is an antineoplastic agent showing antitumor activity against several cells including L1210 leukemia and L5178Y lymphoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoshi, A., et al.: J. Pharmacobio-dynam., 3, 478 (1980);<br></p>

<p>Applications Sodium azide is commonly used as a preservative in aqueous laboratory reagents and biological samples. Sodium azide’s toxicity can be attributed to its role as a reversible inhibitor of mitochondrial respiration and insulin secretion in human pancreatic cells. Acts as a catalyst for: Oxidative decarboxylation &amp; Michael addition reactions.Used as a reagent for synthesis of Blue fluorescent copolymers; Metal phosphonates &amp; Arenes via aminations. Actively involved in regioselective synthesis of prianosin B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, S. &amp; Lamm, S.: Int. J. Toxicol., 22, 175 (2003); Misler, S., et al.: Pflügers Archiv., 421, 289 (1992)<br></p>

<p>Applications Used in the synthesis of (4S,5S)-(-)-isocytoxazone.<br>References Kakeya, H., et al.: J. Antibiot., 51, 1126 (1998), Carter, P., et al.: Bioorg. Med. Chem. Lett., 13, 1237 (2003),<br></p>

<p>Applications 4,4'-Bis(bromomethyl)-1,1'-biphenyl (cas# 20248-86-6) is a useful research chemical.<br></p>

<p>Applications AD-mix-β is a catalyst employed in the Sharpless Asymmetric Dihyroxylation of (E,E)- or (E,Z)-1,3-dienoates. It is also used in the preparation of ß-hydroxy-γ-lactones from ß,γ-unsaturated esters.<br>References Ahmed, M., et al.: J. Org. Chem., 71, 7741 (2006); Tretyakov, E., et al.: Eur. J. Org. Chem., 12, 2669 (2006)<br></p>

<p>Applications (R)-1-[(SP)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine is a Josiphos ligand.<br>References MacQueen, P., et al.: Chemistry - A European Journal, 21, 11006 (2015);<br></p>

<p>Applications Icilin is a potent agonist of the TRPM8 and ENaCδ ion channels.<br>References Noncovich, A., et al.: Bioorganic Med. Chem. Lett., 27, 3931-38 (2017);<br></p>

<p>Stability Light Sensitive<br>Applications Stereomeric with Cinchonidine (C441925). Antimalarial.<br>References Litchfield, J., et al.: J. Pharm. Exp. Ther., 96, 99 (1949), Trager, W., et al.: Science, 193, 673 (1976), Panisko, D., et al.: Drugs, 39, 160 (1990), Karle, J., et al.: Antimicrob. Agents Chemother., 36, 1538 (1992),<br></p>

<p>Applications Citraconic anhydride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications An unsaturated aldehyde used in the manufacture of polymers and synthetic resin. Cancer studies revealed consumption and release of this volatile organic compound in human small cell lung cancer line, a potential cancer biomarker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponring, A. et al.: Cancer Biomarkers, 7, 153 (2010); Ligor, M. et al.; Clin. Chem. Lab. Med., 47, 550 92009);<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.<br>References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),<br></p>

<p>Applications L-Homoserine Lactone Hydrobromide is a reactant in the synthesis of tritium labeled and photoactivatable N-acyl-L-homoserine lactones.<br>References Jakubczyk, D., et. al.: Eur. J. Org. Chem., 592, 2014 (2014)<br></p>

<p>Applications Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.<br>References Seymour, P.A., et al.: Prog. Clin. Biol. Res., 361, 453 (1990), Evans, S.M., et al.: J. Pharmacol. Exp. Ther., 271, 683 (1994),<br></p>

<p>Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.<br>References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)<br></p>