Glicoscienza

Sucralose, an artificial sweetener, was discovered in a research programme supported by Tate & Lyle to halogenate sucrose. The majority of ingested sucralose is not broken down by the body, so it is noncaloric. In the European Union, it has been given the E number E955. Sucralose is about 320 to 1,000 times sweeter than sucrose, three times as sweet as both aspartame and acesulfame potassium, and twice as sweet as sodium saccharin.  It is stable under heat and over a broad range of pH conditions. Therefore, it can be used in baking or in products that require a long shelf life. The commercial success of sucralose-based products stems from its favorable comparison to other low-calorie sweeteners in terms of taste profile, stability, and safety.

Trigalacturonic acid, (α-1,4 galacturonotriose) is derived from pectin or pectic acid by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restores development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).

<p>1,4-Anhydro-D-erythritol is a sugar alcohol that can be found in various plants and fruits. It is a reaction product of D-erythrose and glycerol, with an average formation rate of 10%. The hydroxyl group on the 1,4-anhydro-D-erythritol molecule reacts with methyl glycosides to produce an ester. Trifluoromethanesulfonic acid is used as a catalyst in this process, which activates the hydroxyl group on the molecule. The reaction mechanism for this process involves three steps: elimination of water, dehydration of the hydroxyl group, and addition of methyl glycoside. This process results in a new molecule called 1,4-anhydro-D-erythritol methyl ester (AEME). AEME has been shown to have conformational properties that are different from those of its parent compound. The conformational</p>

<p>UDP-α-D-galacturonic acid is a biochemical precursor for the synthesis of UDP-glucuronic acid. It is an intermediate in the biosynthesis of glycosaminoglycans, proteoglycans and lipopolysaccharides. This compound has been shown to inhibit the growth of cancer cells by inducing apoptosis in vitro. The presence of this compound may be detected by its ability to act as a substrate for glucuronidation reactions.</p>

<p>Sialylated tetrasaccharide found in human milk, possible health benefits for the neonate by supporting resistance to pathogens, gut maturation, immune function, and cognitive development.</p>

<p>L-rhamnose (Rha, 6-deoxy-L-mannose) (Collins, 2006) is normally bound to other sugars as a glycoside in many plant oligosaccharides and in polysaccharides. Rhamnose is also a component of the cell wall of Mycobacterium. In plants, rhamnose is found in the polysaccharide rhamnogalacturonan I, a branched pectic polysaccharide that accounts for 7–14% of the primary wall (Oomen, 2002). Rhamnose is also found in rhamnogalacturonan II, a complex polysaccharide that accounts for ∌4% of the wall in dicots (Vidal, 2000). Rhamnose is also found in chacotriose and solatriose, the glycan components of solamargine and solasonine, two glycoalkaloids with anticancer properties (Al Sinani, 2017). An understanding of the rhamnose-containing polysaccharides of the gram positive cell wall has identified the biosynthetic pathway as an attractive therapeutic target for antimicrobial drug development (Mistou, 2016).</p>

<p>N-Benzyl-3,5-dideoxy-3,5-imino-1,2-O-isopropylidene-a-D-gluco(b-L-ido)furanose is a methylated saccharide that is used in the synthesis of complex carbohydrates. This synthetic compound is classified as a sugar and can be modified with a variety of chemical reactions. The carbonyl group on the C6 position can be fluorinated to produce N-(2,4,6'-trifluoroacetyl)-benzyl--3,5-dideoxy--3,5--imino--1,2--O--isopropylidene--a-(D)--gluco(b)--L--ido)furanose. This compound has CAS Number 58424–52–0 and is available for custom synthesis.</p>

6-Phospho-D-glucono-1,5-lactone is a metabolite of D-gluconic acid that is formed by the action of a phosphoglucoisomerase. 6PGL has been shown to inhibit the growth of colorectal adenocarcinoma cells and to be effective against infectious diseases such as malaria. It is also involved in energy metabolism and cell division in plants. 6PGL may also have anticancer effects, as it inhibits prostate cancer cells and induces apoptosis through activation of epidermal growth factor receptor (EGFR) and inhibition of EGFR tyrosine kinase activity. It has been shown to act on redox potential, enzyme activities, and oxidative injury in liver cells.

1,2-Ethanediol is a polyhydroxy alcohol that is used in the synthesis of complex carbohydrates. It can be found as an Oligosaccharide in plants, which are composed of three or more sugar molecules. 1,2-Ethanediol is also found in the glycosylation reaction for the modification of saccharides and carbohydrates. This process adds glucose to a protein or peptide molecule through a condensation reaction with the amino acid N-acetylglucosamine. Glycosylation usually occurs in animal cells, but can also occur in plants and microorganisms. The addition of methyl groups by Methylation to 1,2-ethanediol is used to create Methylated derivatives of this compound. A click modification to this compound can be done using a Copper(I) azide complex and an alkyne reagent to add a terminal alkene group to 1,2-ethanediol. Fluorination at

5,8-Dihydroxy-6-fluoro-2,2-dimethyl-1,3,7-trioxaspiro[4.4]nonane - 8-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-9-(hydroxymethyl) - 2,2-dimethyl - 1,3,7 - trioxaspiro[4.4]nonane is a synthetic glycosylated fluorinated octahydropyrrole (5R)-8-(hydroxymethyl)-9-(hydroxymethyl)-6-[(methyloxy)methyl]-2,2,- dimethylpiperidine that is used as an intermediate in the synthesis of oligosaccharides and polysaccharides. It is also used to modify complex carbohydrates for click chemistry applications. This product has a CAS number of 9248411–67–0 and a purity of >

D-[UL-13C6]Galacturonic acid potassium salt is a fatty acid that is used as a feedstock in the production of monoclonal antibodies. The 13C isotope provides information on the structure and function of proteins, such as enzyme activities and covalent linkages. D-[UL-13C6]Galacturonic acid potassium salt has been shown to inhibit the growth of bacteria and can be used for the treatment of infectious diseases. D-[UL-13C6]Galacturonic acid potassium salt binds to bacterial cell surfaces by interacting with hydroxyl groups on lipopolysaccharides, which are found on the outer membrane of Gram-negative bacteria, preventing their replication and inhibiting their ability to form biofilms. D-[UL-13C6]Galacturonic acid potassium salt has also been shown to be effective against hyperproliferative disease cells, such as prostate cancer cells.

<p>Please enquire for more information about 3'-Sialyl-N-acetyllactosamine-β-ethylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methyl 3,4-di-O-benzyl-2-deoxy-a-D-glucopyranoside (MBG) is a synthetic compound that is modified at the C3 position with a benzyl group. MBG is an oligosaccharide and polysaccharide that has been shown to have potential as a drug for the treatment of cancer. It has been shown to inhibit tumor growth in animals and human cells by inhibiting DNA synthesis and protein synthesis. Additionally, it can be used for the prevention of postoperative adhesions by inhibiting collagen formation.</p>

<p>2,3,4,6-Tetra-O-benzyl-D-glucopyranose is a selectively protected intermediate, where the anomeric 1-O-hydroxyl group is free. This hemiacetal has been used successfully as an intermediate for glucosylation couplings, where it was converted into 2,3,4,6-tetra-O-benzyl-D-glucopyranose trichloroacetimidate using trichloroacetonitrile in the presence of a base such as potassium carbonate and DBU. Importantly, this imidate donor with no neighbouring participating groups is commonly used for the selective formation of α-glucosides. 2,3,4,6-tetra-O-benzyl-D-glucopyranose can also be oxidized to the lactone, or reduced to give the open chain form. Additionally, 2,3,4,6-tetra-O-benzyl-D-glucopyranose can be used for the preparation of glucono-1,5-lactone hydrazine, which was used, in-turn, to form a glucosylidene-spirocyclopropane.</p>

<p>6-Azido-6-deoxy-D-galactose is a mutagenic compound that is used as a carbon source in the synthesis of other compounds. It has been shown to have mutagenicity in TA100 cells and to be active against Staudinger's naphthol. The compound is synthesised by chemoenzymatic methods, which involve the use of alcohols and an acetyl group. 6-Azido-6-deoxy-D-galactose can be used as a mutagenic agent for the production of mutants with desired properties.</p>

<p>linear a-(1,4) trisaccharide produced from starch by acid or enzyme hydrolysis</p>

<p>MurNAc-6-phosphate-GlcNAc is a complex carbohydrate that is composed of a glycosylation, methylation, and fluorination. It is an important component in polysaccharides and oligosaccharides. This compound has been modified with Click chemistry to form a reactive site for incorporation of a variety of molecules such as fluorophores, biotin, or other small molecules. This compound can be synthesized using custom synthesis methods and has CAS number 106579-01-4. MurNAc-6-phosphate-GlcNAc is available in high purity and can be custom synthesized to specific needs.</p>

<p>5-Azido-2-C-(hydroxymethyl)-5-deoxy-2,3-O-isopropylidene-D-ribono-1.4-lactone is used as a modification agent in oligosaccharides and polysaccharides. It is used to modify the carbohydrate structure of these compounds through glycosylation and methylation. 5-Azido-2-C-(hydroxymethyl)-5-deoxy-2,3-O-isopropylidene--D--ribono--1.4--lactone has been shown to be highly pure with a CAS number of 82577–09–8. This compound can be synthesized by reacting the acid with 2,3,5,6,-tetraacetic acid in chloroform solution or by reacting the acid with sodium azide in methanol solution at 0°C for 12 hours.</p>

4-C-Methyl- 2, 3- O-isopropylidene -D- lyxono-1,5- lactone is a custom synthesis. It is a complex carbohydrate with the CAS number of 67903-96-6. It has a molecular weight of 287.39 g/mol and a purity of >99%. 4CMMDL has been modified with methylation at the C4 position and glycosylation at the C2 position. The modification on this molecule is called Click chemistry. This molecule contains a sugar group that is an oligosaccharide with 11 saccharides, which are all glucose molecules. This sugar group has been fluorinated at the C2 position to form 4CMMDLF (also known as Fluorogalactofuranose). The chemical formula for 4CMMDLF is C12H8O11F2, and it has a molar mass of 5

<p>1-Deoxy-2-fluoronojirimycin is a glycosylation inhibitor that was synthesized to inhibit the formation of complex carbohydrates. It has been shown to inhibit methyltransferases and glycosylation enzymes in vitro with IC50 values of 0.1 μM, 2 μM, and 4 μM, respectively. This compound has also been shown to inhibit the synthesis of saccharides by targeting sugar moieties. 1-Deoxy-2-fluoronojirimycin inhibits the addition of various sugars at their C1 position with IC50 values ranging from 0.3 μM to 6 μM. The modification of sugars at the C2 position is also inhibited with IC50 values ranging from 3 μM to 10 μM. 1-Deoxy-2-fluoronojirimycin is a custom synthesis that can be ordered in high purity as well as in bulk quantities for research purposes .</p>

<p>D-Xylose-5-phosphate disodium salt is a Custom synthesis that has been fluorinated, methylated, and modified with a click reaction. D-Xylose-5-phosphate disodium salt is also an oligosaccharide and polysaccharide. The CAS No. for this compound is 1083083-57-1.</p>

<p>Lactobionic acid is produced by oxidation of lactose. It is widely used in the food and in pharmaceutical field, due to its excellent biocompatibility, biodegradability, nontoxicity, chelating, amphiphilic and antioxidant properties.  Lactobionic acid is produced as a white solid powder, freely soluble in water and slightly soluble in anhydrous ethanol and methanol.</p>

Sorbitol hexaacetate is a low-energy compound that has a hydroxyl group and a phenolic acid. It is used as an intermediate in the production of detergents, surfactants, and other industrial chemicals. In addition to this, sorbitol hexaacetate can be used as a radiation shield and an effective dose for radiation therapy. Sorbitol hexaacetate is also used as an ingredient in lipolytic enzymes. It has been shown to inhibit the activity of lipolytic enzymes by forming hydrogen bonds with the enzyme active site. Magnetic resonance spectroscopy studies have revealed that sorbitol hexaacetate has a cavity that can be filled with water molecules, which may explain its ability to act as an optical polarizer.

<p>3-O-Benzyl-4,6-O-benzylidene-a-D-glucopyranose is a custom synthesis of a complex carbohydrate. This product has CAS No. and can be found under Polysaccharide in the listing of Modified saccharides. It is modified by Methylation, Glycosylation, Click modification and Carbohydrate. The product is synthesized using Fluorination and Synthetic methods. It is high purity, with a purity level of 99%.</p>

<p>Produced from high maltose syrup by treatment with transglucosidase</p>

<p>Glycyl-chitobiose is an oligosaccharide that can be synthesized from glycerol and chitobiose. This product is often used as a building block for the synthesis of complex carbohydrate molecules. The purity of Glycyl-chitobiose is greater than 98% and it has been modified with fluorine, methyl, and click chemistry. The CAS number for this product is 627-14-1.</p>

<p>1,6-b-Galactotriose is a glycosylation product of 1,6-galactose. It is a complex carbohydrate that is found in nature and can be used for modification of saccharides, sugar, oligosaccharides, or other monosaccharides. The product is also used as a building block for the synthesis of custom polysaccharides. It can be fluorinated or methylated and click modified to produce a desired saccharide structure.</p>

<p>Drug carrier for cancer therapy &amp; imaging, biocompatible, soluble, biodegradable</p>

<p>N-Acetyl-D-lactosamine heptaacetate is a synthetically produced, fluorinated monosaccharide that is used in the production of glycosylations and polysaccharides. N-Acetyl-D-lactosamine heptaacetate can be custom synthesized to meet your needs. This compound is a high purity product.</p>

Ethyl 2,3-O-isopropylidene-a-L-thiorhamnopyranoside (Ip) is a glycosylation inhibitor that inhibits the formation of an alpha-(1,2)-link between glucose and mannose in the glycosylation of the pentasaccharide. The maximum tolerated dosages of Ip have been determined in HL-60 cells. Trichloroacetimidate is used as a substitute for Ip in these experiments because it can be dissolved in water and has a high therapeutic index. Convergent synthesis of Ip was achieved by reacting pentasaccharides with trichloroacetimidate to produce pentasaccharides with substituted mannose residues at position two and three.

1,2,4,6-Tetra-O-acetyl-3-deoxy-D-galactose (1,2,4,6TDA) is a custom synthesis that is a complex carbohydrate. It has been modified with methylation and glycosylation. 1,2,4,6TDA is an oligosaccharide with a molecular weight of 498.06 Da and a CAS number of 90193-74-8. This product is high purity and can be fluorinated. This product can also be synthesized using the click modification reaction.

<p>1,2,6-Tri-O-acetyl-3,4-di-O-benzyl-a-D-mannopyranose is a synthetic sugar that has been modified with three acetates and benzyl groups. It is used in the synthesis of glycosides and oligosaccharides. 1,2,6-Tri-O-acetyl-3,4-di-O-benzyl-a-D-mannopyranose is also an important building block for the synthesis of complex carbohydrates.</p>

Man-3a N-Glycan is a N-linked oligosaccharide with a trimannosyl core

<p>Phenyl 4,6-O-benzylidene-2-deoxy-2-N-(2,2,2-trichloroethyl)-b-D-thioglucopyranoside is an oligosaccharide that has been synthesized by the glycosylation of a benzylidene glycosylamine with a sugar. It is a custom synthesis which has been fluorinated and methylated. This compound is an important intermediate in the synthesis of complex carbohydrates. Phenyl 4,6-O-benzylidene-2-deoxy-2-N-(2,2,2 trichloroethyl)-b -D thioglucopyranoside is not toxic and has a high purity.</p>

Please enquire for more information about Benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>5-Fluoropyrimidin-2-One beta-Ribofuranoside is a subunit of the enzyme cytidine deaminase. It interacts with a substrate binding site, which is located at the active site of cytidine deaminase. This molecule has been shown to stabilize the enzyme and increase its rate of reaction with the substrate. 5-Fluoropyrimidin-2-One beta-Ribofuranoside can also bind with a water molecule, which may be important for enzymatic activity.<br>5-Fluoropyrimidin-2-One beta-Ribofuranoside is homologous to other molecules that are involved in DNA synthesis, such as adenosine monophosphate (AMP), ribose, and uracil.</p>

<p>An anticonvulsant drug</p>

(2R,3S,4R)-4-C-((2R,3S)-N-Benzyl-3-tert.butylsilyloxy-2-azetidinyl)-3-O-tert.butyldimethylsilyl-2,3,4-trihydroxybutanoic acid is a methylated and fluorinated oligosaccharide with a high purity. It is a complex carbohydrate that can be modified to include saccharides and monosaccharides. This product is synthesized using Click chemistry and has been shown to have antiallergic activities.

Ethyl 6-azido-6-deoxy-a-D-thiomannopyranoside is a custom synthesis of a complex carbohydrate that is used in the modification of saccharides and glycosylations. It can be modified with methylation, fluorination, or click chemistry to create new derivatives. The chemical name for this product is Ethyl 6-azido-6-deoxymannopyranoside. This product has CAS Number 141459-18-4 and molecular weight of 308.86 g/mol. It is available in high purity with 98% yield.

<p>Lewis B tetrasaccharide (LBT) is a glycosylated oligosaccharide that is found in the outer membrane of human pathogens, such as Helicobacter pylori. LBT has been shown to inhibit the growth of cancer cells and may be used as a potential therapeutic agent for cancer treatment. It has also been shown to have structural features similar to those found in inflammatory bowel disease patients, suggesting that it may play a role in regulating bowel inflammation. LBT is recognized by monoclonal antibodies and can be used to detect H. pylori in biological samples. Lewis B tetrasaccharide binds with methyl glycosides on human erythrocytes, which inhibits the polymerase chain reaction (PCR). This inhibition leads to reduced DNA synthesis and a decrease in bacterial replication, making it an effective antimicrobial agent.</p>

<p>Galactosyl-Tn-antigen is an antigen that is found in the urine of patients with bladder cancer. It is a glycoprotein that has been shown to be present in the urine of patients with bladder cancer and not in the urine of healthy individuals. Galactosyl-Tn-antigen was detected using a monoclonal antibody against an epitope on the Tn antigen and can be used for diagnosis of bladder cancer. The level of galactosyl-Tn-antigen in the serum varies with age and glomerular filtration rate, suggesting that it may be involved in renal function. Galactosyl-Tn-antigen has also been shown to have a role in cell adhesion and skin reactions, as well as autoimmune diseases such as cancer.</p>

Mannose with an aliphatic 3 carbon amine linker.

<p>Lactitol is a polyol that is used as a sweetener and has the potential to cause diarrhea. It belongs to the group of sugar alcohols, which are not completely digested by humans. Lactitol is produced from lactose, which is derived from milk. The main clinical relevance of lactitol is its high intestinal permeability, low caloric value, and ability to lower blood glucose levels in diabetics. Lactitol undergoes microbial metabolism through the action of certain bacteria in the colon and can be found in products such as probiotics and food supplements. It has been shown to have beneficial effects on chronic viral hepatitis and may be used for treatment of bacterial translocation. Lactitol also inhibits pge2 production in mice with colitis, leading to decreased inflammatory responses in their small intestines and colon. This inhibition may also lead to suppression of tumor growth or promotion of apoptosis in colorectal cancer cells by inhibiting protein synthesis and cell division.br&gt;</p>

<p>(2R, 3S, 4S) -3-Fluoro-4-(fluoromethyl)-1-(phenylmethyl)-2-azetidinecarboxylic acid methyl ester is a synthetic compound that is used in the preparation of modified saccharides and oligosaccharides. These compounds are used in the synthesis of complex carbohydrates. This product also has fluoroquinolone resistance and has been shown to be an inhibitor of RNA polymerase II transcription and DNA topoisomerase I.</p>

Dapagliflozin is an oral antidiabetic drug that acts by inhibiting the SGLT2 enzyme. The SGLT2 enzyme is responsible for reabsorbing glucose from the kidney, so by inhibiting this enzyme, glucose will be excreted in the urine and blood glucose levels will decrease. Dapagliflozin also has a low bioavailability in vivo, which can be improved by administration with food. This drug has been shown to have a longer elimination half-life than canagliflozin and empagliflozin. Dapagliflozin has been shown to have a higher potency than metformin hydrochloride in vitro.

<p>(2S,3R)-3,4-Bis-benzoyloxy-4-azidomethyl-pyrrolidin-2-one is a custom synthesis product. It is a fluorinated pyrrolidinone that has been modified with an azide group. This product can be used as an intermediate in the synthesis of glycoconjugates and saccharides. It can also be used to modify other molecules such as proteins, polymers, and oligosaccharides.<br>(2S,3R)-3,4-Bis-benzoyloxy-4-azidomethyl-pyrrolidin-2-one is a white solid that is insoluble in water. This compound has a molecular weight of 216.26 g/mol and a molecular formula of C11H14N6O5. The CAS number for this compound is 538113–92–1.</p>

Used to treat duodenal ulcers, GERD, stress ulcers; acid buffer; cytoprotective

<p>Diethylgalactarate is a polymer that is solid at room temperature. It has a yield value of 10%. Diethylgalactarate is soluble in organic solvents, but insoluble in water. This polymer has been shown to have good thermal stability and microstructure when used as a monomer with other polymers. Diethylgalactarate has also been shown to have high permeability, which makes it an ideal candidate for use in drug delivery systems.</p>

Gycosaminoglycan in many organs; joint lubricant and shock absorber

Ethyl 6-azido-2,4-di-O-benzoyl-3-O-benzyl-6-deoxy-a-D-thiomannopyranoside is a custom synthesis of a highly purified compound that has been modified to include fluorination. It is an oligosaccharide with a complex carbohydrate structure and high purity. The modification includes Click chemistry and the monosaccharides are sugar, which may be useful for pharmaceutical or biomedical applications.