Prodotti naturali e sostanze fitochimiche per origine botanica

<p>Applications Cyanidin 3-O-Rutinoside retards absorption of carbohydrates by inhibition of α-glucosidase which may be useful as a potential inhibitor for prevention and treatment of diabetes mellitus.<br>References Raptis, S., et al.: Exp Clin Endocrinol Diabetes 2001, 109, S265,,Ceriello, A; Diabetes 2005, 54, 1,,Chiasson, J; Endocr Pract 2006, 12, 25,,,Misra, A; J Clin Endocrinol Metab 2008, 93, S9<br></p>

<p>Applications A hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been shown to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent studies show that it may also have antioxidant and anticancer activities.<br>References Lian, Q. et al.: Zhongcaoyao, 27, 347 (1996); He, W. et al.: Zhong. Yao. Tong., 25, 668 (2009); Prasad, K.N. et al.: Food Chem., 118, 62 (2009);<br></p>

<p>Applications 4-O-β-D-Glucosyl-5-O-methyllvisamminol is a novel epigenetic suppressor of histone H3 phosphorylation. Potent anti-inflammatory and anti-carcinogenic agent.<br>References Kang, J. et al.: Bioorg. Med. Chem. Lett., 24, 4763 (2014); Kong, X. et al.: J. Ethnopharm., 148, 842 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Morusin is an inhibitor of human cervical cancer stem cell growth, attenuating NF-kB activity, and initiating apoptosis.<br>References Wang, L. et al.: Mol. Cell. Biochem., 379, 7 (2013);<br></p>

<p>Applications Limetol, is the cyclized derivative of linalool (L465950), melanol, and other unsaturated alcohols, that was shown to give a product mixture that can be used in fragrance and perfumery industry.<br>References Klimánková, E., et al.: Food Chem., 107, 464 (2008); Nakamura, A., et al.: J. Agric. Food Chem., 57, 5480 (2009); Soni, A. et al.: Synth. Comm., 40, 74 (2010);<br></p>

<p>Applications Squalene 2,3:22,23-Dioxide is formed from the epoxidation of 2,3-oxidosqualene, by squalene epoxidase. Squalene 2,3:22,23-Dioxide is accumulated intracellularly during the inhibition of cholesterol biosynthesis in Chinese hamster ovary cells.<br>References Bai, M.: et al: Biochem. Biophys. Res. Commun., 185, 323 (1992); Chang, T. et al.: J. Biol. Chem., 254, 11258 (1979)<br></p>

<p>Applications Lanosterol is a sterol cholesterol precursor that maintains a stable concentration in the cortex of rats during aging however concentrations of Lanosterol increases in the liver during aging. Lanosterol is found in Mushroom Inonotus obliquus (I.obliquus) which is known to have anti-inflammatory and anticancer properties.<br>References Smiljanic, K., et. al.: Lipids, 48, 1069 (2013); Ma, L., et. al.: Food Chem., 139, 503 (2013)<br></p>

<p>Applications Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent.<br>References Bhadra, K. et al.: Med. Res. Rev., 31, 821 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.<br>References Song, L., et. al.: Brain Res., 1564, 52 (2014)<br></p>

<p>Applications Withanolide A, is a neuritogenic steroid. It may act as deterrent for feeding insect larva and other herbivores. Withaferin A, causes activation of Notch2 and Notch4 in human breast cancer cells, and thus used as novel anticancer agents.<br>References Liffert, R., et al.: Chemical Science, 4, 2851 (2013); Lee. J., et al.: Breast Cancer, Res. treat., 136, 45 (2012);<br></p>

<p>Applications Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.<br>References Wonh, J.H. et al.: Planta Med., 76, 251 (2010); Kwon, M.C. et al.: J. Biotechnol., 157, 100 (2012); Loiseau, A. et al.: Cosm. Toil., 115, 63 (2000);<br></p>

<p>Applications 2-(Hydroxymethyl)butanoic Acid was used as a substrate to study the activity of 2-methyl-3hydroxybutyryl-CoA dehydrogenase deficiency in patients and carriers.<br>References Garcia-Villoria., J., et al.: Clin. Biochem., 42, 27 (2009);<br></p>

<p>Stability Air Sensitive<br>Applications Levopimaric Acid is a major component of pine oleoresin. It is an abietane-type of diterpene resin acid and has antibacterial, cardiovascular, and antioxidant properties.<br>References Kersten, P. J., et al.: J. Chem. Ecol., 32(12), 2679-85 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications Stachydrine Chloride is a constituent of the Chinese herb leonurus heterophyllus sweet. its used in clinics to support blood circulation and dispel blood stasis.<br>References Yin, J. et al.: Am. J. Chin. Med., 38, 157 (2010); Servillo, L. et al.: J. Cell. Biochem., 114, 2522 (2013);<br></p>

<p>Applications JHSB3 is an acyclic sesquiterpenoid that regulates many aspects of insect physiology. Juvenile Hormone regulate development, reproduction, diapause, and polyphenisms.<br>References Kotaki, T., et al.: Org. Let., 11, 5234 (2009); Riddiford, L.: Adv. Insect Physiol., 24, 213 (1994); Wyatt, G., Davey, K.: Adv. Insect Physiol., 26, 1 (1996); Nijhout, H.: Insect Hormones (Princeton Univ. Press, Princeton) (1994)<br></p>

<p>Applications A potent novel activators of large-conductance Ca2+-activated K+ channel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Imaizumei, Y. et al.: Mol. Pharmacol., 62, 836 (2002); Chang, S. et al.: AM. J. Physiol., 298, F1416 (2010);<br></p>

<p>Applications 4-(4-Hydroxybutyl)benzoic Acid Methyl Ester is a benzoic acid derivative used in the preparation of yrrolo[2,3-d]pyrimidine-based antitumor agents as well as other biologically active compounds.<br>References Barnett, C.J. et al.: Org. Proc. Res. Dev., 3, 184 (1999); Zhao, D. et al.: Zhong. Yao. Huax. Zaz., 18, 445 (2008);<br></p>

<p>Applications Sinapine, is an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800).It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer’s disease (AD).<br>References Tzagoloff, A., et al.: plant Physiology, 38, 202 (1963); Karvela, E., et al.: Food Chem., 110, 263 (2008),<br></p>

<p>Applications Spinosin is a C-glycoside flavonoid extracted from Zizhiphi Spinozae, improved pentobarbital-induced sleep.<br>References Wang, Li. et al.: Pharm. Biochem. Behav., 90, 399 (2008);<br></p>

<p>5-delta-Hydroxybutylhydantoin is a specialized chemical compound, classified within the category of hydantoins. Derived synthetically, it is designed to interact at a molecular level, offering unique properties through its hydroxy functionality, which can participate in hydrogen bonding and alter physical properties in complex systems.</p>

<p>Rotenone is an insecticide and piscicide, which is derived from the roots of several plant species, specifically those belonging to the genera *Derris* and *Lonchocarpus*. It functions by inhibiting the electron transport chain in mitochondria, specifically targeting complex I (NADH:ubiquinone oxidoreductase). This disruption of cellular respiration halts ATP production, which ultimately leads to cell death.</p>

<p>Jaceosidin is a flavonoid compound, which is derived from various plant species, notably those belonging to the genus Artemisia. This naturally occurring product is known for its diverse pharmacological effects, primarily due to its polyphenolic structure, which allows it to scavenge free radicals and modulate cell signaling pathways. The mode of action of jaceosidin involves inhibition of pro-inflammatory cytokine production and modulation of key signaling pathways such as NF-κB and MAPK. Additionally, it exhibits cytoprotective effects by enhancing the activity of antioxidant enzymes.</p>

<p>Please enquire for more information about [(1aR, 2S, 2aR, 6aS, 7aR) - Decahydro- 1a, 2a, 6, 6- tetramethyl- 7- oxonaphth[2, 3- b] oxiren- 2- yl] -hexadecanoic acid methyl est er including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-(+)-Cystathionine is a naturally occurring amino acid derivative, which is an intermediate in the metabolic pathway of homocysteine to cysteine. It is primarily found in various metabolic processes within the human body and other organisms, indicating its endogenous origin.</p>

<p>Dimerization product of the toxin protoanemonin; antispasmodic properties</p>

<p>Dehydrocavidine is an alkaloid compound, which is a naturally occurring organic molecule isolated from the root of the Corydalis plant, particularly found in Corydalis turtschaninovii and related species. Its mode of action primarily involves a variety of pharmacological pathways, including modulation of neurotransmitter systems and inhibition of specific enzyme activities. Dehydrocavidine has shown significant activity in influencing central nervous system processes, as well as exhibiting anti-inflammatory and anti-cancer properties.</p>

<p>Ascorbigen is a bioactive compound, which is a naturally occurring glucosinolate breakdown product found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. It is formed through the enzymatic interaction of vitamin C and glucobrassicin during food processing or digestion. Ascorbigen’s mode of action involves its potential to modulate biochemical pathways related to antioxidative stress and cellular detoxification. This compound is believed to influence the expression of various detoxifying and antioxidant enzymes, contributing to its beneficial effects on cellular health.</p>

<p>Dehydromillettone is a naturally occurring rotenoid, which is a type of isoflavonoid compound. It is primarily sourced from the roots or stems of plants within the legume family, specifically from Millettia species. The mode of action of dehydromillettone involves its interaction with neurotransmitter pathways, where it exhibits inhibitory effects on certain neurotransmitter receptors, leading to potential neuromodulatory outcomes.</p>

<p>Krabbe disease marker</p>

<p>Falcarindiol is a naturally occurring polyacetylene, which is predominantly found in several species of the Apiaceae family, including carrots and related plants. As a secondary metabolite, it is primarily extracted from these plant sources where it serves as a natural defense compound against pathogens.</p>

<p>2,4,6-Trihydroxy-3',4'-methylenedioxydesoxybenzoin is a naturally occurring benzoin derivative, typically found in certain plant species. This compound is primarily derived from plants known for their rich phenolic content, such as Rhododendron species and other related taxa. Its molecular structure is characterized by multiple hydroxyl groups and a methylenedioxy bridge, contributing to its biochemical activity.</p>

<p>Calystegine B3 is a potent glycosidase inhibitor, which is a naturally occurring alkaloid isolated primarily from certain plant species within the Solanaceae family. As an iminosugar, it mimics the structure of monosaccharides, allowing it to interfere effectively with glycosidase enzymes. This mode of action involves binding to the active sites of glycosidases, competitively inhibiting the cleavage of glycosidic bonds in carbohydrates.</p>

<p>Thevetoside is a pharmaceutical dosage form of the cardiac glycoside ouabain. It is an inhibitor of fatty acid synthesis and hydrolysis in the liver, which may contribute to its anti-inflammatory properties. Thevetoside has also been shown to bind to protocatechuic acid and inflammatory diseases. This drug has been found to have biological properties that inhibit the growth of cancer cells, including cervical cancer and cancers of the heart and other organs. Thevetoside binds with high affinity to cell membranes, which may be due to its ability to inhibit potassium channels.</p>

<p>Oleoside dimethylester is a natural compound derived from oleuropein, a prominent secoiridoid glycoside found in olive leaves and other parts of the olive tree. This compound is a result of the biotransformation processes that occur in the complex metabolism of oleuropein. It is characterized by its potential bioactive properties, which are of interest for various scientific research endeavors.</p>

<p>Melicopicene is a bioactive compound, specifically a natural substance, which is derived from the secretions or metabolic processes of honeybees. This compound exhibits potent antimicrobial properties, acting primarily by disrupting microbial cell walls and interfering with essential enzymatic processes within pathogenic microorganisms. Its mode of action is characterized by the ability to inhibit the growth and proliferation of various bacterial and fungal species effectively.</p>

<p>Dimethylmatairesinol is a naturally occurring lignan derivative, which is predominantly sourced from plant materials such as the bark and heartwood of trees. It serves as a precursor to enterolignans, which are phytoestrogens. These compounds are metabolized by gut microbiota into enterodiol and enterolactone, exerting estrogen-like activity in the human body.</p>