Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8901 prodotti di "Derivati delle Purine e Pirimidine"
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Glycylglycyl-L-tyrosine
CAS:<p>Applications Fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.<br>References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),<br></p>Formula:C13H17N3O5Colore e forma:NeatPeso molecolare:295.2912Pemetrexed L-Glutamic Acid Trisodium Salt (~90%)
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Pemetrexed L-Glutamic acid is an impurity of Pemetrexed (P219500). Pemetrexed impurity D.<br></p>Formula:C25H25N6O9·3NaPurezza:~90%Colore e forma:NeatPeso molecolare:622.47Diethyl p-Toluenesulfonyloxymethylphosphonate
CAS:Prodotto controllato<p>Applications Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formula:C12H19O6PSColore e forma:NeatPeso molecolare:322.31Tetrabenazine
CAS:Prodotto controllato<p>Applications Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formula:C19H27NO3Colore e forma:NeatPeso molecolare:317.424-[2-(4-Chlorobutylidene)hydrazinyl]-N-methylbenzenemethanesulfonamide
CAS:Prodotto controllato<p>Stability Hygroscopic, Temperature Sensitive<br>Applications 4-[2-(4-Chlorobutylidene)hydrazinyl]-N-methylbenzenemethanesulfonamide is an intermediate in the synthesis of 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide (Didesmethyl Sumatriptan) (Sumatriptan EP Impurity E) (A609165), which is an antimigraine agent. A Sumatriptan intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C12H18ClN3O2SColore e forma:NeatPeso molecolare:303.81N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid
CAS:Prodotto controllato<p>Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).<br>References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);<br></p>Formula:C20H21N5O6Colore e forma:NeatPeso molecolare:427.41cis (2,3)-Dihydro Tetrabenazine
CAS:Prodotto controllato<p>Applications A metabolite of Tetrabenazine in vivo, which is likely the active pharmacological agent. The cis isomer of Dihydrotetrabenazine is used for the treatment of hyperkinetic movement disorders.<br>References Kilbourn, M., et al.: Eur. J. Pharmacol., 278, 249 (1995), Perera, R., et al.: J. Med. Chem., 46, 2599 (2003), Mager, D., et al.: J. Pharm. Sci., 94, 2475 (2005), Zheng, G., et al.: Bioorg. Med. Chem., 16, 5018 (2006),<br></p>Formula:C19H29NO3Colore e forma:NeatPeso molecolare:319.44D-Alanine Isopropyl Ester Hydrochloride
CAS:Prodotto controllato<p>Applications D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners.<br>References Sofia, M. et al.: J. Med. Chem., 53, 7202 (2010); Mazur, R. et al.: J. Med. Chem., 16, 1284 (1973);<br></p>Formula:C6H14ClNO2Purezza:~90%Colore e forma:NeatPeso molecolare:167.633-Descyano Febuxostat Ethyl Ester
CAS:Prodotto controllato<p>Applications 3-Descyano Febuxostat Ethyl Ester is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C17H21NO3SColore e forma:NeatPeso molecolare:319.42rac-Clopidogrel Carboxylic Acid Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications rac-Clopidogrel Carboxylic Acid Hydrochloride is a salt metabolite of rac-Clopidogrel.<br></p>Formula:C15H15Cl2NO2SColore e forma:NeatPeso molecolare:344.26Almotriptan-d6 Hydrochloride
CAS:Prodotto controllato<p>Applications: Labelled Almotriptan (A575200). Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>Formula:C172H6H19N3O2S·ClHColore e forma:NeatPeso molecolare:377.96(+)-9-deMe-DTBZ
CAS:<p>Applications (+)-9-deMe-DTBZ is a desmethyl derivative of Tetrabenzine (T284000), a dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formula:C18H27NO3Colore e forma:NeatPeso molecolare:305.41Thiamine Thiocarbamate
CAS:Prodotto controllato<p>Applications Thiamine (T344185) impurity.<br></p>Formula:C14H20N4O3S2Colore e forma:NeatPeso molecolare:356.462-Hydroxy-N-(pyridin-4-yl)butanamide
CAS:Prodotto controllato<p>Applications 2-Hydroxy-N-(pyridin-4-yl)butanamide is a useful synthetic intermediate.<br></p>Formula:C9H12N2O2Colore e forma:NeatPeso molecolare:180.2Pemetrexed Disodium Heptahydrate
CAS:Prodotto controllato<p>Applications Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Formula:C20H19N5O6·2Na·7H2OColore e forma:NeatPeso molecolare:597.48Diethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)
CAS:Prodotto controllato<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral. Tenofovir (T018500) impurity.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C20H33N6O9PColore e forma:NeatPeso molecolare:532.484-Hydroxy-1,3-benzenedicarbonitrile
CAS:Prodotto controllato<p>Applications 4-Hydroxy-1,3-benzenedicarbonitrile is used in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout.<br>References Smith, C.J., et al.: Bioorg. Med. Chem. Lett., 20, 346 (2010); Cramp. S., et al.: BIoorg. Med. Chem. Lett., 20, 2516 (2010); Sato, T., et al.: Bioorg. Med. Chem. Lett., 19, 184 (2009);<br></p>Formula:C8H4N2OColore e forma:NeatPeso molecolare:144.13Hydroxy Urea-15N
CAS:Prodotto controllato<p>Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>Formula:CH415NNO2Colore e forma:NeatPeso molecolare:77.052-Oxo Clopidogrel-13C,d3 Hydrochloride(Mixture of Diastereomers)
CAS:Prodotto controllatoFormula:C1513CH14D3Cl2NO3SColore e forma:NeatPeso molecolare:378.29Methotrexate Hexaglutamate Trifluoroacetate
CAS:<p>Stability Hygroscopic<br>Applications Methotrexate Hexaglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C45H57N13O20·x(C2HF3O2)Colore e forma:Yellow SolidPeso molecolare:1214.03
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