H-Phe-Arg-βNA · 2 HCl
- H-Phe-Arg-.beta.NA . 2 HCl
- Phe-Arg Beta-Naphthylamide Dihydrochloride
Substrate for dipeptidyl aminopeptidase I (cathepsin C). A broad-spectrum efflux pump inhibitor in gram-negative bacteria. PAbN has been evaluated as an adjunct to antibiotics, as efflux in bacteria mediates antibiotic resistance. Vecchione et al. demonstrated that Phe-Arg-b-naphthylamide could potentiate drug activity also against a gram-positive bacterium. PAbN permeabilizes the outer membrane of gram-negative bacteria (Lamers et al.).
Technical inquiry about: 01-4000885 H-Phe-Arg-βNA · 2 HCl
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